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P11597

- CETP_HUMAN

UniProt

P11597 - CETP_HUMAN

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Protein

Cholesteryl ester transfer protein

Gene

CETP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.

GO - Molecular functioni

  1. cholesterol binding Source: BHF-UCL
  2. cholesterol transporter activity Source: BHF-UCL
  3. lipid binding Source: BHF-UCL
  4. lipid transporter activity Source: BHF-UCL
  5. phosphatidylcholine binding Source: BHF-UCL
  6. phospholipid transporter activity Source: BHF-UCL
  7. triglyceride binding Source: BHF-UCL

GO - Biological processi

  1. cholesterol homeostasis Source: BHF-UCL
  2. cholesterol metabolic process Source: BHF-UCL
  3. cholesterol transport Source: BHF-UCL
  4. high-density lipoprotein particle remodeling Source: BHF-UCL
  5. lipid homeostasis Source: BHF-UCL
  6. lipid transport Source: BHF-UCL
  7. lipoprotein metabolic process Source: Reactome
  8. low-density lipoprotein particle remodeling Source: BHF-UCL
  9. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  10. phosphatidylcholine metabolic process Source: BHF-UCL
  11. phospholipid homeostasis Source: BHF-UCL
  12. phospholipid transport Source: BHF-UCL
  13. receptor-mediated endocytosis Source: Reactome
  14. regulation of cholesterol efflux Source: BHF-UCL
  15. reverse cholesterol transport Source: BHF-UCL
  16. small molecule metabolic process Source: Reactome
  17. triglyceride homeostasis Source: BHF-UCL
  18. triglyceride metabolic process Source: BHF-UCL
  19. very-low-density lipoprotein particle remodeling Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiREACT_13621. HDL-mediated lipid transport.
REACT_6934. LDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesteryl ester transfer protein
Alternative name(s):
Lipid transfer protein I
Gene namesi
Name:CETP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:1869. CETP.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: BHF-UCL
  3. extracellular vesicular exosome Source: UniProtKB
  4. high-density lipoprotein particle Source: BHF-UCL
  5. vesicle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.3 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti168 – 1681L → P in HALP1; reduced secretion into plasma. 1 Publication
VAR_033099
Natural varianti299 – 2991R → C in HALP1; reduced secretion into plasma. 1 Publication
VAR_033100
Natural varianti459 – 4591D → G in HALP1. 1 Publication
Corresponds to variant rs2303790 [ dbSNP | Ensembl ].
VAR_004172

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi155 – 1551T → Y: Reduces triglyceride transfer and cholesteryl ester transfer 5-fold. 1 Publication
Mutagenesisi215 – 2151V → W: Reduces triglyceride transfer 10-fold. No effect on cholesteryl ester transfer. 1 Publication
Mutagenesisi218 – 2181R → S: Reduces triglyceride transfer 10-fold. Slight reduction of cholesteryl ester transfer. 1 Publication
Mutagenesisi247 – 2471S → A: Reduces triglyceride transfer 5-fold. Slight reduction of cholesteryl ester transfer. 1 Publication
Mutagenesisi282 – 2821F → R: Not secreted. 1 Publication
Mutagenesisi287 – 2871F → R: Not secreted. 1 Publication
Mutagenesisi309 – 3091F → D: Not secreted. 1 Publication
Mutagenesisi313 – 3131L → Q: Reduces cholesteryl ester transfer by 60%. 1 Publication
Mutagenesisi392 – 3921Y → S: Not secreted. 1 Publication
Mutagenesisi399 – 3991L → W: Not secreted. 1 Publication
Mutagenesisi433 – 4331V → R: Reduces activity by 60%. 1 Publication

Keywords - Diseasei

Atherosclerosis, Disease mutation

Organism-specific databases

MIMi143470. phenotype.
Orphaneti79506. Cholesterol-ester transfer protein deficiency.
PharmGKBiPA108.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Add
BLAST
Chaini18 – 493476Cholesteryl ester transfer proteinPRO_0000017155Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...) (complex)1 Publication
Disulfide bondi160 ↔ 2011 Publication
Glycosylationi257 – 2571N-linked (GlcNAc...)1 Publication
Glycosylationi358 – 3581N-linked (GlcNAc...)1 Publication
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP11597.
PeptideAtlasiP11597.
PRIDEiP11597.

PTM databases

PhosphoSiteiP11597.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiP11597.
CleanExiHS_CETP.
ExpressionAtlasiP11597. baseline and differential.
GenevestigatoriP11597.

Interactioni

Protein-protein interaction databases

BioGridi107498. 2 interactions.
IntActiP11597. 3 interactions.
STRINGi9606.ENSP00000200676.

Structurei

Secondary structure

1
493
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 337
Helixi34 – 407
Helixi41 – 433
Helixi44 – 5411
Beta strandi60 – 667
Turni67 – 693
Beta strandi70 – 9425
Turni95 – 973
Beta strandi98 – 12023
Helixi122 – 1243
Beta strandi128 – 14922
Beta strandi152 – 17120
Helixi172 – 1743
Helixi180 – 1878
Helixi189 – 22234
Beta strandi228 – 2314
Beta strandi234 – 2363
Beta strandi242 – 2498
Beta strandi252 – 2554
Helixi269 – 2713
Beta strandi274 – 28310
Helixi284 – 29613
Beta strandi300 – 3045
Helixi306 – 31510
Helixi323 – 3253
Helixi326 – 3294
Helixi333 – 3353
Beta strandi337 – 3448
Beta strandi347 – 3515
Beta strandi354 – 36714
Helixi372 – 3743
Beta strandi378 – 39316
Beta strandi396 – 41621
Helixi420 – 43213
Helixi434 – 45118
Turni452 – 4543
Helixi455 – 4573
Beta strandi458 – 46811
Beta strandi471 – 4799
Helixi482 – 4909

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OBDX-ray2.10A18-493[»]
4EWSX-ray2.59A18-493[»]
4F2AX-ray3.11A18-493[»]
ProteinModelPortaliP11597.
SMRiP11597. Positions 22-493.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11597.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG252260.
GeneTreeiENSGT00390000008226.
HOGENOMiHOG000111553.
HOVERGENiHBG005310.
InParanoidiP11597.
KOiK16835.
OMAiPGWLKQL.
OrthoDBiEOG783MV4.
PhylomeDBiP11597.
TreeFamiTF333484.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR017130. Cholesteryl_ester_transfer.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504:SF12. PTHR10504:SF12. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF037185. Cholesteryl_ester_transf. 1 hit.
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P11597-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLAATVLTLA LLGNAHACSK GTSHEAGIVC RITKPALLVL NHETAKVIQT
60 70 80 90 100
AFQRASYPDI TGEKAMMLLG QVKYGLHNIQ ISHLSIASSQ VELVEAKSID
110 120 130 140 150
VSIQNVSVVF KGTLKYGYTT AWWLGIDQSI DFEIDSAIDL QINTQLTCDS
160 170 180 190 200
GRVRTDAPDC YLSFHKLLLH LQGEREPGWI KQLFTNFISF TLKLVLKGQI
210 220 230 240 250
CKEINVISNI MADFVQTRAA SILSDGDIGV DISLTGDPVI TASYLESHHK
260 270 280 290 300
GHFIYKNVSE DLPLPTFSPT LLGDSRMLYF WFSERVFHSL AKVAFQDGRL
310 320 330 340 350
MLSLMGDEFK AVLETWGFNT NQEIFQEVVG GFPSQAQVTV HCLKMPKISC
360 370 380 390 400
QNKGVVVNSS VMVKFLFPRP DQQHSVAYTF EEDIVTTVQA SYSKKKLFLS
410 420 430 440 450
LLDFQITPKT VSNLTESSSE SVQSFLQSMI TAVGIPEVMS RLEVVFTALM
460 470 480 490
NSKGVSLFDI INPEIITRDG FLLLQMDFGF PEHLLVDFLQ SLS
Length:493
Mass (Da):54,756
Last modified:July 19, 2005 - v2
Checksum:iCD7762766A9B062E
GO
Isoform 2 (identifier: P11597-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-310: Missing.

Show »
Length:433
Mass (Da):47,787
Checksum:iED675FD1456F78F7
GO

Polymorphismi

Genetic variations in CETP define the high density lipoprotein cholesterol level quantitative trait locus 10 (HDLCQ10) [MIMi:143470].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151A → G.1 Publication
Corresponds to variant rs34065661 [ dbSNP | Ensembl ].
VAR_017018
Natural varianti154 – 1541R → W.
Corresponds to variant rs34716057 [ dbSNP | Ensembl ].
VAR_033098
Natural varianti168 – 1681L → P in HALP1; reduced secretion into plasma. 1 Publication
VAR_033099
Natural varianti299 – 2991R → C in HALP1; reduced secretion into plasma. 1 Publication
VAR_033100
Natural varianti331 – 3311G → S.1 Publication
Corresponds to variant rs5881 [ dbSNP | Ensembl ].
VAR_013919
Natural varianti385 – 3851V → M.1 Publication
Corresponds to variant rs34855278 [ dbSNP | Ensembl ].
VAR_017019
Natural varianti390 – 3901A → P.2 Publications
Corresponds to variant rs5880 [ dbSNP | Ensembl ].
VAR_013920
Natural varianti422 – 4221V → I.6 Publications
Corresponds to variant rs5882 [ dbSNP | Ensembl ].
VAR_013921
Natural varianti455 – 4551V → M.
Corresponds to variant rs2228667 [ dbSNP | Ensembl ].
VAR_031127
Natural varianti459 – 4591D → G in HALP1. 1 Publication
Corresponds to variant rs2303790 [ dbSNP | Ensembl ].
VAR_004172
Natural varianti468 – 4681R → Q.1 Publication
Corresponds to variant rs1800777 [ dbSNP | Ensembl ].
VAR_013922
Natural varianti486 – 4861V → M.1 Publication
Corresponds to variant rs5887 [ dbSNP | Ensembl ].
VAR_013923

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei251 – 31060Missing in isoform 2. 1 PublicationVSP_023645Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30185 mRNA. Translation: AAA51977.1.
M32998
, M32992, M32993, M32994, M32995, M32996, M32997 Genomic DNA. Translation: AAA51978.1.
AY422211 Genomic DNA. Translation: AAR03500.1.
BC025739 mRNA. Translation: AAH25739.1.
U71187 Genomic DNA. Translation: AAD14876.1.
AF027656 Genomic DNA. Translation: AAB86604.1.
M83573 mRNA. Translation: AAB59388.1.
CCDSiCCDS10772.1. [P11597-1]
CCDS67032.1. [P11597-2]
PIRiA26941.
RefSeqiNP_000069.2. NM_000078.2. [P11597-1]
UniGeneiHs.89538.

Genome annotation databases

EnsembliENST00000200676; ENSP00000200676; ENSG00000087237. [P11597-1]
ENST00000379780; ENSP00000369106; ENSG00000087237. [P11597-2]
GeneIDi1071.
KEGGihsa:1071.
UCSCiuc002eki.2. human. [P11597-1]
uc002ekj.2. human. [P11597-2]

Polymorphism databases

DMDMi71153497.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Cholesterylester transfer protein entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30185 mRNA. Translation: AAA51977.1 .
M32998
, M32992 , M32993 , M32994 , M32995 , M32996 , M32997 Genomic DNA. Translation: AAA51978.1 .
AY422211 Genomic DNA. Translation: AAR03500.1 .
BC025739 mRNA. Translation: AAH25739.1 .
U71187 Genomic DNA. Translation: AAD14876.1 .
AF027656 Genomic DNA. Translation: AAB86604.1 .
M83573 mRNA. Translation: AAB59388.1 .
CCDSi CCDS10772.1. [P11597-1 ]
CCDS67032.1. [P11597-2 ]
PIRi A26941.
RefSeqi NP_000069.2. NM_000078.2. [P11597-1 ]
UniGenei Hs.89538.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2OBD X-ray 2.10 A 18-493 [» ]
4EWS X-ray 2.59 A 18-493 [» ]
4F2A X-ray 3.11 A 18-493 [» ]
ProteinModelPortali P11597.
SMRi P11597. Positions 22-493.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107498. 2 interactions.
IntActi P11597. 3 interactions.
STRINGi 9606.ENSP00000200676.

Chemistry

BindingDBi P11597.
ChEMBLi CHEMBL3572.

PTM databases

PhosphoSitei P11597.

Polymorphism databases

DMDMi 71153497.

Proteomic databases

PaxDbi P11597.
PeptideAtlasi P11597.
PRIDEi P11597.

Protocols and materials databases

DNASUi 1071.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000200676 ; ENSP00000200676 ; ENSG00000087237 . [P11597-1 ]
ENST00000379780 ; ENSP00000369106 ; ENSG00000087237 . [P11597-2 ]
GeneIDi 1071.
KEGGi hsa:1071.
UCSCi uc002eki.2. human. [P11597-1 ]
uc002ekj.2. human. [P11597-2 ]

Organism-specific databases

CTDi 1071.
GeneCardsi GC16P056996.
HGNCi HGNC:1869. CETP.
MIMi 118470. gene.
143470. phenotype.
neXtProti NX_P11597.
Orphaneti 79506. Cholesterol-ester transfer protein deficiency.
PharmGKBi PA108.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG252260.
GeneTreei ENSGT00390000008226.
HOGENOMi HOG000111553.
HOVERGENi HBG005310.
InParanoidi P11597.
KOi K16835.
OMAi PGWLKQL.
OrthoDBi EOG783MV4.
PhylomeDBi P11597.
TreeFami TF333484.

Enzyme and pathway databases

Reactomei REACT_13621. HDL-mediated lipid transport.
REACT_6934. LDL-mediated lipid transport.

Miscellaneous databases

EvolutionaryTracei P11597.
GeneWikii Cholesterylester_transfer_protein.
GenomeRNAii 1071.
NextBioi 4472.
PROi P11597.
SOURCEi Search...

Gene expression databases

Bgeei P11597.
CleanExi HS_CETP.
ExpressionAtlasi P11597. baseline and differential.
Genevestigatori P11597.

Family and domain databases

InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR017130. Cholesteryl_ester_transfer.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view ]
PANTHERi PTHR10504:SF12. PTHR10504:SF12. 1 hit.
Pfami PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF037185. Cholesteryl_ester_transf. 1 hit.
SMARTi SM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view ]
SUPFAMi SSF55394. SSF55394. 2 hits.
PROSITEi PS00400. LBP_BPI_CETP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of human cholesteryl ester transfer protein cDNA."
    Drayna D., Jarnagin A.S., McLean J., Henzel W., Kohr W., Fielding C., Lawn R.
    Nature 327:632-634(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, VARIANT ILE-422.
  2. "Organization of the human cholesteryl ester transfer protein gene."
    Agellon L.B., Quinet E.M., Gillette T.G., Drayna D.T., Brown M.L., Tall A.R.
    Biochemistry 29:1372-1376(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Rieder M.J., da Ponte S.H., Kuldanek S.A., Rajkumar N., Smith J.D., Toth E.J., Nickerson D.A.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-422.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-422.
    Tissue: Pancreas and Spleen.
  5. "Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5'-distal sequences. Cis-acting sequences mapped in transgenic mice."
    Oliveira C.F.O., Chouinard R.A., Agellon L.B., Bruce C., Ma L., Walsh A., Breslow J.L., Tall A.R.
    J. Biol. Chem. 271:31831-31838(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15.
  6. "Sequencing of the cholesteryl ester transfer protein 5' regulatory region using artificial transposons."
    Williams S., Hayes L., Elsenboss L., Williams A., Andre C., Abramson R., Thompson J.F., Milos P.M.
    Gene 197:101-107(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
  7. Dinchuk J.E., Hart J.T., Wirak D.O.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-493 (ISOFORM 2), VARIANT ILE-422.
    Tissue: Liver.
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-257 AND ASN-358.
    Tissue: Plasma.
  9. Cited for: GLYCOSYLATION AT ASN-105.
  10. Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 19-493 IN COMPLEX WITH LIPID, DISULFIDE BOND, MUTAGENESIS OF THR-155; VAL-215; ARG-218; SER-247; PHE-282; PHE-287; PHE-309; LEU-313; TYR-392; LEU-399 AND VAL-433.
  11. "Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation."
    Inazu A., Brown M.L., Hesler C.B., Agellon L.B., Koizumi J., Takata K., Maruhama Y., Mabuchi H., Tall A.R.
    N. Engl. J. Med. 323:1234-1238(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN HALP1.
  12. "A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins."
    Takahashi K., Jiang X.-C., Sakai N., Yamashita S., Hirano K., Bujo H., Yamazaki H., Kusunoki J., Miura T., Kussie P., Matsuzawa Y., Saito Y., Tall A.
    J. Clin. Invest. 92:2060-2064(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HALP1 GLY-459.
  13. Cited for: VARIANTS SER-331; PRO-390; ILE-422 AND MET-486.
  14. "Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader assay."
    Nagano M., Yamashita S., Hirano K., Ito M., Maruyama T., Ishihara M., Sagehashi Y., Oka T., Kujiraoka T., Hattori H., Nakajima N., Egashira T., Kondo M., Sakai N., Matsuzawa Y.
    J. Lipid Res. 43:1011-1018(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HALP1 PRO-168 AND CYS-299, CHARACTERIZATION OF VARIANTS HALP1 PRO-168 AND CYS-299.
  15. "Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."
    Morabia A., Cayanis E., Costanza M.C., Ross B.M., Flaherty M.S., Alvin G.B., Das K., Gilliam T.C.
    Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GLY-15; MET-385; PRO-390; ILE-422 AND GLN-468.

Entry informationi

Entry nameiCETP_HUMAN
AccessioniPrimary (citable) accession number: P11597
Secondary accession number(s): Q13987, Q13988, Q53YZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3