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P11597

- CETP_HUMAN

UniProt

P11597 - CETP_HUMAN

Protein

Cholesteryl ester transfer protein

Gene

CETP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.

    GO - Molecular functioni

    1. cholesterol binding Source: BHF-UCL
    2. cholesterol transporter activity Source: BHF-UCL
    3. lipid binding Source: BHF-UCL
    4. lipid transporter activity Source: BHF-UCL
    5. phosphatidylcholine binding Source: BHF-UCL
    6. phospholipid transporter activity Source: BHF-UCL
    7. triglyceride binding Source: BHF-UCL

    GO - Biological processi

    1. cholesterol homeostasis Source: BHF-UCL
    2. cholesterol metabolic process Source: BHF-UCL
    3. cholesterol transport Source: BHF-UCL
    4. high-density lipoprotein particle remodeling Source: BHF-UCL
    5. lipid homeostasis Source: BHF-UCL
    6. lipid transport Source: BHF-UCL
    7. lipoprotein metabolic process Source: Reactome
    8. low-density lipoprotein particle remodeling Source: BHF-UCL
    9. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
    10. phosphatidylcholine metabolic process Source: BHF-UCL
    11. phospholipid homeostasis Source: BHF-UCL
    12. phospholipid transport Source: BHF-UCL
    13. receptor-mediated endocytosis Source: Reactome
    14. regulation of cholesterol efflux Source: BHF-UCL
    15. reverse cholesterol transport Source: BHF-UCL
    16. small molecule metabolic process Source: Reactome
    17. triglyceride homeostasis Source: BHF-UCL
    18. triglyceride metabolic process Source: BHF-UCL
    19. very-low-density lipoprotein particle remodeling Source: BHF-UCL

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

    Enzyme and pathway databases

    ReactomeiREACT_13621. HDL-mediated lipid transport.
    REACT_6934. LDL-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholesteryl ester transfer protein
    Alternative name(s):
    Lipid transfer protein I
    Gene namesi
    Name:CETP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:1869. CETP.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: BHF-UCL
    3. extracellular vesicular exosome Source: UniProt
    4. high-density lipoprotein particle Source: BHF-UCL
    5. vesicle Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti168 – 1681L → P in HALP1; reduced secretion into plasma. 1 Publication
    VAR_033099
    Natural varianti299 – 2991R → C in HALP1; reduced secretion into plasma. 1 Publication
    VAR_033100
    Natural varianti459 – 4591D → G in HALP1. 1 Publication
    Corresponds to variant rs2303790 [ dbSNP | Ensembl ].
    VAR_004172

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi155 – 1551T → Y: Reduces triglyceride transfer and cholesteryl ester transfer 5-fold. 1 Publication
    Mutagenesisi215 – 2151V → W: Reduces triglyceride transfer 10-fold. No effect on cholesteryl ester transfer. 1 Publication
    Mutagenesisi218 – 2181R → S: Reduces triglyceride transfer 10-fold. Slight reduction of cholesteryl ester transfer. 1 Publication
    Mutagenesisi247 – 2471S → A: Reduces triglyceride transfer 5-fold. Slight reduction of cholesteryl ester transfer. 1 Publication
    Mutagenesisi282 – 2821F → R: Not secreted. 1 Publication
    Mutagenesisi287 – 2871F → R: Not secreted. 1 Publication
    Mutagenesisi309 – 3091F → D: Not secreted. 1 Publication
    Mutagenesisi313 – 3131L → Q: Reduces cholesteryl ester transfer by 60%. 1 Publication
    Mutagenesisi392 – 3921Y → S: Not secreted. 1 Publication
    Mutagenesisi399 – 3991L → W: Not secreted. 1 Publication
    Mutagenesisi433 – 4331V → R: Reduces activity by 60%. 1 Publication

    Keywords - Diseasei

    Atherosclerosis, Disease mutation

    Organism-specific databases

    MIMi143470. phenotype.
    Orphaneti79506. Cholesterol-ester transfer protein deficiency.
    PharmGKBiPA108.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Add
    BLAST
    Chaini18 – 493476Cholesteryl ester transfer proteinPRO_0000017155Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi105 – 1051N-linked (GlcNAc...) (complex)1 Publication
    Disulfide bondi160 ↔ 2011 Publication
    Glycosylationi257 – 2571N-linked (GlcNAc...)1 Publication
    Glycosylationi358 – 3581N-linked (GlcNAc...)1 Publication
    Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP11597.
    PeptideAtlasiP11597.
    PRIDEiP11597.

    PTM databases

    PhosphoSiteiP11597.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.

    Gene expression databases

    ArrayExpressiP11597.
    BgeeiP11597.
    CleanExiHS_CETP.
    GenevestigatoriP11597.

    Interactioni

    Protein-protein interaction databases

    BioGridi107498. 2 interactions.
    IntActiP11597. 3 interactions.
    STRINGi9606.ENSP00000200676.

    Structurei

    Secondary structure

    1
    493
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 337
    Helixi34 – 407
    Helixi41 – 433
    Helixi44 – 5411
    Beta strandi60 – 667
    Turni67 – 693
    Beta strandi70 – 9425
    Turni95 – 973
    Beta strandi98 – 12023
    Helixi122 – 1243
    Beta strandi128 – 14922
    Beta strandi152 – 17120
    Helixi172 – 1743
    Helixi180 – 1878
    Helixi189 – 22234
    Beta strandi228 – 2314
    Beta strandi234 – 2363
    Beta strandi242 – 2498
    Beta strandi252 – 2554
    Helixi269 – 2713
    Beta strandi274 – 28310
    Helixi284 – 29613
    Beta strandi300 – 3045
    Helixi306 – 31510
    Helixi323 – 3253
    Helixi326 – 3294
    Helixi333 – 3353
    Beta strandi337 – 3448
    Beta strandi347 – 3515
    Beta strandi354 – 36714
    Helixi372 – 3743
    Beta strandi378 – 39316
    Beta strandi396 – 41621
    Helixi420 – 43213
    Helixi434 – 45118
    Turni452 – 4543
    Helixi455 – 4573
    Beta strandi458 – 46811
    Beta strandi471 – 4799
    Helixi482 – 4909

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2OBDX-ray2.10A18-493[»]
    4EWSX-ray2.59A18-493[»]
    4F2AX-ray3.11A18-493[»]
    ProteinModelPortaliP11597.
    SMRiP11597. Positions 22-493.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11597.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG252260.
    HOGENOMiHOG000111553.
    HOVERGENiHBG005310.
    InParanoidiP11597.
    KOiK16835.
    OMAiPGWLKQL.
    OrthoDBiEOG783MV4.
    PhylomeDBiP11597.
    TreeFamiTF333484.

    Family and domain databases

    InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR017130. Cholesteryl_ester_transfer.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017954. Lipid-bd_serum_glycop_CS.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view]
    PANTHERiPTHR10504:SF12. PTHR10504:SF12. 1 hit.
    PfamiPF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037185. Cholesteryl_ester_transf. 1 hit.
    SMARTiSM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55394. SSF55394. 2 hits.
    PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P11597-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLAATVLTLA LLGNAHACSK GTSHEAGIVC RITKPALLVL NHETAKVIQT    50
    AFQRASYPDI TGEKAMMLLG QVKYGLHNIQ ISHLSIASSQ VELVEAKSID 100
    VSIQNVSVVF KGTLKYGYTT AWWLGIDQSI DFEIDSAIDL QINTQLTCDS 150
    GRVRTDAPDC YLSFHKLLLH LQGEREPGWI KQLFTNFISF TLKLVLKGQI 200
    CKEINVISNI MADFVQTRAA SILSDGDIGV DISLTGDPVI TASYLESHHK 250
    GHFIYKNVSE DLPLPTFSPT LLGDSRMLYF WFSERVFHSL AKVAFQDGRL 300
    MLSLMGDEFK AVLETWGFNT NQEIFQEVVG GFPSQAQVTV HCLKMPKISC 350
    QNKGVVVNSS VMVKFLFPRP DQQHSVAYTF EEDIVTTVQA SYSKKKLFLS 400
    LLDFQITPKT VSNLTESSSE SVQSFLQSMI TAVGIPEVMS RLEVVFTALM 450
    NSKGVSLFDI INPEIITRDG FLLLQMDFGF PEHLLVDFLQ SLS 493
    Length:493
    Mass (Da):54,756
    Last modified:July 19, 2005 - v2
    Checksum:iCD7762766A9B062E
    GO
    Isoform 2 (identifier: P11597-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         251-310: Missing.

    Show »
    Length:433
    Mass (Da):47,787
    Checksum:iED675FD1456F78F7
    GO

    Polymorphismi

    Genetic variations in CETP define the high density lipoprotein cholesterol level quantitative trait locus 10 (HDLCQ10) [MIMi:143470].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151A → G.1 Publication
    Corresponds to variant rs34065661 [ dbSNP | Ensembl ].
    VAR_017018
    Natural varianti154 – 1541R → W.
    Corresponds to variant rs34716057 [ dbSNP | Ensembl ].
    VAR_033098
    Natural varianti168 – 1681L → P in HALP1; reduced secretion into plasma. 1 Publication
    VAR_033099
    Natural varianti299 – 2991R → C in HALP1; reduced secretion into plasma. 1 Publication
    VAR_033100
    Natural varianti331 – 3311G → S.1 Publication
    Corresponds to variant rs5881 [ dbSNP | Ensembl ].
    VAR_013919
    Natural varianti385 – 3851V → M.1 Publication
    Corresponds to variant rs34855278 [ dbSNP | Ensembl ].
    VAR_017019
    Natural varianti390 – 3901A → P.2 Publications
    Corresponds to variant rs5880 [ dbSNP | Ensembl ].
    VAR_013920
    Natural varianti422 – 4221V → I.6 Publications
    Corresponds to variant rs5882 [ dbSNP | Ensembl ].
    VAR_013921
    Natural varianti455 – 4551V → M.
    Corresponds to variant rs2228667 [ dbSNP | Ensembl ].
    VAR_031127
    Natural varianti459 – 4591D → G in HALP1. 1 Publication
    Corresponds to variant rs2303790 [ dbSNP | Ensembl ].
    VAR_004172
    Natural varianti468 – 4681R → Q.1 Publication
    Corresponds to variant rs1800777 [ dbSNP | Ensembl ].
    VAR_013922
    Natural varianti486 – 4861V → M.1 Publication
    Corresponds to variant rs5887 [ dbSNP | Ensembl ].
    VAR_013923

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei251 – 31060Missing in isoform 2. 1 PublicationVSP_023645Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30185 mRNA. Translation: AAA51977.1.
    M32998
    , M32992, M32993, M32994, M32995, M32996, M32997 Genomic DNA. Translation: AAA51978.1.
    AY422211 Genomic DNA. Translation: AAR03500.1.
    BC025739 mRNA. Translation: AAH25739.1.
    U71187 Genomic DNA. Translation: AAD14876.1.
    AF027656 Genomic DNA. Translation: AAB86604.1.
    M83573 mRNA. Translation: AAB59388.1.
    CCDSiCCDS10772.1. [P11597-1]
    CCDS67032.1. [P11597-2]
    PIRiA26941.
    RefSeqiNP_000069.2. NM_000078.2. [P11597-1]
    UniGeneiHs.89538.

    Genome annotation databases

    EnsembliENST00000200676; ENSP00000200676; ENSG00000087237. [P11597-1]
    ENST00000379780; ENSP00000369106; ENSG00000087237. [P11597-2]
    GeneIDi1071.
    KEGGihsa:1071.
    UCSCiuc002eki.2. human. [P11597-1]
    uc002ekj.2. human. [P11597-2]

    Polymorphism databases

    DMDMi71153497.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Wikipedia

    Cholesterylester transfer protein entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30185 mRNA. Translation: AAA51977.1 .
    M32998
    , M32992 , M32993 , M32994 , M32995 , M32996 , M32997 Genomic DNA. Translation: AAA51978.1 .
    AY422211 Genomic DNA. Translation: AAR03500.1 .
    BC025739 mRNA. Translation: AAH25739.1 .
    U71187 Genomic DNA. Translation: AAD14876.1 .
    AF027656 Genomic DNA. Translation: AAB86604.1 .
    M83573 mRNA. Translation: AAB59388.1 .
    CCDSi CCDS10772.1. [P11597-1 ]
    CCDS67032.1. [P11597-2 ]
    PIRi A26941.
    RefSeqi NP_000069.2. NM_000078.2. [P11597-1 ]
    UniGenei Hs.89538.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2OBD X-ray 2.10 A 18-493 [» ]
    4EWS X-ray 2.59 A 18-493 [» ]
    4F2A X-ray 3.11 A 18-493 [» ]
    ProteinModelPortali P11597.
    SMRi P11597. Positions 22-493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107498. 2 interactions.
    IntActi P11597. 3 interactions.
    STRINGi 9606.ENSP00000200676.

    Chemistry

    BindingDBi P11597.
    ChEMBLi CHEMBL3572.

    PTM databases

    PhosphoSitei P11597.

    Polymorphism databases

    DMDMi 71153497.

    Proteomic databases

    PaxDbi P11597.
    PeptideAtlasi P11597.
    PRIDEi P11597.

    Protocols and materials databases

    DNASUi 1071.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000200676 ; ENSP00000200676 ; ENSG00000087237 . [P11597-1 ]
    ENST00000379780 ; ENSP00000369106 ; ENSG00000087237 . [P11597-2 ]
    GeneIDi 1071.
    KEGGi hsa:1071.
    UCSCi uc002eki.2. human. [P11597-1 ]
    uc002ekj.2. human. [P11597-2 ]

    Organism-specific databases

    CTDi 1071.
    GeneCardsi GC16P056996.
    HGNCi HGNC:1869. CETP.
    MIMi 118470. gene.
    143470. phenotype.
    neXtProti NX_P11597.
    Orphaneti 79506. Cholesterol-ester transfer protein deficiency.
    PharmGKBi PA108.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252260.
    HOGENOMi HOG000111553.
    HOVERGENi HBG005310.
    InParanoidi P11597.
    KOi K16835.
    OMAi PGWLKQL.
    OrthoDBi EOG783MV4.
    PhylomeDBi P11597.
    TreeFami TF333484.

    Enzyme and pathway databases

    Reactomei REACT_13621. HDL-mediated lipid transport.
    REACT_6934. LDL-mediated lipid transport.

    Miscellaneous databases

    EvolutionaryTracei P11597.
    GeneWikii Cholesterylester_transfer_protein.
    GenomeRNAii 1071.
    NextBioi 4472.
    PROi P11597.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11597.
    Bgeei P11597.
    CleanExi HS_CETP.
    Genevestigatori P11597.

    Family and domain databases

    InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR017130. Cholesteryl_ester_transfer.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017954. Lipid-bd_serum_glycop_CS.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view ]
    PANTHERi PTHR10504:SF12. PTHR10504:SF12. 1 hit.
    Pfami PF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037185. Cholesteryl_ester_transf. 1 hit.
    SMARTi SM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55394. SSF55394. 2 hits.
    PROSITEi PS00400. LBP_BPI_CETP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of human cholesteryl ester transfer protein cDNA."
      Drayna D., Jarnagin A.S., McLean J., Henzel W., Kohr W., Fielding C., Lawn R.
      Nature 327:632-634(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, VARIANT ILE-422.
    2. "Organization of the human cholesteryl ester transfer protein gene."
      Agellon L.B., Quinet E.M., Gillette T.G., Drayna D.T., Brown M.L., Tall A.R.
      Biochemistry 29:1372-1376(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Rieder M.J., da Ponte S.H., Kuldanek S.A., Rajkumar N., Smith J.D., Toth E.J., Nickerson D.A.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-422.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-422.
      Tissue: Pancreas and Spleen.
    5. "Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5'-distal sequences. Cis-acting sequences mapped in transgenic mice."
      Oliveira C.F.O., Chouinard R.A., Agellon L.B., Bruce C., Ma L., Walsh A., Breslow J.L., Tall A.R.
      J. Biol. Chem. 271:31831-31838(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15.
    6. "Sequencing of the cholesteryl ester transfer protein 5' regulatory region using artificial transposons."
      Williams S., Hayes L., Elsenboss L., Williams A., Andre C., Abramson R., Thompson J.F., Milos P.M.
      Gene 197:101-107(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
    7. Dinchuk J.E., Hart J.T., Wirak D.O.
      Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-493 (ISOFORM 2), VARIANT ILE-422.
      Tissue: Liver.
    8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-257 AND ASN-358.
      Tissue: Plasma.
    9. Cited for: GLYCOSYLATION AT ASN-105.
    10. Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 19-493 IN COMPLEX WITH LIPID, DISULFIDE BOND, MUTAGENESIS OF THR-155; VAL-215; ARG-218; SER-247; PHE-282; PHE-287; PHE-309; LEU-313; TYR-392; LEU-399 AND VAL-433.
    11. "Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation."
      Inazu A., Brown M.L., Hesler C.B., Agellon L.B., Koizumi J., Takata K., Maruhama Y., Mabuchi H., Tall A.R.
      N. Engl. J. Med. 323:1234-1238(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN HALP1.
    12. "A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins."
      Takahashi K., Jiang X.-C., Sakai N., Yamashita S., Hirano K., Bujo H., Yamazaki H., Kusunoki J., Miura T., Kussie P., Matsuzawa Y., Saito Y., Tall A.
      J. Clin. Invest. 92:2060-2064(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HALP1 GLY-459.
    13. Cited for: VARIANTS SER-331; PRO-390; ILE-422 AND MET-486.
    14. "Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader assay."
      Nagano M., Yamashita S., Hirano K., Ito M., Maruyama T., Ishihara M., Sagehashi Y., Oka T., Kujiraoka T., Hattori H., Nakajima N., Egashira T., Kondo M., Sakai N., Matsuzawa Y.
      J. Lipid Res. 43:1011-1018(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HALP1 PRO-168 AND CYS-299, CHARACTERIZATION OF VARIANTS HALP1 PRO-168 AND CYS-299.
    15. "Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."
      Morabia A., Cayanis E., Costanza M.C., Ross B.M., Flaherty M.S., Alvin G.B., Das K., Gilliam T.C.
      Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS GLY-15; MET-385; PRO-390; ILE-422 AND GLN-468.

    Entry informationi

    Entry nameiCETP_HUMAN
    AccessioniPrimary (citable) accession number: P11597
    Secondary accession number(s): Q13987, Q13988, Q53YZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 154 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3