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Protein

Major urinary protein 2

Gene

Mup2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandPheromone-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major urinary protein 2
Short name:
MUP 2
Gene namesi
Name:Mup2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97234 Mup2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei478 Mus m 1
8430 Mus m 1.0102

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001792819 – 180Major urinary protein 2Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 175By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP11589
PaxDbiP11589
PeptideAtlasiP11589
PRIDEiP11589

2D gel databases

SWISS-2DPAGEP11589

PTM databases

iPTMnetiP11589
PhosphoSitePlusiP11589
SwissPalmiP11589

Expressioni

Tissue specificityi

Abundant in the urine of adult male mice but absent from that of females.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 25Combined sources3
Helixi30 – 33Combined sources4
Beta strandi38 – 46Combined sources9
Helixi47 – 50Combined sources4
Beta strandi59 – 65Combined sources7
Beta strandi67 – 78Combined sources12
Beta strandi81 – 91Combined sources11
Turni94 – 96Combined sources3
Beta strandi98 – 113Combined sources16
Beta strandi115 – 127Combined sources13
Beta strandi130 – 142Combined sources13
Helixi146 – 158Combined sources13
Helixi163 – 165Combined sources3
Beta strandi166 – 168Combined sources3
Turni170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DF3NMR-A19-180[»]
1JV4X-ray1.75A19-180[»]
1ZNDX-ray1.60A19-180[»]
1ZNEX-ray2.00A19-180[»]
1ZNGX-ray1.60A19-180[»]
1ZNHX-ray2.10A19-180[»]
1ZNKX-ray1.60A19-180[»]
1ZNLX-ray1.70A19-180[»]
2DM5X-ray1.70A19-180[»]
2NNDX-ray1.60A19-180[»]
2NNEX-ray1.60A19-180[»]
2OZQX-ray1.80A19-180[»]
ProteinModelPortaliP11589
SMRiP11589
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11589

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5XW Eukaryota
ENOG411154J LUCA
HOGENOMiHOG000231458
HOVERGENiHBG000215
InParanoidiP11589

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002971 Maj_urinary
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01221 MAJORURINARY
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMLLLLCLG LTLVCVHAEE ASSTGRNFNV EKINGEWHTI ILASDKREKI
60 70 80 90 100
EDNGNFRLFL EQIHVLEKSL VLKFHTVRDE ECSELSMVAD KTEKAGEYSV
110 120 130 140 150
TYDGFNTFTI PKTDYDNFLM AHLINEKDGE TFQLMGLYGR EPDLSSDIKE
160 170 180
RFAKLCEEHG ILRENIIDLS NANRCLQARE
Length:180
Mass (Da):20,664
Last modified:October 1, 1989 - v1
Checksum:i477F5971ACAB622A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154K → Q in CAC34259 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16356 mRNA Translation: AAA39768.1
AJ309921 mRNA Translation: CAC34259.1
BC012259 mRNA Translation: AAH12259.1
BC059097 mRNA Translation: AAH59097.1
UniGeneiMm.335875
Mm.457980
Mm.457982
Mm.482557

Similar proteinsi

Entry informationi

Entry nameiMUP2_MOUSE
AccessioniPrimary (citable) accession number: P11589
Secondary accession number(s): Q99JF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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