Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Major urinary protein 2

Gene

Mup2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Pheromone-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major urinary protein 2
Short name:
MUP 2
Gene namesi
Name:Mup2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97234. Mup2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei478. Mus m 1.
8430. Mus m 1.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001792819 – 180Major urinary protein 2Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 175By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP11589.
PaxDbiP11589.
PeptideAtlasiP11589.
PRIDEiP11589.

2D gel databases

SWISS-2DPAGEP11589.

PTM databases

iPTMnetiP11589.
PhosphoSitePlusiP11589.

Expressioni

Tissue specificityi

Abundant in the urine of adult male mice but absent from that of females.

Interactioni

Protein-protein interaction databases

MINTiMINT-1864997.
STRINGi10090.ENSMUSP00000095655.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 25Combined sources3
Helixi30 – 33Combined sources4
Beta strandi38 – 46Combined sources9
Helixi47 – 50Combined sources4
Beta strandi59 – 65Combined sources7
Beta strandi67 – 78Combined sources12
Beta strandi81 – 91Combined sources11
Turni94 – 96Combined sources3
Beta strandi98 – 113Combined sources16
Beta strandi115 – 127Combined sources13
Beta strandi130 – 142Combined sources13
Helixi146 – 158Combined sources13
Helixi163 – 165Combined sources3
Beta strandi166 – 168Combined sources3
Turni170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DF3NMR-A19-180[»]
1JV4X-ray1.75A19-180[»]
1ZNDX-ray1.60A19-180[»]
1ZNEX-ray2.00A19-180[»]
1ZNGX-ray1.60A19-180[»]
1ZNHX-ray2.10A19-180[»]
1ZNKX-ray1.60A19-180[»]
1ZNLX-ray1.70A19-180[»]
2DM5X-ray1.70A19-180[»]
2NNDX-ray1.60A19-180[»]
2NNEX-ray1.60A19-180[»]
2OZQX-ray1.80A19-180[»]
ProteinModelPortaliP11589.
SMRiP11589.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11589.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5XW. Eukaryota.
ENOG411154J. LUCA.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiP11589.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMLLLLCLG LTLVCVHAEE ASSTGRNFNV EKINGEWHTI ILASDKREKI
60 70 80 90 100
EDNGNFRLFL EQIHVLEKSL VLKFHTVRDE ECSELSMVAD KTEKAGEYSV
110 120 130 140 150
TYDGFNTFTI PKTDYDNFLM AHLINEKDGE TFQLMGLYGR EPDLSSDIKE
160 170 180
RFAKLCEEHG ILRENIIDLS NANRCLQARE
Length:180
Mass (Da):20,664
Last modified:October 1, 1989 - v1
Checksum:i477F5971ACAB622A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154K → Q in CAC34259 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16356 mRNA. Translation: AAA39768.1.
AJ309921 mRNA. Translation: CAC34259.1.
BC012259 mRNA. Translation: AAH12259.1.
BC059097 mRNA. Translation: AAH59097.1.
UniGeneiMm.335875.
Mm.457980.
Mm.457982.
Mm.482557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16356 mRNA. Translation: AAA39768.1.
AJ309921 mRNA. Translation: CAC34259.1.
BC012259 mRNA. Translation: AAH12259.1.
BC059097 mRNA. Translation: AAH59097.1.
UniGeneiMm.335875.
Mm.457980.
Mm.457982.
Mm.482557.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DF3NMR-A19-180[»]
1JV4X-ray1.75A19-180[»]
1ZNDX-ray1.60A19-180[»]
1ZNEX-ray2.00A19-180[»]
1ZNGX-ray1.60A19-180[»]
1ZNHX-ray2.10A19-180[»]
1ZNKX-ray1.60A19-180[»]
1ZNLX-ray1.70A19-180[»]
2DM5X-ray1.70A19-180[»]
2NNDX-ray1.60A19-180[»]
2NNEX-ray1.60A19-180[»]
2OZQX-ray1.80A19-180[»]
ProteinModelPortaliP11589.
SMRiP11589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1864997.
STRINGi10090.ENSMUSP00000095655.

Protein family/group databases

Allergomei478. Mus m 1.
8430. Mus m 1.0102.

PTM databases

iPTMnetiP11589.
PhosphoSitePlusiP11589.

2D gel databases

SWISS-2DPAGEP11589.

Proteomic databases

MaxQBiP11589.
PaxDbiP11589.
PeptideAtlasiP11589.
PRIDEiP11589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97234. Mup2.

Phylogenomic databases

eggNOGiENOG410J5XW. Eukaryota.
ENOG411154J. LUCA.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiP11589.

Miscellaneous databases

EvolutionaryTraceiP11589.
PROiP11589.
SOURCEiSearch...

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUP2_MOUSE
AccessioniPrimary (citable) accession number: P11589
Secondary accession number(s): Q99JF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.