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Protein

Major urinary protein 1

Gene

Mup1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.

GO - Molecular functioni

  • insulin-activated receptor activity Source: UniProtKB
  • pheromone activity Source: MGI
  • pheromone binding Source: UniProtKB
  • small molecule binding Source: InterPro

GO - Biological processi

  • aerobic respiration Source: UniProtKB
  • cellular response to food Source: UniProtKB
  • cellular response to lipid Source: UniProtKB
  • cellular response to starvation Source: UniProtKB
  • cellular response to testosterone stimulus Source: UniProtKB
  • energy reserve metabolic process Source: UniProtKB
  • glucose homeostasis Source: UniProtKB
  • heat generation Source: UniProtKB
  • locomotor rhythm Source: UniProtKB
  • mitochondrion morphogenesis Source: UniProtKB
  • negative regulation of gluconeogenesis Source: UniProtKB
  • negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  • negative regulation of lipid biosynthetic process Source: UniProtKB
  • negative regulation of lipid storage Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of glucose metabolic process Source: UniProtKB
  • positive regulation of lipid metabolic process Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: UniProtKB
  • response to stilbenoid Source: UniProtKB

Keywordsi

Biological processTransport
LigandPheromone-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major urinary protein 1
Short name:
MUP 1
Gene namesi
Name:Mup1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97233 Mup1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei478 Mus m 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001792719 – 180Major urinary protein 1Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 175

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP11588
PRIDEiP11588

PTM databases

iPTMnetiP11588
PhosphoSitePlusiP11588
SwissPalmiP11588

Expressioni

Tissue specificityi

Abundant in the urine of adult male mice but absent from that of females.

Gene expression databases

BgeeiENSMUSG00000094793
ExpressionAtlasiP11588 baseline and differential
GenevisibleiP11588 MM

Interactioni

GO - Molecular functioni

  • pheromone activity Source: MGI

Protein-protein interaction databases

IntActiP11588, 4 interactors
MINTiP11588

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 33Combined sources4
Beta strandi38 – 46Combined sources9
Helixi47 – 50Combined sources4
Beta strandi59 – 65Combined sources7
Beta strandi67 – 78Combined sources12
Beta strandi81 – 91Combined sources11
Beta strandi98 – 113Combined sources16
Beta strandi115 – 127Combined sources13
Beta strandi130 – 142Combined sources13
Helixi146 – 157Combined sources12
Turni158 – 160Combined sources3
Helixi163 – 165Combined sources3
Beta strandi166 – 168Combined sources3
Turni170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QY0X-ray1.80A23-180[»]
1QY1X-ray1.70A19-180[»]
1QY2X-ray1.75A19-180[»]
1YP6X-ray1.80A19-180[»]
1YP7X-ray2.00A19-180[»]
2DM5X-ray1.70A20-180[»]
ProteinModelPortaliP11588
SMRiP11588
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11588

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5XW Eukaryota
ENOG411154J LUCA
GeneTreeiENSGT00530000063356
HOGENOMiHOG000231458
HOVERGENiHBG000215
InParanoidiP11588
PhylomeDBiP11588
TreeFamiTF338197

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002971 Maj_urinary
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01221 MAJORURINARY
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMLLLLCLG LTLVCVHAEE ASSTGRNFNV EKINGEWHTI ILASDKREKI
60 70 80 90 100
EDNGNFRLFL EQIHVLENSL VLKFHTVRDE ECSELSMVAD KTEKAGEYSV
110 120 130 140 150
TYDGFNTFTI PKTDYDNFLM AHLINEKDGE TFQLMGLYGR EPDLSSDIKE
160 170 180
RFAQLCEKHG ILRENIIDLS NANRCLQARE
Length:180
Mass (Da):20,648
Last modified:October 1, 1989 - v1
Checksum:i5AA429BDA0700347
GO

Sequence cautioni

The sequence AAA39764 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44S → F in AAA39764 (PubMed:2888770).Curated1
Sequence conflicti127K → N in AAA39764 (PubMed:2888770).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16355 mRNA Translation: AAA39767.1
M28649 mRNA Translation: AAA39764.1 Different initiation.
BC012221 mRNA Translation: AAH12221.1
CCDSiCCDS18231.1
RefSeqiNP_001186924.1, NM_001199995.1
UniGeneiMm.335875
Mm.422695
Mm.457982
Mm.482072
Mm.482236

Genome annotation databases

EnsembliENSMUST00000117932; ENSMUSP00000112787; ENSMUSG00000094793
GeneIDi100039054
KEGGimmu:100039054
UCSCiuc008tay.3 mouse

Similar proteinsi

Entry informationi

Entry nameiMUP1_MOUSE
AccessioniPrimary (citable) accession number: P11588
Secondary accession number(s): Q61921
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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