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Protein

Major urinary protein 1

Gene

Mup1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.

GO - Molecular functioni

  • insulin-activated receptor activity Source: UniProtKB
  • pheromone activity Source: MGI
  • pheromone binding Source: UniProtKB
  • small molecule binding Source: InterPro
  • transporter activity Source: InterPro

GO - Biological processi

  • aerobic respiration Source: UniProtKB
  • cellular response to food Source: UniProtKB
  • cellular response to lipid Source: UniProtKB
  • cellular response to starvation Source: UniProtKB
  • cellular response to testosterone stimulus Source: UniProtKB
  • energy reserve metabolic process Source: UniProtKB
  • glucose homeostasis Source: UniProtKB
  • heat generation Source: UniProtKB
  • locomotor rhythm Source: UniProtKB
  • mitochondrion morphogenesis Source: UniProtKB
  • negative regulation of gluconeogenesis Source: UniProtKB
  • negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  • negative regulation of lipid biosynthetic process Source: UniProtKB
  • negative regulation of lipid storage Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of glucose metabolic process Source: UniProtKB
  • positive regulation of lipid metabolic process Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: UniProtKB
  • response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Pheromone-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major urinary protein 1
Short name:
MUP 1
Gene namesi
Name:Mup1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97233. Mup1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular space Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei478. Mus m 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001792719 – 180Major urinary protein 1Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 175

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP11588.
PRIDEiP11588.

PTM databases

iPTMnetiP11588.
PhosphoSitePlusiP11588.

Expressioni

Tissue specificityi

Abundant in the urine of adult male mice but absent from that of females.

Gene expression databases

BgeeiENSMUSG00000094793.
ExpressionAtlasiP11588. baseline and differential.
GenevisibleiP11588. MM.

Interactioni

GO - Molecular functioni

  • pheromone activity Source: MGI

Protein-protein interaction databases

IntActiP11588. 4 interactors.
MINTiMINT-1865367.
STRINGi10090.ENSMUSP00000112787.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 33Combined sources4
Beta strandi38 – 46Combined sources9
Helixi47 – 50Combined sources4
Beta strandi59 – 65Combined sources7
Beta strandi67 – 78Combined sources12
Beta strandi81 – 91Combined sources11
Beta strandi98 – 113Combined sources16
Beta strandi115 – 127Combined sources13
Beta strandi130 – 142Combined sources13
Helixi146 – 157Combined sources12
Turni158 – 160Combined sources3
Helixi163 – 165Combined sources3
Beta strandi166 – 168Combined sources3
Turni170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QY0X-ray1.80A23-180[»]
1QY1X-ray1.70A19-180[»]
1QY2X-ray1.75A19-180[»]
1YP6X-ray1.80A19-180[»]
1YP7X-ray2.00A19-180[»]
2DM5X-ray1.70A20-180[»]
ProteinModelPortaliP11588.
SMRiP11588.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11588.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5XW. Eukaryota.
ENOG411154J. LUCA.
GeneTreeiENSGT00530000063356.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiP11588.
PhylomeDBiP11588.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMLLLLCLG LTLVCVHAEE ASSTGRNFNV EKINGEWHTI ILASDKREKI
60 70 80 90 100
EDNGNFRLFL EQIHVLENSL VLKFHTVRDE ECSELSMVAD KTEKAGEYSV
110 120 130 140 150
TYDGFNTFTI PKTDYDNFLM AHLINEKDGE TFQLMGLYGR EPDLSSDIKE
160 170 180
RFAQLCEKHG ILRENIIDLS NANRCLQARE
Length:180
Mass (Da):20,648
Last modified:October 1, 1989 - v1
Checksum:i5AA429BDA0700347
GO

Sequence cautioni

The sequence AAA39764 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44S → F in AAA39764 (PubMed:2888770).Curated1
Sequence conflicti127K → N in AAA39764 (PubMed:2888770).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16355 mRNA. Translation: AAA39767.1.
M28649 mRNA. Translation: AAA39764.1. Different initiation.
BC012221 mRNA. Translation: AAH12221.1.
CCDSiCCDS18231.1.
RefSeqiNP_001186924.1. NM_001199995.1.
UniGeneiMm.335875.
Mm.422695.
Mm.457982.
Mm.482072.
Mm.482236.

Genome annotation databases

EnsembliENSMUST00000117932; ENSMUSP00000112787; ENSMUSG00000094793.
GeneIDi100039054.
KEGGimmu:100039054.
UCSCiuc008tay.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16355 mRNA. Translation: AAA39767.1.
M28649 mRNA. Translation: AAA39764.1. Different initiation.
BC012221 mRNA. Translation: AAH12221.1.
CCDSiCCDS18231.1.
RefSeqiNP_001186924.1. NM_001199995.1.
UniGeneiMm.335875.
Mm.422695.
Mm.457982.
Mm.482072.
Mm.482236.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QY0X-ray1.80A23-180[»]
1QY1X-ray1.70A19-180[»]
1QY2X-ray1.75A19-180[»]
1YP6X-ray1.80A19-180[»]
1YP7X-ray2.00A19-180[»]
2DM5X-ray1.70A20-180[»]
ProteinModelPortaliP11588.
SMRiP11588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11588. 4 interactors.
MINTiMINT-1865367.
STRINGi10090.ENSMUSP00000112787.

Protein family/group databases

Allergomei478. Mus m 1.

PTM databases

iPTMnetiP11588.
PhosphoSitePlusiP11588.

Proteomic databases

PaxDbiP11588.
PRIDEiP11588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117932; ENSMUSP00000112787; ENSMUSG00000094793.
GeneIDi100039054.
KEGGimmu:100039054.
UCSCiuc008tay.3. mouse.

Organism-specific databases

CTDi100039054.
MGIiMGI:97233. Mup1.

Phylogenomic databases

eggNOGiENOG410J5XW. Eukaryota.
ENOG411154J. LUCA.
GeneTreeiENSGT00530000063356.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiP11588.
PhylomeDBiP11588.
TreeFamiTF338197.

Miscellaneous databases

EvolutionaryTraceiP11588.
PROiP11588.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000094793.
ExpressionAtlasiP11588. baseline and differential.
GenevisibleiP11588. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUP1_MOUSE
AccessioniPrimary (citable) accession number: P11588
Secondary accession number(s): Q61921
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.