Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin beta-PS

Gene

mys

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-PS1/beta-PS is a receptor for laminin (PubMed:7972082). Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m (PubMed:7924982, PubMed:7972082, PubMed:9660786). Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle (PubMed:15469969). Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium (PubMed:15469969). The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not (PubMed:15469969). Required for rhea/talin correct cellular localization in the midgut (PubMed:15469969). Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development) (PubMed:8119134, PubMed:7924982, PubMed:7972082, PubMed:10821184). Involved in the function and/or development of the olfactory system (PubMed:10821184). In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip (PubMed:27191715). Plays a role in timely border cell migration during oogenesis (PubMed:19035354).8 Publications

Miscellaneous

The absence of the beta-PS subunit results in detachment and rounding up of the muscles, thus the gene encoding beta-PS is called myospheroid.

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

GO - Biological processi

  • actin filament organization Source: FlyBase
  • apposition of dorsal and ventral imaginal disc-derived wing surfaces Source: FlyBase
  • axon guidance Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  • calcium-dependent cell-matrix adhesion Source: FlyBase
  • cell adhesion mediated by integrin Source: FlyBase
  • cell-matrix adhesion Source: FlyBase
  • cell migration Source: FlyBase
  • cell-substrate adhesion Source: FlyBase
  • central nervous system development Source: FlyBase
  • central nervous system morphogenesis Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • dorsal closure Source: FlyBase
  • dorsal trunk growth, open tracheal system Source: FlyBase
  • epithelial cell migration, open tracheal system Source: FlyBase
  • flight behavior Source: UniProtKB-KW
  • germ-band extension Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • hemocyte migration Source: FlyBase
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  • imaginal disc-derived male genitalia morphogenesis Source: FlyBase
  • integrin-mediated signaling pathway Source: FlyBase
  • larval heart development Source: FlyBase
  • maintenance of epithelial integrity, open tracheal system Source: FlyBase
  • midgut development Source: FlyBase
  • muscle attachment Source: FlyBase
  • muscle organ development Source: FlyBase
  • negative regulation of cell migration Source: UniProtKB
  • pericardium morphogenesis Source: FlyBase
  • positive regulation of synapse maturation Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • regulation of stress fiber assembly Source: FlyBase
  • salivary gland development Source: FlyBase
  • sarcomere organization Source: FlyBase
  • sensory perception of smell Source: FlyBase
  • substrate adhesion-dependent cell spreading Source: FlyBase
  • substrate-dependent cell migration, cell extension Source: FlyBase
  • tracheal outgrowth, open tracheal system Source: FlyBase
  • ventral cord development Source: FlyBase
  • visual perception Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, Integrin, Receptor
Biological processBehavior, Cell adhesion, Flight, Olfaction, Sensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-DME-114608 Platelet degranulation
R-DME-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-DME-1566948 Elastic fibre formation
R-DME-1566977 Fibronectin matrix formation
R-DME-202733 Cell surface interactions at the vascular wall
R-DME-210991 Basigin interactions
R-DME-2129379 Molecules associated with elastic fibres
R-DME-216083 Integrin cell surface interactions
R-DME-3000157 Laminin interactions
R-DME-3000170 Syndecan interactions
R-DME-3000178 ECM proteoglycans
R-DME-354192 Integrin alphaIIb beta3 signaling
R-DME-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-DME-372708 p130Cas linkage to MAPK signaling for integrins
R-DME-445144 Signal transduction by L1
R-DME-445355 Smooth Muscle Contraction
R-DME-446107 Type I hemidesmosome assembly
R-DME-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-DME-5674135 MAP2K and MAPK activation
R-DME-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-PS
Alternative name(s):
Position-specific antigen beta subunit
Protein myospheroid
Protein olfactory C
Gene namesi
Name:mys
Synonyms:l(1)mys, olfC
ORF Names:CG1560
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004657 mys

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 776ExtracellularSequence analysisAdd BLAST753
Transmembranei777 – 799HelicalSequence analysisAdd BLAST23
Topological domaini800 – 846CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

In zygotic mutant embryos, midgut forms primary constrictions but fails to elongate and the visceral muscle does not flatten but remains attached to the midgut epithelium. Embryos lacking maternal and zygotic mys show a delay in midgut migration. Mutant larvae present an olfactory phenotype, showing reduced response to isoamyl acetate but normal response to ethyl acetate.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi807D → A: Rescues dorsal closure defect, muscle attachment defect, disorganized ommatidial array and loss of cell layer attachment in mutants; when associated with A-817. 1 Publication1
Mutagenesisi811F → A: Rescues muscle attachment defect and loss of cell layer attachment in mutants; when associated with A-814. 1 Publication1
Mutagenesisi814F → A: Rescues muscle attachment defect and loss of cell layer attachment in mutants; when associated with A-811. 1 Publication1
Mutagenesisi817E → A: Rescues dorsal closure defect, muscle attachment defects, disorganized ommatidial array and loss of cell layer attachment in mutants; when associated with A-807. 1 Publication1
Mutagenesisi831Y → A: No effect on lethality; when associated with A-843. 1 Publication1
Mutagenesisi843Y → A: No effect on lethality; when associated with A-831. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001635624 – 846Integrin beta-PSAdd BLAST823

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 55By similarity
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 252By similarity
Glycosylationi266N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi300 ↔ 341By similarity
Glycosylationi403N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi441 ↔ 453By similarity
Disulfide bondi473 ↔ 741By similarity
Disulfide bondi503 ↔ 507By similarity
Disulfide bondi522 ↔ 533By similarity
Disulfide bondi530 ↔ 571By similarity
Disulfide bondi535 ↔ 544By similarity
Disulfide bondi546 ↔ 561By similarity
Glycosylationi557N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi584 ↔ 599By similarity
Disulfide bondi601 ↔ 606By similarity
Glycosylationi603N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi622 ↔ 627By similarity
Disulfide bondi624 ↔ 656By similarity
Disulfide bondi629 ↔ 638By similarity
Disulfide bondi640 ↔ 647By similarity
Glycosylationi644N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi662 ↔ 667By similarity
Disulfide bondi664 ↔ 715By similarity
Disulfide bondi669 ↔ 682By similarity
Disulfide bondi685 ↔ 688By similarity
Disulfide bondi692 ↔ 701By similarity
Disulfide bondi698 ↔ 771By similarity
Glycosylationi718N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi719 ↔ 749By similarity
Modified residuei831PhosphotyrosineBy similarity1
Modified residuei843PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP11584
PRIDEiP11584

PTM databases

iPTMnetiP11584

Expressioni

Tissue specificityi

In ovaries, strongly expressed in follicle cells (PubMed:19035354). In oocytes, expressed in the forming dorsal appendages (at protein level) (PubMed:19035354). Expressed in the embryonic dorsal cuticle, the larval eye and the wing imaginal disk (PubMed:8119134). In testes, detected at the interface between somatic hub cells and cyst stem cells (PubMed:27191715).3 Publications

Gene expression databases

BgeeiFBgn0004657
ExpressionAtlasiP11584 baseline and differential
GenevisibleiP11584 DM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-PS associates with either alpha-PS1, alpha-PS2, alpha-PS3, alpha-PS4 or alpha-PS5.

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi69357, 44 interactors
IntActiP11584, 1 interactor
STRINGi7227.FBpp0071061

Structurei

3D structure databases

ProteinModelPortaliP11584
SMRiP11584
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 419VWFAAdd BLAST234
Repeati507 – 560IAdd BLAST54
Repeati561 – 605IIAdd BLAST45
Repeati606 – 646IIIAdd BLAST41
Repeati647 – 687IVAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni507 – 687Cysteine-rich tandem repeatsAdd BLAST181

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi115 – 143Ser-richAdd BLAST29

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
InParanoidiP11584
KOiK05719
OrthoDBiEOG091G029W
PhylomeDBiP11584

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013111 EGF_extracell
IPR015812 Integrin_bsu
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 1 hit
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS00243 INTEGRIN_BETA, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILERNRRCQ LALLMIAILA AIAGQTDAQK AAKLTAVSTC ASKEKCHTCI
60 70 80 90 100
QTEGCAWCMQ PDFKGQSRCY QNTSSLCPEE FAYSPITVEQ ILVNNKLTNQ
110 120 130 140 150
YKAELAAGGG GSAMSGSSSS SYSSSSSSSS FYSQSSSGSS SASGYEEYSA
160 170 180 190 200
GEIVQIQPQS MRLALRVNEK HNIKISYSQA EGYPVDLYYL MDLSKSMEDD
210 220 230 240 250
KAKLSTLGDK LSETMKRITN NFHLGFGSFV DKVLMPYVST IPKKLEHPCE
260 270 280 290 300
NCKAPYGYQN HMPLNNNTES FSNEVKNATV SGNLDAPEGG FDAIMQAIAC
310 320 330 340 350
RSQIGWREQA RRLLVFSTDA GFHYAGDGKL GGVIAPNDGE CHLSPKGEYT
360 370 380 390 400
HSTLQDYPSI SQINQKVKDN AINIIFAVTA SQLSVYEKLV EHIQGSSAAK
410 420 430 440 450
LDNDSSNVVE LVKEEYRKIS SSVEMKDNAT GDVKITYFSS CLSNGPEVQT
460 470 480 490 500
SKCDNLKEGQ QVSFTAQIQL LKCPEDPRDW TQTIHISPVG INEVMQIQLT
510 520 530 540 550
MLCSCPCENP GSIGYQVQAN SCSGHGTSMC GICNCDDSYF GNKCECSATD
560 570 580 590 600
LTSKFANDTS CRADSTSTTD CSGRGHCVCG ACECHKRPNP IEIISGKHCE
610 620 630 640 650
CDNFSCERNR NQLCSGPDHG TCECGRCKCK PGWTGSNCGC QESNDTCMPP
660 670 680 690 700
GGGEICSGHG TCECGVCKCT VNDQGRFSGR HCEKCPTCSG RCQELKDCVQ
710 720 730 740 750
CQMYKTGELK NGDDCARNCT QFVPVGVEKV EIDETKDEQM CKFFDEDDCK
760 770 780 790 800
FMFKYSEQGE LHVYAQENKE CPAKVFMLGI VMGVIAAIVL VGLAILLLWK
810 820 830 840
LLTTIHDRRE FARFEKERMN AKWDTGENPI YKQATSTFKN PMYAGK
Length:846
Mass (Da):92,656
Last modified:June 20, 2003 - v3
Checksum:i3618C74FA1B99AFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18I → M in AAA28714 (PubMed:3128792).Curated1
Sequence conflicti24G → A in AAA28714 (PubMed:3128792).Curated1
Sequence conflicti27D → N in AAA28714 (PubMed:3128792).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03251 mRNA Translation: AAA28714.1
AE014298 Genomic DNA Translation: AAF46313.2
AY113499 mRNA Translation: AAM29504.1
PIRiA30889
RefSeqiNP_001284998.1, NM_001298069.1
NP_001284999.1, NM_001298070.1
NP_524793.2, NM_080054.3
UniGeneiDm.1814

Genome annotation databases

EnsemblMetazoaiFBtr0071105; FBpp0071061; FBgn0004657
FBtr0340136; FBpp0309122; FBgn0004657
FBtr0340137; FBpp0309123; FBgn0004657
GeneIDi44885
KEGGidme:Dmel_CG1560

Similar proteinsi

Entry informationi

Entry nameiITBX_DROME
AccessioniPrimary (citable) accession number: P11584
Secondary accession number(s): Q8MYX9, Q9W3L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 20, 2003
Last modified: May 23, 2018
This is version 197 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health