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Protein

Integrin beta-PS

Gene

mys

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for many embryonic (dorsal closure and somatic muscle attachments) and post-embryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development). Involved in the function and/or development of the olfactory system. Plays a role in timely border cell migration during oogenesis.7 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase
  • receptor activity Source: FlyBase

GO - Biological processi

  • actin filament organization Source: FlyBase
  • apposition of dorsal and ventral imaginal disc-derived wing surfaces Source: FlyBase
  • axon guidance Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  • calcium-dependent cell-matrix adhesion Source: FlyBase
  • cell adhesion Source: FlyBase
  • cell adhesion mediated by integrin Source: FlyBase
  • cell-matrix adhesion Source: FlyBase
  • cell migration Source: FlyBase
  • cell-substrate adhesion Source: FlyBase
  • central nervous system development Source: FlyBase
  • central nervous system morphogenesis Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • dorsal closure Source: FlyBase
  • dorsal trunk growth, open tracheal system Source: FlyBase
  • epithelial cell migration, open tracheal system Source: FlyBase
  • flight behavior Source: UniProtKB-KW
  • germ-band extension Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • hemocyte migration Source: FlyBase
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  • imaginal disc-derived male genitalia morphogenesis Source: FlyBase
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • larval heart development Source: FlyBase
  • maintenance of epithelial integrity, open tracheal system Source: FlyBase
  • midgut development Source: FlyBase
  • muscle attachment Source: FlyBase
  • muscle organ development Source: FlyBase
  • negative regulation of cell migration Source: UniProtKB
  • pericardium morphogenesis Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • regulation of stress fiber assembly Source: FlyBase
  • salivary gland development Source: FlyBase
  • sarcomere organization Source: FlyBase
  • sensory perception of smell Source: FlyBase
  • substrate adhesion-dependent cell spreading Source: FlyBase
  • substrate-dependent cell migration, cell extension Source: FlyBase
  • tracheal outgrowth, open tracheal system Source: FlyBase
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Integrin, Receptor

Keywords - Biological processi

Behavior, Cell adhesion, Flight, Olfaction, Sensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-DME-1566948. Elastic fibre formation.
R-DME-210991. Basigin interactions.
R-DME-2129379. Molecules associated with elastic fibres.
R-DME-216083. Integrin cell surface interactions.
R-DME-3000170. Syndecan interactions.
R-DME-3000178. ECM proteoglycans.
R-DME-354192. Integrin alphaIIb beta3 signaling.
R-DME-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-DME-372708. p130Cas linkage to MAPK signaling for integrins.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-445144. Signal transduction by L1.
R-DME-445355. Smooth Muscle Contraction.
R-DME-446107. Type I hemidesmosome assembly.
R-DME-446343. Localization of the PINCH-ILK-PARVIN complex to focal adhesions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-PS
Alternative name(s):
Position-specific antigen beta subunit
Protein myospheroid
Protein olfactory C
Gene namesi
Name:mys
Synonyms:l(1)mys, olfC
ORF Names:CG1560
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004657. mys.

Subcellular locationi

  • Apical cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
  • Lateral cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
  • Basal cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

  • Note: In ovary, localizes to the apical, lateral and basal membranes of follicle cells through oogenesis stage 10A. Apical membrane expression peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte but decreases in the most posterior follicle cells. Thereafter, it is down-regulated. Localization to lateral and basal membranes persists during dorsal appendage morphogenesis.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 776753ExtracellularSequence analysisAdd
BLAST
Transmembranei777 – 79923HelicalSequence analysisAdd
BLAST
Topological domaini800 – 84647CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB-SubCell
  • basal plasma membrane Source: UniProtKB
  • cell leading edge Source: FlyBase
  • costamere Source: FlyBase
  • focal adhesion Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • integrin complex Source: FlyBase
  • lateral plasma membrane Source: UniProtKB
  • muscle tendon junction Source: FlyBase
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

In zygotic mutant embryos, midgut forms primary constrictions but fails to elongate and the visceral muscle does not flatten but remains attached to the midgut epithelium. Embryos lacking maternal and zygotic mys show a delay in midgut migration. Mutant larvae present an olfatory phenotype, showing reduced response to isoamyl acetate but normal response to ethyl acetate.2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi807 – 8071D → A: Rescues dorsal closure defect, muscle attachment defect, disorganized ommatidial array and loss of cell layer attachment in mutants; when associated with A-817. 1 Publication
Mutagenesisi811 – 8111F → A: Rescues muscle attachment defect and loss of cell layer attachment in mutants; when associated with A-814. 1 Publication
Mutagenesisi814 – 8141F → A: Rescues muscle attachment defect and loss of cell layer attachment in mutants; when associated with A-811. 1 Publication
Mutagenesisi817 – 8171E → A: Rescues dorsal closure defect, muscle attachment defects, disorganized ommatidial array and loss of cell layer attachment in mutants; when associated with A-807. 1 Publication
Mutagenesisi831 – 8311Y → A: No effect on lethality; when associated with A-843. 1 Publication
Mutagenesisi843 – 8431Y → A: No effect on lethality; when associated with A-831. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 846823Integrin beta-PSPRO_0000016356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 55By similarity
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi249 ↔ 252By similarity
Glycosylationi266 – 2661N-linked (GlcNAc...)1 Publication
Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi300 ↔ 341By similarity
Glycosylationi403 – 4031N-linked (GlcNAc...)2 Publications
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi441 ↔ 453By similarity
Disulfide bondi473 ↔ 741By similarity
Disulfide bondi503 ↔ 507By similarity
Disulfide bondi522 ↔ 533By similarity
Disulfide bondi530 ↔ 571By similarity
Disulfide bondi535 ↔ 544By similarity
Disulfide bondi546 ↔ 561By similarity
Glycosylationi557 – 5571N-linked (GlcNAc...)2 Publications
Disulfide bondi584 ↔ 599By similarity
Disulfide bondi601 ↔ 606By similarity
Glycosylationi603 – 6031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi622 ↔ 627By similarity
Disulfide bondi624 ↔ 656By similarity
Disulfide bondi629 ↔ 638By similarity
Disulfide bondi640 ↔ 647By similarity
Glycosylationi644 – 6441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi662 ↔ 667By similarity
Disulfide bondi664 ↔ 715By similarity
Disulfide bondi669 ↔ 682By similarity
Disulfide bondi685 ↔ 688By similarity
Disulfide bondi692 ↔ 701By similarity
Disulfide bondi698 ↔ 771By similarity
Glycosylationi718 – 7181N-linked (GlcNAc...)2 Publications
Disulfide bondi719 ↔ 749By similarity
Modified residuei831 – 8311PhosphotyrosineBy similarity
Modified residuei843 – 8431PhosphotyrosineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP11584.
PRIDEiP11584.

Expressioni

Tissue specificityi

In ovaries, strongly expressed in follicle cells. In oocytes, expressed in the forming dorsal appendages (at protein level). Expressed in the embryonic dorsal cuticle, the larval eye and the wing imaginal disk.2 Publications

Gene expression databases

BgeeiFBgn0004657.
ExpressionAtlasiP11584. differential.
GenevisibleiP11584. DM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-PS associates with either alpha-PS1, alpha-PS2, alpha-PS3, alpha-PS4 or alpha-PS5.

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi69357. 18 interactions.
IntActiP11584. 1 interaction.
STRINGi7227.FBpp0071061.

Structurei

3D structure databases

ProteinModelPortaliP11584.
SMRiP11584. Positions 149-771, 800-832.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 419234VWFAAdd
BLAST
Repeati507 – 56054IAdd
BLAST
Repeati561 – 60545IIAdd
BLAST
Repeati606 – 64641IIIAdd
BLAST
Repeati647 – 68741IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni507 – 687181Cysteine-rich tandem repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi115 – 14329Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
InParanoidiP11584.
KOiK05719.
OMAiSSVCCVF.
OrthoDBiEOG091G029W.
PhylomeDBiP11584.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 2 hits.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILERNRRCQ LALLMIAILA AIAGQTDAQK AAKLTAVSTC ASKEKCHTCI
60 70 80 90 100
QTEGCAWCMQ PDFKGQSRCY QNTSSLCPEE FAYSPITVEQ ILVNNKLTNQ
110 120 130 140 150
YKAELAAGGG GSAMSGSSSS SYSSSSSSSS FYSQSSSGSS SASGYEEYSA
160 170 180 190 200
GEIVQIQPQS MRLALRVNEK HNIKISYSQA EGYPVDLYYL MDLSKSMEDD
210 220 230 240 250
KAKLSTLGDK LSETMKRITN NFHLGFGSFV DKVLMPYVST IPKKLEHPCE
260 270 280 290 300
NCKAPYGYQN HMPLNNNTES FSNEVKNATV SGNLDAPEGG FDAIMQAIAC
310 320 330 340 350
RSQIGWREQA RRLLVFSTDA GFHYAGDGKL GGVIAPNDGE CHLSPKGEYT
360 370 380 390 400
HSTLQDYPSI SQINQKVKDN AINIIFAVTA SQLSVYEKLV EHIQGSSAAK
410 420 430 440 450
LDNDSSNVVE LVKEEYRKIS SSVEMKDNAT GDVKITYFSS CLSNGPEVQT
460 470 480 490 500
SKCDNLKEGQ QVSFTAQIQL LKCPEDPRDW TQTIHISPVG INEVMQIQLT
510 520 530 540 550
MLCSCPCENP GSIGYQVQAN SCSGHGTSMC GICNCDDSYF GNKCECSATD
560 570 580 590 600
LTSKFANDTS CRADSTSTTD CSGRGHCVCG ACECHKRPNP IEIISGKHCE
610 620 630 640 650
CDNFSCERNR NQLCSGPDHG TCECGRCKCK PGWTGSNCGC QESNDTCMPP
660 670 680 690 700
GGGEICSGHG TCECGVCKCT VNDQGRFSGR HCEKCPTCSG RCQELKDCVQ
710 720 730 740 750
CQMYKTGELK NGDDCARNCT QFVPVGVEKV EIDETKDEQM CKFFDEDDCK
760 770 780 790 800
FMFKYSEQGE LHVYAQENKE CPAKVFMLGI VMGVIAAIVL VGLAILLLWK
810 820 830 840
LLTTIHDRRE FARFEKERMN AKWDTGENPI YKQATSTFKN PMYAGK
Length:846
Mass (Da):92,656
Last modified:June 20, 2003 - v3
Checksum:i3618C74FA1B99AFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181I → M in AAA28714 (PubMed:3128792).Curated
Sequence conflicti24 – 241G → A in AAA28714 (PubMed:3128792).Curated
Sequence conflicti27 – 271D → N in AAA28714 (PubMed:3128792).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03251 mRNA. Translation: AAA28714.1.
AE014298 Genomic DNA. Translation: AAF46313.2.
AY113499 mRNA. Translation: AAM29504.1.
PIRiA30889.
RefSeqiNP_001284998.1. NM_001298069.1.
NP_001284999.1. NM_001298070.1.
NP_524793.2. NM_080054.3.
UniGeneiDm.1814.

Genome annotation databases

EnsemblMetazoaiFBtr0071105; FBpp0071061; FBgn0004657.
FBtr0340136; FBpp0309122; FBgn0004657.
FBtr0340137; FBpp0309123; FBgn0004657.
GeneIDi44885.
KEGGidme:Dmel_CG1560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03251 mRNA. Translation: AAA28714.1.
AE014298 Genomic DNA. Translation: AAF46313.2.
AY113499 mRNA. Translation: AAM29504.1.
PIRiA30889.
RefSeqiNP_001284998.1. NM_001298069.1.
NP_001284999.1. NM_001298070.1.
NP_524793.2. NM_080054.3.
UniGeneiDm.1814.

3D structure databases

ProteinModelPortaliP11584.
SMRiP11584. Positions 149-771, 800-832.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi69357. 18 interactions.
IntActiP11584. 1 interaction.
STRINGi7227.FBpp0071061.

Proteomic databases

PaxDbiP11584.
PRIDEiP11584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071105; FBpp0071061; FBgn0004657.
FBtr0340136; FBpp0309122; FBgn0004657.
FBtr0340137; FBpp0309123; FBgn0004657.
GeneIDi44885.
KEGGidme:Dmel_CG1560.

Organism-specific databases

CTDi44885.
FlyBaseiFBgn0004657. mys.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
InParanoidiP11584.
KOiK05719.
OMAiSSVCCVF.
OrthoDBiEOG091G029W.
PhylomeDBiP11584.

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-DME-1566948. Elastic fibre formation.
R-DME-210991. Basigin interactions.
R-DME-2129379. Molecules associated with elastic fibres.
R-DME-216083. Integrin cell surface interactions.
R-DME-3000170. Syndecan interactions.
R-DME-3000178. ECM proteoglycans.
R-DME-354192. Integrin alphaIIb beta3 signaling.
R-DME-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-DME-372708. p130Cas linkage to MAPK signaling for integrins.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-445144. Signal transduction by L1.
R-DME-445355. Smooth Muscle Contraction.
R-DME-446107. Type I hemidesmosome assembly.
R-DME-446343. Localization of the PINCH-ILK-PARVIN complex to focal adhesions.

Miscellaneous databases

ChiTaRSimys. fly.
GenomeRNAii44885.
PROiP11584.

Gene expression databases

BgeeiFBgn0004657.
ExpressionAtlasiP11584. differential.
GenevisibleiP11584. DM.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 2 hits.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITBX_DROME
AccessioniPrimary (citable) accession number: P11584
Secondary accession number(s): Q8MYX9, Q9W3L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 20, 2003
Last modified: September 7, 2016
This is version 180 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

The absence of the beta-PS subunit results in detachment and rounding up of the muscles, thus the gene encoding beta-PS is called myospheroid.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.