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Protein

V-type proton ATPase subunit B1

Gene

VHA-B1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  • actin filament binding Source: TAIR
  • ATP binding Source: InterPro
  • hydrolase activity Source: UniProtKB-KW

GO - Biological processi

  • actin filament bundle assembly Source: TAIR
  • actin filament capping Source: TAIR
  • ATP hydrolysis coupled proton transport Source: InterPro
  • ATP metabolic process Source: InterPro
  • glucose mediated signaling pathway Source: TAIR
  • negative regulation of actin filament depolymerization Source: TAIR
  • regulation of transcription by RNA polymerase II Source: CAFA
  • response to cadmium ion Source: TAIR

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciARA:AT1G76030-MONOMER
ReactomeiR-ATH-1222556 ROS, RNS production in phagocytes
R-ATH-77387 Insulin receptor recycling
R-ATH-917977 Transferrin endocytosis and recycling

Protein family/group databases

MoonProtiP11574
TCDBi3.A.2.2.5 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit B1
Short name:
V-ATPase subunit B1
Alternative name(s):
V-ATPase 57 kDa subunit
Vacuolar H(+)-ATPase subunit B isoform 1
Vacuolar proton pump subunit B1
Gene namesi
Name:VHA-B1
Synonyms:AT57
Ordered Locus Names:At1g76030
ORF Names:T4O12.24
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G76030
TAIRilocus:2204430 AT1G76030

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001446392 – 486V-type proton ATPase subunit B1Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP11574
PRIDEiP11574

PTM databases

iPTMnetiP11574

Expressioni

Gene expression databases

ExpressionAtlasiP11574 baseline and differential
GenevisibleiP11574 AT

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c'', d and e).

GO - Molecular functioni

  • actin filament binding Source: TAIR

Protein-protein interaction databases

BioGridi29153, 5 interactors
IntActiP11574, 2 interactors
STRINGi3702.AT1G76030.1

Structurei

3D structure databases

ProteinModelPortaliP11574
SMRiP11574
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiKOG1351 Eukaryota
COG1156 LUCA
HOGENOMiHOG000165320
InParanoidiP11574
KOiK02147
OMAiMLIEHSE
OrthoDBiEOG093607DL
PhylomeDBiP11574

Family and domain databases

HAMAPiMF_00310 ATP_synth_B_arch, 1 hit
InterProiView protein in InterPro
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723 ATPase_V1-cplx_bsu
IPR027417 P-loop_NTPase
IPR022879 V-ATPase_su_B/beta
PANTHERiPTHR43389 PTHR43389, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039114 V-ATPsynth_beta/V-ATPase_B, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01040 V-ATPase_V1_B, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTNDLDIEE GTLEIGMEYR TVSGVAGPLV ILDKVKGPKY QEIVNIRLGD
60 70 80 90 100
GSTRRGQVLE VDGEKAVVQV FEGTSGIDNK FTTVQFTGEV LKTPVSLDML
110 120 130 140 150
GRIFNGSGKP IDNGPPILPE AYLDISGSSI NPSERTYPEE MIQTGISTID
160 170 180 190 200
VMNSIARGQK IPLFSAAGLP HNEIAAQICR QAGLVKRLEK TVDLLEDHGE
210 220 230 240 250
DNFAIVFAAM GVNMETAQFF KRDFEENGSM ERVTLFLNLA NDPTIERIIT
260 270 280 290 300
PRIALTTAEY LAYECGKHVL VILTDMSSYA DALREVSAAR EEVPGRRGYP
310 320 330 340 350
GYMYTDLATI YERAGRIEGR KGSITQIPIL TMPNDDITHP TPDLTGYITE
360 370 380 390 400
GQIYIDRQLH NRQIYPPINV LPSLSRLMKS AIGEGMTRKD HSDVSNQLYA
410 420 430 440 450
NYAIGKDVQA MKAVVGEEAL SSEDLLYLEF LDKFERKFVM QGAYDTRNIF
460 470 480
QSLDLAWTLL RIFPRELLHR IPAKTLDQFY SRDSTS
Length:486
Mass (Da):54,108
Last modified:January 10, 2003 - v2
Checksum:i0EC3B68E92CC9F0A
GO

Sequence cautioni

The sequence AAC36485 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti297R → V in CAA82390 (PubMed:8580968).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04185 mRNA Translation: AAC36485.1 Different initiation.
AC007396 Genomic DNA Translation: AAF26763.1
CP002684 Genomic DNA Translation: AEE35786.1
AY094424 mRNA Translation: AAM19797.1
AY125532 mRNA Translation: AAM78042.1
Z29126 mRNA Translation: CAA82390.1
PIRiA31886
G96788
RefSeqiNP_177729.1, NM_106251.5
UniGeneiAt.21359
At.68155

Genome annotation databases

EnsemblPlantsiAT1G76030.1; AT1G76030.1; AT1G76030
GeneIDi843934
GrameneiAT1G76030.1; AT1G76030.1; AT1G76030
KEGGiath:AT1G76030

Similar proteinsi

Entry informationi

Entry nameiVATB1_ARATH
AccessioniPrimary (citable) accession number: P11574
Secondary accession number(s): Q42205, Q8L584, Q9LQR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 10, 2003
Last modified: May 23, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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