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Protein

Methyl-coenzyme M reductase subunit gamma

Gene

mcrG

Organism
Methanococcus voltae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase subunit alpha (mcrA), Methyl-coenzyme M reductase subunit beta (mcrB), Methyl-coenzyme M reductase subunit gamma (mcrG)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMethanogenesis

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase subunit gamma (EC:2.8.4.1)
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma
Gene namesi
Name:mcrG
OrganismiMethanococcus voltae
Taxonomic identifieri2188 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001474841 – 261Methyl-coenzyme M reductase subunit gammaAdd BLAST261

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Structurei

3D structure databases

ProteinModelPortaliP11563.
SMRiP11563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04858. Archaea.
COG4057. LUCA.

Family and domain databases

Gene3Di3.90.320.20. 1 hit.
InterProiView protein in InterPro
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
PfamiView protein in Pfam
PF02240. MCR_gamma. 1 hit.
PIRSFiPIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005845. Me_CoM_Rdtase_gsu. 1 hit.
SUPFAMiSSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03259. met_CoM_red_gam. 1 hit.

Sequencei

Sequence statusi: Complete.

P11563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYKPQFYPS ATKVAENRRN HINPAFELEK LREIPDEDVV KIMGHRQPSE
60 70 80 90 100
DYKTVHPPLE EMDLAEDYVR DLVGPINGAK EGHRIRYIQF ADSMYFAPSQ
110 120 130 140 150
PYDRSRLYMS RFRGVDCGTL SGRQVVELRE SNLEDISKNY LVDTELFDPA
160 170 180 190 200
TTGMRGATVH GHSLRLDENG VMFDALQRYE FDEATGHILY VKDQVGRPWD
210 220 230 240 250
EPVDVGEPVP QEKLKEITTI YRKDGVAMRD DMEVVEVVKR IHRARTLGGY
260
CPLNEIFDTY L
Length:261
Mass (Da):30,132
Last modified:October 1, 1989 - v1
Checksum:i236BA6C71F5AAA49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07793 Genomic DNA. Translation: CAA30632.1.
PIRiS03260.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMCRG_METVO
AccessioniPrimary (citable) accession number: P11563
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 5, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways