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P11563 (MCRG_METVO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methyl-coenzyme M reductase subunit gamma

EC=2.8.4.1
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma
Gene names
Name:mcrG
OrganismMethanococcus voltae
Taxonomic identifier2188 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activity

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Cofactor

Binds 2 coenzyme F430 noncovalently per hexamer. Coenzyme F430 is a yellow nickel porphinoid By similarity.

Pathway

One-carbon metabolism; methyl-coenzyme M reduction; methane from methyl-coenzyme M: step 1/1.

Subunit structure

Hexamer of two alpha, two beta, and two gamma chains.

Ontologies

Keywords
   Biological processMethanogenesis
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processmethanogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncoenzyme-B sulfoethylthiotransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Methyl-coenzyme M reductase subunit gamma
PRO_0000147484

Sequences

Sequence LengthMass (Da)Tools
P11563 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 236BA6C71F5AAA49

FASTA26130,132
        10         20         30         40         50         60 
MAYKPQFYPS ATKVAENRRN HINPAFELEK LREIPDEDVV KIMGHRQPSE DYKTVHPPLE 

        70         80         90        100        110        120 
EMDLAEDYVR DLVGPINGAK EGHRIRYIQF ADSMYFAPSQ PYDRSRLYMS RFRGVDCGTL 

       130        140        150        160        170        180 
SGRQVVELRE SNLEDISKNY LVDTELFDPA TTGMRGATVH GHSLRLDENG VMFDALQRYE 

       190        200        210        220        230        240 
FDEATGHILY VKDQVGRPWD EPVDVGEPVP QEKLKEITTI YRKDGVAMRD DMEVVEVVKR 

       250        260 
IHRARTLGGY CPLNEIFDTY L 

« Hide

References

[1]"Comparative analysis of genes encoding methyl coenzyme M reductase in methanogenic bacteria."
Klein A., Allmansberger R., Bokranz M., Knaub S., Mueller B., Muth E.
Mol. Gen. Genet. 213:409-420(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 33273 / DSM 1537 / NBRC 100457 / OCM 70 / PS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07793 Genomic DNA. Translation: CAA30632.1.
PIRS03260.

3D structure databases

ProteinModelPortalP11563.
SMRP11563. Positions 6-250.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00646; UER00699.

Family and domain databases

Gene3D3.90.320.20. 1 hit.
InterProIPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view]
PfamPF02240. MCR_gamma. 1 hit.
[Graphical view]
PIRSFPIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomPD005845. Me_CoM_Rdtase_gsu. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF55088. SSF55088. 1 hit.
TIGRFAMsTIGR03259. met_CoM_red_gam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMCRG_METVO
AccessionPrimary (citable) accession number: P11563
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 16, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways