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Protein

Methyl-coenzyme M reductase subunit beta

Gene

mcrB

Organism
Methanococcus voltae
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase subunit alpha (mcrA), Methyl-coenzyme M reductase subunit beta (mcrB), Methyl-coenzyme M reductase subunit gamma (mcrG)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMethanogenesis

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase subunit beta (EC:2.8.4.1)
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase beta
Gene namesi
Name:mcrB
OrganismiMethanococcus voltae
Taxonomic identifieri2188 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001474721 – 443Methyl-coenzyme M reductase subunit betaAdd BLAST443

Proteomic databases

PRIDEiP11561

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Structurei

3D structure databases

ProteinModelPortaliP11561
SMRiP11561
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04860 Archaea
COG4054 LUCA

Family and domain databases

Gene3Di1.20.840.10, 2 hits
3.30.70.470, 1 hit
InterProiView protein in InterPro
IPR008924 Me_CoM_Rdtase_asu/bsu_C
IPR015823 Me_CoM_Rdtase_asu_N_sub2
IPR003179 Me_CoM_Rdtase_bsu
IPR022679 Me_CoM_Rdtase_bsu_C
IPR022680 Me_CoM_Rdtase_bsu_N
IPR009024 Me_CoM_Rdtase_Fd-like_fold
PfamiView protein in Pfam
PF02241 MCR_beta, 1 hit
PF02783 MCR_beta_N, 1 hit
PIRSFiPIRSF000263 Meth_CoM_rd_beta, 1 hit
SUPFAMiSSF48081 SSF48081, 1 hit
SSF55088 SSF55088, 1 hit
TIGRFAMsiTIGR03257 met_CoM_red_bet, 1 hit

Sequencei

Sequence statusi: Complete.

P11561-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKYEDKICL FDAKGNQVAE DVPLEAISPL NNPTIMGMVK NIKRTVAVNL
60 70 80 90 100
AGIEESLAKG KIGGKGCQVP GTNIELDVIG DAEAIADKVK SILQVSAGDD
110 120 130 140 150
TEVKLINGGK QMAEQVPSKR LDVAAEYSVS MLSTGMALKE ALITNFNIDM
160 170 180 190 200
FDGSTVHSAI MGQYPQDMDY AGGNIASLLG APSKLEGLGY ALRNIPVNHA
210 220 230 240 250
VATTKKSLMN AIAFSSILEQ TAMFEMGDAV GSFERQHLLG LAYQGLNADN
260 270 280 290 300
LVVELVKANA TGTVGSVVNS IVEKAIADGV IVVDKTLGSG FNMYKPADVN
310 320 330 340 350
KWNAYAAAGL VAAVMVSCGA ARAAQNVAST ILYYNDILEY ETGLPGVDYG
360 370 380 390 400
RSMGTAVGFS FFSHSIYGGG GPGIFNGNHV VTRHSKGFAI PPVCAAMCMD
410 420 430 440
AGTQMFSPEK TSALVGTVYS AFDEFREPLK YVIEGALEVQ NKL
Length:443
Mass (Da):46,681
Last modified:October 1, 1989 - v1
Checksum:iE9E545ED9E48AB3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07793 Genomic DNA Translation: CAA30630.1
PIRiS03257

Similar proteinsi

Entry informationi

Entry nameiMCRB_METVO
AccessioniPrimary (citable) accession number: P11561
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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