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P11561

- MCRB_METVO

UniProt

P11561 - MCRB_METVO

Protein

Methyl-coenzyme M reductase subunit beta

Gene

mcrB

Organism
Methanococcus voltae
Status
Reviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 72 (03 Sep 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

    Catalytic activityi

    Methyl-CoM + CoB = CoM-S-S-CoB + methane.

    Pathwayi

    GO - Molecular functioni

    1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. methanogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Methanogenesis

    Enzyme and pathway databases

    UniPathwayiUPA00646; UER00699.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyl-coenzyme M reductase subunit beta (EC:2.8.4.1)
    Alternative name(s):
    Coenzyme-B sulfoethylthiotransferase beta
    Gene namesi
    Name:mcrB
    OrganismiMethanococcus voltae
    Taxonomic identifieri2188 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Methyl-coenzyme M reductase subunit betaPRO_0000147472Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer of two alpha, two beta, and two gamma chains.

    Structurei

    3D structure databases

    ProteinModelPortaliP11561.
    SMRiP11561. Positions 3-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.20.840.10. 2 hits.
    3.30.70.470. 1 hit.
    InterProiIPR022681. MCR_a/b_chain_a-bundle.
    IPR008924. Me_CoM_Rdtase_asu/bsu_C.
    IPR015823. Me_CoM_Rdtase_asu_N_sub2.
    IPR003179. Me_CoM_Rdtase_bsu.
    IPR022679. Me_CoM_Rdtase_bsu_C.
    IPR022680. Me_CoM_Rdtase_bsu_N.
    IPR009024. Me_CoM_Rdtase_Fd-like_fold.
    [Graphical view]
    PfamiPF02241. MCR_beta. 1 hit.
    PF02783. MCR_beta_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000263. Meth_CoM_rd_beta. 1 hit.
    SUPFAMiSSF48081. SSF48081. 1 hit.
    SSF55088. SSF55088. 1 hit.
    TIGRFAMsiTIGR03257. met_CoM_red_bet. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P11561-1 [UniParc]FASTAAdd to Basket

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    MVKYEDKICL FDAKGNQVAE DVPLEAISPL NNPTIMGMVK NIKRTVAVNL    50
    AGIEESLAKG KIGGKGCQVP GTNIELDVIG DAEAIADKVK SILQVSAGDD 100
    TEVKLINGGK QMAEQVPSKR LDVAAEYSVS MLSTGMALKE ALITNFNIDM 150
    FDGSTVHSAI MGQYPQDMDY AGGNIASLLG APSKLEGLGY ALRNIPVNHA 200
    VATTKKSLMN AIAFSSILEQ TAMFEMGDAV GSFERQHLLG LAYQGLNADN 250
    LVVELVKANA TGTVGSVVNS IVEKAIADGV IVVDKTLGSG FNMYKPADVN 300
    KWNAYAAAGL VAAVMVSCGA ARAAQNVAST ILYYNDILEY ETGLPGVDYG 350
    RSMGTAVGFS FFSHSIYGGG GPGIFNGNHV VTRHSKGFAI PPVCAAMCMD 400
    AGTQMFSPEK TSALVGTVYS AFDEFREPLK YVIEGALEVQ NKL 443
    Length:443
    Mass (Da):46,681
    Last modified:October 1, 1989 - v1
    Checksum:iE9E545ED9E48AB3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07793 Genomic DNA. Translation: CAA30630.1.
    PIRiS03257.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07793 Genomic DNA. Translation: CAA30630.1 .
    PIRi S03257.

    3D structure databases

    ProteinModelPortali P11561.
    SMRi P11561. Positions 3-443.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00646 ; UER00699 .

    Family and domain databases

    Gene3Di 1.20.840.10. 2 hits.
    3.30.70.470. 1 hit.
    InterProi IPR022681. MCR_a/b_chain_a-bundle.
    IPR008924. Me_CoM_Rdtase_asu/bsu_C.
    IPR015823. Me_CoM_Rdtase_asu_N_sub2.
    IPR003179. Me_CoM_Rdtase_bsu.
    IPR022679. Me_CoM_Rdtase_bsu_C.
    IPR022680. Me_CoM_Rdtase_bsu_N.
    IPR009024. Me_CoM_Rdtase_Fd-like_fold.
    [Graphical view ]
    Pfami PF02241. MCR_beta. 1 hit.
    PF02783. MCR_beta_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000263. Meth_CoM_rd_beta. 1 hit.
    SUPFAMi SSF48081. SSF48081. 1 hit.
    SSF55088. SSF55088. 1 hit.
    TIGRFAMsi TIGR03257. met_CoM_red_bet. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of genes encoding methyl coenzyme M reductase in methanogenic bacteria."
      Klein A., Allmansberger R., Bokranz M., Knaub S., Mueller B., Muth E.
      Mol. Gen. Genet. 213:409-420(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 33273 / DSM 1537 / NBRC 100457 / OCM 70 / PS.

    Entry informationi

    Entry nameiMCRB_METVO
    AccessioniPrimary (citable) accession number: P11561
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: September 3, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3