Reviewed, UniProtKB/Swiss-Prot P11557 (DAMX_ECOLI)

Names and origin

Protein names

Recommended name:
    Protein damX

Gene names

Name:	damX
Synonyms:	yhfB
Ordered Locus Names:	b3388, JW3351

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Directly or indirectly interferes with cell division.
Subcellular location	Cell membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Protein damX		PRO_0000079779
Regions
	Transmembrane	104 – 124	21	Potential
Experimental info
	Sequence conflict	6	1	P → T Ref.1
	Sequence conflict	6	1	P → T Ref.2
	Sequence conflict	31	1	R → P Ref.1
	Sequence conflict	31	1	R → P Ref.2
	Sequence conflict	86 – 91	6	RRPRKR → LVRVS Ref.1
	Sequence conflict	86 – 91	6	RRPRKR → LVRVS Ref.2
	Sequence conflict	233	1	V → L in CAA79667. Ref.2
	Sequence conflict	310	1	A → V Ref.1
	Sequence conflict	310	1	A → V Ref.2
	Sequence conflict	366	1	K → N in CAA79667. Ref.2
	Sequence conflict	382	1	G → V Ref.1
	Sequence conflict	382	1	G → V Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P11557-1 [UniParc]. Last modified August 29, 2003. Version 2. Checksum: E3376F88383BE94A	FASTA	428	46,162
	10 20 30 40 50 60 MDEFKPEDEL KPDPSDRRTG RSRQSSERSE RTERGEPQIN FDDIELDDTD DRRPTRAQKE 70 80 90 100 110 120 RNEEPEIEEE IDESEDETVD EERVERRPRK RKKAASKPAS RQYMMMGVGI LVLLLLIIGI 130 140 150 160 170 180 GSALKAPSTT SSDQTASGEK SIDLAGNATD QANGVQPAPG TTSAENTQQD VSLPPISSTP 190 200 210 220 230 240 TQGQTPVATD GQQRVEVQGD LNNALTQPQN QQQLNNVAVN STLPTEPATV APVRNGNASR 250 260 270 280 290 300 DTAKTQTAER PSTTRPARQQ AVIEPKKPQA TVKTEPKPVA QTPKRTEPAA PVASTKAPAA 310 320 330 340 350 360 TSTPAPKETA TTAPVQTASP AQTTATPAAG AKTAGNVGSL KSAPSSHYTL QLSSSSNYDN 370 380 390 400 410 420 LNGWAKKENL KNYVVYETTR NGQPWYVLVS GVYASKEEAK KAVSTLPADV QAKNPWAKPL RQVQADLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Escherichia coli dam gene is expressed as a distal gene of a new operon." Jonczyk P., Hines R., Smith D.W. Mol. Gen. Genet. 217:85-96(1989) [PubMed: 2549371] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Characterization of three genes in the dam-containing operon of Escherichia coli." Lyngstadaas A., Lobner-Olesen A., Boye E. Mol. Gen. Genet. 247:546-554(1995) [PubMed: 7603433] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15162 Genomic DNA. Translation: CAA33253.1. Z19601 Genomic DNA. Translation: CAA79667.1. U18997 Genomic DNA. Translation: AAA58185.1. U00096 Genomic DNA. Translation: AAC76413.1. AP009048 Genomic DNA. Translation: BAE77903.1.
PIR	Q4ECAD. G65133.
RefSeq	AP_004402.1. NP_417847.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-9397N.
IntAct	P11557. 16 interactions.
STRING	P11557.
Genome annotation databases
GeneID	947930.
GenomeReviews	Gene locus JW3351 in contig AP009048_GR. Gene locus b3388 in contig U00096_GR.
KEGG	ecj:JW3351. eco:b3388.
Organism-specific databases
EchoBASE	EB1170.
EcoGene	EG11183. damX.
CMR	Search...
Phylogenomic databases
eggNOG	COG3266.
HOGENOM	HBG637071.
OMA	HLMIGIG.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11183-MONOMER. ECOL168927:B3388-MONOMER.
Gene expression databases
Genevestigator	P11557.
Family and domain databases
InterPro	IPR007730. Sporulation_related_dom. [Graphical view]
Pfam	PF05036. SPOR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAMX_ECOLI

Accession

Primary (citable) accession number: P11557
Secondary accession number(s): P76687, Q2M753

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	August 29, 2003
Last modified:	January 19, 2010
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)