Protein DamX - Escherichia coli (strain K12)

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P11557 (DAMX_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein DamX

Gene names

Name:	damX
Synonyms:	yhfB
Ordered Locus Names:	b3388, JW3351

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Directly or indirectly interferes with cell division.
Subcellular location	Cell membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 SPOR domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Inferred from mutant phenotype Ref.2. Source: EcoCyc
Cellular_component	cell division site part Inferred from direct assay PubMed 19684127. Source: EcoCyc integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 428

428

Protein DamX

PRO_0000079779

Regions

Transmembrane

104 – 124

Helical; Potential

Domain

345 – 417

SPOR

Experimental info

Sequence conflict

P → T Ref.1

Sequence conflict

P → T Ref.2

Sequence conflict

R → P Ref.1

Sequence conflict

R → P Ref.2

Sequence conflict

86 – 91

RRPRKR → LVRVS Ref.1

Sequence conflict

86 – 91

RRPRKR → LVRVS Ref.2

Sequence conflict

233

V → L in CAA79667. Ref.2

Sequence conflict

310

A → V Ref.1

Sequence conflict

310

A → V Ref.2

Sequence conflict

366

K → N in CAA79667. Ref.2

Sequence conflict

382

G → V Ref.1

Sequence conflict

382

G → V Ref.2

Secondary structure

428

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P11557 [UniParc].

Last modified August 29, 2003. Version 2.
Checksum: E3376F88383BE94A
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FASTA

428

46,162

        10         20         30         40         50         60 
MDEFKPEDEL KPDPSDRRTG RSRQSSERSE RTERGEPQIN FDDIELDDTD DRRPTRAQKE 

        70         80         90        100        110        120 
RNEEPEIEEE IDESEDETVD EERVERRPRK RKKAASKPAS RQYMMMGVGI LVLLLLIIGI 

       130        140        150        160        170        180 
GSALKAPSTT SSDQTASGEK SIDLAGNATD QANGVQPAPG TTSAENTQQD VSLPPISSTP 

       190        200        210        220        230        240 
TQGQTPVATD GQQRVEVQGD LNNALTQPQN QQQLNNVAVN STLPTEPATV APVRNGNASR 

       250        260        270        280        290        300 
DTAKTQTAER PSTTRPARQQ AVIEPKKPQA TVKTEPKPVA QTPKRTEPAA PVASTKAPAA 

       310        320        330        340        350        360 
TSTPAPKETA TTAPVQTASP AQTTATPAAG AKTAGNVGSL KSAPSSHYTL QLSSSSNYDN 

       370        380        390        400        410        420 
LNGWAKKENL KNYVVYETTR NGQPWYVLVS GVYASKEEAK KAVSTLPADV QAKNPWAKPL 


RQVQADLK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Escherichia coli dam gene is expressed as a distal gene of a new operon." Jonczyk P., Hines R., Smith D.W. Mol. Gen. Genet. 217:85-96(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Characterization of three genes in the dam-containing operon of Escherichia coli." Lyngstadaas A., Lobner-Olesen A., Boye E. Mol. Gen. Genet. 247:546-554(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X15162 Genomic DNA. Translation: CAA33253.1.
Z19601 Genomic DNA. Translation: CAA79667.1.
U18997 Genomic DNA. Translation: AAA58185.1.
U00096 Genomic DNA. Translation: AAC76413.1.
AP009048 Genomic DNA. Translation: BAE77903.1.

PIR

Q4ECAD. G65133.

RefSeq

NP_417847.1. NC_000913.2.
YP_492044.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LFV	NMR	-	A	338-428	[»]

ProteinModelPortal

P11557.

SMR

P11557. Positions 340-427.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-9397N.

IntAct

P11557. 22 interactions.

STRING

511145.b3388.

Proteomic databases

PaxDb

P11557.

PRIDE

P11557.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC76413; AAC76413; b3388.
BAE77903; BAE77903; BAE77903.

GeneID

12933967.
947930.

KEGG

ecj:Y75_p3788.
eco:b3388.

PATRIC

32122208. VBIEscCol129921_3481.

Organism-specific databases

EchoBASE

EB1170.

EcoGene

EG11183. damX.

Phylogenomic databases

eggNOG

COG3266.

HOGENOM

HOG000125518.

K03112.

OMA

KPDTSDR.

ProtClustDB

PRK10905.

Enzyme and pathway databases

BioCyc

EcoCyc:EG11183-MONOMER.
ECOL316407:JW3351-MONOMER.

Gene expression databases

Genevestigator

P11557.

Family and domain databases

Gene3D

3.30.70.1070. 1 hit.

InterPro

IPR007730. Sporulation-related_dom.
[Graphical view]

Pfam

PF05036. SPOR. 1 hit.
[Graphical view]

SUPFAM

SSF110997. Spore_cell-division_bac. 1 hit.

ProtoNet

Search...

Entry information

Entry name

DAMX_ECOLI

Accession

Primary (citable) accession number: P11557
Secondary accession number(s): P76687, Q2M753

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	August 29, 2003
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents