P11553 (FUCK_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-fuculokinase
EC=2.7.1.51

Alternative name(s):
L-fuculose kinase

Gene names

Name:	fucK
Ordered Locus Names:	b2803, JW2774

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + L-fuculose = ADP + L-fuculose 1-phosphate.
Pathway	Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 2/3.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Fucose metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-arabinose catabolic process Inferred from mutant phenotype PubMed 4928018. Source: EcoCyc L-fucose catabolic process Inferred from mutant phenotype PubMed 4928018. Source: EcoCyc
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW L-fuculokinase activity Inferred from direct assay PubMed 4323967. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 482	482	L-fuculokinase		PRO_0000059423

Sequences

	Sequence		Length	Mass (Da)
	P11553 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: E40DD3BC97C6020A	FASTA	482	53,236
	10 20 30 40 50 60 MLSGYIAGAI MKQEVILVLD CGATNVRAIA VNRQGKIVAR ASTPNASDIA MENNTWHQWS 70 80 90 100 110 120 LDAILQRFAD CCRQINSELT ECHIRGIAVT TFGVDGALVD KQGNLLYPII SWKCPRTAAV 130 140 150 160 170 180 MDNIERLISA QRLQAISGVG AFSFNTLYKL VWLKENHPQL LERAHAWLFI SSLINHRLTG 190 200 210 220 230 240 EFTTDITMAG TSQMLDIQQR DFSPQILQAT GIPRRLFPRL VEAGEQIGTL QNSAAAMLGL 250 260 270 280 290 300 PVGIPVISAG HDTQFALFGA GAEQNEPVLS SGTWEILMVR SAQVDTSLLS QYAGSTCELD 310 320 330 340 350 360 SQAGLYNPGM QWLASGVLEW VRKLFWTAET PWQMLIEEAR LIAPGADGVK MQCDLLSCQN 370 380 390 400 410 420 AGWQGVTLNT TRGHFYRAAL EGLTAQLQRN LQMLEKIGHF KASELLLVGG GSRNTLWNQI 430 440 450 460 470 480 KANMLDIPVK VLDDAETTVA GAALFGWYGV GEFNSPEEAR AQIHYQYRYF YPQTEPEFIE EV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation." Lu Z., Lin E.C.C. Nucleic Acids Res. 17:4883-4884(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15025 Genomic DNA. Translation: CAA33128.1. U29581 Genomic DNA. Translation: AAB40453.1. U00096 Genomic DNA. Translation: AAC75845.1. AP009048 Genomic DNA. Translation: BAE76875.1.
PIR	KIECFK. JS0186.
RefSeq	NP_417283.1. NC_000913.2. YP_491011.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P11553.
SMR	P11553. Positions 16-477.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-9712N.
IntAct	P11553. 4 interactions.
MINT	MINT-1305054.
STRING	511145.b2803.
2D gel databases
SWISS-2DPAGE	P11553.
Proteomic databases
PaxDb	P11553.
PRIDE	P11553.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75845; AAC75845; b2803. BAE76875; BAE76875; BAE76875.
GeneID	12930231. 946022.
KEGG	ecj:Y75_p2740. eco:b2803.
PATRIC	32121022. VBIEscCol129921_2903.
Organism-specific databases
EchoBASE	EB0346.
EcoGene	EG10350. fucK.
Phylogenomic databases
eggNOG	COG1070.
HOGENOM	HOG000124178.
KO	K00879.
OMA	ENISQYM.
ProtClustDB	PRK10331.
Enzyme and pathway databases
BioCyc	EcoCyc:FUCULOKIN-MONOMER. ECOL316407:JW2774-MONOMER. MetaCyc:FUCULOKIN-MONOMER.
UniPathway	UPA00563; UER00625.
Gene expression databases
Genevestigator	P11553.
Family and domain databases
InterPro	IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR013450. Fuculokinase. [Graphical view]
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR02628. fuculo_kin_coli. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUCK_ECOLI

Accession

Primary (citable) accession number: P11553
Secondary accession number(s): Q2MA31

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program