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P11553

- FUCK_ECOLI

UniProt

P11553 - FUCK_ECOLI

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Protein
L-fuculokinase
Gene
fucK, b2803, JW2774
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of L-fuculose. Can also phosphorylate, with lower efficiency, D-ribulose, D-xylulose and D-fructose.1 Publication

Catalytic activityi

ATP + L-fuculose = ADP + L-fuculose 1-phosphate.1 Publication

Cofactori

Divalent metal cation.1 Publication

pH dependencei

Optimum pH is 7.8.1 Publication

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. L-fuculokinase activity Source: EcoCyc

GO - Biological processi

  1. D-arabinose catabolic process Source: EcoCyc
  2. L-fucose catabolic process Source: EcoCyc
  3. carbohydrate phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:FUCULOKIN-MONOMER.
ECOL316407:JW2774-MONOMER.
MetaCyc:FUCULOKIN-MONOMER.
UniPathwayiUPA00563; UER00625.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculokinase (EC:2.7.1.51)
Alternative name(s):
L-fuculose kinase
Gene namesi
Name:fucK
Ordered Locus Names:b2803, JW2774
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10350. fucK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482L-fuculokinaseUniRule annotation
PRO_0000059423Add
BLAST

Proteomic databases

PaxDbiP11553.
PRIDEiP11553.

2D gel databases

SWISS-2DPAGEP11553.

Expressioni

Gene expression databases

GenevestigatoriP11553.

Interactioni

Protein-protein interaction databases

DIPiDIP-9712N.
IntActiP11553. 4 interactions.
MINTiMINT-1305054.
STRINGi511145.b2803.

Structurei

3D structure databases

ProteinModelPortaliP11553.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000124178.
KOiK00879.
OMAiNIENDDW.
OrthoDBiEOG6X9MHN.
PhylomeDBiP11553.

Family and domain databases

HAMAPiMF_00986. Fuculokinase.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR013450. Fuculokinase.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02628. fuculo_kin_coli. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11553-1 [UniParc]FASTAAdd to Basket

« Hide

MLSGYIAGAI MKQEVILVLD CGATNVRAIA VNRQGKIVAR ASTPNASDIA    50
MENNTWHQWS LDAILQRFAD CCRQINSELT ECHIRGIAVT TFGVDGALVD 100
KQGNLLYPII SWKCPRTAAV MDNIERLISA QRLQAISGVG AFSFNTLYKL 150
VWLKENHPQL LERAHAWLFI SSLINHRLTG EFTTDITMAG TSQMLDIQQR 200
DFSPQILQAT GIPRRLFPRL VEAGEQIGTL QNSAAAMLGL PVGIPVISAG 250
HDTQFALFGA GAEQNEPVLS SGTWEILMVR SAQVDTSLLS QYAGSTCELD 300
SQAGLYNPGM QWLASGVLEW VRKLFWTAET PWQMLIEEAR LIAPGADGVK 350
MQCDLLSCQN AGWQGVTLNT TRGHFYRAAL EGLTAQLQRN LQMLEKIGHF 400
KASELLLVGG GSRNTLWNQI KANMLDIPVK VLDDAETTVA GAALFGWYGV 450
GEFNSPEEAR AQIHYQYRYF YPQTEPEFIE EV 482
Length:482
Mass (Da):53,236
Last modified:October 1, 1989 - v1
Checksum:iE40DD3BC97C6020A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15025 Genomic DNA. Translation: CAA33128.1.
U29581 Genomic DNA. Translation: AAB40453.1.
U00096 Genomic DNA. Translation: AAC75845.1.
AP009048 Genomic DNA. Translation: BAE76875.1.
PIRiJS0186. KIECFK.
RefSeqiNP_417283.1. NC_000913.3.
YP_491011.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75845; AAC75845; b2803.
BAE76875; BAE76875; BAE76875.
GeneIDi12930231.
946022.
KEGGiecj:Y75_p2740.
eco:b2803.
PATRICi32121022. VBIEscCol129921_2903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15025 Genomic DNA. Translation: CAA33128.1 .
U29581 Genomic DNA. Translation: AAB40453.1 .
U00096 Genomic DNA. Translation: AAC75845.1 .
AP009048 Genomic DNA. Translation: BAE76875.1 .
PIRi JS0186. KIECFK.
RefSeqi NP_417283.1. NC_000913.3.
YP_491011.1. NC_007779.1.

3D structure databases

ProteinModelPortali P11553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-9712N.
IntActi P11553. 4 interactions.
MINTi MINT-1305054.
STRINGi 511145.b2803.

2D gel databases

SWISS-2DPAGE P11553.

Proteomic databases

PaxDbi P11553.
PRIDEi P11553.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75845 ; AAC75845 ; b2803 .
BAE76875 ; BAE76875 ; BAE76875 .
GeneIDi 12930231.
946022.
KEGGi ecj:Y75_p2740.
eco:b2803.
PATRICi 32121022. VBIEscCol129921_2903.

Organism-specific databases

EchoBASEi EB0346.
EcoGenei EG10350. fucK.

Phylogenomic databases

eggNOGi COG1070.
HOGENOMi HOG000124178.
KOi K00879.
OMAi NIENDDW.
OrthoDBi EOG6X9MHN.
PhylomeDBi P11553.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00625 .
BioCyci EcoCyc:FUCULOKIN-MONOMER.
ECOL316407:JW2774-MONOMER.
MetaCyc:FUCULOKIN-MONOMER.

Miscellaneous databases

PROi P11553.

Gene expression databases

Genevestigatori P11553.

Family and domain databases

HAMAPi MF_00986. Fuculokinase.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR013450. Fuculokinase.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02628. fuculo_kin_coli. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation."
    Lu Z., Lin E.C.C.
    Nucleic Acids Res. 17:4883-4884(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "The metabolism of L-fucose. I. The purification and properties of L-fuculose kinase."
    Heath E.C., Ghalambor M.A.
    J. Biol. Chem. 237:2423-2426(1962) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, COFACTOR, BIOPHYSICOCHEMICAL PROPERTIES, PATHWAY.
    Strain: O111:B4.

Entry informationi

Entry nameiFUCK_ECOLI
AccessioniPrimary (citable) accession number: P11553
Secondary accession number(s): Q2MA31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 11, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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