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P11553

- FUCK_ECOLI

UniProt

P11553 - FUCK_ECOLI

Protein

L-fuculokinase

Gene

fucK

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of L-fuculose. Can also phosphorylate, with lower efficiency, D-ribulose, D-xylulose and D-fructose.1 PublicationUniRule annotation

    Catalytic activityi

    ATP + L-fuculose = ADP + L-fuculose 1-phosphate.1 PublicationUniRule annotation

    Cofactori

    Divalent metal cation.1 PublicationUniRule annotation

    pH dependencei

    Optimum pH is 7.8.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. L-fuculokinase activity Source: EcoCyc

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. D-arabinose catabolic process Source: EcoCyc
    3. L-fucose catabolic process Source: EcoCyc

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:FUCULOKIN-MONOMER.
    ECOL316407:JW2774-MONOMER.
    MetaCyc:FUCULOKIN-MONOMER.
    UniPathwayiUPA00563; UER00625.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fuculokinaseUniRule annotation (EC:2.7.1.51UniRule annotation)
    Alternative name(s):
    L-fuculose kinaseUniRule annotation
    Gene namesi
    Name:fucKUniRule annotation
    Ordered Locus Names:b2803, JW2774
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG10350. fucK.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 482482L-fuculokinasePRO_0000059423Add
    BLAST

    Proteomic databases

    PaxDbiP11553.
    PRIDEiP11553.

    2D gel databases

    SWISS-2DPAGEP11553.

    Expressioni

    Gene expression databases

    GenevestigatoriP11553.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-9712N.
    IntActiP11553. 4 interactions.
    MINTiMINT-1305054.
    STRINGi511145.b2803.

    Structurei

    3D structure databases

    ProteinModelPortaliP11553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1070.
    HOGENOMiHOG000124178.
    KOiK00879.
    OMAiNIENDDW.
    OrthoDBiEOG6X9MHN.
    PhylomeDBiP11553.

    Family and domain databases

    HAMAPiMF_00986. Fuculokinase.
    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR013450. Fuculokinase.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02628. fuculo_kin_coli. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11553-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSGYIAGAI MKQEVILVLD CGATNVRAIA VNRQGKIVAR ASTPNASDIA    50
    MENNTWHQWS LDAILQRFAD CCRQINSELT ECHIRGIAVT TFGVDGALVD 100
    KQGNLLYPII SWKCPRTAAV MDNIERLISA QRLQAISGVG AFSFNTLYKL 150
    VWLKENHPQL LERAHAWLFI SSLINHRLTG EFTTDITMAG TSQMLDIQQR 200
    DFSPQILQAT GIPRRLFPRL VEAGEQIGTL QNSAAAMLGL PVGIPVISAG 250
    HDTQFALFGA GAEQNEPVLS SGTWEILMVR SAQVDTSLLS QYAGSTCELD 300
    SQAGLYNPGM QWLASGVLEW VRKLFWTAET PWQMLIEEAR LIAPGADGVK 350
    MQCDLLSCQN AGWQGVTLNT TRGHFYRAAL EGLTAQLQRN LQMLEKIGHF 400
    KASELLLVGG GSRNTLWNQI KANMLDIPVK VLDDAETTVA GAALFGWYGV 450
    GEFNSPEEAR AQIHYQYRYF YPQTEPEFIE EV 482
    Length:482
    Mass (Da):53,236
    Last modified:October 1, 1989 - v1
    Checksum:iE40DD3BC97C6020A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15025 Genomic DNA. Translation: CAA33128.1.
    U29581 Genomic DNA. Translation: AAB40453.1.
    U00096 Genomic DNA. Translation: AAC75845.1.
    AP009048 Genomic DNA. Translation: BAE76875.1.
    PIRiJS0186. KIECFK.
    RefSeqiNP_417283.1. NC_000913.3.
    YP_491011.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75845; AAC75845; b2803.
    BAE76875; BAE76875; BAE76875.
    GeneIDi12930231.
    946022.
    KEGGiecj:Y75_p2740.
    eco:b2803.
    PATRICi32121022. VBIEscCol129921_2903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15025 Genomic DNA. Translation: CAA33128.1 .
    U29581 Genomic DNA. Translation: AAB40453.1 .
    U00096 Genomic DNA. Translation: AAC75845.1 .
    AP009048 Genomic DNA. Translation: BAE76875.1 .
    PIRi JS0186. KIECFK.
    RefSeqi NP_417283.1. NC_000913.3.
    YP_491011.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P11553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-9712N.
    IntActi P11553. 4 interactions.
    MINTi MINT-1305054.
    STRINGi 511145.b2803.

    2D gel databases

    SWISS-2DPAGE P11553.

    Proteomic databases

    PaxDbi P11553.
    PRIDEi P11553.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75845 ; AAC75845 ; b2803 .
    BAE76875 ; BAE76875 ; BAE76875 .
    GeneIDi 12930231.
    946022.
    KEGGi ecj:Y75_p2740.
    eco:b2803.
    PATRICi 32121022. VBIEscCol129921_2903.

    Organism-specific databases

    EchoBASEi EB0346.
    EcoGenei EG10350. fucK.

    Phylogenomic databases

    eggNOGi COG1070.
    HOGENOMi HOG000124178.
    KOi K00879.
    OMAi NIENDDW.
    OrthoDBi EOG6X9MHN.
    PhylomeDBi P11553.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00625 .
    BioCyci EcoCyc:FUCULOKIN-MONOMER.
    ECOL316407:JW2774-MONOMER.
    MetaCyc:FUCULOKIN-MONOMER.

    Miscellaneous databases

    PROi P11553.

    Gene expression databases

    Genevestigatori P11553.

    Family and domain databases

    HAMAPi MF_00986. Fuculokinase.
    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR013450. Fuculokinase.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02628. fuculo_kin_coli. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation."
      Lu Z., Lin E.C.C.
      Nucleic Acids Res. 17:4883-4884(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "The metabolism of L-fucose. I. The purification and properties of L-fuculose kinase."
      Heath E.C., Ghalambor M.A.
      J. Biol. Chem. 237:2423-2426(1962) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, COFACTOR, BIOPHYSICOCHEMICAL PROPERTIES, PATHWAY.
      Strain: O111:B4.

    Entry informationi

    Entry nameiFUCK_ECOLI
    AccessioniPrimary (citable) accession number: P11553
    Secondary accession number(s): Q2MA31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3