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P11553 (FUCK_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-fuculokinase

EC=2.7.1.51
Alternative name(s):
L-fuculose kinase
Gene names
Name:fucK
Ordered Locus Names:b2803, JW2774
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the phosphorylation of L-fuculose. Can also phosphorylate, with lower efficiency, D-ribulose, D-xylulose and D-fructose. Ref.4

Catalytic activity

ATP + L-fuculose = ADP + L-fuculose 1-phosphate. Ref.4

Cofactor

Divalent metal cation. Ref.4

Pathway

Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 2/3. Ref.4

Sequence similarities

Belongs to the FGGY kinase family.

Biophysicochemical properties

pH dependence:

Optimum pH is 7.8. Ref.4

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 482482L-fuculokinase HAMAP-Rule MF_00986
PRO_0000059423

Sequences

Sequence LengthMass (Da)Tools
P11553 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: E40DD3BC97C6020A

FASTA48253,236
        10         20         30         40         50         60 
MLSGYIAGAI MKQEVILVLD CGATNVRAIA VNRQGKIVAR ASTPNASDIA MENNTWHQWS 

        70         80         90        100        110        120 
LDAILQRFAD CCRQINSELT ECHIRGIAVT TFGVDGALVD KQGNLLYPII SWKCPRTAAV 

       130        140        150        160        170        180 
MDNIERLISA QRLQAISGVG AFSFNTLYKL VWLKENHPQL LERAHAWLFI SSLINHRLTG 

       190        200        210        220        230        240 
EFTTDITMAG TSQMLDIQQR DFSPQILQAT GIPRRLFPRL VEAGEQIGTL QNSAAAMLGL 

       250        260        270        280        290        300 
PVGIPVISAG HDTQFALFGA GAEQNEPVLS SGTWEILMVR SAQVDTSLLS QYAGSTCELD 

       310        320        330        340        350        360 
SQAGLYNPGM QWLASGVLEW VRKLFWTAET PWQMLIEEAR LIAPGADGVK MQCDLLSCQN 

       370        380        390        400        410        420 
AGWQGVTLNT TRGHFYRAAL EGLTAQLQRN LQMLEKIGHF KASELLLVGG GSRNTLWNQI 

       430        440        450        460        470        480 
KANMLDIPVK VLDDAETTVA GAALFGWYGV GEFNSPEEAR AQIHYQYRYF YPQTEPEFIE 


EV 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation."
Lu Z., Lin E.C.C.
Nucleic Acids Res. 17:4883-4884(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"The metabolism of L-fucose. I. The purification and properties of L-fuculose kinase."
Heath E.C., Ghalambor M.A.
J. Biol. Chem. 237:2423-2426(1962) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY, COFACTOR, BIOPHYSICOCHEMICAL PROPERTIES, PATHWAY.
Strain: O111:B4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15025 Genomic DNA. Translation: CAA33128.1.
U29581 Genomic DNA. Translation: AAB40453.1.
U00096 Genomic DNA. Translation: AAC75845.1.
AP009048 Genomic DNA. Translation: BAE76875.1.
PIRKIECFK. JS0186.
RefSeqNP_417283.1. NC_000913.3.
YP_491011.1. NC_007779.1.

3D structure databases

ProteinModelPortalP11553.
SMRP11553. Positions 16-477.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-9712N.
IntActP11553. 4 interactions.
MINTMINT-1305054.
STRING511145.b2803.

2D gel databases

SWISS-2DPAGEP11553.

Proteomic databases

PaxDbP11553.
PRIDEP11553.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75845; AAC75845; b2803.
BAE76875; BAE76875; BAE76875.
GeneID12930231.
946022.
KEGGecj:Y75_p2740.
eco:b2803.
PATRIC32121022. VBIEscCol129921_2903.

Organism-specific databases

EchoBASEEB0346.
EcoGeneEG10350. fucK.

Phylogenomic databases

eggNOGCOG1070.
HOGENOMHOG000124178.
KOK00879.
OMAATNVRAM.
OrthoDBEOG6X9MHN.
PhylomeDBP11553.
ProtClustDBPRK10331.

Enzyme and pathway databases

BioCycEcoCyc:FUCULOKIN-MONOMER.
ECOL316407:JW2774-MONOMER.
MetaCyc:FUCULOKIN-MONOMER.
UniPathwayUPA00563; UER00625.

Gene expression databases

GenevestigatorP11553.

Family and domain databases

HAMAPMF_00986. Fuculokinase.
InterProIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR013450. Fuculokinase.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR02628. fuculo_kin_coli. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP11553.

Entry information

Entry nameFUCK_ECOLI
AccessionPrimary (citable) accession number: P11553
Secondary accession number(s): Q2MA31
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene