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Protein

L-fucose-proton symporter

Gene

fucP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose.1 Publication

GO - Molecular functioni

  • arabinose:proton symporter activity Source: EcoCyc
  • fucose:proton symporter activity Source: EcoCyc
  • galactose:proton symporter activity Source: EcoCyc

GO - Biological processi

  • arabinose transport Source: EcoCyc
  • fucose metabolic process Source: UniProtKB-KW
  • fucose transport Source: EcoCyc
  • galactose transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism, Sugar transport, Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:FUCP-MONOMER.
ECOL316407:JW2772-MONOMER.
MetaCyc:FUCP-MONOMER.

Protein family/group databases

TCDBi2.A.1.7.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose-proton symporter
Alternative name(s):
6-deoxy-L-galactose permease
L-fucose permease
Gene namesi
Name:fucP
Ordered Locus Names:b2801, JW2772
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10352. fucP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 24CytoplasmicCuratedAdd BLAST23
Transmembranei25 – 45HelicalCuratedAdd BLAST21
Topological domaini46 – 55PeriplasmicCurated10
Transmembranei56 – 76HelicalCuratedAdd BLAST21
Topological domaini77 – 95CytoplasmicCuratedAdd BLAST19
Transmembranei96 – 115HelicalCuratedAdd BLAST20
Topological domaini116 – 118PeriplasmicCurated3
Transmembranei119 – 139HelicalCuratedAdd BLAST21
Topological domaini140 – 166CytoplasmicCuratedAdd BLAST27
Transmembranei167 – 187HelicalCuratedAdd BLAST21
Topological domaini188 – 206PeriplasmicCuratedAdd BLAST19
Transmembranei207 – 227HelicalCuratedAdd BLAST21
Topological domaini228 – 265CytoplasmicCuratedAdd BLAST38
Transmembranei266 – 286HelicalCuratedAdd BLAST21
Topological domaini287 – 295PeriplasmicCurated9
Transmembranei296 – 316HelicalCuratedAdd BLAST21
Topological domaini317 – 326CytoplasmicCurated10
Transmembranei327 – 347HelicalCuratedAdd BLAST21
Topological domaini348 – 352PeriplasmicCurated5
Transmembranei353 – 373HelicalCuratedAdd BLAST21
Topological domaini374 – 381CytoplasmicCurated8
Transmembranei382 – 402HelicalCuratedAdd BLAST21
Topological domaini403 – 413PeriplasmicCuratedAdd BLAST11
Transmembranei414 – 434HelicalCuratedAdd BLAST21
Topological domaini435 – 438CytoplasmicCurated4

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000945012 – 438L-fucose-proton symporterAdd BLAST437

Proteomic databases

PaxDbiP11551.
PRIDEiP11551.

Expressioni

Inductioni

By L-fucose.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260704. 18 interactors.
STRINGi511145.b2801.

Structurei

Secondary structure

1438
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 55Combined sources31
Helixi61 – 75Combined sources15
Helixi78 – 87Combined sources10
Helixi90 – 113Combined sources24
Helixi117 – 144Combined sources28
Helixi148 – 150Combined sources3
Helixi151 – 172Combined sources22
Helixi175 – 178Combined sources4
Helixi186 – 191Combined sources6
Helixi194 – 228Combined sources35
Turni235 – 237Combined sources3
Helixi247 – 254Combined sources8
Helixi259 – 288Combined sources30
Helixi294 – 321Combined sources28
Helixi324 – 344Combined sources21
Helixi347 – 361Combined sources15
Helixi364 – 373Combined sources10
Helixi377 – 379Combined sources3
Helixi380 – 389Combined sources10
Helixi392 – 408Combined sources17
Helixi412 – 415Combined sources4
Helixi416 – 429Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O7PX-ray3.20A1-438[»]
3O7QX-ray3.14A1-438[»]
ProteinModelPortaliP11551.
SMRiP11551.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11551.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EDR. Bacteria.
COG0738. LUCA.
HOGENOMiHOG000267862.
InParanoidiP11551.
KOiK02429.
OMAiFESCIFP.
PhylomeDBiP11551.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR005275. Lfuc_permease_FucP.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00885. fucP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTSIQTQS YRAVDKDAGQ SRSYIIPFAL LCSLFFLWAV ANNLNDILLP
60 70 80 90 100
QFQQAFTLTN FQAGLIQSAF YFGYFIIPIP AGILMKKLSY KAGIITGLFL
110 120 130 140 150
YALGAALFWP AAEIMNYTLF LVGLFIIAAG LGCLETAANP FVTVLGPESS
160 170 180 190 200
GHFRLNLAQT FNSFGAIIAV VFGQSLILSN VPHQSQDVLD KMSPEQLSAY
210 220 230 240 250
KHSLVLSVQT PYMIIVAIVL LVALLIMLTK FPALQSDNHS DAKQGSFSAS
260 270 280 290 300
LSRLARIRHW RWAVLAQFCY VGAQTACWSY LIRYAVEEIP GMTAGFAANY
310 320 330 340 350
LTGTMVCFFI GRFTGTWLIS RFAPHKVLAA YALIAMALCL ISAFAGGHVG
360 370 380 390 400
LIALTLCSAF MSIQYPTIFS LGIKNLGQDT KYGSSFIVMT IIGGGIVTPV
410 420 430
MGFVSDAAGN IPTAELIPAL CFAVIFIFAR FRSQTATN
Length:438
Mass (Da):47,545
Last modified:January 23, 2007 - v3
Checksum:iD8AA3785274A0085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15025 Genomic DNA. Translation: CAA33126.1.
U29581 Genomic DNA. Translation: AAB40451.1.
U00096 Genomic DNA. Translation: AAC75843.1.
AP009048 Genomic DNA. Translation: BAE76873.1.
M31059 Genomic DNA. Translation: AAA23822.2.
PIRiJS0184. WQECFP.
RefSeqiNP_417281.1. NC_000913.3.
WP_000528603.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75843; AAC75843; b2801.
BAE76873; BAE76873; BAE76873.
GeneIDi947487.
KEGGiecj:JW2772.
eco:b2801.
PATRICi32121018. VBIEscCol129921_2901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15025 Genomic DNA. Translation: CAA33126.1.
U29581 Genomic DNA. Translation: AAB40451.1.
U00096 Genomic DNA. Translation: AAC75843.1.
AP009048 Genomic DNA. Translation: BAE76873.1.
M31059 Genomic DNA. Translation: AAA23822.2.
PIRiJS0184. WQECFP.
RefSeqiNP_417281.1. NC_000913.3.
WP_000528603.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O7PX-ray3.20A1-438[»]
3O7QX-ray3.14A1-438[»]
ProteinModelPortaliP11551.
SMRiP11551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260704. 18 interactors.
STRINGi511145.b2801.

Protein family/group databases

TCDBi2.A.1.7.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP11551.
PRIDEiP11551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75843; AAC75843; b2801.
BAE76873; BAE76873; BAE76873.
GeneIDi947487.
KEGGiecj:JW2772.
eco:b2801.
PATRICi32121018. VBIEscCol129921_2901.

Organism-specific databases

EchoBASEiEB0348.
EcoGeneiEG10352. fucP.

Phylogenomic databases

eggNOGiENOG4105EDR. Bacteria.
COG0738. LUCA.
HOGENOMiHOG000267862.
InParanoidiP11551.
KOiK02429.
OMAiFESCIFP.
PhylomeDBiP11551.

Enzyme and pathway databases

BioCyciEcoCyc:FUCP-MONOMER.
ECOL316407:JW2772-MONOMER.
MetaCyc:FUCP-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP11551.
PROiP11551.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR005275. Lfuc_permease_FucP.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00885. fucP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUCP_ECOLI
AccessioniPrimary (citable) accession number: P11551
Secondary accession number(s): Q2MA33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.