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Protein

L-fucose-proton symporter

Gene

fucP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose.1 Publication

GO - Molecular functioni

  • arabinose:proton symporter activity Source: EcoCyc
  • fucose:proton symporter activity Source: EcoCyc
  • galactose:proton symporter activity Source: EcoCyc

GO - Biological processi

  • arabinose transport Source: EcoCyc
  • fucose metabolic process Source: UniProtKB-KW
  • fucose transport Source: EcoCyc
  • galactose transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism, Sugar transport, Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:FUCP-MONOMER.
ECOL316407:JW2772-MONOMER.
MetaCyc:FUCP-MONOMER.

Protein family/group databases

TCDBi2.A.1.7.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose-proton symporter
Alternative name(s):
6-deoxy-L-galactose permease
L-fucose permease
Gene namesi
Name:fucP
Ordered Locus Names:b2801, JW2772
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10352. fucP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2423CytoplasmicCuratedAdd
BLAST
Transmembranei25 – 4521HelicalCuratedAdd
BLAST
Topological domaini46 – 5510PeriplasmicCurated
Transmembranei56 – 7621HelicalCuratedAdd
BLAST
Topological domaini77 – 9519CytoplasmicCuratedAdd
BLAST
Transmembranei96 – 11520HelicalCuratedAdd
BLAST
Topological domaini116 – 1183PeriplasmicCurated
Transmembranei119 – 13921HelicalCuratedAdd
BLAST
Topological domaini140 – 16627CytoplasmicCuratedAdd
BLAST
Transmembranei167 – 18721HelicalCuratedAdd
BLAST
Topological domaini188 – 20619PeriplasmicCuratedAdd
BLAST
Transmembranei207 – 22721HelicalCuratedAdd
BLAST
Topological domaini228 – 26538CytoplasmicCuratedAdd
BLAST
Transmembranei266 – 28621HelicalCuratedAdd
BLAST
Topological domaini287 – 2959PeriplasmicCurated
Transmembranei296 – 31621HelicalCuratedAdd
BLAST
Topological domaini317 – 32610CytoplasmicCurated
Transmembranei327 – 34721HelicalCuratedAdd
BLAST
Topological domaini348 – 3525PeriplasmicCurated
Transmembranei353 – 37321HelicalCuratedAdd
BLAST
Topological domaini374 – 3818CytoplasmicCurated
Transmembranei382 – 40221HelicalCuratedAdd
BLAST
Topological domaini403 – 41311PeriplasmicCuratedAdd
BLAST
Transmembranei414 – 43421HelicalCuratedAdd
BLAST
Topological domaini435 – 4384CytoplasmicCurated

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 438437L-fucose-proton symporterPRO_0000094501Add
BLAST

Proteomic databases

PaxDbiP11551.
PRIDEiP11551.

Expressioni

Inductioni

By L-fucose.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260704. 18 interactions.
STRINGi511145.b2801.

Structurei

Secondary structure

1
438
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 5531Combined sources
Helixi61 – 7515Combined sources
Helixi78 – 8710Combined sources
Helixi90 – 11324Combined sources
Helixi117 – 14428Combined sources
Helixi148 – 1503Combined sources
Helixi151 – 17222Combined sources
Helixi175 – 1784Combined sources
Helixi186 – 1916Combined sources
Helixi194 – 22835Combined sources
Turni235 – 2373Combined sources
Helixi247 – 2548Combined sources
Helixi259 – 28830Combined sources
Helixi294 – 32128Combined sources
Helixi324 – 34421Combined sources
Helixi347 – 36115Combined sources
Helixi364 – 37310Combined sources
Helixi377 – 3793Combined sources
Helixi380 – 38910Combined sources
Helixi392 – 40817Combined sources
Helixi412 – 4154Combined sources
Helixi416 – 42914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3O7PX-ray3.20A1-438[»]
3O7QX-ray3.14A1-438[»]
ProteinModelPortaliP11551.
SMRiP11551. Positions 22-435.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11551.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EDR. Bacteria.
COG0738. LUCA.
HOGENOMiHOG000267862.
InParanoidiP11551.
KOiK02429.
OMAiFESCIFP.
PhylomeDBiP11551.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR005275. Lfuc_permease_FucP.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00885. fucP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTSIQTQS YRAVDKDAGQ SRSYIIPFAL LCSLFFLWAV ANNLNDILLP
60 70 80 90 100
QFQQAFTLTN FQAGLIQSAF YFGYFIIPIP AGILMKKLSY KAGIITGLFL
110 120 130 140 150
YALGAALFWP AAEIMNYTLF LVGLFIIAAG LGCLETAANP FVTVLGPESS
160 170 180 190 200
GHFRLNLAQT FNSFGAIIAV VFGQSLILSN VPHQSQDVLD KMSPEQLSAY
210 220 230 240 250
KHSLVLSVQT PYMIIVAIVL LVALLIMLTK FPALQSDNHS DAKQGSFSAS
260 270 280 290 300
LSRLARIRHW RWAVLAQFCY VGAQTACWSY LIRYAVEEIP GMTAGFAANY
310 320 330 340 350
LTGTMVCFFI GRFTGTWLIS RFAPHKVLAA YALIAMALCL ISAFAGGHVG
360 370 380 390 400
LIALTLCSAF MSIQYPTIFS LGIKNLGQDT KYGSSFIVMT IIGGGIVTPV
410 420 430
MGFVSDAAGN IPTAELIPAL CFAVIFIFAR FRSQTATN
Length:438
Mass (Da):47,545
Last modified:January 23, 2007 - v3
Checksum:iD8AA3785274A0085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15025 Genomic DNA. Translation: CAA33126.1.
U29581 Genomic DNA. Translation: AAB40451.1.
U00096 Genomic DNA. Translation: AAC75843.1.
AP009048 Genomic DNA. Translation: BAE76873.1.
M31059 Genomic DNA. Translation: AAA23822.2.
PIRiJS0184. WQECFP.
RefSeqiNP_417281.1. NC_000913.3.
WP_000528603.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75843; AAC75843; b2801.
BAE76873; BAE76873; BAE76873.
GeneIDi947487.
KEGGiecj:JW2772.
eco:b2801.
PATRICi32121018. VBIEscCol129921_2901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15025 Genomic DNA. Translation: CAA33126.1.
U29581 Genomic DNA. Translation: AAB40451.1.
U00096 Genomic DNA. Translation: AAC75843.1.
AP009048 Genomic DNA. Translation: BAE76873.1.
M31059 Genomic DNA. Translation: AAA23822.2.
PIRiJS0184. WQECFP.
RefSeqiNP_417281.1. NC_000913.3.
WP_000528603.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3O7PX-ray3.20A1-438[»]
3O7QX-ray3.14A1-438[»]
ProteinModelPortaliP11551.
SMRiP11551. Positions 22-435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260704. 18 interactions.
STRINGi511145.b2801.

Protein family/group databases

TCDBi2.A.1.7.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP11551.
PRIDEiP11551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75843; AAC75843; b2801.
BAE76873; BAE76873; BAE76873.
GeneIDi947487.
KEGGiecj:JW2772.
eco:b2801.
PATRICi32121018. VBIEscCol129921_2901.

Organism-specific databases

EchoBASEiEB0348.
EcoGeneiEG10352. fucP.

Phylogenomic databases

eggNOGiENOG4105EDR. Bacteria.
COG0738. LUCA.
HOGENOMiHOG000267862.
InParanoidiP11551.
KOiK02429.
OMAiFESCIFP.
PhylomeDBiP11551.

Enzyme and pathway databases

BioCyciEcoCyc:FUCP-MONOMER.
ECOL316407:JW2772-MONOMER.
MetaCyc:FUCP-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP11551.
PROiP11551.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR005275. Lfuc_permease_FucP.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00885. fucP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUCP_ECOLI
AccessioniPrimary (citable) accession number: P11551
Secondary accession number(s): Q2MA33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.