Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P11533 (DMD_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dystrophin
Gene names
Name:DMD
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length3660 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in anchoring the cytoskeleton to the plasma membrane.

Subcellular location

Cell membranesarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcytoskeleton. Cell junctionsynapsepostsynaptic cell membrane By similarity. Note: Localizes to neuromuscular junctions By similarity.

Sequence similarities

Contains 2 CH (calponin-homology) domains.

Contains 22 spectrin repeats.

Contains 1 WW domain.

Contains 1 ZZ-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 36603660Dystrophin
PRO_0000076078

Regions

Domain1 – 244244Actin-binding
Domain19 – 123105CH 1
Domain138 – 241104CH 2
Repeat341 – 449109Spectrin 1
Repeat450 – 558109Spectrin 2
Repeat561 – 669109Spectrin 3
Repeat721 – 830110Spectrin 4
Repeat832 – 936105Spectrin 5
Repeat945 – 1047103Spectrin 6
Repeat1050 – 1156107Spectrin 7
Repeat1159 – 1265107Spectrin 8
Repeat1268 – 1369102Spectrin 9
Repeat1470 – 1570101Spectrin 10
Repeat1573 – 1678106Spectrin 11
Repeat1681 – 1782102Spectrin 12
Repeat1879 – 1981103Spectrin 13
Repeat2013 – 210391Spectrin 14
Repeat2106 – 2211106Spectrin 15
Repeat2214 – 2321108Spectrin 16
Repeat2472 – 2574103Spectrin 17
Repeat2577 – 2683107Spectrin 18
Repeat2686 – 2799114Spectrin 19
Repeat2802 – 2904103Spectrin 20
Repeat2906 – 292823Spectrin 21
Repeat2931 – 3037107Spectrin 22
Domain3052 – 308534WW
Zinc finger3304 – 335148ZZ-type

Natural variations

Natural variant11711Missing.
Natural variant18691Q → H.
Natural variant18851K → R.

Sequences

Sequence LengthMass (Da)Tools
P11533 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 85493DAF6D5B6D4A

FASTA3,660422,881
        10         20         30         40         50         60 
MSAHVLWYEE VEDDYEREDV QKKTFTKWIN AQFAKCGRRC IEDLFNDFRD GRKLLELLEC 

        70         80         90        100        110        120 
LTGQKIAKEK GSTRVHALNN VNKALQILQR NNVDLVNIGS SDIVDGNHKL TLGLIWNIIL 

       130        140        150        160        170        180 
HWQVKDVMKN IMAGLQQTNS EKILLSWVRQ STRNYPQVNV INFTSSWSDG LAFNALLHSH 

       190        200        210        220        230        240 
RPDLFDWNAV ASQQSPVQRL DHAFNIARQH LGIEKLLDPE DVATACPDKK SILMYVTSLF 

       250        260        270        280        290        300 
QVLPQQVTME AIREVEMLPR HSRVTTEEHI QVHHQQHFSQ EITVNIPQRP SPSPKPRFKS 

       310        320        330        340        350        360 
YAYAQTAYVI PPDQKRRQVP PQFLETVEKR TYTTTVMRSE MDLDSYQTAL EEVLTWLLSA 

       370        380        390        400        410        420 
EDALQAQGDI SSDVEVVKEQ FHTHEGFMME LTAHQGRVGN VLQVGSQLLA MGKLSDDEEN 

       430        440        450        460        470        480 
EIQEQMNLLN SRWESLRVAS MEKQSNLHKI LMDLQNQQLA QLADWLTKTE ERTKKIDSEP 

       490        500        510        520        530        540 
LGPDLEDLKR QVEEHKAFQD DLEQEQVKVN SLTHMVVVVD ENSGDKATAA LEEQLQHFGS 

       550        560        570        580        590        600 
RWAAICRWTE DRWVLLQDIL RKWQHFAEEQ CLFDAWLTEK EGSLSKIQTS DFKDENEMLT 

       610        620        630        640        650        660 
SLRKLAILKG DIEMKKQMMS KLKSLSRDLL VAVKNKAVAQ KLESRLENFA QRWDSLVQKL 

       670        680        690        700        710        720 
ESDSKQVSQA VTTTQTSLTQ TTVMETVTMV TTREQILVKH AKEELPPPPP HKKRQLLVDS 

       730        740        750        760        770        780 
EIRKRFDSDT TELHSWMTRS EAVLQSPEFA IYRKEGNLSD LRERVNAIQR EKPEKYRKLQ 

       790        800        810        820        830        840 
DASRSAEALV EQMVNEGLNA DNIRQASEQL KSRWIEFCQL LSERLVWLEY QNSIIDFYSQ 

       850        860        870        880        890        900 
LQRLEQTAIT AENWLKAQPT PATDPATVKI QLEKCKDEII RMSTLQPQIE RLKAQSQALK 

       910        920        930        940        950        960 
EKEQCPVFLD ADLAAFTSHF KQILADMHTR EKQLQTIFDS LPPARYKDTV TTILSWIQQS 

       970        980        990       1000       1010       1020 
ETKVSIPPVA VAEYEIMEQR LGELKALQSS LQEQQKGLKY LNTTVEDLSR KAPAEVSQKY 

      1030       1040       1050       1060       1070       1080 
RSEVELIVGR WKKLSSQLVE HCQKLEDLMT KLQRFQNDTK TLKKWMAEVD VFLKEEWPAL 

      1090       1100       1110       1120       1130       1140 
GDSEALEKQL EQCTALVNDI QTIQPSLNSV NEIGKKMKRE AEPEFASRIA TELKDLNAQW 

      1150       1160       1170       1180       1190       1200 
EHICQQAHAK KAALKGGLDK TVSLRKDLSE MHEWITQAEE EYLERDFEYK TPEELQKAVE 

      1210       1220       1230       1240       1250       1260 
ELKRAKEDAM QKEVKVKLIT DSVNNFIAKA PPAANEALKK ELDVLITSYQ RLCSRLNGKC 

      1270       1280       1290       1300       1310       1320 
KTLEEVWACW HELLSYLDAE NKWLNEVELK LKATENIQGG AEEISESLDS LERLMRHPED 

      1330       1340       1350       1360       1370       1380 
NRNQIRELAQ TLTDGGILDE LINEKLEKFN TRWEELQQEA VRRQKSLEQS IQSAQETDKT 

      1390       1400       1410       1420       1430       1440 
LRLIQESLAA IDKQLTAYTA DRVDAAQVPQ EAQKIQSELT SHEISLEEMK KRNRGKESAK 

      1450       1460       1470       1480       1490       1500 
RVLSQIDVAQ KKLQDVSMKF RLFQKPANFE QRLQECKRIL DEVKLQVPKL ETKSVEQEVV 

      1510       1520       1530       1540       1550       1560 
QSHLDHCMKL YKSLSEVKSE VETVIKTGRQ IVQKQQTENP KELDERLTAL KLQYNELGAK 

      1570       1580       1590       1600       1610       1620 
VTEKKQELEK CLKLSRKLRK EINSLTEWLA ATDVELTKRS AVQGMPSNLD AEIAWGKATR 

      1630       1640       1650       1660       1670       1680 
KEIEKRQVQL KNICDLGENL KTVLKGKESL VEDKLSLLNS NWIAVTSRAE EWLNLLMEYQ 

      1690       1700       1710       1720       1730       1740 
KHMEAFDQKV ANVTTWIYRA EILLDESDKQ KPQQKEETLK RLKAELNDMH PKVDSVRDQA 

      1750       1760       1770       1780       1790       1800 
VDLMTNRGDH CRKVIEPKLS ELNHRFAAIS QRIKSGKPFI PLKELEQFDF DIQKLLEPLE 

      1810       1820       1830       1840       1850       1860 
VEIQQGVNLK EEDFNKDMSE DDESTVKELL QRGDTLQKRI TDERKREEIK IKQQLLQTKH 

      1870       1880       1890       1900       1910       1920 
NALKDLRSQR RKKALEISHQ WYQYKRQADD LMTWLDDIEK KLASLPDHKD EQKLKEIGGE 

      1930       1940       1950       1960       1970       1980 
LEKKKEDLNA VNRQAERLSK DGAAKAVEPT LVQLSKRWRD FESKFAQFRR LNYAQIQTVL 

      1990       2000       2010       2020       2030       2040 
EDTTFVMTES MTVETTYVPS TYLAEILQLL QALSEVEERL NSPVLQAKDC EDLLKQEECL 

      2050       2060       2070       2080       2090       2100 
KNIKDCLGRL QGHIDIIHSK KTPALQSATP RETANIQDKL TQLNSQWEKV NKMYRDRQAR 

      2110       2120       2130       2140       2150       2160 
FDKSKEKWRL FHCEMKSFNE WLTETEEKLS RAQIEAGDVG HVKTKQFLQE LQDGIGRQQT 

      2170       2180       2190       2200       2210       2220 
VVKTLNVTGE EIIEQSSAAD ANVLKEQLGN LNTRWQEICR QLVEKRKRIE EEKNILSEFQ 

      2230       2240       2250       2260       2270       2280 
EDLNKLILWL EETENVIAIP LEPGNEDQLR DCLGKVKLRV EELLPHKGIL KRLNETGGTT 

      2290       2300       2310       2320       2330       2340 
LGSASLNPER KHKLESTLKE ASRRLLKVSR DLPEKQKEIE ILLKDFIELN QQINQLTLWI 

      2350       2360       2370       2380       2390       2400 
TPVKNQLELY NQVGQPGAFD IKETEAAVQA KQPNVEEVLS KGCHLYKEKP ATHPVKKKLE 

      2410       2420       2430       2440       2450       2460 
DLNADWKAIN HLILQLKEKP TFGEPALTSP GVLTSGQTVA VDTQARVTKE TTSFTPEMPS 

      2470       2480       2490       2500       2510       2520 
SVLLEVPALA DFNKAWAELT DWLSRLDREI KAQRVTVGDL DDINDMIIKQ KANMQDLEQR 

      2530       2540       2550       2560       2570       2580 
RPQLDELITA AQNLKNKTSN QEARTIITDR IEKIQSQWDD VHGYLQNRRQ QLHEMQKDST 

      2590       2600       2610       2620       2630       2640 
QWLEAKQEAE QVLEQAKAKL ESWKEISYTV EALKKQNSEL KQFSKEIRQW QMNIEGVNDV 

      2650       2660       2670       2680       2690       2700 
ALKPVRDYSA DDTRKVELMT DNINATWATI NKRVSEREAA LESALLMLQE FYLDLEKFLA 

      2710       2720       2730       2740       2750       2760 
WLTEAETTAN VLQDATHKEK TLEDPQMVRE LMKQWQDLQA EIDAHTDIFH NLDENGQKIL 

      2770       2780       2790       2800       2810       2820 
RSLEGSEDAV LLQRRLDNMN FRWSELRKKS LNIRSHLEAS TDQWKRLHLS LQELLAWLQL 

      2830       2840       2850       2860       2870       2880 
KEDELKQQAP IGGDIPTVQK QNDVHRTFKR ELKTKEPVIM NALETVRLFL ADQPVEGLEK 

      2890       2900       2910       2920       2930       2940 
VYPEPRDLSP EERAQNVTKV LRRQADDVRT EWDKLNLRSA DWQKKIDDAL ERLQGLQEAM 

      2950       2960       2970       2980       2990       3000 
DELDLKLRQA EAFKGSWQPV GDLLIDSLQD HLEKVKVYRA EMVPLKEKVH QVNELAHRFA 

      3010       3020       3030       3040       3050       3060 
PPDIQLSPYT LSCLEDLNTR WKVLQVAIDE RIRQLHEAHR DFGPTSQHFL TTSVQGPWER 

      3070       3080       3090       3100       3110       3120 
AISPNKVPYY INHETQTTCW DHPKMTELYQ SLADLNNVRF SAYRTAMKLR RLQKALCLDL 

      3130       3140       3150       3160       3170       3180 
LNLSAACDAL DQHNLKQNDQ PMDILQIINC LTTIYDRLEQ EHNNLVNVPL CVDMCLNWLL 

      3190       3200       3210       3220       3230       3240 
NVYDTGRTGR IRVLSFKTGV VSLCKAHLED KYRYLFKQVA SSTGFCDQRR LGLLLHDSIQ 

      3250       3260       3270       3280       3290       3300 
IPRQLGEVAS FGGSNIEPSV RSCFQFANNK PEIEAALFLD WMRLEPQSMV WLPVLHRVAA 

      3310       3320       3330       3340       3350       3360 
AETAKHQAKC NICKECPIIG FRYRSLKHFN YDICQSCFFS GRVAKGHKMH YPMVEYCTPT 

      3370       3380       3390       3400       3410       3420 
TSGEDVRDFA KVLKNKFRTK RYFAKHPRMG YLPVQTVLEG DNMETPVTLI NFWPVDSALA 

      3430       3440       3450       3460       3470       3480 
EMENSNGSYL NDSISPNESI DDEHLLIQHY CQSLNQESPL SQPRSPAQIL ISLESEERGE 

      3490       3500       3510       3520       3530       3540 
LERILADLEE ENRNLQAEYD RLKQQHDHKG LSPLPSPPEM MPVSPQSPRD AELIAEAKLL 

      3550       3560       3570       3580       3590       3600 
RQHKGRLEAR MQILEDHNKQ LESQLHRLRQ LLEQPQADAK VNGTTLSSPS TSLQRSDSSQ 

      3610       3620       3630       3640       3650       3660 
PMLLRVVGSQ TSETMGEDDL LSPPQDTSTG LEEVMEQLNN SFPSSRGRNA PGKPVREATM 

« Hide

References

[1]"Nucleotide sequence of chicken dystrophin cDNA."
Lemaire C., Heilig R., Mandel J.-L.
Nucleic Acids Res. 16:11815-11815(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The chicken dystrophin cDNA: striking conservation of the C-terminal coding and 3' untranslated regions between man and chicken."
Lemaire C., Heilig R., Mandel J.L.
EMBO J. 7:4157-4162(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13369 mRNA. Translation: CAA31746.1.
PIRS02041.
RefSeqNP_990630.1. NM_205299.1.
UniGeneGga.718.

3D structure databases

ProteinModelPortalP11533.
SMRP11533. Positions 13-250, 3044-3303.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP11533.
PRIDEP11533.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396236.
KEGGgga:396236.

Organism-specific databases

CTD1756.

Phylogenomic databases

eggNOGCOG5069.
HOGENOMHOG000231173.
HOVERGENHBG005495.
InParanoidP11533.
KOK10366.
PhylomeDBP11533.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
1.10.418.10. 2 hits.
InterProIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR016344. Dystrophin/utrophin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamPF00307. CH. 2 hits.
PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 17 hits.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFPIRSF002341. Dystrophin/utrophin. 1 hit.
SMARTSM00033. CH. 2 hits.
SM00150. SPEC. 21 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMSSF47576. SSF47576. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816288.

Entry information

Entry nameDMD_CHICK
AccessionPrimary (citable) accession number: P11533
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families