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P11533

- DMD_CHICK

UniProt

P11533 - DMD_CHICK

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Protein
Dystrophin
Gene
DMD
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in anchoring the cytoskeleton to the plasma membrane.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3304 – 335148ZZ-type
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrophin
Gene namesi
Name:DMD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membranesarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcytoskeleton. Cell junctionsynapsepostsynaptic cell membrane By similarity
Note: Localizes to neuromuscular junctions By similarity.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-SubCell
  4. postsynaptic membrane Source: UniProtKB-SubCell
  5. sarcolemma Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 36603660Dystrophin
PRO_0000076078Add
BLAST

Proteomic databases

PaxDbiP11533.
PRIDEiP11533.

Structurei

3D structure databases

ProteinModelPortaliP11533.
SMRiP11533. Positions 13-250, 3044-3303.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 244244Actin-binding
Add
BLAST
Domaini19 – 123105CH 1
Add
BLAST
Domaini138 – 241104CH 2
Add
BLAST
Repeati341 – 449109Spectrin 1
Add
BLAST
Repeati450 – 558109Spectrin 2
Add
BLAST
Repeati561 – 669109Spectrin 3
Add
BLAST
Repeati721 – 830110Spectrin 4
Add
BLAST
Repeati832 – 936105Spectrin 5
Add
BLAST
Repeati945 – 1047103Spectrin 6
Add
BLAST
Repeati1050 – 1156107Spectrin 7
Add
BLAST
Repeati1159 – 1265107Spectrin 8
Add
BLAST
Repeati1268 – 1369102Spectrin 9
Add
BLAST
Repeati1470 – 1570101Spectrin 10
Add
BLAST
Repeati1573 – 1678106Spectrin 11
Add
BLAST
Repeati1681 – 1782102Spectrin 12
Add
BLAST
Repeati1879 – 1981103Spectrin 13
Add
BLAST
Repeati2013 – 210391Spectrin 14
Add
BLAST
Repeati2106 – 2211106Spectrin 15
Add
BLAST
Repeati2214 – 2321108Spectrin 16
Add
BLAST
Repeati2472 – 2574103Spectrin 17
Add
BLAST
Repeati2577 – 2683107Spectrin 18
Add
BLAST
Repeati2686 – 2799114Spectrin 19
Add
BLAST
Repeati2802 – 2904103Spectrin 20
Add
BLAST
Repeati2906 – 292823Spectrin 21
Add
BLAST
Repeati2931 – 3037107Spectrin 22
Add
BLAST
Domaini3052 – 308534WW
Add
BLAST

Sequence similaritiesi

Contains 22 spectrin repeats.
Contains 1 WW domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5069.
HOGENOMiHOG000231173.
HOVERGENiHBG005495.
InParanoidiP11533.
KOiK10366.
PhylomeDBiP11533.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR016344. Dystrophin/utrophin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00307. CH. 2 hits.
PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 17 hits.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF002341. Dystrophin/utrophin. 1 hit.
SMARTiSM00033. CH. 2 hits.
SM00150. SPEC. 21 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11533-1 [UniParc]FASTAAdd to Basket

« Hide

MSAHVLWYEE VEDDYEREDV QKKTFTKWIN AQFAKCGRRC IEDLFNDFRD     50
GRKLLELLEC LTGQKIAKEK GSTRVHALNN VNKALQILQR NNVDLVNIGS 100
SDIVDGNHKL TLGLIWNIIL HWQVKDVMKN IMAGLQQTNS EKILLSWVRQ 150
STRNYPQVNV INFTSSWSDG LAFNALLHSH RPDLFDWNAV ASQQSPVQRL 200
DHAFNIARQH LGIEKLLDPE DVATACPDKK SILMYVTSLF QVLPQQVTME 250
AIREVEMLPR HSRVTTEEHI QVHHQQHFSQ EITVNIPQRP SPSPKPRFKS 300
YAYAQTAYVI PPDQKRRQVP PQFLETVEKR TYTTTVMRSE MDLDSYQTAL 350
EEVLTWLLSA EDALQAQGDI SSDVEVVKEQ FHTHEGFMME LTAHQGRVGN 400
VLQVGSQLLA MGKLSDDEEN EIQEQMNLLN SRWESLRVAS MEKQSNLHKI 450
LMDLQNQQLA QLADWLTKTE ERTKKIDSEP LGPDLEDLKR QVEEHKAFQD 500
DLEQEQVKVN SLTHMVVVVD ENSGDKATAA LEEQLQHFGS RWAAICRWTE 550
DRWVLLQDIL RKWQHFAEEQ CLFDAWLTEK EGSLSKIQTS DFKDENEMLT 600
SLRKLAILKG DIEMKKQMMS KLKSLSRDLL VAVKNKAVAQ KLESRLENFA 650
QRWDSLVQKL ESDSKQVSQA VTTTQTSLTQ TTVMETVTMV TTREQILVKH 700
AKEELPPPPP HKKRQLLVDS EIRKRFDSDT TELHSWMTRS EAVLQSPEFA 750
IYRKEGNLSD LRERVNAIQR EKPEKYRKLQ DASRSAEALV EQMVNEGLNA 800
DNIRQASEQL KSRWIEFCQL LSERLVWLEY QNSIIDFYSQ LQRLEQTAIT 850
AENWLKAQPT PATDPATVKI QLEKCKDEII RMSTLQPQIE RLKAQSQALK 900
EKEQCPVFLD ADLAAFTSHF KQILADMHTR EKQLQTIFDS LPPARYKDTV 950
TTILSWIQQS ETKVSIPPVA VAEYEIMEQR LGELKALQSS LQEQQKGLKY 1000
LNTTVEDLSR KAPAEVSQKY RSEVELIVGR WKKLSSQLVE HCQKLEDLMT 1050
KLQRFQNDTK TLKKWMAEVD VFLKEEWPAL GDSEALEKQL EQCTALVNDI 1100
QTIQPSLNSV NEIGKKMKRE AEPEFASRIA TELKDLNAQW EHICQQAHAK 1150
KAALKGGLDK TVSLRKDLSE MHEWITQAEE EYLERDFEYK TPEELQKAVE 1200
ELKRAKEDAM QKEVKVKLIT DSVNNFIAKA PPAANEALKK ELDVLITSYQ 1250
RLCSRLNGKC KTLEEVWACW HELLSYLDAE NKWLNEVELK LKATENIQGG 1300
AEEISESLDS LERLMRHPED NRNQIRELAQ TLTDGGILDE LINEKLEKFN 1350
TRWEELQQEA VRRQKSLEQS IQSAQETDKT LRLIQESLAA IDKQLTAYTA 1400
DRVDAAQVPQ EAQKIQSELT SHEISLEEMK KRNRGKESAK RVLSQIDVAQ 1450
KKLQDVSMKF RLFQKPANFE QRLQECKRIL DEVKLQVPKL ETKSVEQEVV 1500
QSHLDHCMKL YKSLSEVKSE VETVIKTGRQ IVQKQQTENP KELDERLTAL 1550
KLQYNELGAK VTEKKQELEK CLKLSRKLRK EINSLTEWLA ATDVELTKRS 1600
AVQGMPSNLD AEIAWGKATR KEIEKRQVQL KNICDLGENL KTVLKGKESL 1650
VEDKLSLLNS NWIAVTSRAE EWLNLLMEYQ KHMEAFDQKV ANVTTWIYRA 1700
EILLDESDKQ KPQQKEETLK RLKAELNDMH PKVDSVRDQA VDLMTNRGDH 1750
CRKVIEPKLS ELNHRFAAIS QRIKSGKPFI PLKELEQFDF DIQKLLEPLE 1800
VEIQQGVNLK EEDFNKDMSE DDESTVKELL QRGDTLQKRI TDERKREEIK 1850
IKQQLLQTKH NALKDLRSQR RKKALEISHQ WYQYKRQADD LMTWLDDIEK 1900
KLASLPDHKD EQKLKEIGGE LEKKKEDLNA VNRQAERLSK DGAAKAVEPT 1950
LVQLSKRWRD FESKFAQFRR LNYAQIQTVL EDTTFVMTES MTVETTYVPS 2000
TYLAEILQLL QALSEVEERL NSPVLQAKDC EDLLKQEECL KNIKDCLGRL 2050
QGHIDIIHSK KTPALQSATP RETANIQDKL TQLNSQWEKV NKMYRDRQAR 2100
FDKSKEKWRL FHCEMKSFNE WLTETEEKLS RAQIEAGDVG HVKTKQFLQE 2150
LQDGIGRQQT VVKTLNVTGE EIIEQSSAAD ANVLKEQLGN LNTRWQEICR 2200
QLVEKRKRIE EEKNILSEFQ EDLNKLILWL EETENVIAIP LEPGNEDQLR 2250
DCLGKVKLRV EELLPHKGIL KRLNETGGTT LGSASLNPER KHKLESTLKE 2300
ASRRLLKVSR DLPEKQKEIE ILLKDFIELN QQINQLTLWI TPVKNQLELY 2350
NQVGQPGAFD IKETEAAVQA KQPNVEEVLS KGCHLYKEKP ATHPVKKKLE 2400
DLNADWKAIN HLILQLKEKP TFGEPALTSP GVLTSGQTVA VDTQARVTKE 2450
TTSFTPEMPS SVLLEVPALA DFNKAWAELT DWLSRLDREI KAQRVTVGDL 2500
DDINDMIIKQ KANMQDLEQR RPQLDELITA AQNLKNKTSN QEARTIITDR 2550
IEKIQSQWDD VHGYLQNRRQ QLHEMQKDST QWLEAKQEAE QVLEQAKAKL 2600
ESWKEISYTV EALKKQNSEL KQFSKEIRQW QMNIEGVNDV ALKPVRDYSA 2650
DDTRKVELMT DNINATWATI NKRVSEREAA LESALLMLQE FYLDLEKFLA 2700
WLTEAETTAN VLQDATHKEK TLEDPQMVRE LMKQWQDLQA EIDAHTDIFH 2750
NLDENGQKIL RSLEGSEDAV LLQRRLDNMN FRWSELRKKS LNIRSHLEAS 2800
TDQWKRLHLS LQELLAWLQL KEDELKQQAP IGGDIPTVQK QNDVHRTFKR 2850
ELKTKEPVIM NALETVRLFL ADQPVEGLEK VYPEPRDLSP EERAQNVTKV 2900
LRRQADDVRT EWDKLNLRSA DWQKKIDDAL ERLQGLQEAM DELDLKLRQA 2950
EAFKGSWQPV GDLLIDSLQD HLEKVKVYRA EMVPLKEKVH QVNELAHRFA 3000
PPDIQLSPYT LSCLEDLNTR WKVLQVAIDE RIRQLHEAHR DFGPTSQHFL 3050
TTSVQGPWER AISPNKVPYY INHETQTTCW DHPKMTELYQ SLADLNNVRF 3100
SAYRTAMKLR RLQKALCLDL LNLSAACDAL DQHNLKQNDQ PMDILQIINC 3150
LTTIYDRLEQ EHNNLVNVPL CVDMCLNWLL NVYDTGRTGR IRVLSFKTGV 3200
VSLCKAHLED KYRYLFKQVA SSTGFCDQRR LGLLLHDSIQ IPRQLGEVAS 3250
FGGSNIEPSV RSCFQFANNK PEIEAALFLD WMRLEPQSMV WLPVLHRVAA 3300
AETAKHQAKC NICKECPIIG FRYRSLKHFN YDICQSCFFS GRVAKGHKMH 3350
YPMVEYCTPT TSGEDVRDFA KVLKNKFRTK RYFAKHPRMG YLPVQTVLEG 3400
DNMETPVTLI NFWPVDSALA EMENSNGSYL NDSISPNESI DDEHLLIQHY 3450
CQSLNQESPL SQPRSPAQIL ISLESEERGE LERILADLEE ENRNLQAEYD 3500
RLKQQHDHKG LSPLPSPPEM MPVSPQSPRD AELIAEAKLL RQHKGRLEAR 3550
MQILEDHNKQ LESQLHRLRQ LLEQPQADAK VNGTTLSSPS TSLQRSDSSQ 3600
PMLLRVVGSQ TSETMGEDDL LSPPQDTSTG LEEVMEQLNN SFPSSRGRNA 3650
PGKPVREATM 3660
Length:3,660
Mass (Da):422,881
Last modified:October 1, 1989 - v1
Checksum:i85493DAF6D5B6D4A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1171 – 11711Missing.
Natural varianti1869 – 18691Q → H.
Natural varianti1885 – 18851K → R.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13369 mRNA. Translation: CAA31746.1.
PIRiS02041.
RefSeqiNP_990630.1. NM_205299.1.
UniGeneiGga.718.

Genome annotation databases

GeneIDi396236.
KEGGigga:396236.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13369 mRNA. Translation: CAA31746.1 .
PIRi S02041.
RefSeqi NP_990630.1. NM_205299.1.
UniGenei Gga.718.

3D structure databases

ProteinModelPortali P11533.
SMRi P11533. Positions 13-250, 3044-3303.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P11533.
PRIDEi P11533.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396236.
KEGGi gga:396236.

Organism-specific databases

CTDi 1756.

Phylogenomic databases

eggNOGi COG5069.
HOGENOMi HOG000231173.
HOVERGENi HBG005495.
InParanoidi P11533.
KOi K10366.
PhylomeDBi P11533.

Miscellaneous databases

NextBioi 20816288.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
1.10.418.10. 2 hits.
InterProi IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR016344. Dystrophin/utrophin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF00307. CH. 2 hits.
PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 17 hits.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view ]
PIRSFi PIRSF002341. Dystrophin/utrophin. 1 hit.
SMARTi SM00033. CH. 2 hits.
SM00150. SPEC. 21 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEi PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The chicken dystrophin cDNA: striking conservation of the C-terminal coding and 3' untranslated regions between man and chicken."
    Lemaire C., Heilig R., Mandel J.L.
    EMBO J. 7:4157-4162(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiDMD_CHICK
AccessioniPrimary (citable) accession number: P11533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi