Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P11533

- DMD_CHICK

UniProt

P11533 - DMD_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dystrophin

Gene

DMD

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in anchoring the cytoskeleton to the plasma membrane.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3304 – 335148ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrophin
Gene namesi
Name:DMD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membranesarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcytoskeleton. Cell junctionsynapsepostsynaptic cell membrane By similarity
Note: Localizes to neuromuscular junctions.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-KW
  4. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 36603660DystrophinPRO_0000076078Add
BLAST

Proteomic databases

PaxDbiP11533.
PRIDEiP11533.

Structurei

3D structure databases

ProteinModelPortaliP11533.
SMRiP11533. Positions 13-250, 3044-3303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 244244Actin-bindingAdd
BLAST
Domaini19 – 123105CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 241104CH 2PROSITE-ProRule annotationAdd
BLAST
Repeati341 – 449109Spectrin 1Add
BLAST
Repeati450 – 558109Spectrin 2Add
BLAST
Repeati561 – 669109Spectrin 3Add
BLAST
Repeati721 – 830110Spectrin 4Add
BLAST
Repeati832 – 936105Spectrin 5Add
BLAST
Repeati945 – 1047103Spectrin 6Add
BLAST
Repeati1050 – 1156107Spectrin 7Add
BLAST
Repeati1159 – 1265107Spectrin 8Add
BLAST
Repeati1268 – 1369102Spectrin 9Add
BLAST
Repeati1470 – 1570101Spectrin 10Add
BLAST
Repeati1573 – 1678106Spectrin 11Add
BLAST
Repeati1681 – 1782102Spectrin 12Add
BLAST
Repeati1879 – 1981103Spectrin 13Add
BLAST
Repeati2013 – 210391Spectrin 14Add
BLAST
Repeati2106 – 2211106Spectrin 15Add
BLAST
Repeati2214 – 2321108Spectrin 16Add
BLAST
Repeati2472 – 2574103Spectrin 17Add
BLAST
Repeati2577 – 2683107Spectrin 18Add
BLAST
Repeati2686 – 2799114Spectrin 19Add
BLAST
Repeati2802 – 2904103Spectrin 20Add
BLAST
Repeati2906 – 292823Spectrin 21Add
BLAST
Repeati2931 – 3037107Spectrin 22Add
BLAST
Domaini3052 – 308534WWPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 22 spectrin repeats.Curated
Contains 1 WW domain.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3304 – 335148ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5069.
HOGENOMiHOG000231173.
HOVERGENiHBG005495.
InParanoidiP11533.
KOiK10366.
PhylomeDBiP11533.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR016344. Dystrophin/utrophin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00307. CH. 2 hits.
PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 17 hits.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF002341. Dystrophin/utrophin. 1 hit.
SMARTiSM00033. CH. 2 hits.
SM00150. SPEC. 21 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11533-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAHVLWYEE VEDDYEREDV QKKTFTKWIN AQFAKCGRRC IEDLFNDFRD
60 70 80 90 100
GRKLLELLEC LTGQKIAKEK GSTRVHALNN VNKALQILQR NNVDLVNIGS
110 120 130 140 150
SDIVDGNHKL TLGLIWNIIL HWQVKDVMKN IMAGLQQTNS EKILLSWVRQ
160 170 180 190 200
STRNYPQVNV INFTSSWSDG LAFNALLHSH RPDLFDWNAV ASQQSPVQRL
210 220 230 240 250
DHAFNIARQH LGIEKLLDPE DVATACPDKK SILMYVTSLF QVLPQQVTME
260 270 280 290 300
AIREVEMLPR HSRVTTEEHI QVHHQQHFSQ EITVNIPQRP SPSPKPRFKS
310 320 330 340 350
YAYAQTAYVI PPDQKRRQVP PQFLETVEKR TYTTTVMRSE MDLDSYQTAL
360 370 380 390 400
EEVLTWLLSA EDALQAQGDI SSDVEVVKEQ FHTHEGFMME LTAHQGRVGN
410 420 430 440 450
VLQVGSQLLA MGKLSDDEEN EIQEQMNLLN SRWESLRVAS MEKQSNLHKI
460 470 480 490 500
LMDLQNQQLA QLADWLTKTE ERTKKIDSEP LGPDLEDLKR QVEEHKAFQD
510 520 530 540 550
DLEQEQVKVN SLTHMVVVVD ENSGDKATAA LEEQLQHFGS RWAAICRWTE
560 570 580 590 600
DRWVLLQDIL RKWQHFAEEQ CLFDAWLTEK EGSLSKIQTS DFKDENEMLT
610 620 630 640 650
SLRKLAILKG DIEMKKQMMS KLKSLSRDLL VAVKNKAVAQ KLESRLENFA
660 670 680 690 700
QRWDSLVQKL ESDSKQVSQA VTTTQTSLTQ TTVMETVTMV TTREQILVKH
710 720 730 740 750
AKEELPPPPP HKKRQLLVDS EIRKRFDSDT TELHSWMTRS EAVLQSPEFA
760 770 780 790 800
IYRKEGNLSD LRERVNAIQR EKPEKYRKLQ DASRSAEALV EQMVNEGLNA
810 820 830 840 850
DNIRQASEQL KSRWIEFCQL LSERLVWLEY QNSIIDFYSQ LQRLEQTAIT
860 870 880 890 900
AENWLKAQPT PATDPATVKI QLEKCKDEII RMSTLQPQIE RLKAQSQALK
910 920 930 940 950
EKEQCPVFLD ADLAAFTSHF KQILADMHTR EKQLQTIFDS LPPARYKDTV
960 970 980 990 1000
TTILSWIQQS ETKVSIPPVA VAEYEIMEQR LGELKALQSS LQEQQKGLKY
1010 1020 1030 1040 1050
LNTTVEDLSR KAPAEVSQKY RSEVELIVGR WKKLSSQLVE HCQKLEDLMT
1060 1070 1080 1090 1100
KLQRFQNDTK TLKKWMAEVD VFLKEEWPAL GDSEALEKQL EQCTALVNDI
1110 1120 1130 1140 1150
QTIQPSLNSV NEIGKKMKRE AEPEFASRIA TELKDLNAQW EHICQQAHAK
1160 1170 1180 1190 1200
KAALKGGLDK TVSLRKDLSE MHEWITQAEE EYLERDFEYK TPEELQKAVE
1210 1220 1230 1240 1250
ELKRAKEDAM QKEVKVKLIT DSVNNFIAKA PPAANEALKK ELDVLITSYQ
1260 1270 1280 1290 1300
RLCSRLNGKC KTLEEVWACW HELLSYLDAE NKWLNEVELK LKATENIQGG
1310 1320 1330 1340 1350
AEEISESLDS LERLMRHPED NRNQIRELAQ TLTDGGILDE LINEKLEKFN
1360 1370 1380 1390 1400
TRWEELQQEA VRRQKSLEQS IQSAQETDKT LRLIQESLAA IDKQLTAYTA
1410 1420 1430 1440 1450
DRVDAAQVPQ EAQKIQSELT SHEISLEEMK KRNRGKESAK RVLSQIDVAQ
1460 1470 1480 1490 1500
KKLQDVSMKF RLFQKPANFE QRLQECKRIL DEVKLQVPKL ETKSVEQEVV
1510 1520 1530 1540 1550
QSHLDHCMKL YKSLSEVKSE VETVIKTGRQ IVQKQQTENP KELDERLTAL
1560 1570 1580 1590 1600
KLQYNELGAK VTEKKQELEK CLKLSRKLRK EINSLTEWLA ATDVELTKRS
1610 1620 1630 1640 1650
AVQGMPSNLD AEIAWGKATR KEIEKRQVQL KNICDLGENL KTVLKGKESL
1660 1670 1680 1690 1700
VEDKLSLLNS NWIAVTSRAE EWLNLLMEYQ KHMEAFDQKV ANVTTWIYRA
1710 1720 1730 1740 1750
EILLDESDKQ KPQQKEETLK RLKAELNDMH PKVDSVRDQA VDLMTNRGDH
1760 1770 1780 1790 1800
CRKVIEPKLS ELNHRFAAIS QRIKSGKPFI PLKELEQFDF DIQKLLEPLE
1810 1820 1830 1840 1850
VEIQQGVNLK EEDFNKDMSE DDESTVKELL QRGDTLQKRI TDERKREEIK
1860 1870 1880 1890 1900
IKQQLLQTKH NALKDLRSQR RKKALEISHQ WYQYKRQADD LMTWLDDIEK
1910 1920 1930 1940 1950
KLASLPDHKD EQKLKEIGGE LEKKKEDLNA VNRQAERLSK DGAAKAVEPT
1960 1970 1980 1990 2000
LVQLSKRWRD FESKFAQFRR LNYAQIQTVL EDTTFVMTES MTVETTYVPS
2010 2020 2030 2040 2050
TYLAEILQLL QALSEVEERL NSPVLQAKDC EDLLKQEECL KNIKDCLGRL
2060 2070 2080 2090 2100
QGHIDIIHSK KTPALQSATP RETANIQDKL TQLNSQWEKV NKMYRDRQAR
2110 2120 2130 2140 2150
FDKSKEKWRL FHCEMKSFNE WLTETEEKLS RAQIEAGDVG HVKTKQFLQE
2160 2170 2180 2190 2200
LQDGIGRQQT VVKTLNVTGE EIIEQSSAAD ANVLKEQLGN LNTRWQEICR
2210 2220 2230 2240 2250
QLVEKRKRIE EEKNILSEFQ EDLNKLILWL EETENVIAIP LEPGNEDQLR
2260 2270 2280 2290 2300
DCLGKVKLRV EELLPHKGIL KRLNETGGTT LGSASLNPER KHKLESTLKE
2310 2320 2330 2340 2350
ASRRLLKVSR DLPEKQKEIE ILLKDFIELN QQINQLTLWI TPVKNQLELY
2360 2370 2380 2390 2400
NQVGQPGAFD IKETEAAVQA KQPNVEEVLS KGCHLYKEKP ATHPVKKKLE
2410 2420 2430 2440 2450
DLNADWKAIN HLILQLKEKP TFGEPALTSP GVLTSGQTVA VDTQARVTKE
2460 2470 2480 2490 2500
TTSFTPEMPS SVLLEVPALA DFNKAWAELT DWLSRLDREI KAQRVTVGDL
2510 2520 2530 2540 2550
DDINDMIIKQ KANMQDLEQR RPQLDELITA AQNLKNKTSN QEARTIITDR
2560 2570 2580 2590 2600
IEKIQSQWDD VHGYLQNRRQ QLHEMQKDST QWLEAKQEAE QVLEQAKAKL
2610 2620 2630 2640 2650
ESWKEISYTV EALKKQNSEL KQFSKEIRQW QMNIEGVNDV ALKPVRDYSA
2660 2670 2680 2690 2700
DDTRKVELMT DNINATWATI NKRVSEREAA LESALLMLQE FYLDLEKFLA
2710 2720 2730 2740 2750
WLTEAETTAN VLQDATHKEK TLEDPQMVRE LMKQWQDLQA EIDAHTDIFH
2760 2770 2780 2790 2800
NLDENGQKIL RSLEGSEDAV LLQRRLDNMN FRWSELRKKS LNIRSHLEAS
2810 2820 2830 2840 2850
TDQWKRLHLS LQELLAWLQL KEDELKQQAP IGGDIPTVQK QNDVHRTFKR
2860 2870 2880 2890 2900
ELKTKEPVIM NALETVRLFL ADQPVEGLEK VYPEPRDLSP EERAQNVTKV
2910 2920 2930 2940 2950
LRRQADDVRT EWDKLNLRSA DWQKKIDDAL ERLQGLQEAM DELDLKLRQA
2960 2970 2980 2990 3000
EAFKGSWQPV GDLLIDSLQD HLEKVKVYRA EMVPLKEKVH QVNELAHRFA
3010 3020 3030 3040 3050
PPDIQLSPYT LSCLEDLNTR WKVLQVAIDE RIRQLHEAHR DFGPTSQHFL
3060 3070 3080 3090 3100
TTSVQGPWER AISPNKVPYY INHETQTTCW DHPKMTELYQ SLADLNNVRF
3110 3120 3130 3140 3150
SAYRTAMKLR RLQKALCLDL LNLSAACDAL DQHNLKQNDQ PMDILQIINC
3160 3170 3180 3190 3200
LTTIYDRLEQ EHNNLVNVPL CVDMCLNWLL NVYDTGRTGR IRVLSFKTGV
3210 3220 3230 3240 3250
VSLCKAHLED KYRYLFKQVA SSTGFCDQRR LGLLLHDSIQ IPRQLGEVAS
3260 3270 3280 3290 3300
FGGSNIEPSV RSCFQFANNK PEIEAALFLD WMRLEPQSMV WLPVLHRVAA
3310 3320 3330 3340 3350
AETAKHQAKC NICKECPIIG FRYRSLKHFN YDICQSCFFS GRVAKGHKMH
3360 3370 3380 3390 3400
YPMVEYCTPT TSGEDVRDFA KVLKNKFRTK RYFAKHPRMG YLPVQTVLEG
3410 3420 3430 3440 3450
DNMETPVTLI NFWPVDSALA EMENSNGSYL NDSISPNESI DDEHLLIQHY
3460 3470 3480 3490 3500
CQSLNQESPL SQPRSPAQIL ISLESEERGE LERILADLEE ENRNLQAEYD
3510 3520 3530 3540 3550
RLKQQHDHKG LSPLPSPPEM MPVSPQSPRD AELIAEAKLL RQHKGRLEAR
3560 3570 3580 3590 3600
MQILEDHNKQ LESQLHRLRQ LLEQPQADAK VNGTTLSSPS TSLQRSDSSQ
3610 3620 3630 3640 3650
PMLLRVVGSQ TSETMGEDDL LSPPQDTSTG LEEVMEQLNN SFPSSRGRNA
3660
PGKPVREATM
Length:3,660
Mass (Da):422,881
Last modified:October 1, 1989 - v1
Checksum:i85493DAF6D5B6D4A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1171 – 11711Missing.
Natural varianti1869 – 18691Q → H.
Natural varianti1885 – 18851K → R.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13369 mRNA. Translation: CAA31746.1.
PIRiS02041.
RefSeqiNP_990630.1. NM_205299.1.
UniGeneiGga.718.

Genome annotation databases

GeneIDi396236.
KEGGigga:396236.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13369 mRNA. Translation: CAA31746.1 .
PIRi S02041.
RefSeqi NP_990630.1. NM_205299.1.
UniGenei Gga.718.

3D structure databases

ProteinModelPortali P11533.
SMRi P11533. Positions 13-250, 3044-3303.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P11533.
PRIDEi P11533.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396236.
KEGGi gga:396236.

Organism-specific databases

CTDi 1756.

Phylogenomic databases

eggNOGi COG5069.
HOGENOMi HOG000231173.
HOVERGENi HBG005495.
InParanoidi P11533.
KOi K10366.
PhylomeDBi P11533.

Miscellaneous databases

NextBioi 20816288.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
1.10.418.10. 2 hits.
InterProi IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR016344. Dystrophin/utrophin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF00307. CH. 2 hits.
PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 17 hits.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view ]
PIRSFi PIRSF002341. Dystrophin/utrophin. 1 hit.
SMARTi SM00033. CH. 2 hits.
SM00150. SPEC. 21 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEi PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The chicken dystrophin cDNA: striking conservation of the C-terminal coding and 3' untranslated regions between man and chicken."
    Lemaire C., Heilig R., Mandel J.L.
    EMBO J. 7:4157-4162(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiDMD_CHICK
AccessioniPrimary (citable) accession number: P11533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3