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P11533

- DMD_CHICK

UniProt

P11533 - DMD_CHICK

Protein

Dystrophin

Gene

DMD

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    May play a role in anchoring the cytoskeleton to the plasma membrane.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri3304 – 335148ZZ-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dystrophin
    Gene namesi
    Name:DMD
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell membranesarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcytoskeleton. Cell junctionsynapsepostsynaptic cell membrane By similarity
    Note: Localizes to neuromuscular junctions.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-KW
    3. cytoskeleton Source: UniProtKB-SubCell
    4. postsynaptic membrane Source: UniProtKB-SubCell
    5. sarcolemma Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 36603660DystrophinPRO_0000076078Add
    BLAST

    Proteomic databases

    PaxDbiP11533.
    PRIDEiP11533.

    Structurei

    3D structure databases

    ProteinModelPortaliP11533.
    SMRiP11533. Positions 13-250, 3044-3303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 244244Actin-bindingAdd
    BLAST
    Domaini19 – 123105CH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 241104CH 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati341 – 449109Spectrin 1Add
    BLAST
    Repeati450 – 558109Spectrin 2Add
    BLAST
    Repeati561 – 669109Spectrin 3Add
    BLAST
    Repeati721 – 830110Spectrin 4Add
    BLAST
    Repeati832 – 936105Spectrin 5Add
    BLAST
    Repeati945 – 1047103Spectrin 6Add
    BLAST
    Repeati1050 – 1156107Spectrin 7Add
    BLAST
    Repeati1159 – 1265107Spectrin 8Add
    BLAST
    Repeati1268 – 1369102Spectrin 9Add
    BLAST
    Repeati1470 – 1570101Spectrin 10Add
    BLAST
    Repeati1573 – 1678106Spectrin 11Add
    BLAST
    Repeati1681 – 1782102Spectrin 12Add
    BLAST
    Repeati1879 – 1981103Spectrin 13Add
    BLAST
    Repeati2013 – 210391Spectrin 14Add
    BLAST
    Repeati2106 – 2211106Spectrin 15Add
    BLAST
    Repeati2214 – 2321108Spectrin 16Add
    BLAST
    Repeati2472 – 2574103Spectrin 17Add
    BLAST
    Repeati2577 – 2683107Spectrin 18Add
    BLAST
    Repeati2686 – 2799114Spectrin 19Add
    BLAST
    Repeati2802 – 2904103Spectrin 20Add
    BLAST
    Repeati2906 – 292823Spectrin 21Add
    BLAST
    Repeati2931 – 3037107Spectrin 22Add
    BLAST
    Domaini3052 – 308534WWPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
    Contains 22 spectrin repeats.Curated
    Contains 1 WW domain.PROSITE-ProRule annotation
    Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri3304 – 335148ZZ-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5069.
    HOGENOMiHOG000231173.
    HOVERGENiHBG005495.
    InParanoidiP11533.
    KOiK10366.
    PhylomeDBiP11533.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    1.10.418.10. 2 hits.
    InterProiIPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR016344. Dystrophin/utrophin.
    IPR011992. EF-hand-dom_pair.
    IPR015153. EF-hand_dom_typ1.
    IPR015154. EF-hand_dom_typ2.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    IPR001202. WW_dom.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF00307. CH. 2 hits.
    PF09068. EF-hand_2. 1 hit.
    PF09069. EF-hand_3. 1 hit.
    PF00435. Spectrin. 17 hits.
    PF00397. WW. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002341. Dystrophin/utrophin. 1 hit.
    SMARTiSM00033. CH. 2 hits.
    SM00150. SPEC. 21 hits.
    SM00456. WW. 1 hit.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF51045. SSF51045. 1 hit.
    PROSITEiPS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11533-1 [UniParc]FASTAAdd to Basket

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    MSAHVLWYEE VEDDYEREDV QKKTFTKWIN AQFAKCGRRC IEDLFNDFRD     50
    GRKLLELLEC LTGQKIAKEK GSTRVHALNN VNKALQILQR NNVDLVNIGS 100
    SDIVDGNHKL TLGLIWNIIL HWQVKDVMKN IMAGLQQTNS EKILLSWVRQ 150
    STRNYPQVNV INFTSSWSDG LAFNALLHSH RPDLFDWNAV ASQQSPVQRL 200
    DHAFNIARQH LGIEKLLDPE DVATACPDKK SILMYVTSLF QVLPQQVTME 250
    AIREVEMLPR HSRVTTEEHI QVHHQQHFSQ EITVNIPQRP SPSPKPRFKS 300
    YAYAQTAYVI PPDQKRRQVP PQFLETVEKR TYTTTVMRSE MDLDSYQTAL 350
    EEVLTWLLSA EDALQAQGDI SSDVEVVKEQ FHTHEGFMME LTAHQGRVGN 400
    VLQVGSQLLA MGKLSDDEEN EIQEQMNLLN SRWESLRVAS MEKQSNLHKI 450
    LMDLQNQQLA QLADWLTKTE ERTKKIDSEP LGPDLEDLKR QVEEHKAFQD 500
    DLEQEQVKVN SLTHMVVVVD ENSGDKATAA LEEQLQHFGS RWAAICRWTE 550
    DRWVLLQDIL RKWQHFAEEQ CLFDAWLTEK EGSLSKIQTS DFKDENEMLT 600
    SLRKLAILKG DIEMKKQMMS KLKSLSRDLL VAVKNKAVAQ KLESRLENFA 650
    QRWDSLVQKL ESDSKQVSQA VTTTQTSLTQ TTVMETVTMV TTREQILVKH 700
    AKEELPPPPP HKKRQLLVDS EIRKRFDSDT TELHSWMTRS EAVLQSPEFA 750
    IYRKEGNLSD LRERVNAIQR EKPEKYRKLQ DASRSAEALV EQMVNEGLNA 800
    DNIRQASEQL KSRWIEFCQL LSERLVWLEY QNSIIDFYSQ LQRLEQTAIT 850
    AENWLKAQPT PATDPATVKI QLEKCKDEII RMSTLQPQIE RLKAQSQALK 900
    EKEQCPVFLD ADLAAFTSHF KQILADMHTR EKQLQTIFDS LPPARYKDTV 950
    TTILSWIQQS ETKVSIPPVA VAEYEIMEQR LGELKALQSS LQEQQKGLKY 1000
    LNTTVEDLSR KAPAEVSQKY RSEVELIVGR WKKLSSQLVE HCQKLEDLMT 1050
    KLQRFQNDTK TLKKWMAEVD VFLKEEWPAL GDSEALEKQL EQCTALVNDI 1100
    QTIQPSLNSV NEIGKKMKRE AEPEFASRIA TELKDLNAQW EHICQQAHAK 1150
    KAALKGGLDK TVSLRKDLSE MHEWITQAEE EYLERDFEYK TPEELQKAVE 1200
    ELKRAKEDAM QKEVKVKLIT DSVNNFIAKA PPAANEALKK ELDVLITSYQ 1250
    RLCSRLNGKC KTLEEVWACW HELLSYLDAE NKWLNEVELK LKATENIQGG 1300
    AEEISESLDS LERLMRHPED NRNQIRELAQ TLTDGGILDE LINEKLEKFN 1350
    TRWEELQQEA VRRQKSLEQS IQSAQETDKT LRLIQESLAA IDKQLTAYTA 1400
    DRVDAAQVPQ EAQKIQSELT SHEISLEEMK KRNRGKESAK RVLSQIDVAQ 1450
    KKLQDVSMKF RLFQKPANFE QRLQECKRIL DEVKLQVPKL ETKSVEQEVV 1500
    QSHLDHCMKL YKSLSEVKSE VETVIKTGRQ IVQKQQTENP KELDERLTAL 1550
    KLQYNELGAK VTEKKQELEK CLKLSRKLRK EINSLTEWLA ATDVELTKRS 1600
    AVQGMPSNLD AEIAWGKATR KEIEKRQVQL KNICDLGENL KTVLKGKESL 1650
    VEDKLSLLNS NWIAVTSRAE EWLNLLMEYQ KHMEAFDQKV ANVTTWIYRA 1700
    EILLDESDKQ KPQQKEETLK RLKAELNDMH PKVDSVRDQA VDLMTNRGDH 1750
    CRKVIEPKLS ELNHRFAAIS QRIKSGKPFI PLKELEQFDF DIQKLLEPLE 1800
    VEIQQGVNLK EEDFNKDMSE DDESTVKELL QRGDTLQKRI TDERKREEIK 1850
    IKQQLLQTKH NALKDLRSQR RKKALEISHQ WYQYKRQADD LMTWLDDIEK 1900
    KLASLPDHKD EQKLKEIGGE LEKKKEDLNA VNRQAERLSK DGAAKAVEPT 1950
    LVQLSKRWRD FESKFAQFRR LNYAQIQTVL EDTTFVMTES MTVETTYVPS 2000
    TYLAEILQLL QALSEVEERL NSPVLQAKDC EDLLKQEECL KNIKDCLGRL 2050
    QGHIDIIHSK KTPALQSATP RETANIQDKL TQLNSQWEKV NKMYRDRQAR 2100
    FDKSKEKWRL FHCEMKSFNE WLTETEEKLS RAQIEAGDVG HVKTKQFLQE 2150
    LQDGIGRQQT VVKTLNVTGE EIIEQSSAAD ANVLKEQLGN LNTRWQEICR 2200
    QLVEKRKRIE EEKNILSEFQ EDLNKLILWL EETENVIAIP LEPGNEDQLR 2250
    DCLGKVKLRV EELLPHKGIL KRLNETGGTT LGSASLNPER KHKLESTLKE 2300
    ASRRLLKVSR DLPEKQKEIE ILLKDFIELN QQINQLTLWI TPVKNQLELY 2350
    NQVGQPGAFD IKETEAAVQA KQPNVEEVLS KGCHLYKEKP ATHPVKKKLE 2400
    DLNADWKAIN HLILQLKEKP TFGEPALTSP GVLTSGQTVA VDTQARVTKE 2450
    TTSFTPEMPS SVLLEVPALA DFNKAWAELT DWLSRLDREI KAQRVTVGDL 2500
    DDINDMIIKQ KANMQDLEQR RPQLDELITA AQNLKNKTSN QEARTIITDR 2550
    IEKIQSQWDD VHGYLQNRRQ QLHEMQKDST QWLEAKQEAE QVLEQAKAKL 2600
    ESWKEISYTV EALKKQNSEL KQFSKEIRQW QMNIEGVNDV ALKPVRDYSA 2650
    DDTRKVELMT DNINATWATI NKRVSEREAA LESALLMLQE FYLDLEKFLA 2700
    WLTEAETTAN VLQDATHKEK TLEDPQMVRE LMKQWQDLQA EIDAHTDIFH 2750
    NLDENGQKIL RSLEGSEDAV LLQRRLDNMN FRWSELRKKS LNIRSHLEAS 2800
    TDQWKRLHLS LQELLAWLQL KEDELKQQAP IGGDIPTVQK QNDVHRTFKR 2850
    ELKTKEPVIM NALETVRLFL ADQPVEGLEK VYPEPRDLSP EERAQNVTKV 2900
    LRRQADDVRT EWDKLNLRSA DWQKKIDDAL ERLQGLQEAM DELDLKLRQA 2950
    EAFKGSWQPV GDLLIDSLQD HLEKVKVYRA EMVPLKEKVH QVNELAHRFA 3000
    PPDIQLSPYT LSCLEDLNTR WKVLQVAIDE RIRQLHEAHR DFGPTSQHFL 3050
    TTSVQGPWER AISPNKVPYY INHETQTTCW DHPKMTELYQ SLADLNNVRF 3100
    SAYRTAMKLR RLQKALCLDL LNLSAACDAL DQHNLKQNDQ PMDILQIINC 3150
    LTTIYDRLEQ EHNNLVNVPL CVDMCLNWLL NVYDTGRTGR IRVLSFKTGV 3200
    VSLCKAHLED KYRYLFKQVA SSTGFCDQRR LGLLLHDSIQ IPRQLGEVAS 3250
    FGGSNIEPSV RSCFQFANNK PEIEAALFLD WMRLEPQSMV WLPVLHRVAA 3300
    AETAKHQAKC NICKECPIIG FRYRSLKHFN YDICQSCFFS GRVAKGHKMH 3350
    YPMVEYCTPT TSGEDVRDFA KVLKNKFRTK RYFAKHPRMG YLPVQTVLEG 3400
    DNMETPVTLI NFWPVDSALA EMENSNGSYL NDSISPNESI DDEHLLIQHY 3450
    CQSLNQESPL SQPRSPAQIL ISLESEERGE LERILADLEE ENRNLQAEYD 3500
    RLKQQHDHKG LSPLPSPPEM MPVSPQSPRD AELIAEAKLL RQHKGRLEAR 3550
    MQILEDHNKQ LESQLHRLRQ LLEQPQADAK VNGTTLSSPS TSLQRSDSSQ 3600
    PMLLRVVGSQ TSETMGEDDL LSPPQDTSTG LEEVMEQLNN SFPSSRGRNA 3650
    PGKPVREATM 3660
    Length:3,660
    Mass (Da):422,881
    Last modified:October 1, 1989 - v1
    Checksum:i85493DAF6D5B6D4A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1171 – 11711Missing.
    Natural varianti1869 – 18691Q → H.
    Natural varianti1885 – 18851K → R.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13369 mRNA. Translation: CAA31746.1.
    PIRiS02041.
    RefSeqiNP_990630.1. NM_205299.1.
    UniGeneiGga.718.

    Genome annotation databases

    GeneIDi396236.
    KEGGigga:396236.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13369 mRNA. Translation: CAA31746.1 .
    PIRi S02041.
    RefSeqi NP_990630.1. NM_205299.1.
    UniGenei Gga.718.

    3D structure databases

    ProteinModelPortali P11533.
    SMRi P11533. Positions 13-250, 3044-3303.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P11533.
    PRIDEi P11533.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396236.
    KEGGi gga:396236.

    Organism-specific databases

    CTDi 1756.

    Phylogenomic databases

    eggNOGi COG5069.
    HOGENOMi HOG000231173.
    HOVERGENi HBG005495.
    InParanoidi P11533.
    KOi K10366.
    PhylomeDBi P11533.

    Miscellaneous databases

    NextBioi 20816288.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    1.10.418.10. 2 hits.
    InterProi IPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR016344. Dystrophin/utrophin.
    IPR011992. EF-hand-dom_pair.
    IPR015153. EF-hand_dom_typ1.
    IPR015154. EF-hand_dom_typ2.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    IPR001202. WW_dom.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF00307. CH. 2 hits.
    PF09068. EF-hand_2. 1 hit.
    PF09069. EF-hand_3. 1 hit.
    PF00435. Spectrin. 17 hits.
    PF00397. WW. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002341. Dystrophin/utrophin. 1 hit.
    SMARTi SM00033. CH. 2 hits.
    SM00150. SPEC. 21 hits.
    SM00456. WW. 1 hit.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    SSF51045. SSF51045. 1 hit.
    PROSITEi PS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The chicken dystrophin cDNA: striking conservation of the C-terminal coding and 3' untranslated regions between man and chicken."
      Lemaire C., Heilig R., Mandel J.L.
      EMBO J. 7:4157-4162(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Muscle.

    Entry informationi

    Entry nameiDMD_CHICK
    AccessioniPrimary (citable) accession number: P11533
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3