Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P11531

- DMD_MOUSE

UniProt

P11531 - DMD_MOUSE

Protein

Dystrophin

Gene

Dmd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri3300 – 334748ZZ-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. nitric-oxide synthase binding Source: BHF-UCL
    3. protein binding Source: IntAct
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cardiac muscle cell action potential Source: BHF-UCL
    2. cellular protein complex assembly Source: BHF-UCL
    3. cellular protein localization Source: BHF-UCL
    4. establishment of blood-nerve barrier Source: MGI
    5. establishment of glial blood-brain barrier Source: MGI
    6. muscle cell cellular homeostasis Source: MGI
    7. muscle fiber development Source: MGI
    8. muscle organ development Source: MGI
    9. myotube cell development Source: MGI
    10. negative regulation of peptidyl-cysteine S-nitrosylation Source: BHF-UCL
    11. negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
    12. neurotransmitter receptor metabolic process Source: MGI
    13. nucleus localization Source: MGI
    14. olfactory nerve structural organization Source: MGI
    15. positive regulation of cell-matrix adhesion Source: BHF-UCL
    16. positive regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
    17. regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
    18. regulation of gene expression Source: MGI
    19. regulation of heart rate Source: BHF-UCL
    20. regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
    21. regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
    22. regulation of skeletal muscle contraction Source: BHF-UCL
    23. regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Source: BHF-UCL
    24. regulation of transcription, DNA-templated Source: MGI
    25. regulation of voltage-gated calcium channel activity Source: BHF-UCL
    26. skeletal muscle tissue development Source: MGI

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dystrophin
    Gene namesi
    Name:Dmd
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:94909. Dmd.

    Subcellular locationi

    Cell membranesarcolemma 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmcytoskeleton 1 Publication. Cell junctionsynapsepostsynaptic cell membrane 1 Publication
    Note: In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs). In adult muscle, NMJ localization depends upon ANK2 presence, but not in newborn animals.

    GO - Cellular componenti

    1. cell-substrate junction Source: MGI
    2. cytoskeleton Source: UniProtKB-SubCell
    3. dystrophin-associated glycoprotein complex Source: MGI
    4. membrane raft Source: MGI
    5. neuron projection terminus Source: MGI
    6. plasma membrane Source: MGI
    7. postsynaptic membrane Source: UniProtKB-SubCell
    8. protein complex Source: MGI
    9. sarcolemma Source: MGI
    10. synapse Source: MGI
    11. Z disc Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 36783678DystrophinPRO_0000076076Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei3476 – 34761PhosphoserineBy similarity
    Modified residuei3605 – 36051PhosphoserineBy similarity
    Modified residuei3606 – 36061PhosphoserineBy similarity
    Modified residuei3610 – 36101PhosphoserineBy similarity
    Modified residuei3616 – 36161Phosphoserine1 Publication
    Modified residuei3617 – 36171Phosphoserine1 Publication
    Modified residuei3659 – 36591PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP11531.
    PaxDbiP11531.
    PRIDEiP11531.

    PTM databases

    PhosphoSiteiP11531.

    Expressioni

    Tissue specificityi

    Differentially expressed during skeletal muscle, heart, and brain development. Also expressed in retina.1 Publication

    Gene expression databases

    ArrayExpressiP11531.
    BgeeiP11531.
    CleanExiMM_DMD.
    GenevestigatoriP11531.

    Interactioni

    Subunit structurei

    Interacts with SYNM. Interacts with the syntrophins SNTG1 and SNTG2. Interacts with KRT19. Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1 By similarity. Interacts with SYNM; SNTA1 and SNTB1. Interacts with CMYA5. Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells.By similarity6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Snta1Q612342EBI-295928,EBI-295952

    Protein-protein interaction databases

    BioGridi199245. 19 interactions.
    DIPiDIP-32899N.
    IntActiP11531. 6 interactions.
    MINTiMINT-85369.

    Structurei

    3D structure databases

    ProteinModelPortaliP11531.
    SMRiP11531. Positions 9-246, 340-455, 3040-3299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 240240Actin-bindingAdd
    BLAST
    Domaini15 – 119105CH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 237104CH 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati341 – 449109Spectrin 1Add
    BLAST
    Repeati450 – 558109Spectrin 2Add
    BLAST
    Repeati561 – 669109Spectrin 3Add
    BLAST
    Repeati721 – 830110Spectrin 4Add
    BLAST
    Repeati832 – 936105Spectrin 5Add
    BLAST
    Repeati945 – 1047103Spectrin 6Add
    BLAST
    Repeati1050 – 1156107Spectrin 7Add
    BLAST
    Repeati1159 – 1265107Spectrin 8Add
    BLAST
    Repeati1268 – 1369102Spectrin 9Add
    BLAST
    Repeati1370 – 146596Spectrin 10Add
    BLAST
    Repeati1470 – 1570101Spectrin 11Add
    BLAST
    Repeati1573 – 1678106Spectrin 12Add
    BLAST
    Repeati1681 – 1780100Spectrin 13Add
    BLAST
    Repeati1781 – 187696Spectrin 14Add
    BLAST
    Repeati1879 – 1981103Spectrin 15Add
    BLAST
    Repeati1994 – 2103110Spectrin 16Add
    BLAST
    Repeati2106 – 2210105Spectrin 17Add
    BLAST
    Repeati2213 – 2318106Spectrin 18Add
    BLAST
    Repeati2319 – 241698Spectrin 19Add
    BLAST
    Repeati2468 – 2570103Spectrin 20Add
    BLAST
    Repeati2573 – 2679107Spectrin 21Add
    BLAST
    Repeati2682 – 2795114Spectrin 22Add
    BLAST
    Repeati2801 – 2923123Spectrin 23Add
    BLAST
    Repeati2928 – 3033106Spectrin 24Add
    BLAST
    Domaini3048 – 308134WWPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni63 – 7210ANK2- and ANK-3 binding
    Regioni1417 – 1915499Interaction with SYNMAdd
    BLAST
    Regioni3051 – 3401351Interaction with SYNMAdd
    BLAST
    Regioni3459 – 351153Binds to SNTB1By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
    Contains 24 spectrin repeats.Curated
    Contains 1 WW domain.PROSITE-ProRule annotation
    Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri3300 – 334748ZZ-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5069.
    GeneTreeiENSGT00740000115262.
    HOGENOMiHOG000231173.
    HOVERGENiHBG005495.
    InParanoidiA2A9Z0.
    KOiK10366.
    OMAiEGPYTMD.
    OrthoDBiEOG7V765N.
    TreeFamiTF320178.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    1.10.418.10. 2 hits.
    InterProiIPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR016344. Dystrophin/utrophin.
    IPR011992. EF-hand-dom_pair.
    IPR015153. EF-hand_dom_typ1.
    IPR015154. EF-hand_dom_typ2.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    IPR001202. WW_dom.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF00307. CH. 2 hits.
    PF09068. EF-hand_2. 1 hit.
    PF09069. EF-hand_3. 1 hit.
    PF00435. Spectrin. 16 hits.
    PF00397. WW. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002341. Dystrophin/utrophin. 1 hit.
    SMARTiSM00033. CH. 2 hits.
    SM00150. SPEC. 22 hits.
    SM00456. WW. 1 hit.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF51045. SSF51045. 1 hit.
    PROSITEiPS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: At least 11 isoforms are produced.

    Isoform 1 (identifier: P11531-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLWWEEVEDC YEREDVQKKT FTKWINAQFS KFGKQHIDNL FSDLQDGKRL     50
    LDLLEGLTGQ KLPKEKGSTR VHALNNVNKA LRVLQKNNVD LVNIGSTDIV 100
    DGNHKLTLGL IWNIILHWQV KNVMKTIMAG LQQTNSEKIL LSWVRQSTRN 150
    YPQVNVINFT SSWSDGLALN ALIHSHRPDL FDWNSVVSQH SATQRLEHAF 200
    NIAKCQLGIE KLLDPEDVAT TYPDKKSILM YITSLFQVLP QQVSIEAIQE 250
    VEMLPRTSSK VTREEHFQLH HQMHYSQQIT VSLAQGYEQT SSSPKPRFKS 300
    YAFTQAAYVA TSDSTQSPYP SQHLEAPRDK SLDSSLMETE VNLDSYQTAL 350
    EEVLSWLLSA EDTLRAQGEI SNDVEEVKEQ FHAHEGFMMD LTSHQGLVGN 400
    VLQLGSQLVG KGKLSEDEEA EVQEQMNLLN SRWECLRVAS MEKQSKLHKV 450
    LMDLQNQKLK ELDDWLTKTE ERTKKMEEEP FGPDLEDLKC QVQQHKVLQE 500
    DLEQEQVRVN SLTHMVVVVD ESSGDHATAA LEEQLKVLGD RWANICRWTE 550
    DRWIVLQDIL LKWQHFTEEQ CLFSTWLSEK EDAMKNIQTS GFKDQNEMMS 600
    SLHKISTLKI DLEKKKPTME KLSSLNQDLL SALKNKSVTQ KMEIWMENFA 650
    QRWDNLTQKL EKSSAQISQA VTTTQPSLTQ TTVMETVTMV TTREQIMVKH 700
    AQEELPPPPP QKKRQITVDS ELRKRLDVDI TELHSWITRS EAVLQSSEFA 750
    VYRKEGNISD LQEKVNAIAR EKAEKFRKLQ DASRSAQALV EQMANEGVNA 800
    ESIRQASEQL NSRWTEFCQL LSERVNWLEY QTNIITFYNQ LQQLEQMTTT 850
    AENLLKTQST TLSEPTAIKS QLKICKDEVN RLSALQPQIE QLKIQSLQLK 900
    EKGQGPMFLD ADFVAFTNHF NHIFDGVRAK EKELQTIFDT LPPMRYQETM 950
    SSIRTWIQQS ESKLSVPYLS VTEYEIMEER LGKLQALQSS LKEQQNGFNY 1000
    LSDTVKEMAK KAPSEICQKY LSEFEEIEGH WKKLSSQLVE SCQKLEEHMN 1050
    KLRKFQNHIK TLQKWMAEVD VFLKEEWPAL GDAEILKKQL KQCRLLVGDI 1100
    QTIQPSLNSV NEGGQKIKSE AELEFASRLE TELRELNTQW DHICRQVYTR 1150
    KEALKAGLDK TVSLQKDLSE MHEWMTQAEE EYLERDFEYK TPDELQTAVE 1200
    EMKRAKEEAL QKETKVKLLT ETVNSVIAHA PPSAQEALKK ELETLTTNYQ 1250
    WLCTRLNGKC KTLEEVWACW HELLSYLEKA NKWLNEVELK LKTMENVPAG 1300
    PEEITEVLES LENLMHHSEE NPNQIRLLAQ TLTDGGVMDE LINEELETFN 1350
    SRWRELHEEA VRKQKLLEQS IQSAQEIEKS LHLIQESLEF IDKQLAAYIT 1400
    DKVDAAQMPQ EAQKIQSDLT SHEISLEEMK KHNQGKDANQ RVLSQIDVAQ 1450
    KKLQDVSMKF RLFQKPANFE QRLEESKMIL DEVKMHLPAL ETKSVEQEVI 1500
    QSQLSHCVNL YKSLSEVKSE VEMVIKTGRQ IVQKKQTENP KELDERVTAL 1550
    KLHYNELGAK VTERKQQLEK CLKLSRKMRK EMNVLTEWLA ATDTELTKRS 1600
    AVEGMPSNLD SEVAWGKATQ KEIEKQKAHL KSVTELGESL KMVLGKKETL 1650
    VEDKLSLLNS NWIAVTSRVE EWLNLLLEYQ KHMETFDQNI EQITKWIIHA 1700
    DELLDESEKK KPQQKEDILK RLKAEMNDMR PKVDSTRDQA AKLMANRGDH 1750
    CRKVVEPQIS ELNRRFAAIS HRIKTGKASI PLKELEQFNS DIQKLLEPLE 1800
    AEIQQGVNLK EEDFNKDMSE DNEGTVNELL QRGDNLQQRI TDERKREEIK 1850
    IKQQLLQTKH NALKDLRSQR RKKALEISHQ WYQYKRQADD LLKCLDEIEK 1900
    KLASLPEPRD ERKLKEIDRE LQKKKEELNA VRRQAEGLSE NGAAMAVEPT 1950
    QIQLSKRWRQ IESNFAQFRR LNFAQIHTLH EETMVVTTED MPLDVSYVPS 2000
    TYLTEISHIL QALSEVDHLL NTPELCAKDF EDLFKQEESL KNIKDNLQQI 2050
    SGRIDIIHKK KTAALQSATS MEKVKVQEAV AQMDFQGEKL HRMYKERQGR 2100
    FDRSVEKWRH FHYDMKVFNQ WLNEVEQFFK KTQNPENWEH AKYKWYLKEL 2150
    QDGIGQRQAV VRTLNATGEE IIQQSSKTDV NILQEKLGSL SLRWHDICKE 2200
    LAERRKRIEE QKNVLSEFQR DLNEFVLWLE EADNIAITPL GDEQQLKEQL 2250
    EQVKLLAEEL PLRQGILKQL NETGGAVLVS APIRPEEQDK LEKKLKQTNL 2300
    QWIKVSRALP EKQGELEVHL KDFRQLEEQL DHLLLWLSPI RNQLEIYNQP 2350
    SQAGPFDIKE IEVTVHGKQA DVERLLSKGQ HLYKEKPSTQ PVKRKLEDLR 2400
    SEWEAVNHLL RELRTKQPDR APGLSTTGAS ASQTVTLVTQ SVVTKETVIS 2450
    KLEMPSSLLL EVPALADFNR AWTELTDWLS LLDRVIKSQR VMVGDLEDIN 2500
    EMIIKQKATL QDLEQRRPQL EELITAAQNL KNKTSNQEAR TIITDRIERI 2550
    QIQWDEVQEQ LQNRRQQLNE MLKDSTQWLE AKEEAEQVIG QVRGKLDSWK 2600
    EGPHTVDAIQ KKITETKQLA KDLRQRQISV DVANDLALKL LRDYSADDTR 2650
    KVHMITENIN TSWGNIHKRV SEQEAALEET HRLLQQFPLD LEKFLSWITE 2700
    AETTANVLQD ASRKEKLLED SRGVRELMKP WQDLQGEIET HTDIYHNLDE 2750
    NGQKILRSLE GSDEAPLLQR RLDNMNFKWS ELQKKSLNIR SHLEASSDQW 2800
    KRLHLSLQEL LVWLQLKDDE LSRQAPIGGD FPAVQKQNDI HRAFKRELKT 2850
    KEPVIMSTLE TVRIFLTEQP LEGLEKLYQE PRELPPEERA QNVTRLLRKQ 2900
    AEEVNAEWDK LNLRSADWQR KIDEALERLQ ELQEAADELD LKLRQAEVIK 2950
    GSWQPVGDLL IDSLQDHLEK VKALRGEIAP LKENVNRVND LAHQLTTLGI 3000
    QLSPYNLSTL EDLNTRWRLL QVAVEDRVRQ LHEAHRDFGP ASQHFLSTSV 3050
    QGPWERAISP NKVPYYINHE TQTTCWDHPK MTELYQSLAD LNNVRFSAYR 3100
    TAMKLRRLQK ALCLDLLSLS AACDALDQHN LKQNDQPMDI LQIINCLTTI 3150
    YDRLEQEHNN LVNVPLCVDM CLNWLLNVYD TGRTGRIRVL SFKTGIISLC 3200
    KAHLEDKYRY LFKQVASSTG FCDQRRLGLL LHDSIQIPRQ LGEVASFGGS 3250
    NIEPSVRSCF QFANNKPEIE AALFLDWMRL EPQSMVWLPV LHRVAAAETA 3300
    KHQAKCNICK ECPIIGFRYR SLKHFNYDIC QSCFFSGRVA KGHKMHYPMV 3350
    EYCTPTTSGE DVRDFAKVLK NKFRTKRYFA KHPRMGYLPV QTVLEGDNME 3400
    TPVTLINFWP VDSAPASSPQ LSHDDTHSRI EHYASRLAEM ENSNGSYLND 3450
    SISPNESIDD EHLLIQHYCQ SLNQDSPLSQ PRSPAQILIS LESEERGELE 3500
    RILADLEEEN RNLQAEYDRL KQQHEHKGLS PLPSPPEMMP TSPQSPRDAE 3550
    LIAEAKLLRQ HKGRLEARMQ ILEDHNKQLE SQLHRLRQLL EQPQAEAKVN 3600
    GTTVSSPSTS LQRSDSSQPM LLRVVGSQTS ESMGEEDLLS PPQDTSTGLE 3650
    EVMEQLNNSF PSSRGRNAPG KPMREDTM 3678
    Length:3,678
    Mass (Da):425,832
    Last modified:July 27, 2011 - v3
    Checksum:i53487B1E27104228
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti463 – 4631D → H in AAA37530. (PubMed:3659917)Curated
    Sequence conflicti677 – 6771S → F in AAA37530. (PubMed:3659917)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68859 mRNA. Translation: AAB02797.1.
    AL645848
    , AL645477, AL645857, AL672146, AL731776, AL732449, AL806516, AL808024, AL833800, AL844151, BX000479, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM14696.1.
    BX000479
    , AL645477, AL645848, AL645857, AL672146, AL731776, AL732449, AL806516, AL808024, AL833800, AL844151, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM14885.1.
    AL808024
    , AL645477, AL645848, AL645857, AL672146, AL731776, AL732449, AL806516, AL833800, AL844151, BX000479, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM15174.1.
    AL833800
    , AL645477, AL645848, AL645857, AL672146, AL731776, AL732449, AL806516, AL808024, AL844151, BX000479, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM15349.1.
    AL645477
    , AL645848, AL645857, AL672146, AL731776, AL732449, AL806516, AL808024, AL833800, AL844151, BX000479, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM15656.1.
    AL645857
    , AL645477, AL645848, AL672146, AL731776, AL732449, AL806516, AL808024, AL833800, AL844151, BX000479, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM16090.1.
    AL732449
    , AL645477, AL645848, AL645857, AL672146, AL731776, AL806516, AL808024, AL833800, AL844151, BX000479, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM17038.1.
    BX294443
    , AL645477, AL645848, AL645857, AL672146, AL731776, AL732449, AL806516, AL808024, AL833800, AL844151, BX000479, CR352330, CR382328 Genomic DNA. Translation: CAM20240.1.
    CR382328
    , AL645477, AL645848, AL645857, AL672146, AL731776, AL732449, AL806516, AL808024, AL833800, AL844151, BX000479, BX294443, CR352330 Genomic DNA. Translation: CAM20576.1.
    CR352330
    , AL645477, AL645848, AL645857, AL672146, AL731776, AL732449, AL806516, AL808024, AL833800, AL844151, BX000479, BX294443, CR382328 Genomic DNA. Translation: CAM22468.1.
    AL672146
    , AL645477, AL645848, AL645857, AL731776, AL732449, AL806516, AL808024, AL833800, AL844151, BX000479, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM22949.1.
    AL806516
    , AL645477, AL645848, AL645857, AL672146, AL731776, AL732449, AL808024, AL833800, AL844151, BX000479, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM24749.1.
    AL731776
    , AL645477, AL645848, AL645857, AL672146, AL732449, AL806516, AL808024, AL833800, AL844151, BX000479, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM26197.1.
    AL844151
    , AL645477, AL645848, AL645857, AL672146, AL731776, AL732449, AL806516, AL808024, AL833800, BX000479, BX294443, CR352330, CR382328 Genomic DNA. Translation: CAM26796.1.
    X58153 Genomic DNA. Translation: CAA41157.1.
    M18025 mRNA. Translation: AAA37530.1.
    U56724 Genomic DNA. Translation: AAB01216.1.
    U15218 mRNA. Translation: AAA87068.1.
    CCDSiCCDS41047.1. [P11531-1]
    PIRiS28916.
    RefSeqiNP_031894.1. NM_007868.5. [P11531-1]
    UniGeneiMm.275608.
    Mm.416750.

    Genome annotation databases

    EnsembliENSMUST00000114000; ENSMUSP00000109633; ENSMUSG00000045103. [P11531-1]
    GeneIDi13405.
    KEGGimmu:13405.
    UCSCiuc009tri.2. mouse. [P11531-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68859 mRNA. Translation: AAB02797.1 .
    AL645848
    , AL645477 , AL645857 , AL672146 , AL731776 , AL732449 , AL806516 , AL808024 , AL833800 , AL844151 , BX000479 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM14696.1 .
    BX000479
    , AL645477 , AL645848 , AL645857 , AL672146 , AL731776 , AL732449 , AL806516 , AL808024 , AL833800 , AL844151 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM14885.1 .
    AL808024
    , AL645477 , AL645848 , AL645857 , AL672146 , AL731776 , AL732449 , AL806516 , AL833800 , AL844151 , BX000479 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM15174.1 .
    AL833800
    , AL645477 , AL645848 , AL645857 , AL672146 , AL731776 , AL732449 , AL806516 , AL808024 , AL844151 , BX000479 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM15349.1 .
    AL645477
    , AL645848 , AL645857 , AL672146 , AL731776 , AL732449 , AL806516 , AL808024 , AL833800 , AL844151 , BX000479 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM15656.1 .
    AL645857
    , AL645477 , AL645848 , AL672146 , AL731776 , AL732449 , AL806516 , AL808024 , AL833800 , AL844151 , BX000479 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM16090.1 .
    AL732449
    , AL645477 , AL645848 , AL645857 , AL672146 , AL731776 , AL806516 , AL808024 , AL833800 , AL844151 , BX000479 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM17038.1 .
    BX294443
    , AL645477 , AL645848 , AL645857 , AL672146 , AL731776 , AL732449 , AL806516 , AL808024 , AL833800 , AL844151 , BX000479 , CR352330 , CR382328 Genomic DNA. Translation: CAM20240.1 .
    CR382328
    , AL645477 , AL645848 , AL645857 , AL672146 , AL731776 , AL732449 , AL806516 , AL808024 , AL833800 , AL844151 , BX000479 , BX294443 , CR352330 Genomic DNA. Translation: CAM20576.1 .
    CR352330
    , AL645477 , AL645848 , AL645857 , AL672146 , AL731776 , AL732449 , AL806516 , AL808024 , AL833800 , AL844151 , BX000479 , BX294443 , CR382328 Genomic DNA. Translation: CAM22468.1 .
    AL672146
    , AL645477 , AL645848 , AL645857 , AL731776 , AL732449 , AL806516 , AL808024 , AL833800 , AL844151 , BX000479 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM22949.1 .
    AL806516
    , AL645477 , AL645848 , AL645857 , AL672146 , AL731776 , AL732449 , AL808024 , AL833800 , AL844151 , BX000479 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM24749.1 .
    AL731776
    , AL645477 , AL645848 , AL645857 , AL672146 , AL732449 , AL806516 , AL808024 , AL833800 , AL844151 , BX000479 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM26197.1 .
    AL844151
    , AL645477 , AL645848 , AL645857 , AL672146 , AL731776 , AL732449 , AL806516 , AL808024 , AL833800 , BX000479 , BX294443 , CR352330 , CR382328 Genomic DNA. Translation: CAM26796.1 .
    X58153 Genomic DNA. Translation: CAA41157.1 .
    M18025 mRNA. Translation: AAA37530.1 .
    U56724 Genomic DNA. Translation: AAB01216.1 .
    U15218 mRNA. Translation: AAA87068.1 .
    CCDSi CCDS41047.1. [P11531-1 ]
    PIRi S28916.
    RefSeqi NP_031894.1. NM_007868.5. [P11531-1 ]
    UniGenei Mm.275608.
    Mm.416750.

    3D structure databases

    ProteinModelPortali P11531.
    SMRi P11531. Positions 9-246, 340-455, 3040-3299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199245. 19 interactions.
    DIPi DIP-32899N.
    IntActi P11531. 6 interactions.
    MINTi MINT-85369.

    PTM databases

    PhosphoSitei P11531.

    Proteomic databases

    MaxQBi P11531.
    PaxDbi P11531.
    PRIDEi P11531.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114000 ; ENSMUSP00000109633 ; ENSMUSG00000045103 . [P11531-1 ]
    GeneIDi 13405.
    KEGGi mmu:13405.
    UCSCi uc009tri.2. mouse. [P11531-1 ]

    Organism-specific databases

    CTDi 1756.
    MGIi MGI:94909. Dmd.

    Phylogenomic databases

    eggNOGi COG5069.
    GeneTreei ENSGT00740000115262.
    HOGENOMi HOG000231173.
    HOVERGENi HBG005495.
    InParanoidi A2A9Z0.
    KOi K10366.
    OMAi EGPYTMD.
    OrthoDBi EOG7V765N.
    TreeFami TF320178.

    Miscellaneous databases

    NextBioi 283803.
    PROi P11531.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11531.
    Bgeei P11531.
    CleanExi MM_DMD.
    Genevestigatori P11531.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    1.10.418.10. 2 hits.
    InterProi IPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR016344. Dystrophin/utrophin.
    IPR011992. EF-hand-dom_pair.
    IPR015153. EF-hand_dom_typ1.
    IPR015154. EF-hand_dom_typ2.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    IPR001202. WW_dom.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF00307. CH. 2 hits.
    PF09068. EF-hand_2. 1 hit.
    PF09069. EF-hand_3. 1 hit.
    PF00435. Spectrin. 16 hits.
    PF00397. WW. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002341. Dystrophin/utrophin. 1 hit.
    SMARTi SM00033. CH. 2 hits.
    SM00150. SPEC. 22 hits.
    SM00456. WW. 1 hit.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    SSF51045. SSF51045. 1 hit.
    PROSITEi PS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human and murine dystrophin mRNA transcripts are differentially expressed during skeletal muscle, heart, and brain development."
      Bies R.D., Phelps S.F., Cortez M.D., Roberts R., Caskey C.T., Chamberlain J.S.
      Nucleic Acids Res. 20:1725-1731(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/10.
      Tissue: Skeletal muscle.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals."
      Koenig M., Hoffman E.P., Bertelson C.J., Monaco A.P., Feener C., Kunkel L.M.
      Cell 50:509-517(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-201.
    4. "Sequence analysis of two exons from the murine dystrophin locus."
      Maconochie M.K., Brown S.D.M., Greenfield A.J.
      Mamm. Genome 2:64-68(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-176.
      Strain: 129/J.
    5. "Conservation of the Duchenne muscular dystrophy gene in mice and humans."
      Hoffman E.P., Monaco A.P., Feener C.C., Kunkel L.M.
      Science 238:347-350(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 300-1390.
    6. "PCR analysis of muscular dystrophy in mdx mice."
      Chamberlain J.S., Phelps S.F., Cox G.A., Maichele A.J., Greenwood A.D.
      Mol. Cell Biol. Hum. Dis. Ser. 3:167-189(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 986-1056.
      Strain: C57BL/10.
      Tissue: Skeletal muscle.
    7. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1129-1134, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    8. "Characterization and cell type distribution of a novel, major transcript of the Duchenne muscular dystrophy gene."
      Rapaport D., Lederfein D., den Dunnen J.T., Grootscholten P.M., van Ommen G.J.B., Fuchs O., Nudel U., Yaffe D.
      Differentiation 49:187-193(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3069-3181.
    9. "A novel dystrophin isoform is required for normal retinal electrophysiology."
      D'Souza V.N., Nguyen T.M., Morris G.E., Karges W., Pillers D.-A.M., Ray P.N.
      Hum. Mol. Genet. 4:837-842(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/10.
      Tissue: Retina.
    10. "Interactions between dystrophin glycoprotein complex proteins."
      Madhavan R., Jarrett H.W.
      Biochemistry 34:12204-12209(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNTA1 IN THE DYSTROPHIN-ASSOCIATED GLYCOPROTEIN COMPLEX.
    11. "Differential association of syntrophin pairs with the dystrophin complex."
      Peters M.F., Adams M.E., Froehner S.C.
      J. Cell Biol. 138:81-93(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNTB1 IN THE DYSTROPHIN-ASSOCIATED GLYCOPROTEIN COMPLEX.
    12. "Dystroglycan contributes to the formation of multiple dystrophin-like complexes in brain."
      Moukhles H., Carbonetto S.
      J. Neurochem. 78:824-834(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DAG1 IN THE DYSTROPHIN-ASSOCIATED GLYCOPROTEIN COMPLEX.
    13. "Interactions of intermediate filament protein synemin with dystrophin and utrophin."
      Bhosle R.C., Michele D.E., Campbell K.P., Li Z., Robson R.M.
      Biochem. Biophys. Res. Commun. 346:768-777(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SYNM.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3616 AND SER-3617, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    15. "An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan."
      Ayalon G., Davis J.Q., Scotland P.B., Bennett V.
      Cell 135:1189-1200(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ANK2 AND ANK3, SUBCELLULAR LOCATION.
    16. "Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies."
      Sarparanta J., Blandin G., Charton K., Vihola A., Marchand S., Milic A., Hackman P., Ehler E., Richard I., Udd B.
      J. Biol. Chem. 285:30304-30315(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CMYA5.

    Entry informationi

    Entry nameiDMD_MOUSE
    AccessioniPrimary (citable) accession number: P11531
    Secondary accession number(s): A2A9Z0, O35653, Q60703
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 150 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3