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Protein

DNA-directed RNA polymerase subunit A''

Gene

rpoA2

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciSACI330779:GH9J-680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit A'' (EC:2.7.7.6)
Short name:
Subunit C
Gene namesi
Name:rpoA2
Synonyms:rpoC
Ordered Locus Names:Saci_0691
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393DNA-directed RNA polymerase subunit A''PRO_0000074025Add
BLAST

Interactioni

Subunit structurei

This RNA polymerase is composed of 13 subunits.

Protein-protein interaction databases

STRINGi330779.Saci_0691.

Structurei

3D structure databases

ProteinModelPortaliP11514.
SMRiP11514. Positions 9-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

eggNOGiarCOG04256. Archaea.
COG0086. LUCA.
HOGENOMiHOG000222986.
KOiK03042.
OMAiRPIGRHG.

Family and domain databases

HAMAPiMF_00411. RNApol_arch_A. 1 hit.
InterProiIPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view]
PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.

Sequencei

Sequence statusi: Complete.

P11514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDEKLKGYI DKRLNEIKDK IPDKLHEDLR AAIMDINGVE LTEEDIDRII
60 70 80 90 100
DLTIREYQQS LIEPGEAIGV VTAQSVGEPG TQMTLRTFHF AGIRELNVTL
110 120 130 140 150
GLPRLIEIVD ARKVPSTPMM TIYLTDEYKT DKDKALDIAR RIEYTRVENV
160 170 180 190 200
VSSVSVDISN MSITLQFDQE MLKDKGVSIE EIKKIITKLK LGEIRIEDND
210 220 230 240 250
EYSFTIYFEK IDSIMALFKM REKILNTKIK GVKGIKRAIV QKKGDEYVII
260 270 280 290 300
TDGSNLEGIM NVTGVDINKI QTNNIHEVEE VLGIEAAREL ISREIKKVLE
310 320 330 340 350
EQGLDVDMRH IVLVSDIMTR TGDIRQIGRH GVTGEKSSVL ARAAFEVTVK
360 370 380 390
HLLDAAARGE REEFKGVIEN IIIGQPIRLG TGIVELTMKP NMR
Length:393
Mass (Da):44,444
Last modified:August 30, 2005 - v2
Checksum:iF7AA444ABAF088CC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 23510NTKIKGVKGI → IQDKGSQGY in CAA32926 (PubMed:2501756).Curated
Sequence conflicti284 – 2841I → M in CAA32926 (PubMed:2501756).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14818 Genomic DNA. Translation: CAA32926.1.
CP000077 Genomic DNA. Translation: AAY80071.1.
PIRiS04718.
RefSeqiWP_011277573.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80071; AAY80071; Saci_0691.
GeneIDi3472537.
KEGGisai:Saci_0691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14818 Genomic DNA. Translation: CAA32926.1.
CP000077 Genomic DNA. Translation: AAY80071.1.
PIRiS04718.
RefSeqiWP_011277573.1. NC_007181.1.

3D structure databases

ProteinModelPortaliP11514.
SMRiP11514. Positions 9-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_0691.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY80071; AAY80071; Saci_0691.
GeneIDi3472537.
KEGGisai:Saci_0691.

Phylogenomic databases

eggNOGiarCOG04256. Archaea.
COG0086. LUCA.
HOGENOMiHOG000222986.
KOiK03042.
OMAiRPIGRHG.

Enzyme and pathway databases

BioCyciSACI330779:GH9J-680-MONOMER.

Family and domain databases

HAMAPiMF_00411. RNApol_arch_A. 1 hit.
InterProiIPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view]
PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPOA2_SULAC
AccessioniPrimary (citable) accession number: P11514
Secondary accession number(s): Q4JAV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 30, 2005
Last modified: December 9, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.