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Protein

Aromatase

Gene

CYP19A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei309Substrate1
Binding sitei374Substrate; via amide nitrogen1
Metal bindingi437Iron (heme axial ligand)1

GO - Molecular functioni

  • aromatase activity Source: UniProtKB
  • electron carrier activity Source: UniProtKB
  • heme binding Source: UniProtKB
  • iron ion binding Source: InterPro
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: UniProtKB
  • oxygen binding Source: ProtInc
  • steroid hydroxylase activity Source: Reactome

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06413-MONOMER.
ZFISH:HS06413-MONOMER.
BRENDAi1.14.14.14. 2681.
ReactomeiR-HSA-193144. Estrogen biosynthesis.
R-HSA-211976. Endogenous sterols.
SABIO-RKP11511.
SIGNORiP11511.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:ARO1, CYAR, CYP19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:2594. CYP19A1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: LIFEdb
  • endoplasmic reticulum membrane Source: Reactome
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Aromatase excess syndrome (AEXS)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females.
See also OMIM:139300
Aromatase deficiency (AROD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.
See also OMIM:613546
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072784192R → H in AROD; strongly reduced aromatase activity; 81% reduction of androstenedione metabolism compared to wild-type. 1 PublicationCorresponds to variant rs765057534dbSNPEnsembl.1
Natural variantiVAR_016962365R → Q in AROD; 0.4% of wild-type activity. 1 PublicationCorresponds to variant rs80051519dbSNPEnsembl.1
Natural variantiVAR_016963375R → C in AROD. 1 PublicationCorresponds to variant rs121434536dbSNPEnsembl.1
Natural variantiVAR_016964435R → C in AROD; 1.1% of wild-type activity. 1 PublicationCorresponds to variant rs121434534dbSNPEnsembl.1
Natural variantiVAR_016965437C → Y in AROD; complete loss of activity. 1 PublicationCorresponds to variant rs78310315dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Pseudohermaphroditism

Organism-specific databases

DisGeNETi1588.
MalaCardsiCYP19A1.
MIMi139300. phenotype.
613546. phenotype.
OpenTargetsiENSG00000137869.
Orphaneti91. Aromatase deficiency.
178345. Aromatase excess syndrome.
PharmGKBiPA27091.

Chemistry databases

ChEMBLiCHEMBL1978.
DrugBankiDB00357. Aminoglutethimide.
DB01217. Anastrozole.
DB00443. Betamethasone.
DB04794. Bifonazole.
DB06719. Buserelin.
DB00389. Carbimazole.
DB00856. Chlorphenesin.
DB00882. Clomifene.
DB00257. Clotrimazole.
DB04839. Cyproterone acetate.
DB01406. Danazol.
DB01234. Dexamethasone.
DB00255. Diethylstilbestrol.
DB00917. Dinoprostone.
DB00858. Drostanolone.
DB01127. Econazole.
DB00974. Edetic Acid.
DB00292. Etomidate.
DB00990. Exemestane.
DB01026. Ketoconazole.
DB01006. Letrozole.
DB01227. Levomethadyl Acetate.
DB00367. Levonorgestrel.
DB00358. Mefloquine.
DB01065. Melatonin.
DB00333. Methadone.
DB06710. Methyltestosterone.
DB01110. Miconazole.
DB08804. Nandrolone decanoate.
DB00984. Nandrolone phenpropionate.
DB00184. Nicotine.
DB01229. Paclitaxel.
DB00481. Raloxifene.
DB06147. Sulfathiazole.
DB00675. Tamoxifen.
DB00857. Terbinafine.
DB00894. Testolactone.
DB00624. Testosterone.
DB01007. Tioconazole.
DB00072. Trastuzumab.
GuidetoPHARMACOLOGYi1362.

Polymorphism and mutation databases

BioMutaiCYP19A1.
DMDMi117293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519551 – 503AromataseAdd BLAST503

Proteomic databases

PaxDbiP11511.
PeptideAtlasiP11511.
PRIDEiP11511.

PTM databases

iPTMnetiP11511.
PhosphoSitePlusiP11511.

Expressioni

Tissue specificityi

Brain, placenta and gonads.4 Publications

Gene expression databases

BgeeiENSG00000137869.
CleanExiHS_CYP19A1.
ExpressionAtlasiP11511. baseline and differential.
GenevisibleiP11511. HS.

Organism-specific databases

HPAiCAB000355.
HPA051194.

Interactioni

Protein-protein interaction databases

BioGridi107960. 5 interactors.
IntActiP11511. 1 interactor.
MINTiMINT-4054553.
STRINGi9606.ENSP00000260433.

Chemistry databases

BindingDBiP11511.

Structurei

Secondary structure

1503
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi54 – 56Combined sources3
Helixi57 – 68Combined sources12
Helixi70 – 80Combined sources11
Beta strandi83 – 97Combined sources15
Helixi100 – 108Combined sources9
Helixi110 – 112Combined sources3
Helixi119 – 125Combined sources7
Beta strandi130 – 132Combined sources3
Helixi138 – 151Combined sources14
Helixi155 – 172Combined sources18
Helixi173 – 177Combined sources5
Beta strandi183 – 185Combined sources3
Helixi187 – 203Combined sources17
Helixi210 – 227Combined sources18
Helixi232 – 236Combined sources5
Helixi238 – 240Combined sources3
Helixi242 – 267Combined sources26
Turni270 – 275Combined sources6
Helixi278 – 287Combined sources10
Turni288 – 290Combined sources3
Helixi293 – 324Combined sources32
Helixi326 – 339Combined sources14
Turni340 – 342Combined sources3
Helixi347 – 349Combined sources3
Turni350 – 352Combined sources3
Helixi354 – 366Combined sources13
Beta strandi373 – 376Combined sources4
Beta strandi381 – 383Combined sources3
Beta strandi386 – 388Combined sources3
Beta strandi393 – 396Combined sources4
Helixi398 – 401Combined sources4
Turni402 – 404Combined sources3
Helixi415 – 418Combined sources4
Turni424 – 426Combined sources3
Helixi433 – 435Combined sources3
Helixi440 – 455Combined sources16
Beta strandi458 – 463Combined sources6
Turni468 – 470Combined sources3
Beta strandi473 – 481Combined sources9
Beta strandi483 – 485Combined sources3
Beta strandi490 – 494Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TQAmodel-A53-495[»]
3EQMX-ray2.90A1-503[»]
3S79X-ray2.75A1-503[»]
3S7SX-ray3.21A1-503[»]
4GL5X-ray3.48A1-503[»]
4GL7X-ray3.90A1-503[»]
4KQ8X-ray3.29A45-503[»]
ProteinModelPortaliP11511.
SMRiP11511.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11511.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129915.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP11511.
KOiK07434.
OMAiPELWKTT.
OrthoDBiEOG091G056R.
PhylomeDBiP11511.
TreeFamiTF352039.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP
60 70 80 90 100
GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS
110 120 130 140 150
SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK
160 170 180 190 200
ALSGPGLVRM VTVCAESLKT HLDRLEEVTN ESGYVDVLTL LRRVMLDTSN
210 220 230 240 250
TLFLRIPLDE SAIVVKIQGY FDAWQALLIK PDIFFKISWL YKKYEKSVKD
260 270 280 290 300
LKDAIEVLIA EKRRRISTEE KLEECMDFAT ELILAEKRGD LTRENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIIKEIQTVI GERDIKIDDI
360 370 380 390 400
QKLKVMENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKAI
460 470 480 490 500
LVTLLRRFHV KTLQGQCVES IQKIHDLSLH PDETKNMLEM IFTPRNSDRC

LEH
Length:503
Mass (Da):57,883
Last modified:January 23, 2007 - v3
Checksum:i9BD9B28651D9A69A
GO
Isoform 2 (identifier: P11511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-218: ESAIVVKIQ → GTEIFTLTS
     219-503: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):24,518
Checksum:i9C15EFD1B411087C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti496N → S in AAA35557 (PubMed:2973313).Curated1
Sequence conflicti496N → S in CAA31929 (PubMed:2973313).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02342839W → R.1 PublicationCorresponds to variant rs2236722dbSNPEnsembl.1
Natural variantiVAR_072784192R → H in AROD; strongly reduced aromatase activity; 81% reduction of androstenedione metabolism compared to wild-type. 1 PublicationCorresponds to variant rs765057534dbSNPEnsembl.1
Natural variantiVAR_023429201T → M.2 PublicationsCorresponds to variant rs28757184dbSNPEnsembl.1
Natural variantiVAR_018406264R → C.3 PublicationsCorresponds to variant rs700519dbSNPEnsembl.1
Natural variantiVAR_016962365R → Q in AROD; 0.4% of wild-type activity. 1 PublicationCorresponds to variant rs80051519dbSNPEnsembl.1
Natural variantiVAR_016963375R → C in AROD. 1 PublicationCorresponds to variant rs121434536dbSNPEnsembl.1
Natural variantiVAR_054152375R → L.1 Publication1
Natural variantiVAR_016964435R → C in AROD; 1.1% of wild-type activity. 1 PublicationCorresponds to variant rs121434534dbSNPEnsembl.1
Natural variantiVAR_016965437C → Y in AROD; complete loss of activity. 1 PublicationCorresponds to variant rs78310315dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055583210 – 218ESAIVVKIQ → GTEIFTLTS in isoform 2. 1 Publication9
Alternative sequenceiVSP_055584219 – 503Missing in isoform 2. 1 PublicationAdd BLAST285

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22246 mRNA. Translation: AAA35557.1.
X13589 mRNA. Translation: CAA31929.1.
M18856 mRNA. Translation: AAA35556.1.
J04127 mRNA. Translation: AAA52132.1.
Y07508 mRNA. Translation: CAA68807.1.
M30804
, M30796, M30797, M30798, M30800, M30801, M30802, M30803 Genomic DNA. Translation: AAA35728.1.
AY957953 Genomic DNA. Translation: AAX44046.1.
AC012169 Genomic DNA. No translation available.
AC020891 Genomic DNA. No translation available.
BC035714 mRNA. Translation: AAH35714.1.
BC107785 mRNA. Translation: AAI07786.1.
M28420 mRNA. Translation: AAA52141.1.
CCDSiCCDS10139.1. [P11511-1]
PIRiA34451. O4HU19.
RefSeqiNP_000094.2. NM_000103.3. [P11511-1]
NP_112503.1. NM_031226.2. [P11511-1]
XP_005254248.1. XM_005254191.1. [P11511-1]
UniGeneiHs.260074.

Genome annotation databases

EnsembliENST00000396402; ENSP00000379683; ENSG00000137869. [P11511-1]
ENST00000396404; ENSP00000379685; ENSG00000137869. [P11511-1]
ENST00000405913; ENSP00000383930; ENSG00000137869. [P11511-2]
ENST00000557858; ENSP00000452627; ENSG00000137869. [P11511-2]
ENST00000559878; ENSP00000453149; ENSG00000137869. [P11511-1]
GeneIDi1588.
KEGGihsa:1588.
UCSCiuc001zyz.5. human. [P11511-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Aromatase entry

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22246 mRNA. Translation: AAA35557.1.
X13589 mRNA. Translation: CAA31929.1.
M18856 mRNA. Translation: AAA35556.1.
J04127 mRNA. Translation: AAA52132.1.
Y07508 mRNA. Translation: CAA68807.1.
M30804
, M30796, M30797, M30798, M30800, M30801, M30802, M30803 Genomic DNA. Translation: AAA35728.1.
AY957953 Genomic DNA. Translation: AAX44046.1.
AC012169 Genomic DNA. No translation available.
AC020891 Genomic DNA. No translation available.
BC035714 mRNA. Translation: AAH35714.1.
BC107785 mRNA. Translation: AAI07786.1.
M28420 mRNA. Translation: AAA52141.1.
CCDSiCCDS10139.1. [P11511-1]
PIRiA34451. O4HU19.
RefSeqiNP_000094.2. NM_000103.3. [P11511-1]
NP_112503.1. NM_031226.2. [P11511-1]
XP_005254248.1. XM_005254191.1. [P11511-1]
UniGeneiHs.260074.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TQAmodel-A53-495[»]
3EQMX-ray2.90A1-503[»]
3S79X-ray2.75A1-503[»]
3S7SX-ray3.21A1-503[»]
4GL5X-ray3.48A1-503[»]
4GL7X-ray3.90A1-503[»]
4KQ8X-ray3.29A45-503[»]
ProteinModelPortaliP11511.
SMRiP11511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107960. 5 interactors.
IntActiP11511. 1 interactor.
MINTiMINT-4054553.
STRINGi9606.ENSP00000260433.

Chemistry databases

BindingDBiP11511.
ChEMBLiCHEMBL1978.
DrugBankiDB00357. Aminoglutethimide.
DB01217. Anastrozole.
DB00443. Betamethasone.
DB04794. Bifonazole.
DB06719. Buserelin.
DB00389. Carbimazole.
DB00856. Chlorphenesin.
DB00882. Clomifene.
DB00257. Clotrimazole.
DB04839. Cyproterone acetate.
DB01406. Danazol.
DB01234. Dexamethasone.
DB00255. Diethylstilbestrol.
DB00917. Dinoprostone.
DB00858. Drostanolone.
DB01127. Econazole.
DB00974. Edetic Acid.
DB00292. Etomidate.
DB00990. Exemestane.
DB01026. Ketoconazole.
DB01006. Letrozole.
DB01227. Levomethadyl Acetate.
DB00367. Levonorgestrel.
DB00358. Mefloquine.
DB01065. Melatonin.
DB00333. Methadone.
DB06710. Methyltestosterone.
DB01110. Miconazole.
DB08804. Nandrolone decanoate.
DB00984. Nandrolone phenpropionate.
DB00184. Nicotine.
DB01229. Paclitaxel.
DB00481. Raloxifene.
DB06147. Sulfathiazole.
DB00675. Tamoxifen.
DB00857. Terbinafine.
DB00894. Testolactone.
DB00624. Testosterone.
DB01007. Tioconazole.
DB00072. Trastuzumab.
GuidetoPHARMACOLOGYi1362.

PTM databases

iPTMnetiP11511.
PhosphoSitePlusiP11511.

Polymorphism and mutation databases

BioMutaiCYP19A1.
DMDMi117293.

Proteomic databases

PaxDbiP11511.
PeptideAtlasiP11511.
PRIDEiP11511.

Protocols and materials databases

DNASUi1588.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396402; ENSP00000379683; ENSG00000137869. [P11511-1]
ENST00000396404; ENSP00000379685; ENSG00000137869. [P11511-1]
ENST00000405913; ENSP00000383930; ENSG00000137869. [P11511-2]
ENST00000557858; ENSP00000452627; ENSG00000137869. [P11511-2]
ENST00000559878; ENSP00000453149; ENSG00000137869. [P11511-1]
GeneIDi1588.
KEGGihsa:1588.
UCSCiuc001zyz.5. human. [P11511-1]

Organism-specific databases

CTDi1588.
DisGeNETi1588.
GeneCardsiCYP19A1.
HGNCiHGNC:2594. CYP19A1.
HPAiCAB000355.
HPA051194.
MalaCardsiCYP19A1.
MIMi107910. gene.
139300. phenotype.
613546. phenotype.
neXtProtiNX_P11511.
OpenTargetsiENSG00000137869.
Orphaneti91. Aromatase deficiency.
178345. Aromatase excess syndrome.
PharmGKBiPA27091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129915.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP11511.
KOiK07434.
OMAiPELWKTT.
OrthoDBiEOG091G056R.
PhylomeDBiP11511.
TreeFamiTF352039.

Enzyme and pathway databases

BioCyciMetaCyc:HS06413-MONOMER.
ZFISH:HS06413-MONOMER.
BRENDAi1.14.14.14. 2681.
ReactomeiR-HSA-193144. Estrogen biosynthesis.
R-HSA-211976. Endogenous sterols.
SABIO-RKP11511.
SIGNORiP11511.

Miscellaneous databases

ChiTaRSiCYP19A1. human.
EvolutionaryTraceiP11511.
GeneWikiiAromatase.
GenomeRNAii1588.
PROiP11511.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137869.
CleanExiHS_CYP19A1.
ExpressionAtlasiP11511. baseline and differential.
GenevisibleiP11511. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP19A_HUMAN
AccessioniPrimary (citable) accession number: P11511
Secondary accession number(s): Q16731
, Q3B764, Q58FA0, Q8IYJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 187 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.