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Protein

Aromatase

Gene

CYP19A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091Substrate
Binding sitei374 – 3741Substrate; via amide nitrogen
Metal bindingi437 – 4371Iron (heme axial ligand)

GO - Molecular functioni

  • aromatase activity Source: UniProtKB
  • electron carrier activity Source: UniProtKB
  • heme binding Source: UniProtKB
  • iron ion binding Source: InterPro
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: UniProtKB
  • oxygen binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06413-MONOMER.
BRENDAi1.14.14.14. 2681.
ReactomeiREACT_11037. Estrogen biosynthesis.
REACT_13812. Endogenous sterols.
REACT_268478. Defective CYP19A1 causes Aromatase excess syndrome (AEXS).
SABIO-RKP11511.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:ARO1, CYAR, CYP19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:2594. CYP19A1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: LIFEdb
  • endoplasmic reticulum membrane Source: Reactome
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Aromatase excess syndrome (AEXS)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females.

See also OMIM:139300
Aromatase deficiency (AROD)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.

See also OMIM:613546
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti192 – 1921R → H in AROD; strongly reduced aromatase activity; 81% reduction of androstenedione metabolism compared to wild-type. 1 Publication
VAR_072784
Natural varianti365 – 3651R → Q in AROD; 0.4% of wild-type activity. 1 Publication
VAR_016962
Natural varianti375 – 3751R → C in AROD. 1 Publication
VAR_016963
Natural varianti435 – 4351R → C in AROD; 1.1% of wild-type activity. 1 Publication
VAR_016964
Natural varianti437 – 4371C → Y in AROD; complete loss of activity. 1 Publication
VAR_016965

Keywords - Diseasei

Disease mutation, Pseudohermaphroditism

Organism-specific databases

MIMi139300. phenotype.
613546. phenotype.
Orphaneti91. Aromatase deficiency.
178345. Aromatase excess syndrome.
PharmGKBiPA27091.

Chemistry

DrugBankiDB00357. Aminoglutethimide.
DB01217. Anastrozole.
DB00443. Betamethasone.
DB04794. Bifonazole.
DB06719. Buserelin.
DB00389. Carbimazole.
DB00856. Chlorphenesin.
DB00882. Clomifene.
DB00257. Clotrimazole.
DB04839. Cyproterone acetate.
DB01406. Danazol.
DB01234. Dexamethasone.
DB00255. Diethylstilbestrol.
DB00917. Dinoprostone.
DB00858. Drostanolone.
DB01127. Econazole.
DB00974. Edetic Acid.
DB00292. Etomidate.
DB00990. Exemestane.
DB01026. Ketoconazole.
DB01006. Letrozole.
DB01227. Levomethadyl Acetate.
DB00367. Levonorgestrel.
DB00358. Mefloquine.
DB01065. Melatonin.
DB00333. Methadone.
DB06710. Methyltestosterone.
DB01110. Miconazole.
DB08804. Nandrolone decanoate.
DB00984. Nandrolone phenpropionate.
DB00184. Nicotine.
DB01229. Paclitaxel.
DB00481. Raloxifene.
DB06147. Sulfathiazole.
DB00675. Tamoxifen.
DB00857. Terbinafine.
DB00894. Testolactone.
DB00624. Testosterone.
DB01007. Tioconazole.
DB00072. Trastuzumab.

Polymorphism and mutation databases

BioMutaiCYP19A1.
DMDMi117293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503AromatasePRO_0000051955Add
BLAST

Proteomic databases

PaxDbiP11511.
PRIDEiP11511.

PTM databases

PhosphoSiteiP11511.

Expressioni

Tissue specificityi

Brain, placenta and gonads.4 Publications

Gene expression databases

BgeeiP11511.
CleanExiHS_CYP19A1.
ExpressionAtlasiP11511. baseline and differential.
GenevisibleiP11511. HS.

Organism-specific databases

HPAiCAB000355.
HPA051194.

Interactioni

Protein-protein interaction databases

IntActiP11511. 1 interaction.
MINTiMINT-4054553.
STRINGi9606.ENSP00000260433.

Structurei

Secondary structure

1
503
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi54 – 563Combined sources
Helixi57 – 6812Combined sources
Helixi70 – 8011Combined sources
Beta strandi83 – 9715Combined sources
Helixi100 – 1089Combined sources
Helixi110 – 1123Combined sources
Helixi119 – 1257Combined sources
Beta strandi130 – 1323Combined sources
Helixi138 – 15114Combined sources
Helixi155 – 17218Combined sources
Helixi173 – 1775Combined sources
Beta strandi183 – 1853Combined sources
Helixi187 – 20317Combined sources
Helixi210 – 22718Combined sources
Helixi232 – 2365Combined sources
Helixi238 – 2403Combined sources
Helixi242 – 26726Combined sources
Turni270 – 2756Combined sources
Helixi278 – 28710Combined sources
Turni288 – 2903Combined sources
Helixi293 – 32432Combined sources
Helixi326 – 33914Combined sources
Turni340 – 3423Combined sources
Helixi347 – 3493Combined sources
Turni350 – 3523Combined sources
Helixi354 – 36613Combined sources
Beta strandi373 – 3764Combined sources
Beta strandi381 – 3833Combined sources
Beta strandi386 – 3883Combined sources
Beta strandi393 – 3964Combined sources
Helixi398 – 4014Combined sources
Turni402 – 4043Combined sources
Helixi415 – 4184Combined sources
Turni424 – 4263Combined sources
Helixi433 – 4353Combined sources
Helixi440 – 45516Combined sources
Beta strandi458 – 4636Combined sources
Turni468 – 4703Combined sources
Beta strandi473 – 4819Combined sources
Beta strandi483 – 4853Combined sources
Beta strandi490 – 4945Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TQAmodel-A53-495[»]
3EQMX-ray2.90A1-503[»]
3S79X-ray2.75A1-503[»]
3S7SX-ray3.21A1-503[»]
4GL5X-ray3.48A1-503[»]
4GL7X-ray3.90A1-503[»]
4KQ8X-ray3.29A45-503[»]
ProteinModelPortaliP11511.
SMRiP11511. Positions 45-496.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11511.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00800000124164.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP11511.
KOiK07434.
OMAiPELWKTT.
OrthoDBiEOG7D85W5.
PhylomeDBiP11511.
TreeFamiTF352039.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP
60 70 80 90 100
GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS
110 120 130 140 150
SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK
160 170 180 190 200
ALSGPGLVRM VTVCAESLKT HLDRLEEVTN ESGYVDVLTL LRRVMLDTSN
210 220 230 240 250
TLFLRIPLDE SAIVVKIQGY FDAWQALLIK PDIFFKISWL YKKYEKSVKD
260 270 280 290 300
LKDAIEVLIA EKRRRISTEE KLEECMDFAT ELILAEKRGD LTRENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIIKEIQTVI GERDIKIDDI
360 370 380 390 400
QKLKVMENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKAI
460 470 480 490 500
LVTLLRRFHV KTLQGQCVES IQKIHDLSLH PDETKNMLEM IFTPRNSDRC

LEH
Length:503
Mass (Da):57,883
Last modified:January 23, 2007 - v3
Checksum:i9BD9B28651D9A69A
GO
Isoform 2 (identifier: P11511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-218: ESAIVVKIQ → GTEIFTLTS
     219-503: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):24,518
Checksum:i9C15EFD1B411087C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti496 – 4961N → S in AAA35557 (PubMed:2973313).Curated
Sequence conflicti496 – 4961N → S in CAA31929 (PubMed:2973313).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391W → R.1 Publication
Corresponds to variant rs2236722 [ dbSNP | Ensembl ].
VAR_023428
Natural varianti192 – 1921R → H in AROD; strongly reduced aromatase activity; 81% reduction of androstenedione metabolism compared to wild-type. 1 Publication
VAR_072784
Natural varianti201 – 2011T → M.2 Publications
Corresponds to variant rs28757184 [ dbSNP | Ensembl ].
VAR_023429
Natural varianti264 – 2641R → C.3 Publications
Corresponds to variant rs700519 [ dbSNP | Ensembl ].
VAR_018406
Natural varianti365 – 3651R → Q in AROD; 0.4% of wild-type activity. 1 Publication
VAR_016962
Natural varianti375 – 3751R → C in AROD. 1 Publication
VAR_016963
Natural varianti375 – 3751R → L.1 Publication
VAR_054152
Natural varianti435 – 4351R → C in AROD; 1.1% of wild-type activity. 1 Publication
VAR_016964
Natural varianti437 – 4371C → Y in AROD; complete loss of activity. 1 Publication
VAR_016965

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei210 – 2189ESAIVVKIQ → GTEIFTLTS in isoform 2. 1 PublicationVSP_055583
Alternative sequencei219 – 503285Missing in isoform 2. 1 PublicationVSP_055584Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22246 mRNA. Translation: AAA35557.1.
X13589 mRNA. Translation: CAA31929.1.
M18856 mRNA. Translation: AAA35556.1.
J04127 mRNA. Translation: AAA52132.1.
Y07508 mRNA. Translation: CAA68807.1.
M30804
, M30796, M30797, M30798, M30800, M30801, M30802, M30803 Genomic DNA. Translation: AAA35728.1.
AY957953 Genomic DNA. Translation: AAX44046.1.
AC012169 Genomic DNA. No translation available.
AC020891 Genomic DNA. No translation available.
BC035714 mRNA. Translation: AAH35714.1.
BC107785 mRNA. Translation: AAI07786.1.
M28420 mRNA. Translation: AAA52141.1.
CCDSiCCDS10139.1. [P11511-1]
PIRiA34451. O4HU19.
RefSeqiNP_000094.2. NM_000103.3. [P11511-1]
NP_112503.1. NM_031226.2. [P11511-1]
XP_005254247.1. XM_005254190.1. [P11511-1]
XP_005254248.1. XM_005254191.1. [P11511-1]
UniGeneiHs.260074.

Genome annotation databases

EnsembliENST00000260433; ENSP00000260433; ENSG00000137869.
ENST00000396402; ENSP00000379683; ENSG00000137869.
ENST00000396404; ENSP00000379685; ENSG00000137869.
ENST00000405913; ENSP00000383930; ENSG00000137869. [P11511-2]
ENST00000557858; ENSP00000452627; ENSG00000137869. [P11511-2]
ENST00000559878; ENSP00000453149; ENSG00000137869.
GeneIDi1588.
KEGGihsa:1588.
UCSCiuc001zyz.4. human. [P11511-1]
uc001zzd.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Aromatase entry

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22246 mRNA. Translation: AAA35557.1.
X13589 mRNA. Translation: CAA31929.1.
M18856 mRNA. Translation: AAA35556.1.
J04127 mRNA. Translation: AAA52132.1.
Y07508 mRNA. Translation: CAA68807.1.
M30804
, M30796, M30797, M30798, M30800, M30801, M30802, M30803 Genomic DNA. Translation: AAA35728.1.
AY957953 Genomic DNA. Translation: AAX44046.1.
AC012169 Genomic DNA. No translation available.
AC020891 Genomic DNA. No translation available.
BC035714 mRNA. Translation: AAH35714.1.
BC107785 mRNA. Translation: AAI07786.1.
M28420 mRNA. Translation: AAA52141.1.
CCDSiCCDS10139.1. [P11511-1]
PIRiA34451. O4HU19.
RefSeqiNP_000094.2. NM_000103.3. [P11511-1]
NP_112503.1. NM_031226.2. [P11511-1]
XP_005254247.1. XM_005254190.1. [P11511-1]
XP_005254248.1. XM_005254191.1. [P11511-1]
UniGeneiHs.260074.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TQAmodel-A53-495[»]
3EQMX-ray2.90A1-503[»]
3S79X-ray2.75A1-503[»]
3S7SX-ray3.21A1-503[»]
4GL5X-ray3.48A1-503[»]
4GL7X-ray3.90A1-503[»]
4KQ8X-ray3.29A45-503[»]
ProteinModelPortaliP11511.
SMRiP11511. Positions 45-496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11511. 1 interaction.
MINTiMINT-4054553.
STRINGi9606.ENSP00000260433.

Chemistry

BindingDBiP11511.
ChEMBLiCHEMBL1978.
DrugBankiDB00357. Aminoglutethimide.
DB01217. Anastrozole.
DB00443. Betamethasone.
DB04794. Bifonazole.
DB06719. Buserelin.
DB00389. Carbimazole.
DB00856. Chlorphenesin.
DB00882. Clomifene.
DB00257. Clotrimazole.
DB04839. Cyproterone acetate.
DB01406. Danazol.
DB01234. Dexamethasone.
DB00255. Diethylstilbestrol.
DB00917. Dinoprostone.
DB00858. Drostanolone.
DB01127. Econazole.
DB00974. Edetic Acid.
DB00292. Etomidate.
DB00990. Exemestane.
DB01026. Ketoconazole.
DB01006. Letrozole.
DB01227. Levomethadyl Acetate.
DB00367. Levonorgestrel.
DB00358. Mefloquine.
DB01065. Melatonin.
DB00333. Methadone.
DB06710. Methyltestosterone.
DB01110. Miconazole.
DB08804. Nandrolone decanoate.
DB00984. Nandrolone phenpropionate.
DB00184. Nicotine.
DB01229. Paclitaxel.
DB00481. Raloxifene.
DB06147. Sulfathiazole.
DB00675. Tamoxifen.
DB00857. Terbinafine.
DB00894. Testolactone.
DB00624. Testosterone.
DB01007. Tioconazole.
DB00072. Trastuzumab.
GuidetoPHARMACOLOGYi1362.

PTM databases

PhosphoSiteiP11511.

Polymorphism and mutation databases

BioMutaiCYP19A1.
DMDMi117293.

Proteomic databases

PaxDbiP11511.
PRIDEiP11511.

Protocols and materials databases

DNASUi1588.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260433; ENSP00000260433; ENSG00000137869.
ENST00000396402; ENSP00000379683; ENSG00000137869.
ENST00000396404; ENSP00000379685; ENSG00000137869.
ENST00000405913; ENSP00000383930; ENSG00000137869. [P11511-2]
ENST00000557858; ENSP00000452627; ENSG00000137869. [P11511-2]
ENST00000559878; ENSP00000453149; ENSG00000137869.
GeneIDi1588.
KEGGihsa:1588.
UCSCiuc001zyz.4. human. [P11511-1]
uc001zzd.3. human.

Organism-specific databases

CTDi1588.
GeneCardsiGC15M051500.
HGNCiHGNC:2594. CYP19A1.
HPAiCAB000355.
HPA051194.
MIMi107910. gene.
139300. phenotype.
613546. phenotype.
neXtProtiNX_P11511.
Orphaneti91. Aromatase deficiency.
178345. Aromatase excess syndrome.
PharmGKBiPA27091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00800000124164.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP11511.
KOiK07434.
OMAiPELWKTT.
OrthoDBiEOG7D85W5.
PhylomeDBiP11511.
TreeFamiTF352039.

Enzyme and pathway databases

BioCyciMetaCyc:HS06413-MONOMER.
BRENDAi1.14.14.14. 2681.
ReactomeiREACT_11037. Estrogen biosynthesis.
REACT_13812. Endogenous sterols.
REACT_268478. Defective CYP19A1 causes Aromatase excess syndrome (AEXS).
SABIO-RKP11511.

Miscellaneous databases

ChiTaRSiCYP19A1. human.
EvolutionaryTraceiP11511.
GeneWikiiAromatase.
GenomeRNAii1588.
NextBioi6526.
PROiP11511.
SOURCEiSearch...

Gene expression databases

BgeeiP11511.
CleanExiHS_CYP19A1.
ExpressionAtlasiP11511. baseline and differential.
GenevisibleiP11511. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a complete cDNA encoding human aromatase: immunochemical identification and sequence analysis."
    Harada N.
    Biochem. Biophys. Res. Commun. 156:725-732(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Human aromatase: cDNA cloning, Southern blot analysis, and assignment of the gene to chromosome 15."
    Chen S., Besman M.J., Sparkes R.S., Zollman S., Klisak I., Mohandas T., Hall P.F., Shively J.E.
    DNA 7:27-38(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells."
    Corbin C.J., Graham-Lorence S., McPhaul M., Mason J.I., Mendelson C.R., Simpson E.R.
    Proc. Natl. Acad. Sci. U.S.A. 85:8948-8952(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-264.
  4. "Alternative usage of different poly(A) addition signals for two major species of mRNA encoding human aromatase P-450."
    Toda K., Terashima M., Mitsuuchi Y., Yamasaki Y., Yokoyama Y., Nojima S., Ushiro H., Maeda T., Yamamoto Y., Sagara Y., Shizuta Y.
    FEBS Lett. 247:371-376(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. "Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis."
    Means G.D., Mahendroo M.S., Corbin C.J., Mathis J.M., Powell F.E., Mendelson C.R., Simpson E.R.
    J. Biol. Chem. 264:19385-19391(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Expression of human placental aromatase in Saccharomyces cerevisiae."
    Pompon D., Liu R.Y., Besman M.J., Wang P.L., Shively J.E., Chen S.
    Mol. Endocrinol. 3:1477-1487(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  7. "Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency."
    Harada N., Ogawa H., Shozu M., Yamada K., Suhara K., Nishida E., Takagi Y.
    J. Biol. Chem. 267:4781-4785(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  8. NIEHS SNPs program
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-39; MET-201 AND CYS-264.
  9. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-201.
    Tissue: Ovary and Placenta.
  11. "Isolation and characterization of a complementary DNA specific for human aromatase-system cytochrome P-450 mRNA."
    Evans C.T., Ledesma D.B., Schulz T.Z., Simpson E.R., Mendelson C.R.
    Proc. Natl. Acad. Sci. U.S.A. 83:6387-6391(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-503 (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Placenta.
  12. "Sequencing of cDNA inserts encoding aromatase cytochrome P-450 (P-450AROM)."
    Simpson E.R., Evans C.T., Corbin C.J., Powell F.E., Ledesma D.B., Mendelson C.R.
    Mol. Cell. Endocrinol. 52:267-272(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-503 (ISOFORM 1), VARIANT CYS-264.
  13. "Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta."
    Mahendroo M.S., Means G.D., Mendelson C.R., Simpson E.R.
    J. Biol. Chem. 266:11276-11281(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-49, TISSUE SPECIFICITY.
  14. "Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue."
    Mahendroo M.S., Mendelson C.R., Simpson E.R.
    J. Biol. Chem. 268:19463-19470(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-49, TISSUE SPECIFICITY, ALTERNATIVE PROMOTER USAGE.
  15. "Amino terminal sequence analysis of human placenta aromatase."
    Chen S., Shively J.E., Nakajin S., Shinoda M., Hall P.F.
    Biochem. Biophys. Res. Commun. 135:713-719(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF N-TERMINUS.
    Tissue: Placenta.
  16. "Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain."
    Honda S., Harada N., Takagi Y.
    Biochem. Biophys. Res. Commun. 198:1153-1160(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY.
  17. "Structural basis for androgen specificity and oestrogen synthesis in human aromatase."
    Ghosh D., Griswold J., Erman M., Pangborn W.
    Nature 457:219-223(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) IN COMPLEX WITH ANDROSTENEDIONE, HEME.
  18. "Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries."
    Ito Y., Fisher C.R., Conte F.A., Grumbach M.M., Simpson E.R.
    Proc. Natl. Acad. Sci. U.S.A. 90:11673-11677(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS AROD CYS-435 AND TYR-437.
  19. "Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens."
    Morishima A., Grumbach M.M., Simpson E.R., Fisher C., Qin K.
    J. Clin. Endocrinol. Metab. 80:3689-3698(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AROD CYS-375.
  20. "Effect of testosterone and estradiol in a man with aromatase deficiency."
    Carani C., Qin K., Simoni M., Faustini-Fustini M., Serpente S., Boyd J., Korach K.S., Simpson E.R.
    N. Engl. J. Med. 337:91-95(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AROD GLN-365.
  21. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-375.
  22. "Characterization of a novel CYP19A1 (aromatase) R192H mutation causing virilization of a 46,XX newborn, undervirilization of the 46,XY brother, but no virilization of the mother during pregnancies."
    Bouchoucha N., Samara-Boustani D., Pandey A.V., Bony-Trifunovic H., Hofer G., Aigrain Y., Polak M., Fluck C.E.
    Mol. Cell. Endocrinol. 390:8-17(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AROD HIS-192, CHARACTERIZATION OF VARIANT AROD HIS-192.

Entry informationi

Entry nameiCP19A_HUMAN
AccessioniPrimary (citable) accession number: P11511
Secondary accession number(s): Q16731
, Q3B764, Q58FA0, Q8IYJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 173 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.