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Protein

Cytochrome P450 2C12, female-specific

Gene

Cyp2c12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This P450 is active in 15-beta-hydroxylation of steroid sulfates.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C12, female-specific (EC:1.14.14.1)
Alternative name(s):
CYPIIC12
Cytochrome P450 15-beta
Cytochrome P450-UT-1
Cytochrome P450-UT-I
Cytochrome P450I
Gene namesi
Name:Cyp2c12
Synonyms:Cyp2c-12, Cyp2c40
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2470. Cyp2c12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517021 – 490Cytochrome P450 2C12, female-specificAdd BLAST490

Proteomic databases

PaxDbiP11510.
PRIDEiP11510.

Expressioni

Inductioni

By growth hormone.

Interactioni

Protein-protein interaction databases

IntActiP11510. 1 interactor.
MINTiMINT-4577921.
STRINGi10116.ENSRNOP00000015802.

Structurei

3D structure databases

ProteinModelPortaliP11510.
SMRiP11510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOVERGENiHBG015789.
InParanoidiP11510.
KOiK07413.
PhylomeDBiP11510.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P11510-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFVVLVLS LSFLLLLYLW RPSPGRGKLP PGPTPLPIFG NFLQIDMKDI
60 70 80 90 100
RQSISNFSKT YGPVFTLYFG SQPTVVLHGY EAVKEALIDY GEEFSGRGRM
110 120 130 140 150
PVFEKATKGL GISFSRGNVW RATRHFTVNT LRSLGMGKRT IEIKVQEEAE
160 170 180 190 200
WLVMELKKTK GSPCDPKFII GCAPCNVICS IIFQNRFDYK DKDFLSLIEN
210 220 230 240 250
VNEYIKIVST PAFQVFNAFP ILLDYCPGNH KTHSKHFAAI KSYLLKKIKE
260 270 280 290 300
HEESLDVSNP RDFIDYFLIQ RCQENGNQQM NYTQEHLAIL VTNLFIGGTE
310 320 330 340 350
TSSLTLRFAL LLLMKYPHIT DKVQEEIGQV IGRHRSPCML DRIHMPYTNA
360 370 380 390 400
MIHEVQRYID LAPNGLLHEV TCDTKFRDYF IPKGTAVLTS LTSVLHARKE
410 420 430 440 450
FPNPEMFDPG HFLDENGNFK KSDYFMPFSA GKRKCVGEGL ASMELFLFLT
460 470 480 490
TILQNFKLKS LSDPKDIDIN SIRSEFSSIP PTFQLCFIPV
Length:490
Mass (Da):55,919
Last modified:October 1, 1989 - v1
Checksum:iC2B637DA69F62C82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03786 mRNA. Translation: AAA41005.1.
PIRiA32140.
RefSeqiNP_113760.1. NM_031572.1.
UniGeneiRn.2586.

Genome annotation databases

GeneIDi25011.
KEGGirno:25011.

Similar proteinsi

Entry informationi

Entry nameiCP2CC_RAT
AccessioniPrimary (citable) accession number: P11510
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: August 30, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families