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P11510

- CP2CC_RAT

UniProt

P11510 - CP2CC_RAT

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Protein
Cytochrome P450 2C12, female-specific
Gene
Cyp2c12, Cyp2c-12, Cyp2c40
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This P450 is active in 15-beta-hydroxylation of steroid sulfates.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C12, female-specific (EC:1.14.14.1)
Alternative name(s):
CYPIIC12
Cytochrome P450 15-beta
Cytochrome P450-UT-1
Cytochrome P450-UT-I
Cytochrome P450I
Gene namesi
Name:Cyp2c12
Synonyms:Cyp2c-12, Cyp2c40
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2470. Cyp2c12.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C12, female-specific
PRO_0000051702Add
BLAST

Proteomic databases

PRIDEiP11510.

Expressioni

Inductioni

By growth hormone.

Gene expression databases

GenevestigatoriP11510.

Interactioni

Protein-protein interaction databases

IntActiP11510. 1 interaction.
MINTiMINT-4577921.

Structurei

3D structure databases

ProteinModelPortaliP11510.
SMRiP11510. Positions 30-490.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG015789.
KOiK07413.
PhylomeDBiP11510.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11510-1 [UniParc]FASTAAdd to Basket

« Hide

MDPFVVLVLS LSFLLLLYLW RPSPGRGKLP PGPTPLPIFG NFLQIDMKDI    50
RQSISNFSKT YGPVFTLYFG SQPTVVLHGY EAVKEALIDY GEEFSGRGRM 100
PVFEKATKGL GISFSRGNVW RATRHFTVNT LRSLGMGKRT IEIKVQEEAE 150
WLVMELKKTK GSPCDPKFII GCAPCNVICS IIFQNRFDYK DKDFLSLIEN 200
VNEYIKIVST PAFQVFNAFP ILLDYCPGNH KTHSKHFAAI KSYLLKKIKE 250
HEESLDVSNP RDFIDYFLIQ RCQENGNQQM NYTQEHLAIL VTNLFIGGTE 300
TSSLTLRFAL LLLMKYPHIT DKVQEEIGQV IGRHRSPCML DRIHMPYTNA 350
MIHEVQRYID LAPNGLLHEV TCDTKFRDYF IPKGTAVLTS LTSVLHARKE 400
FPNPEMFDPG HFLDENGNFK KSDYFMPFSA GKRKCVGEGL ASMELFLFLT 450
TILQNFKLKS LSDPKDIDIN SIRSEFSSIP PTFQLCFIPV 490
Length:490
Mass (Da):55,919
Last modified:October 1, 1989 - v1
Checksum:iC2B637DA69F62C82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03786 mRNA. Translation: AAA41005.1.
PIRiA32140.
RefSeqiNP_113760.1. NM_031572.1.
UniGeneiRn.2586.

Genome annotation databases

GeneIDi25011.
KEGGirno:25011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03786 mRNA. Translation: AAA41005.1 .
PIRi A32140.
RefSeqi NP_113760.1. NM_031572.1.
UniGenei Rn.2586.

3D structure databases

ProteinModelPortali P11510.
SMRi P11510. Positions 30-490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P11510. 1 interaction.
MINTi MINT-4577921.

Proteomic databases

PRIDEi P11510.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25011.
KEGGi rno:25011.

Organism-specific databases

CTDi 25011.
RGDi 2470. Cyp2c12.

Phylogenomic databases

HOVERGENi HBG015789.
KOi K07413.
PhylomeDBi P11510.

Miscellaneous databases

NextBioi 605089.

Gene expression databases

Genevestigatori P11510.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning, sequence, and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15 beta-hydroxylation of steroid sulfates."
    Zaphiropoulos P.G., Mode A., Stroem A., Moeller C., Fernandez C., Gustafsson J.-A.
    Proc. Natl. Acad. Sci. U.S.A. 85:4214-4217(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha."
    Zaphiropoulos P.G., Mode A., Stroem A., Husman B., Andersson G., Gustafsson J.-A.
    Acta Med. Scand. Suppl. 723:161-167(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP2CC_RAT
AccessioniPrimary (citable) accession number: P11510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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