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P11510

- CP2CC_RAT

UniProt

P11510 - CP2CC_RAT

Protein

Cytochrome P450 2C12, female-specific

Gene

Cyp2c12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    This P450 is active in 15-beta-hydroxylation of steroid sulfates.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C12, female-specific (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC12
    Cytochrome P450 15-beta
    Cytochrome P450-UT-1
    Cytochrome P450-UT-I
    Cytochrome P450I
    Gene namesi
    Name:Cyp2c12
    Synonyms:Cyp2c-12, Cyp2c40
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2470. Cyp2c12.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C12, female-specificPRO_0000051702Add
    BLAST

    Proteomic databases

    PRIDEiP11510.

    Expressioni

    Inductioni

    By growth hormone.

    Gene expression databases

    GenevestigatoriP11510.

    Interactioni

    Protein-protein interaction databases

    IntActiP11510. 1 interaction.
    MINTiMINT-4577921.

    Structurei

    3D structure databases

    ProteinModelPortaliP11510.
    SMRiP11510. Positions 30-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG015789.
    KOiK07413.
    PhylomeDBiP11510.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11510-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPFVVLVLS LSFLLLLYLW RPSPGRGKLP PGPTPLPIFG NFLQIDMKDI    50
    RQSISNFSKT YGPVFTLYFG SQPTVVLHGY EAVKEALIDY GEEFSGRGRM 100
    PVFEKATKGL GISFSRGNVW RATRHFTVNT LRSLGMGKRT IEIKVQEEAE 150
    WLVMELKKTK GSPCDPKFII GCAPCNVICS IIFQNRFDYK DKDFLSLIEN 200
    VNEYIKIVST PAFQVFNAFP ILLDYCPGNH KTHSKHFAAI KSYLLKKIKE 250
    HEESLDVSNP RDFIDYFLIQ RCQENGNQQM NYTQEHLAIL VTNLFIGGTE 300
    TSSLTLRFAL LLLMKYPHIT DKVQEEIGQV IGRHRSPCML DRIHMPYTNA 350
    MIHEVQRYID LAPNGLLHEV TCDTKFRDYF IPKGTAVLTS LTSVLHARKE 400
    FPNPEMFDPG HFLDENGNFK KSDYFMPFSA GKRKCVGEGL ASMELFLFLT 450
    TILQNFKLKS LSDPKDIDIN SIRSEFSSIP PTFQLCFIPV 490
    Length:490
    Mass (Da):55,919
    Last modified:October 1, 1989 - v1
    Checksum:iC2B637DA69F62C82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03786 mRNA. Translation: AAA41005.1.
    PIRiA32140.
    RefSeqiNP_113760.1. NM_031572.1.
    UniGeneiRn.2586.

    Genome annotation databases

    GeneIDi25011.
    KEGGirno:25011.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03786 mRNA. Translation: AAA41005.1 .
    PIRi A32140.
    RefSeqi NP_113760.1. NM_031572.1.
    UniGenei Rn.2586.

    3D structure databases

    ProteinModelPortali P11510.
    SMRi P11510. Positions 30-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P11510. 1 interaction.
    MINTi MINT-4577921.

    Proteomic databases

    PRIDEi P11510.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25011.
    KEGGi rno:25011.

    Organism-specific databases

    CTDi 25011.
    RGDi 2470. Cyp2c12.

    Phylogenomic databases

    HOVERGENi HBG015789.
    KOi K07413.
    PhylomeDBi P11510.

    Miscellaneous databases

    NextBioi 605089.

    Gene expression databases

    Genevestigatori P11510.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning, sequence, and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15 beta-hydroxylation of steroid sulfates."
      Zaphiropoulos P.G., Mode A., Stroem A., Moeller C., Fernandez C., Gustafsson J.-A.
      Proc. Natl. Acad. Sci. U.S.A. 85:4214-4217(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha."
      Zaphiropoulos P.G., Mode A., Stroem A., Husman B., Andersson G., Gustafsson J.-A.
      Acta Med. Scand. Suppl. 723:161-167(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP2CC_RAT
    AccessioniPrimary (citable) accession number: P11510
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3