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P11510 (CP2CC_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C12, female-specific

EC=1.14.14.1
Alternative name(s):
CYPIIC12
Cytochrome P450 15-beta
Cytochrome P450-UT-1
Cytochrome P450-UT-I
Cytochrome P450I
Gene names
Name:Cyp2c12
Synonyms:Cyp2c-12, Cyp2c40
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This P450 is active in 15-beta-hydroxylation of steroid sulfates.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By growth hormone.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C12, female-specific
PRO_0000051702

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P11510 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: C2B637DA69F62C82

FASTA49055,919
        10         20         30         40         50         60 
MDPFVVLVLS LSFLLLLYLW RPSPGRGKLP PGPTPLPIFG NFLQIDMKDI RQSISNFSKT 

        70         80         90        100        110        120 
YGPVFTLYFG SQPTVVLHGY EAVKEALIDY GEEFSGRGRM PVFEKATKGL GISFSRGNVW 

       130        140        150        160        170        180 
RATRHFTVNT LRSLGMGKRT IEIKVQEEAE WLVMELKKTK GSPCDPKFII GCAPCNVICS 

       190        200        210        220        230        240 
IIFQNRFDYK DKDFLSLIEN VNEYIKIVST PAFQVFNAFP ILLDYCPGNH KTHSKHFAAI 

       250        260        270        280        290        300 
KSYLLKKIKE HEESLDVSNP RDFIDYFLIQ RCQENGNQQM NYTQEHLAIL VTNLFIGGTE 

       310        320        330        340        350        360 
TSSLTLRFAL LLLMKYPHIT DKVQEEIGQV IGRHRSPCML DRIHMPYTNA MIHEVQRYID 

       370        380        390        400        410        420 
LAPNGLLHEV TCDTKFRDYF IPKGTAVLTS LTSVLHARKE FPNPEMFDPG HFLDENGNFK 

       430        440        450        460        470        480 
KSDYFMPFSA GKRKCVGEGL ASMELFLFLT TILQNFKLKS LSDPKDIDIN SIRSEFSSIP 

       490 
PTFQLCFIPV 

« Hide

References

[1]"cDNA cloning, sequence, and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15 beta-hydroxylation of steroid sulfates."
Zaphiropoulos P.G., Mode A., Stroem A., Moeller C., Fernandez C., Gustafsson J.-A.
Proc. Natl. Acad. Sci. U.S.A. 85:4214-4217(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha."
Zaphiropoulos P.G., Mode A., Stroem A., Husman B., Andersson G., Gustafsson J.-A.
Acta Med. Scand. Suppl. 723:161-167(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03786 mRNA. Translation: AAA41005.1.
PIRA32140.
RefSeqNP_113760.1. NM_031572.1.
UniGeneRn.2586.

3D structure databases

ProteinModelPortalP11510.
SMRP11510. Positions 30-490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP11510. 1 interaction.
MINTMINT-4577921.

Proteomic databases

PRIDEP11510.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25011.
KEGGrno:25011.

Organism-specific databases

CTD25011.
RGD2470. Cyp2c12.

Phylogenomic databases

HOVERGENHBG015789.
KOK07413.
PhylomeDBP11510.

Gene expression databases

GenevestigatorP11510.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605089.

Entry information

Entry nameCP2CC_RAT
AccessionPrimary (citable) accession number: P11510
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families