##gff-version 3 P11509 UniProtKB Chain 1 494 . . . ID=PRO_0000051668;Note=Cytochrome P450 2A6 P11509 UniProtKB Binding site 107 107 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 P11509 UniProtKB Binding site 297 297 . . . . P11509 UniProtKB Binding site 439 439 . . . Note=Axial binding residue P11509 UniProtKB Natural variant 5 5 . . . ID=VAR_018330;Note=In allele CYP2A6*13. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15469410,ECO:0000269|PubMed:15618701;Dbxref=dbSNP:rs28399434,PMID:15469410,PMID:15618701 P11509 UniProtKB Natural variant 29 29 . . . ID=VAR_018331;Note=In allele CYP2A6*14. S->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15469410,ECO:0000269|PubMed:15618701,ECO:0000269|PubMed:2726448;Dbxref=dbSNP:rs28399435,PMID:15469410,PMID:15618701,PMID:2726448 P11509 UniProtKB Natural variant 110 110 . . . ID=VAR_055035;Note=In allele CYP2A6*24%3B increases phenacetin O-deethylation activity 4 fold. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18360915,ECO:0000269|PubMed:18779312;Dbxref=dbSNP:rs72549435,PMID:18360915,PMID:18779312 P11509 UniProtKB Natural variant 118 118 . . . ID=VAR_024711;Note=In allele CYP2A6*25 and allele CYP2A6*26. F->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15469410,ECO:0000269|PubMed:18360915;Dbxref=dbSNP:rs28399440,PMID:15469410,PMID:18360915 P11509 UniProtKB Natural variant 128 128 . . . ID=VAR_055036;Note=In allele CYP2A6*26. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18360915;Dbxref=dbSNP:rs4986891,PMID:18360915 P11509 UniProtKB Natural variant 128 128 . . . ID=VAR_011577;Note=In allele CYP2A6*6%3B loss of activity. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11278503,ECO:0000269|PubMed:15469410;Dbxref=dbSNP:rs4986891,PMID:11278503,PMID:15469410 P11509 UniProtKB Natural variant 131 131 . . . ID=VAR_055037;Note=In allele CYP2A6*26. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18360915;Dbxref=dbSNP:rs59552350,PMID:18360915 P11509 UniProtKB Natural variant 160 160 . . . ID=VAR_001249;Note=In allele CYP2A6*2%3B unable to catalyze 7-hydroxylation of coumarin%3B causes switching from coumarin 7-hydroxylation to 3-hydroxylation. L->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:2322567,ECO:0000269|PubMed:2748347,ECO:0000269|PubMed:9409631;Dbxref=dbSNP:rs1801272,PMID:15489334,PMID:2322567,PMID:2748347,PMID:9409631 P11509 UniProtKB Natural variant 194 194 . . . ID=VAR_018332;Note=In allele CYP2A6*15. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15618701;Dbxref=dbSNP:rs199916117,PMID:15618701 P11509 UniProtKB Natural variant 203 203 . . . ID=VAR_055034;Note=In allele CYP2A6*23%3B greatly reduced activity toward nicotine C-oxidation as well as reduced coumarin 7-hydroxylation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18216723;Dbxref=dbSNP:rs56256500,PMID:18216723 P11509 UniProtKB Natural variant 203 203 . . . ID=VAR_018333;Note=In allele CYP2A6*16. R->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15618701,ECO:0000269|PubMed:18216723;Dbxref=dbSNP:rs56256500,PMID:15618701,PMID:18216723 P11509 UniProtKB Natural variant 224 224 . . . ID=VAR_024712;Note=S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15469410;Dbxref=dbSNP:rs28399447,PMID:15469410 P11509 UniProtKB Natural variant 292 292 . . . ID=VAR_059149;Note=V->M;Dbxref=dbSNP:rs2644906 P11509 UniProtKB Natural variant 294 294 . . . ID=VAR_048448;Note=T->S;Dbxref=dbSNP:rs4997557 P11509 UniProtKB Natural variant 365 365 . . . ID=VAR_024713;Note=In allele CYP2A6*17%3B increases phenacetin O-deethylation activity 2 fold. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15469410,ECO:0000269|PubMed:18216723,ECO:0000269|PubMed:18779312;Dbxref=dbSNP:rs28399454,PMID:15469410,PMID:18216723,PMID:18779312 P11509 UniProtKB Natural variant 392 392 . . . ID=VAR_055033;Note=Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs1809810 P11509 UniProtKB Natural variant 418 418 . . . ID=VAR_024714;Note=In allele CYP2A6*28. N->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15469410,ECO:0000269|PubMed:18360915;Dbxref=dbSNP:rs28399463,PMID:15469410,PMID:18360915 P11509 UniProtKB Natural variant 419 419 . . . ID=VAR_018375;Note=In allele CYP2A6*28. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12721789,ECO:0000269|PubMed:15469410,ECO:0000269|PubMed:18360915;Dbxref=dbSNP:rs8192730,PMID:12721789,PMID:15469410,PMID:18360915 P11509 UniProtKB Natural variant 438 438 . . . ID=VAR_055038;Note=In allele CYP2A6*24. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18360915;Dbxref=dbSNP:rs143731390,PMID:18360915 P11509 UniProtKB Natural variant 471 471 . . . ID=VAR_011578;Note=In allele CYP2A6*7. I->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11237731,ECO:0000269|PubMed:12721789,ECO:0000269|PubMed:15469410;Dbxref=dbSNP:rs5031016,PMID:11237731,PMID:12721789,PMID:15469410 P11509 UniProtKB Natural variant 476 476 . . . ID=VAR_024715;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15469410,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6413474,PMID:15469410,PMID:15489334 P11509 UniProtKB Natural variant 479 479 . . . ID=VAR_008356;Note=In allele CYP2A6*5%3B loss of activity. G->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10544257,ECO:0000269|Ref.4;Dbxref=dbSNP:rs5031017,PMID:10544257 P11509 UniProtKB Natural variant 485 485 . . . ID=VAR_011579;Note=In allele CYP2A6*8. R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11237731,ECO:0000269|PubMed:15469410;Dbxref=dbSNP:rs28399468,PMID:11237731,PMID:15469410 P11509 UniProtKB Mutagenesis 208 208 . . . Note=Increases phenacetin O-deethylation activity 10 fold%3B when associated with F-300 and A-301. Increases phenacetin O-deethylation activity 38 fold%3B when associated with F-300%3B A-301 and G-369. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18779312;Dbxref=PMID:18779312 P11509 UniProtKB Mutagenesis 213 213 . . . Note=No effect on phenacetin O-deethylation activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18779312;Dbxref=PMID:18779312 P11509 UniProtKB Mutagenesis 300 300 . . . Note=Increases phenacetin O-deethylation activity 3 fold. Increases phenacetin O-deethylation activity 8 fold%3B when associated with A-301. Increases phenacetin O-deethylation activity 10 fold%3B when associated with S-208 and A-301. Increases phenacetin O-deethylation activity 12 fold%3B when associated with A-301 and G-369. Increases phenacetin O-deethylation activity 38 fold%3B when associated with S-208%3B A-301 and G-369. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18779312;Dbxref=PMID:18779312 P11509 UniProtKB Mutagenesis 301 301 . . . Note=Slightly decreases phenacetin O-deethylation activity. Increases phenacetin O-deethylation activity 8 fold%3B when associated with F-300. Increases phenacetin O-deethylation activity 10 fold%3B when associated with S-208 and F-300. Increases phenacetin O-deethylation activity 12 fold%3B when associated with F-300 and G-369. Increases phenacetin O-deethylation activity 38 fold%3B when associated with S-208%3B F-300 and G-369. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18779312;Dbxref=PMID:18779312 P11509 UniProtKB Mutagenesis 369 369 . . . Note=Increases phenacetin O-deethylation activity 3 fold. Increases phenacetin O-deethylation activity 38 fold%3B when associated with S-208%3B F-300 and A-301. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18779312;Dbxref=PMID:18779312 P11509 UniProtKB Mutagenesis 372 372 . . . Note=Increases phenacetin O-deethylation activity 2 fold. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18779312;Dbxref=PMID:18779312 P11509 UniProtKB Sequence conflict 3 7 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11509 UniProtKB Sequence conflict 255 255 . . . Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11509 UniProtKB Sequence conflict 326 326 . . . Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11509 UniProtKB Turn 41 43 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 46 48 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 51 53 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDU P11509 UniProtKB Helix 54 65 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 67 73 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 76 81 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 84 91 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Turn 92 98 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 105 111 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 115 118 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 121 137 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Turn 138 141 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 143 162 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Turn 163 165 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 171 187 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 196 212 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 215 227 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 230 232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDY P11509 UniProtKB Helix 233 256 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 267 277 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Turn 278 280 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 288 319 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 321 334 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 337 339 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 343 348 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 350 363 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 378 380 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 383 385 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 390 393 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 395 399 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Turn 402 404 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 405 407 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RUI P11509 UniProtKB Helix 413 416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 419 421 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3T3Q P11509 UniProtKB Helix 442 459 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 460 466 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Helix 468 470 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 476 483 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV P11509 UniProtKB Beta strand 489 493 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FDV