Plasma membrane calcium-transporting ATPase 2

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Reviewed, UniProtKB/Swiss-Prot P11506 (AT2B2_RAT)

Last modified October 13, 2009. Version 101. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Plasma membrane calcium-transporting ATPase 2
      Short name=PMCA2
    EC=3.6.3.8
Alternative name(s):
    Plasma membrane calcium ATPase isoform 2
    Plasma membrane calcium pump isoform 2

Gene names

Name:

Atp2b2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	1243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Catalytic activity	ATP + H₂O + Ca²⁺(Cis) = ADP + phosphate + Ca²⁺(Trans).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Isoforms containing segment B are found in brain, uterus, liver and kidney and in low levels in other tissues. Isoforms containing segment W are found in kidney, uterus, and pancreas. Isoforms containing segment Y are found in pancreas and in low levels in brain and heart. Isoforms containing segment Z are found in brain and heart and isoforms containing segment X are found in low levels in brain. Isoforms containing segment A are found in low levels in heart and small intestine while isoforms containing segment C are found in testis and in low levels in other tissues.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily.

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Ligand	ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB sensory perception of sound Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	apical plasma membrane Inferred from direct assay. Source: RGD cell soma Inferred from direct assay. Source: RGD cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB dendrite Inferred from direct assay. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Ref.1 Inferred from direct assay. Source: RGD PDZ domain binding Inferred from physical interaction. Source: RGD calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Ref.1 Inferred from direct assay. Source: RGD calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein C-terminus binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

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Alternative products

This entry describes 12 isoforms produced by alternative splicing. [Align] [Select] Note: There is a combination of two alternatively spliced domains at N-terminal site A (W, X, Y and Z) and at C-terminal site C (A, B and C). So far the splice sites have only been studied independently. Experimental confirmation may be lacking for some isoforms.

Isoform WB (identifier: P11506-1) Also known as: AIIICI; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform WA (identifier: P11506-2) Also known as: AIIICII; The sequence of this isoform differs from the canonical sequence as follows: 1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Isoform XA (identifier: P11506-3) Also known as: AIICII; The sequence of this isoform differs from the canonical sequence as follows: 303-333: Missing. 1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Isoform YA (identifier: P11506-4) Also known as: AIIICII; The sequence of this isoform differs from the canonical sequence as follows: 334-347: Missing. 1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Isoform ZA (identifier: P11506-5) Also known as: AICII; The sequence of this isoform differs from the canonical sequence as follows: 303-347: Missing. 1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Isoform XB (identifier: P11506-6) Also known as: AIICI; The sequence of this isoform differs from the canonical sequence as follows: 303-333: Missing.

Isoform YB (identifier: P11506-7) Also known as: AIIICI; The sequence of this isoform differs from the canonical sequence as follows: 334-347: Missing.

Isoform ZB (identifier: P11506-8) Also known as: AICI; The sequence of this isoform differs from the canonical sequence as follows: 303-347: Missing.

Isoform WC (identifier: P11506-9) Also known as: AIIICIII; The sequence of this isoform differs from the canonical sequence as follows: 1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...AGHPRREGVP

Isoform XC (identifier: P11506-10) Also known as: AIICIII; The sequence of this isoform differs from the canonical sequence as follows: 303-333: Missing. 1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...AGHPRREGVP

Isoform YC (identifier: P11506-11) Also known as: AIIICIII; The sequence of this isoform differs from the canonical sequence as follows: 334-347: Missing. 1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...AGHPRREGVP

Isoform ZC (identifier: P11506-12) Also known as: AICIII; The sequence of this isoform differs from the canonical sequence as follows: 303-347: Missing. 1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...AGHPRREGVP

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1243

1243

Plasma membrane calcium-transporting ATPase 2

PRO_0000046216

Regions

Topological domain

1 – 94

Cytoplasmic Potential

Transmembrane

95 – 115

Potential

Topological domain

116 – 152

Extracellular Potential

Transmembrane

153 – 173

Potential

Topological domain

174 – 390

217

Cytoplasmic Potential

Transmembrane

391 – 410

Potential

Topological domain

411 – 443

Extracellular Potential

Transmembrane

444 – 461

Potential

Topological domain

462 – 875

414

Cytoplasmic Potential

Transmembrane

876 – 895

Potential

Topological domain

896 – 905

Extracellular Potential

Transmembrane

906 – 926

Potential

Topological domain

927 – 946

Cytoplasmic Potential

Transmembrane

947 – 969

Potential

Topological domain

970 – 987

Extracellular Potential

Transmembrane

988 – 1009

Potential

Topological domain

1010 – 1028

Cytoplasmic Potential

Transmembrane

1029 – 1050

Potential

Topological domain

1051 – 1060

Extracellular Potential

Transmembrane

1061 – 1082

Potential

Topological domain

1083 – 1243

161

Cytoplasmic Potential

Region

1123 – 1140

Calmodulin-binding subdomain A By similarity

Region

1141 – 1150

Calmodulin-binding subdomain B By similarity

Compositional bias

294 – 297

Poly-Glu

Sites

Active site

499

4-aspartylphosphate intermediate

Metal binding

820

Magnesium By similarity

Metal binding

824

Magnesium By similarity

Amino acid modifications

Modified residue

1139

Phosphothreonine; by PKC By similarity

Modified residue

1201

Phosphoserine; by PKA By similarity

Modified residue

1231

Phosphoserine By similarity

Modified residue

1234

Phosphoserine By similarity

Modified residue

1238

Phosphoserine By similarity

Modified residue

1241

Phosphothreonine By similarity

Modified residue

1242

Phosphoserine By similarity

Natural variations

Alternative sequence

303 – 347

Missing in isoform ZA, isoform ZB and isoform ZC.

VSP_000388

Alternative sequence

303 – 333

Missing in isoform XA, isoform XB and isoform XC.

VSP_000387

Alternative sequence

334 – 347

Missing in isoform YA, isoform YB and isoform YC.

VSP_000389

Alternative sequence

1141 – 1243

103

IRVVK…LETSL → IEVVNTFKSGASFQGALRRQ SSVTSQSQDVANLSSPSRVS LSNALSSPTSLPPAAAGQG in isoform WA, isoform XA, isoform YA and isoform ZA.

VSP_000390

Alternative sequence

1141 – 1243

103

IRVVK…LETSL → IEVVNTFKSGASFQGALRRQ SSVTSQSQDVANLSSPSRVS LSNALSSPTSLPPAAAGHPR REGVP in isoform WC, isoform XC, isoform YC and isoform ZC.

VSP_000391

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Sequences

Sequence		Length	Mass (Da)
Isoform WB (AIIICI) [UniParc]. Last modified June 1, 2001. Version 2. Checksum: 1DC324836BFD5D59 Show »	FASTA	1,243	136,811
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGVKKGDGL QLPAADGAAP ANAAGSANAS LVNGKMQDGS ADSSQSKAKQ QDGAAAMEMQ 370 380 390 400 410 420 PLKSAEGGDA DDKKKANMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 430 440 450 460 470 480 FVVNKKPWLT ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 490 500 510 520 530 540 VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NAKTLELLVN 550 560 570 580 590 600 AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL RQDYEPVRSQ MPEEKLYKVY 610 620 630 640 650 660 TFNSVRKSMS TVIKMPDESF RMYSKGASEI VLKKCCKILS GAGEPRVFRP RDRDEMVKKV 670 680 690 700 710 720 IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 730 740 750 760 770 780 QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 790 800 810 820 830 840 IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 850 860 870 880 890 900 GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 910 920 930 940 950 960 QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 970 980 990 1000 1010 1020 YQLTLIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER 1030 1040 1050 1060 1070 1080 NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV 1090 1100 1110 1120 1130 1140 IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ 1150 1160 1170 1180 1190 1200 IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS 1210 1220 1230 1240 SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL « Hide
Isoform WA (AIIICII). Checksum: 702E8C5EE0D003B4 Show »	FASTA	1,199	131,552
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGVKKGDGL QLPAADGAAP ANAAGSANAS LVNGKMQDGS ADSSQSKAKQ QDGAAAMEMQ 370 380 390 400 410 420 PLKSAEGGDA DDKKKANMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 430 440 450 460 470 480 FVVNKKPWLT ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 490 500 510 520 530 540 VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NAKTLELLVN 550 560 570 580 590 600 AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL RQDYEPVRSQ MPEEKLYKVY 610 620 630 640 650 660 TFNSVRKSMS TVIKMPDESF RMYSKGASEI VLKKCCKILS GAGEPRVFRP RDRDEMVKKV 670 680 690 700 710 720 IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 730 740 750 760 770 780 QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 790 800 810 820 830 840 IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 850 860 870 880 890 900 GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 910 920 930 940 950 960 QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 970 980 990 1000 1010 1020 YQLTLIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER 1030 1040 1050 1060 1070 1080 NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV 1090 1100 1110 1120 1130 1140 IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ 1150 1160 1170 1180 1190 IEVVNTFKSG ASFQGALRRQ SSVTSQSQDV ANLSSPSRVS LSNALSSPTS LPPAAAGQG « Hide
Isoform XA (AIICII). Checksum: 6AB32E12491365BB Show »	FASTA	1,168	128,764
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGKMQDGSA DSSQSKAKQQ DGAAAMEMQP LKSAEGGDAD DKKKANMHKK EKSVLQGKLT 370 380 390 400 410 420 KLAVQIGKAG LVMSAITVII LVLYFTVDTF VVNKKPWLTE CTPVYVQYFV KFFIIGVTVL 430 440 450 460 470 480 VVAVPEGLPL AVTISLAYSV KKMMKDNNLV RHLDACETMG NATAICSDKT GTLTTNRMTV 490 500 510 520 530 540 VQAYVGDVHY KEIPDPSSIN AKTLELLVNA IAINSAYTTK ILPPEKEGAL PRQVGNKTEC 550 560 570 580 590 600 GLLGFVLDLR QDYEPVRSQM PEEKLYKVYT FNSVRKSMST VIKMPDESFR MYSKGASEIV 610 620 630 640 650 660 LKKCCKILSG AGEPRVFRPR DRDEMVKKVI EPMACDGLRT ICVAYRDFPS SPEPDWDNEN 670 680 690 700 710 720 DILNELTCIC VVGIEDPVRP EVPEAIRKCQ RAGITVRMVT GDNINTARAI AIKCGIIHPG 730 740 750 760 770 780 EDFLCLEGKE FNRRIRNEKG EIEQERIDKI WPKLRVLARS SPTDKHTLVK GIIDSTHTEQ 790 800 810 820 830 840 RQVVAVTGDG TNDGPALKKA DVGFAMGIAG TDVAKEASDI ILTDDNFSSI VKAVMWGRNV 850 860 870 880 890 900 YDSISKFLQF QLTVNVVAVI VAFTGACITQ DSPLKAVQML WVNLIMDTFA SLALATEPPT 910 920 930 940 950 960 ETLLLRKPYG RNKPLISRTM MKNILGHAVY QLTLIFTLLF VGEKMFQIDS GRNAPLHSPP 970 980 990 1000 1010 1020 SEHYTIIFNT FVMMQLFNEI NARKIHGERN VFDGIFRNPI FCTIVLGTFA IQIVIVQFGG 1030 1040 1050 1060 1070 1080 KPFSCSPLQL DQWMWCIFIG LGELVWGQVI ATIPTSRLKF LKEAGRLTQK EEIPEEELNE 1090 1100 1110 1120 1130 1140 DVEEIDHAER ELRRGQILWF RGLNRIQTQI EVVNTFKSGA SFQGALRRQS SVTSQSQDVA 1150 1160 NLSSPSRVSL SNALSSPTSL PPAAAGQG « Hide
Isoform YA (AIIICII). Checksum: 5D4B80A8A5627C1E Show »	FASTA	1,185	130,145
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGVKKGDGL QLPAADGAAP ANAAGSANAS LVNAKQQDGA AAMEMQPLKS AEGGDADDKK 370 380 390 400 410 420 KANMHKKEKS VLQGKLTKLA VQIGKAGLVM SAITVIILVL YFTVDTFVVN KKPWLTECTP 430 440 450 460 470 480 VYVQYFVKFF IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT 490 500 510 520 530 540 AICSDKTGTL TTNRMTVVQA YVGDVHYKEI PDPSSINAKT LELLVNAIAI NSAYTTKILP 550 560 570 580 590 600 PEKEGALPRQ VGNKTECGLL GFVLDLRQDY EPVRSQMPEE KLYKVYTFNS VRKSMSTVIK 610 620 630 640 650 660 MPDESFRMYS KGASEIVLKK CCKILSGAGE PRVFRPRDRD EMVKKVIEPM ACDGLRTICV 670 680 690 700 710 720 AYRDFPSSPE PDWDNENDIL NELTCICVVG IEDPVRPEVP EAIRKCQRAG ITVRMVTGDN 730 740 750 760 770 780 INTARAIAIK CGIIHPGEDF LCLEGKEFNR RIRNEKGEIE QERIDKIWPK LRVLARSSPT 790 800 810 820 830 840 DKHTLVKGII DSTHTEQRQV VAVTGDGTND GPALKKADVG FAMGIAGTDV AKEASDIILT 850 860 870 880 890 900 DDNFSSIVKA VMWGRNVYDS ISKFLQFQLT VNVVAVIVAF TGACITQDSP LKAVQMLWVN 910 920 930 940 950 960 LIMDTFASLA LATEPPTETL LLRKPYGRNK PLISRTMMKN ILGHAVYQLT LIFTLLFVGE 970 980 990 1000 1010 1020 KMFQIDSGRN APLHSPPSEH YTIIFNTFVM MQLFNEINAR KIHGERNVFD GIFRNPIFCT 1030 1040 1050 1060 1070 1080 IVLGTFAIQI VIVQFGGKPF SCSPLQLDQW MWCIFIGLGE LVWGQVIATI PTSRLKFLKE 1090 1100 1110 1120 1130 1140 AGRLTQKEEI PEEELNEDVE EIDHAERELR RGQILWFRGL NRIQTQIEVV NTFKSGASFQ 1150 1160 1170 1180 GALRRQSSVT SQSQDVANLS SPSRVSLSNA LSSPTSLPPA AAGQG « Hide
Isoform ZA (AICII). Checksum: 22BF0F734827E168 Show »	FASTA	1,154	127,357
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKAKQQDGAA AMEMQPLKSA EGGDADDKKK ANMHKKEKSV LQGKLTKLAV QIGKAGLVMS 370 380 390 400 410 420 AITVIILVLY FTVDTFVVNK KPWLTECTPV YVQYFVKFFI IGVTVLVVAV PEGLPLAVTI 430 440 450 460 470 480 SLAYSVKKMM KDNNLVRHLD ACETMGNATA ICSDKTGTLT TNRMTVVQAY VGDVHYKEIP 490 500 510 520 530 540 DPSSINAKTL ELLVNAIAIN SAYTTKILPP EKEGALPRQV GNKTECGLLG FVLDLRQDYE 550 560 570 580 590 600 PVRSQMPEEK LYKVYTFNSV RKSMSTVIKM PDESFRMYSK GASEIVLKKC CKILSGAGEP 610 620 630 640 650 660 RVFRPRDRDE MVKKVIEPMA CDGLRTICVA YRDFPSSPEP DWDNENDILN ELTCICVVGI 670 680 690 700 710 720 EDPVRPEVPE AIRKCQRAGI TVRMVTGDNI NTARAIAIKC GIIHPGEDFL CLEGKEFNRR 730 740 750 760 770 780 IRNEKGEIEQ ERIDKIWPKL RVLARSSPTD KHTLVKGIID STHTEQRQVV AVTGDGTNDG 790 800 810 820 830 840 PALKKADVGF AMGIAGTDVA KEASDIILTD DNFSSIVKAV MWGRNVYDSI SKFLQFQLTV 850 860 870 880 890 900 NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTETLL LRKPYGRNKP 910 920 930 940 950 960 LISRTMMKNI LGHAVYQLTL IFTLLFVGEK MFQIDSGRNA PLHSPPSEHY TIIFNTFVMM 970 980 990 1000 1010 1020 QLFNEINARK IHGERNVFDG IFRNPIFCTI VLGTFAIQIV IVQFGGKPFS CSPLQLDQWM 1030 1040 1050 1060 1070 1080 WCIFIGLGEL VWGQVIATIP TSRLKFLKEA GRLTQKEEIP EEELNEDVEE IDHAERELRR 1090 1100 1110 1120 1130 1140 GQILWFRGLN RIQTQIEVVN TFKSGASFQG ALRRQSSVTS QSQDVANLSS PSRVSLSNAL 1150 SSPTSLPPAA AGQG « Hide
Isoform XB (AIICI). Checksum: 011EA48CC5EA5536 Show »	FASTA	1,212	134,023
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGKMQDGSA DSSQSKAKQQ DGAAAMEMQP LKSAEGGDAD DKKKANMHKK EKSVLQGKLT 370 380 390 400 410 420 KLAVQIGKAG LVMSAITVII LVLYFTVDTF VVNKKPWLTE CTPVYVQYFV KFFIIGVTVL 430 440 450 460 470 480 VVAVPEGLPL AVTISLAYSV KKMMKDNNLV RHLDACETMG NATAICSDKT GTLTTNRMTV 490 500 510 520 530 540 VQAYVGDVHY KEIPDPSSIN AKTLELLVNA IAINSAYTTK ILPPEKEGAL PRQVGNKTEC 550 560 570 580 590 600 GLLGFVLDLR QDYEPVRSQM PEEKLYKVYT FNSVRKSMST VIKMPDESFR MYSKGASEIV 610 620 630 640 650 660 LKKCCKILSG AGEPRVFRPR DRDEMVKKVI EPMACDGLRT ICVAYRDFPS SPEPDWDNEN 670 680 690 700 710 720 DILNELTCIC VVGIEDPVRP EVPEAIRKCQ RAGITVRMVT GDNINTARAI AIKCGIIHPG 730 740 750 760 770 780 EDFLCLEGKE FNRRIRNEKG EIEQERIDKI WPKLRVLARS SPTDKHTLVK GIIDSTHTEQ 790 800 810 820 830 840 RQVVAVTGDG TNDGPALKKA DVGFAMGIAG TDVAKEASDI ILTDDNFSSI VKAVMWGRNV 850 860 870 880 890 900 YDSISKFLQF QLTVNVVAVI VAFTGACITQ DSPLKAVQML WVNLIMDTFA SLALATEPPT 910 920 930 940 950 960 ETLLLRKPYG RNKPLISRTM MKNILGHAVY QLTLIFTLLF VGEKMFQIDS GRNAPLHSPP 970 980 990 1000 1010 1020 SEHYTIIFNT FVMMQLFNEI NARKIHGERN VFDGIFRNPI FCTIVLGTFA IQIVIVQFGG 1030 1040 1050 1060 1070 1080 KPFSCSPLQL DQWMWCIFIG LGELVWGQVI ATIPTSRLKF LKEAGRLTQK EEIPEEELNE 1090 1100 1110 1120 1130 1140 DVEEIDHAER ELRRGQILWF RGLNRIQTQI RVVKAFRSSL YEGLEKPESR TSIHNFMAHP 1150 1160 1170 1180 1190 1200 EFRIEDSQPH IPLIDDTDLE EDAALKQNSS PPSSLNKNNS AIDSGINLTT DTSKSATSSS 1210 PGSPIHSLET SL « Hide
Isoform YB (AIIICI). Checksum: A84D25AAE960A542 Show »	FASTA	1,229	135,404
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGVKKGDGL QLPAADGAAP ANAAGSANAS LVNAKQQDGA AAMEMQPLKS AEGGDADDKK 370 380 390 400 410 420 KANMHKKEKS VLQGKLTKLA VQIGKAGLVM SAITVIILVL YFTVDTFVVN KKPWLTECTP 430 440 450 460 470 480 VYVQYFVKFF IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT 490 500 510 520 530 540 AICSDKTGTL TTNRMTVVQA YVGDVHYKEI PDPSSINAKT LELLVNAIAI NSAYTTKILP 550 560 570 580 590 600 PEKEGALPRQ VGNKTECGLL GFVLDLRQDY EPVRSQMPEE KLYKVYTFNS VRKSMSTVIK 610 620 630 640 650 660 MPDESFRMYS KGASEIVLKK CCKILSGAGE PRVFRPRDRD EMVKKVIEPM ACDGLRTICV 670 680 690 700 710 720 AYRDFPSSPE PDWDNENDIL NELTCICVVG IEDPVRPEVP EAIRKCQRAG ITVRMVTGDN 730 740 750 760 770 780 INTARAIAIK CGIIHPGEDF LCLEGKEFNR RIRNEKGEIE QERIDKIWPK LRVLARSSPT 790 800 810 820 830 840 DKHTLVKGII DSTHTEQRQV VAVTGDGTND GPALKKADVG FAMGIAGTDV AKEASDIILT 850 860 870 880 890 900 DDNFSSIVKA VMWGRNVYDS ISKFLQFQLT VNVVAVIVAF TGACITQDSP LKAVQMLWVN 910 920 930 940 950 960 LIMDTFASLA LATEPPTETL LLRKPYGRNK PLISRTMMKN ILGHAVYQLT LIFTLLFVGE 970 980 990 1000 1010 1020 KMFQIDSGRN APLHSPPSEH YTIIFNTFVM MQLFNEINAR KIHGERNVFD GIFRNPIFCT 1030 1040 1050 1060 1070 1080 IVLGTFAIQI VIVQFGGKPF SCSPLQLDQW MWCIFIGLGE LVWGQVIATI PTSRLKFLKE 1090 1100 1110 1120 1130 1140 AGRLTQKEEI PEEELNEDVE EIDHAERELR RGQILWFRGL NRIQTQIRVV KAFRSSLYEG 1150 1160 1170 1180 1190 1200 LEKPESRTSI HNFMAHPEFR IEDSQPHIPL IDDTDLEEDA ALKQNSSPPS SLNKNNSAID 1210 1220 SGINLTTDTS KSATSSSPGS PIHSLETSL « Hide
Isoform ZB (AICI). Checksum: 0362C0738CFA439F Show »	FASTA	1,198	132,616
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKAKQQDGAA AMEMQPLKSA EGGDADDKKK ANMHKKEKSV LQGKLTKLAV QIGKAGLVMS 370 380 390 400 410 420 AITVIILVLY FTVDTFVVNK KPWLTECTPV YVQYFVKFFI IGVTVLVVAV PEGLPLAVTI 430 440 450 460 470 480 SLAYSVKKMM KDNNLVRHLD ACETMGNATA ICSDKTGTLT TNRMTVVQAY VGDVHYKEIP 490 500 510 520 530 540 DPSSINAKTL ELLVNAIAIN SAYTTKILPP EKEGALPRQV GNKTECGLLG FVLDLRQDYE 550 560 570 580 590 600 PVRSQMPEEK LYKVYTFNSV RKSMSTVIKM PDESFRMYSK GASEIVLKKC CKILSGAGEP 610 620 630 640 650 660 RVFRPRDRDE MVKKVIEPMA CDGLRTICVA YRDFPSSPEP DWDNENDILN ELTCICVVGI 670 680 690 700 710 720 EDPVRPEVPE AIRKCQRAGI TVRMVTGDNI NTARAIAIKC GIIHPGEDFL CLEGKEFNRR 730 740 750 760 770 780 IRNEKGEIEQ ERIDKIWPKL RVLARSSPTD KHTLVKGIID STHTEQRQVV AVTGDGTNDG 790 800 810 820 830 840 PALKKADVGF AMGIAGTDVA KEASDIILTD DNFSSIVKAV MWGRNVYDSI SKFLQFQLTV 850 860 870 880 890 900 NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTETLL LRKPYGRNKP 910 920 930 940 950 960 LISRTMMKNI LGHAVYQLTL IFTLLFVGEK MFQIDSGRNA PLHSPPSEHY TIIFNTFVMM 970 980 990 1000 1010 1020 QLFNEINARK IHGERNVFDG IFRNPIFCTI VLGTFAIQIV IVQFGGKPFS CSPLQLDQWM 1030 1040 1050 1060 1070 1080 WCIFIGLGEL VWGQVIATIP TSRLKFLKEA GRLTQKEEIP EEELNEDVEE IDHAERELRR 1090 1100 1110 1120 1130 1140 GQILWFRGLN RIQTQIRVVK AFRSSLYEGL EKPESRTSIH NFMAHPEFRI EDSQPHIPLI 1150 1160 1170 1180 1190 DDTDLEEDAA LKQNSSPPSS LNKNNSAIDS GINLTTDTSK SATSSSPGSP IHSLETSL « Hide
Isoform WC (AIIICIII). Checksum: 894D6AD40637CF29 Show »	FASTA	1,205	132,296
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGVKKGDGL QLPAADGAAP ANAAGSANAS LVNGKMQDGS ADSSQSKAKQ QDGAAAMEMQ 370 380 390 400 410 420 PLKSAEGGDA DDKKKANMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 430 440 450 460 470 480 FVVNKKPWLT ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 490 500 510 520 530 540 VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NAKTLELLVN 550 560 570 580 590 600 AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL RQDYEPVRSQ MPEEKLYKVY 610 620 630 640 650 660 TFNSVRKSMS TVIKMPDESF RMYSKGASEI VLKKCCKILS GAGEPRVFRP RDRDEMVKKV 670 680 690 700 710 720 IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 730 740 750 760 770 780 QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 790 800 810 820 830 840 IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 850 860 870 880 890 900 GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 910 920 930 940 950 960 QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 970 980 990 1000 1010 1020 YQLTLIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER 1030 1040 1050 1060 1070 1080 NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV 1090 1100 1110 1120 1130 1140 IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ 1150 1160 1170 1180 1190 1200 IEVVNTFKSG ASFQGALRRQ SSVTSQSQDV ANLSSPSRVS LSNALSSPTS LPPAAAGHPR REGVP « Hide
Isoform XC (AIICIII). Checksum: 644AC852899E45B4 Show »	FASTA	1,174	129,508
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGKMQDGSA DSSQSKAKQQ DGAAAMEMQP LKSAEGGDAD DKKKANMHKK EKSVLQGKLT 370 380 390 400 410 420 KLAVQIGKAG LVMSAITVII LVLYFTVDTF VVNKKPWLTE CTPVYVQYFV KFFIIGVTVL 430 440 450 460 470 480 VVAVPEGLPL AVTISLAYSV KKMMKDNNLV RHLDACETMG NATAICSDKT GTLTTNRMTV 490 500 510 520 530 540 VQAYVGDVHY KEIPDPSSIN AKTLELLVNA IAINSAYTTK ILPPEKEGAL PRQVGNKTEC 550 560 570 580 590 600 GLLGFVLDLR QDYEPVRSQM PEEKLYKVYT FNSVRKSMST VIKMPDESFR MYSKGASEIV 610 620 630 640 650 660 LKKCCKILSG AGEPRVFRPR DRDEMVKKVI EPMACDGLRT ICVAYRDFPS SPEPDWDNEN 670 680 690 700 710 720 DILNELTCIC VVGIEDPVRP EVPEAIRKCQ RAGITVRMVT GDNINTARAI AIKCGIIHPG 730 740 750 760 770 780 EDFLCLEGKE FNRRIRNEKG EIEQERIDKI WPKLRVLARS SPTDKHTLVK GIIDSTHTEQ 790 800 810 820 830 840 RQVVAVTGDG TNDGPALKKA DVGFAMGIAG TDVAKEASDI ILTDDNFSSI VKAVMWGRNV 850 860 870 880 890 900 YDSISKFLQF QLTVNVVAVI VAFTGACITQ DSPLKAVQML WVNLIMDTFA SLALATEPPT 910 920 930 940 950 960 ETLLLRKPYG RNKPLISRTM MKNILGHAVY QLTLIFTLLF VGEKMFQIDS GRNAPLHSPP 970 980 990 1000 1010 1020 SEHYTIIFNT FVMMQLFNEI NARKIHGERN VFDGIFRNPI FCTIVLGTFA IQIVIVQFGG 1030 1040 1050 1060 1070 1080 KPFSCSPLQL DQWMWCIFIG LGELVWGQVI ATIPTSRLKF LKEAGRLTQK EEIPEEELNE 1090 1100 1110 1120 1130 1140 DVEEIDHAER ELRRGQILWF RGLNRIQTQI EVVNTFKSGA SFQGALRRQS SVTSQSQDVA 1150 1160 1170 NLSSPSRVSL SNALSSPTSL PPAAAGHPRR EGVP « Hide
Isoform YC (AIIICIII). Checksum: 8291A1522E47024C Show »	FASTA	1,191	130,889
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGVKKGDGL QLPAADGAAP ANAAGSANAS LVNAKQQDGA AAMEMQPLKS AEGGDADDKK 370 380 390 400 410 420 KANMHKKEKS VLQGKLTKLA VQIGKAGLVM SAITVIILVL YFTVDTFVVN KKPWLTECTP 430 440 450 460 470 480 VYVQYFVKFF IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT 490 500 510 520 530 540 AICSDKTGTL TTNRMTVVQA YVGDVHYKEI PDPSSINAKT LELLVNAIAI NSAYTTKILP 550 560 570 580 590 600 PEKEGALPRQ VGNKTECGLL GFVLDLRQDY EPVRSQMPEE KLYKVYTFNS VRKSMSTVIK 610 620 630 640 650 660 MPDESFRMYS KGASEIVLKK CCKILSGAGE PRVFRPRDRD EMVKKVIEPM ACDGLRTICV 670 680 690 700 710 720 AYRDFPSSPE PDWDNENDIL NELTCICVVG IEDPVRPEVP EAIRKCQRAG ITVRMVTGDN 730 740 750 760 770 780 INTARAIAIK CGIIHPGEDF LCLEGKEFNR RIRNEKGEIE QERIDKIWPK LRVLARSSPT 790 800 810 820 830 840 DKHTLVKGII DSTHTEQRQV VAVTGDGTND GPALKKADVG FAMGIAGTDV AKEASDIILT 850 860 870 880 890 900 DDNFSSIVKA VMWGRNVYDS ISKFLQFQLT VNVVAVIVAF TGACITQDSP LKAVQMLWVN 910 920 930 940 950 960 LIMDTFASLA LATEPPTETL LLRKPYGRNK PLISRTMMKN ILGHAVYQLT LIFTLLFVGE 970 980 990 1000 1010 1020 KMFQIDSGRN APLHSPPSEH YTIIFNTFVM MQLFNEINAR KIHGERNVFD GIFRNPIFCT 1030 1040 1050 1060 1070 1080 IVLGTFAIQI VIVQFGGKPF SCSPLQLDQW MWCIFIGLGE LVWGQVIATI PTSRLKFLKE 1090 1100 1110 1120 1130 1140 AGRLTQKEEI PEEELNEDVE EIDHAERELR RGQILWFRGL NRIQTQIEVV NTFKSGASFQ 1150 1160 1170 1180 1190 GALRRQSSVT SQSQDVANLS SPSRVSLSNA LSSPTSLPPA AAGHPRREGV P « Hide
Isoform ZC (AICIII). Checksum: 53A179C997F3DDB8 Show »	FASTA	1,160	128,101
10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKAKQQDGAA AMEMQPLKSA EGGDADDKKK ANMHKKEKSV LQGKLTKLAV QIGKAGLVMS 370 380 390 400 410 420 AITVIILVLY FTVDTFVVNK KPWLTECTPV YVQYFVKFFI IGVTVLVVAV PEGLPLAVTI 430 440 450 460 470 480 SLAYSVKKMM KDNNLVRHLD ACETMGNATA ICSDKTGTLT TNRMTVVQAY VGDVHYKEIP 490 500 510 520 530 540 DPSSINAKTL ELLVNAIAIN SAYTTKILPP EKEGALPRQV GNKTECGLLG FVLDLRQDYE 550 560 570 580 590 600 PVRSQMPEEK LYKVYTFNSV RKSMSTVIKM PDESFRMYSK GASEIVLKKC CKILSGAGEP 610 620 630 640 650 660 RVFRPRDRDE MVKKVIEPMA CDGLRTICVA YRDFPSSPEP DWDNENDILN ELTCICVVGI 670 680 690 700 710 720 EDPVRPEVPE AIRKCQRAGI TVRMVTGDNI NTARAIAIKC GIIHPGEDFL CLEGKEFNRR 730 740 750 760 770 780 IRNEKGEIEQ ERIDKIWPKL RVLARSSPTD KHTLVKGIID STHTEQRQVV AVTGDGTNDG 790 800 810 820 830 840 PALKKADVGF AMGIAGTDVA KEASDIILTD DNFSSIVKAV MWGRNVYDSI SKFLQFQLTV 850 860 870 880 890 900 NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTETLL LRKPYGRNKP 910 920 930 940 950 960 LISRTMMKNI LGHAVYQLTL IFTLLFVGEK MFQIDSGRNA PLHSPPSEHY TIIFNTFVMM 970 980 990 1000 1010 1020 QLFNEINARK IHGERNVFDG IFRNPIFCTI VLGTFAIQIV IVQFGGKPFS CSPLQLDQWM 1030 1040 1050 1060 1070 1080 WCIFIGLGEL VWGQVIATIP TSRLKFLKEA GRLTQKEEIP EEELNEDVEE IDHAERELRR 1090 1100 1110 1120 1130 1140 GQILWFRGLN RIQTQIEVVN TFKSGASFQG ALRRQSSVTS QSQDVANLSS PSRVSLSNAL 1150 1160 SSPTSLPPAA AGHPRREGVP « Hide

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References

[1]	"Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases." Shull G.E., Greeb J. J. Biol. Chem. 263:8646-8657(1988) [PubMed: 2837461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB). Strain: Sprague-Dawley.
[2]	"New Ca2+ pump isoforms generated by alternative splicing of rPMCA2 mRNA." Adamo H.P., Penniston J.T. Biochem. J. 283:355-359(1992) [PubMed: 1315513] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS W; X; Y; Z AND A).
[3]	"Alternative splicing of exons encoding the calmodulin-binding domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1, 2, 3, and 4." Keeton T.P., Burk S.E., Shull G.E. J. Biol. Chem. 268:2740-2748(1993) [PubMed: 8428948] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE, ALTERNATIVE SPLICING (ISOFORMS A-C). Strain: Sprague-Dawley.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	J03754 mRNA. Translation: AAA74219.1. L05557 , L05539, L05545, L05556 Genomic DNA. Translation: AAB60703.1.
IPI	IPI00194875. IPI00231309. IPI00231310. IPI00231311. IPI00231312. IPI00231313. IPI00231314. IPI00231315. IPI00231316. IPI00339139. IPI00339140. IPI00339141.
PIR	B28065.
RefSeq	NP_036640.1.
UniGene	Rn.90982
3D structure databases
HSSP	HSSP built from PDB template 1EUL based on UniProtKB P04191.
ModBase	Search...
Protein-protein interaction databases
IntAct	P11506. 1 interaction.
STRING	P11506.
PTM databases
PhosphoSite	P11506.
Genome annotation databases
GeneID	24215.
KEGG	rno:24215.
UCSC	NM_012508. rat.
Organism-specific databases
CTD	24215.
RGD	2176. Atp2b2.
Phylogenomic databases
HOVERGEN	P11506.
Enzyme and pathway databases
BRENDA	3.6.3.8. 248.
Gene expression databases
Genevestigator	P11506.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006069. ATPase_P-typ_cation-exchng_asu. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00121. NAKATPASE.
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 4 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	602633.
PMAP-CutDB	P11506.

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Entry information

Entry name

AT2B2_RAT

Accession

Primary (citable) accession number: P11506
Secondary accession number(s): Q63443

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	June 1, 2001
Last modified:	October 13, 2009
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents