Plasma membrane calcium-transporting ATPase 1

Names and origin

Protein names

Recommended name:
    Plasma membrane calcium-transporting ATPase 1
      Short name=PMCA1
    EC=3.6.3.8
Alternative name(s):
    Plasma membrane calcium ATPase isoform 1
    Plasma membrane calcium pump isoform 1

Gene names

Name:

Atp2b1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	1258 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Catalytic activity	ATP + H₂O + Ca²⁺(Cis) = ADP + phosphate + Ca²⁺(Trans).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Isoform B is ubiquitously expressed. Isoforms A and E have only been found in brain cortex. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily.
Sequence caution	The sequence AAA50878.1 differs from that shown. Reason: Frameshift at several positions.

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Ligand	ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW PDZ domain binding Inferred from physical interaction. Source: RGD calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from electronic annotation. Source: EC calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform D (identifier: P11505-1) Also known as: CIV; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: P11505-2) Also known as: CII; The sequence of this isoform differs from the canonical sequence as follows: 1156-1258: IRVVNAFRSS...SPLHSLETSL → VVFSSSTASTPVGYPSGECIS

Isoform B (identifier: P11505-3) Also known as: CI; The sequence of this isoform differs from the canonical sequence as follows: 1118-1155: Missing.

Isoform C (identifier: P11505-4) Also known as: CIII; The sequence of this isoform differs from the canonical sequence as follows: 1147-1155: Missing.

Isoform E (identifier: P11505-5) Also known as: CV; The sequence of this isoform differs from the canonical sequence as follows: 1156-1258: IRVVNAFRSS...SPLHSLETSL → VVFSSSTASTPVGSEW

Isoform K (identifier: P11505-6) The sequence of this isoform differs from the canonical sequence as follows: 1021-1056: Missing. 1118-1155: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1258

1258

Plasma membrane calcium-transporting ATPase 1

PRO_0000046212

Regions

Topological domain

1 – 97

97

Cytoplasmic Potential

Transmembrane

98 – 118

21

Potential

Topological domain

119 – 154

36

Extracellular Potential

Transmembrane

155 – 175

21

Potential

Topological domain

176 – 366

191

Cytoplasmic Potential

Transmembrane

367 – 386

20

Potential

Topological domain

387 – 419

33

Extracellular Potential

Transmembrane

420 – 437

18

Potential

Topological domain

438 – 852

415

Cytoplasmic Potential

Transmembrane

853 – 872

20

Potential

Topological domain

873 – 882

10

Extracellular Potential

Transmembrane

883 – 903

21

Potential

Topological domain

904 – 923

20

Cytoplasmic Potential

Transmembrane

924 – 946

23

Potential

Topological domain

947 – 964

18

Extracellular Potential

Transmembrane

965 – 986

22

Potential

Topological domain

987 – 1005

19

Cytoplasmic Potential

Transmembrane

1006 – 1027

22

Potential

Topological domain

1028 – 1037

10

Extracellular Potential

Transmembrane

1038 – 1059

22

Potential

Topological domain

1060 – 1258

199

Cytoplasmic Potential

Region

1100 – 1117

18

Calmodulin-binding subdomain A By similarity

Region

1118 – 1127

10

Calmodulin-binding subdomain B By similarity

Compositional bias

296 – 299

4

Poly-Glu

Sites

Active site

475

1

4-aspartylphosphate intermediate

Metal binding

797

1

Magnesium By similarity

Metal binding

801

1

Magnesium By similarity

Amino acid modifications

Modified residue

17

1

Phosphoserine By similarity

Modified residue

1116

1

Phosphothreonine; by PKC By similarity

Modified residue

1193

1

Phosphoserine By similarity

Modified residue

1203

1

Phosphothreonine By similarity

Modified residue

1215

1

Phosphoserine; by PKA By similarity

Modified residue

1220

1

Phosphoserine By similarity

Modified residue

1246

1

Phosphoserine By similarity

Modified residue

1249

1

Phosphoserine By similarity

Modified residue

1253

1

Phosphoserine By similarity

Modified residue

1256

1

Phosphothreonine By similarity

Modified residue

1257

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1021 – 1056

36

Missing in isoform K.

VSP_000379

Alternative sequence

1118 – 1155

38

Missing in isoform B and isoform K.

VSP_000380

Alternative sequence

1147 – 1155

9

Missing in isoform C.

VSP_000381

Alternative sequence

1156 – 1258

103

IRVVN…LETSL → VVFSSSTASTPVGYPSGECI S in isoform A.

VSP_000382

Alternative sequence

1156 – 1258

103

IRVVN…LETSL → VVFSSSTASTPVGSEW in isoform E.

VSP_000383

Experimental info

Sequence conflict

1125

1

Q → R in AAD46085. Ref.2

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Sequences

Sequence		Length	Mass (Da)
Isoform D (CIV) [UniParc]. Last modified June 1, 2001. Version 2. Checksum: D1F19DC331F76B61 Show »	FASTA	1,258	138,719
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GFLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSFRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDV VTGLTCIAVV GIEDPVRPEV PEAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSEQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1090 1100 1110 1120 1130 1140 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQMDV VNAFQSGGSI QGALRRQPSI 1150 1160 1170 1180 1190 1200 ASQHHDVTNV STPTHIRVVN AFRSSLYEGL EKPESRSSIH NFMTHPEFRI EDSEPLIPLI 1210 1220 1230 1240 1250 DDTDAEDDAP TKRNSSPPPS PNKNNNAVDS GIHLTIEMNK SATSSSPGSP LHSLETSL « Hide
Isoform A (CII). Checksum: 96F8E55209C51F2B Show »	FASTA	1,176	129,510
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GFLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSFRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDV VTGLTCIAVV GIEDPVRPEV PEAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSEQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1090 1100 1110 1120 1130 1140 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQMDV VNAFQSGGSI QGALRRQPSI 1150 1160 1170 ASQHHDVTNV STPTHVVFSS STASTPVGYP SGECIS « Hide
Isoform B (CI). Checksum: 29BD18FC2B024746 Show »	FASTA	1,220	134,693
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GFLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSFRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDV VTGLTCIAVV GIEDPVRPEV PEAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSEQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1090 1100 1110 1120 1130 1140 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQIRV VNAFRSSLYE GLEKPESRSS 1150 1160 1170 1180 1190 1200 IHNFMTHPEF RIEDSEPLIP LIDDTDAEDD APTKRNSSPP PSPNKNNNAV DSGIHLTIEM 1210 1220 NKSATSSSPG SPLHSLETSL « Hide
Isoform C (CIII). Checksum: 9DFE64B0DE56EAB5 Show »	FASTA	1,249	137,782
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GFLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSFRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDV VTGLTCIAVV GIEDPVRPEV PEAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSEQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1090 1100 1110 1120 1130 1140 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQMDV VNAFQSGGSI QGALRRQPSI 1150 1160 1170 1180 1190 1200 ASQHHDIRVV NAFRSSLYEG LEKPESRSSI HNFMTHPEFR IEDSEPLIPL IDDTDAEDDA 1210 1220 1230 1240 PTKRNSSPPP SPNKNNNAVD SGIHLTIEMN KSATSSSPGS PLHSLETSL « Hide
Isoform E (CV). Checksum: B3C355489CBA0FE2 Show »	FASTA	1,171	129,076
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GFLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSFRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDV VTGLTCIAVV GIEDPVRPEV PEAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSEQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1090 1100 1110 1120 1130 1140 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQMDV VNAFQSGGSI QGALRRQPSI 1150 1160 1170 ASQHHDVTNV STPTHVVFSS STASTPVGSE W « Hide
Isoform K. Checksum: C93FBF49CB01B7D2 Show »	FASTA	1,184	130,625
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GFLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSFRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDV VTGLTCIAVV GIEDPVRPEV PEAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSEQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 LISTIPTSRL KFLKEAGHGT QKEEIPEEEL AEDVEEIDHA ERELRRGQIL WFRGLNRIQT 1090 1100 1110 1120 1130 1140 QIRVVNAFRS SLYEGLEKPE SRSSIHNFMT HPEFRIEDSE PLIPLIDDTD AEDDAPTKRN 1150 1160 1170 1180 SSPPPSPNKN NNAVDSGIHL TIEMNKSATS SSPGSPLHSL ETSL « Hide

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References

[1]	"Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases." Shull G.E., Greeb J. J. Biol. Chem. 263:8646-8657(1988) [PubMed: 2837461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[2]	"Expression of multiple plasma membrane Ca(2+)-ATPases in rat pancreatic islet cells." Kamagate A., Herchuelz A., Bollen A., Van Eylen F. Cell Calcium 27:231-246(2000) [PubMed: 10858669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 926-1164 (ISOFORM K). Tissue: Pancreatic islet.
[3]	"Alternative splicing of exons encoding the calmodulin-binding domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1, 2, 3, and 4." Keeton T.P., Burk S.E., Shull G.E. J. Biol. Chem. 268:2740-2748(1993) [PubMed: 8428948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1057-1232, ALTERNATIVE SPLICING (ISOFORMS A; B; C; D AND E). Strain: Sprague-Dawley.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	J03753 mRNA. Translation: AAA73898.1. L04739 Genomic DNA. Translation: AAA50878.1. Sequence problems. AF076783 mRNA. Translation: AAD46085.1.
IPI	IPI00194873. IPI00231267. IPI00231268. IPI00231269. IPI00231270. IPI00231271.
PIR	A28065. D45213.
RefSeq	NP_445763.1.
UniGene	Rn.7208
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P11505.
PTM databases
PhosphoSite	P11505.
Genome annotation databases
Ensembl	ENSRNOT00000041354; ENSRNOP00000040092; ENSRNOG00000004026; Rattus norvegicus. [Genome view] ENSRNOT00000066174; ENSRNOP00000059397; ENSRNOG00000004026; Rattus norvegicus. [Genome view]
GeneID	29598.
KEGG	rno:29598.
UCSC	NM_053311. rat.
Organism-specific databases
CTD	29598.
RGD	621303. Atp2b1.
Phylogenomic databases
eggNOG	roNOG14596.
HOVERGEN	P11505.
InParanoid	P11505.
PhylomeDB	P11505.
Enzyme and pathway databases
BRENDA	3.6.3.8. 248.
Gene expression databases
ArrayExpress	P11505.
Genevestigator	P11505.
GermOnline	ENSRNOG00000004026. Rattus norvegicus.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 4 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	609750.

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Entry information

Entry name

AT2B1_RAT

Accession

Primary (citable) accession number: P11505
Secondary accession number(s): Q63442, Q9R1L7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents