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Protein

Heat shock protein HSP 90-alpha

Gene

HSP90AA1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50ATPBy similarity1
Binding sitei92ATPBy similarity1
Binding sitei111ATPBy similarity1
Binding sitei396ATPBy similarity1

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB
  • chaperone binding Source: AgBase
  • estrogen receptor binding Source: AgBase
  • Hsp90 protein binding Source: AgBase
  • nitric-oxide synthase regulator activity Source: UniProtKB
  • progesterone receptor binding Source: AgBase
  • protein C-terminus binding Source: AgBase
  • protein homodimerization activity Source: AgBase
  • TPR domain binding Source: UniProtKB
  • virion binding Source: AgBase
  • virus receptor activity Source: AgBase

GO - Biological processi

  • positive regulation of cell cycle G2/M phase transition Source: AgBase
  • positive regulation of cell proliferation Source: AgBase
  • positive regulation of nitric oxide biosynthetic process Source: UniProtKB
  • protein folding Source: InterPro
  • protein stabilization Source: AgBase
  • response to antibiotic Source: AgBase
  • response to cold Source: AgBase
  • response to heat Source: AgBase
  • response to organic cyclic compound Source: AgBase
  • response to organonitrogen compound Source: AgBase
  • response to progesterone Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein HSP 90-alpha
Gene namesi
Name:HSP90AA1
Synonyms:HSPCA
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • axon Source: AgBase
  • cell Source: AgBase
  • cell surface Source: AgBase
  • cytoplasm Source: AgBase
  • cytosol Source: AgBase
  • extracellular region Source: AgBase
  • melanosome Source: UniProtKB-SubCell
  • nucleus Source: AgBase
  • perikaryon Source: AgBase
  • plasma membrane Source: AgBase
  • receptor complex Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629221 – 728Heat shock protein HSP 90-alphaAdd BLAST728

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP11501.
PRIDEiP11501.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • chaperone binding Source: AgBase
  • estrogen receptor binding Source: AgBase
  • Hsp90 protein binding Source: AgBase
  • progesterone receptor binding Source: AgBase
  • protein C-terminus binding Source: AgBase
  • protein homodimerization activity Source: AgBase
  • TPR domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi683988. 4 interactors.
IntActiP11501. 1 interactor.
STRINGi9031.ENSGALP00000018498.

Structurei

3D structure databases

ProteinModelPortaliP11501.
SMRiP11501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni678 – 728Required for homodimerizationBy similarityAdd BLAST51

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi719 – 728TPR repeat-bindingBy similarity10

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
COG0326. LUCA.
HOVERGENiHBG007374.
InParanoidiP11501.
KOiK04079.
PhylomeDBiP11501.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAVQTQDQ PMEEEVETFA FQAEIAQLMS LIINTFYSNK EIFLRELISN
60 70 80 90 100
SSDALDKIRY ESLTDPSKLD SGKDLKINLI PNKHDRTLTI VDTGIGMTKA
110 120 130 140 150
DLVNNLGTIA KSGTKAFMEA LQAGADISMI GQFGVGSYSA YLVAEKVTVI
160 170 180 190 200
TKHNDDEQYA WESSAGGSFT VRLDNGEPLG RGTKVILHLK EDQTEYLEER
210 220 230 240 250
RIKEIVKKHS QFIGYPIRLF VEKERDKEVS DDEAEEKEEE KEEKEEKTED
260 270 280 290 300
KPEIEDVGSD EEEEKKDGDK KKKKKIKEKY IDEEELNKTK PIWTRNPDDI
310 320 330 340 350
TNEEYGEFYK SLTNDWEDHL AVKHFSVEGQ LEFRALLFVP RRAPFDLFEN
360 370 380 390 400
RKKKNNIKLY VRRVFIMDNC EELIPEYLNF MRGVVDSEDL PLNISREMLQ
410 420 430 440 450
QSKILKVIRK NLVKKCLELF TELAEDKENY KKFYEQFSKN IKLGIHEDSQ
460 470 480 490 500
NRKKLSELLR YYTSASGDEM VSLKDYCTRM KENQKHVYYI TGETKDQVAN
510 520 530 540 550
SAFVERLRKH GLEVIYMIEP IDEYCVQQLK EFEGKTLVSV TKEGLELPED
560 570 580 590 600
EEEKKKQEEK KAKFENLCKI MKDILEKKVE KVVVSNRLVT SPCCIVTSTY
610 620 630 640 650
GWTANMERIM KAQALRDNST MGYMAAKKHL EINPDHSIIE TLRQKAEADK
660 670 680 690 700
NDKSVKDLVI LLYETALLSS GFSLEDPQTH ANRIYRMIKL GLGIDEDDTA
710 720
AEEASPAVTE EMPPLEGDDD TSRMEEVD
Length:728
Mass (Da):84,059
Last modified:August 1, 1990 - v3
Checksum:i6EC5660F4D5006CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07265 Genomic DNA. Translation: CAA30251.1.
X15028 Genomic DNA. Translation: CAA33132.1.
PIRiA32298. HHCH90.
RefSeqiNP_001103255.1. NM_001109785.1.
UniGeneiGga.6482.

Genome annotation databases

GeneIDi423463.
KEGGigga:423463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07265 Genomic DNA. Translation: CAA30251.1.
X15028 Genomic DNA. Translation: CAA33132.1.
PIRiA32298. HHCH90.
RefSeqiNP_001103255.1. NM_001109785.1.
UniGeneiGga.6482.

3D structure databases

ProteinModelPortaliP11501.
SMRiP11501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi683988. 4 interactors.
IntActiP11501. 1 interactor.
STRINGi9031.ENSGALP00000018498.

Proteomic databases

PaxDbiP11501.
PRIDEiP11501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi423463.
KEGGigga:423463.

Organism-specific databases

CTDi3320.

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
COG0326. LUCA.
HOVERGENiHBG007374.
InParanoidiP11501.
KOiK04079.
PhylomeDBiP11501.

Miscellaneous databases

PROiP11501.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHS90A_CHICK
AccessioniPrimary (citable) accession number: P11501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.