Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock protein HSP 90-beta

Gene

Hsp90ab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461ATPBy similarity
Binding sitei88 – 881ATPBy similarity
Binding sitei107 – 1071ATPBy similarity
Binding sitei133 – 1331ATP; via amide nitrogenBy similarity
Binding sitei392 – 3921ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3371511. HSF1 activation.
R-MMU-3371568. Attenuation phase.
R-MMU-3371571. HSF1-dependent transactivation.
R-MMU-399954. Sema3A PAK dependent Axon repulsion.
R-MMU-844456. The NLRP3 inflammasome.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein HSP 90-beta
Alternative name(s):
Heat shock 84 kDa
Short name:
HSP 84
Short name:
HSP84
Tumor-specific transplantation 84 kDa antigen
Short name:
TSTA
Gene namesi
Name:Hsp90ab1
Synonyms:Hsp84, Hsp84-1, Hspcb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:96247. Hsp90ab1.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • basolateral plasma membrane Source: Ensembl
  • brush border membrane Source: Ensembl
  • cell surface Source: Ensembl
  • COP9 signalosome Source: Ensembl
  • cytoplasm Source: MGI
  • cytosol Source: Ensembl
  • extracellular exosome Source: MGI
  • inclusion body Source: Ensembl
  • intracellular Source: MGI
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved3 Publications
Chaini2 – 724723Heat shock protein HSP 90-betaPRO_0000062918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei219 – 2191N6-succinyllysineCombined sources
Modified residuei226 – 2261PhosphoserineCombined sources
Modified residuei255 – 2551PhosphoserineCombined sources
Modified residuei261 – 2611PhosphoserineCombined sources
Modified residuei297 – 2971PhosphothreonineBy similarity
Modified residuei305 – 3051PhosphotyrosineCombined sources
Modified residuei307 – 3071PhosphoserineBy similarity
Modified residuei399 – 3991N6-malonyllysineBy similarity
Glycosylationi434 – 4341O-linked (GlcNAc)1 Publication
Modified residuei435 – 4351N6-acetyllysineBy similarity
Modified residuei445 – 4451PhosphoserineBy similarity
Modified residuei452 – 4521Phosphoserine; alternateBy similarity
Glycosylationi452 – 4521O-linked (GlcNAc); alternate1 Publication
Modified residuei479 – 4791PhosphothreonineBy similarity
Modified residuei481 – 4811N6-acetyllysineBy similarity
Modified residuei484 – 4841PhosphotyrosineCombined sources
Modified residuei531 – 5311N6-succinyllysineCombined sources
Modified residuei532 – 5321PhosphoserineBy similarity
Modified residuei577 – 5771N6-succinyllysineCombined sources
Modified residuei624 – 6241N6-acetyllysineCombined sources
Modified residuei669 – 6691PhosphoserineBy similarity
Modified residuei718 – 7181Phosphoserine; by PLK2 and PLK3By similarity

Post-translational modificationi

Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).By similarity
ISGylated.1 Publication
S-nitrosylated; negatively regulates the ATPase activity.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP11499.
PaxDbiP11499.
PeptideAtlasiP11499.
PRIDEiP11499.

2D gel databases

SWISS-2DPAGEP11499.

PTM databases

iPTMnetiP11499.
PhosphoSiteiP11499.
SwissPalmiP11499.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023944.
ExpressionAtlasiP11499. baseline and differential.
GenevisibleiP11499. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1. Interacts with DNAJC7 (By similarity). Interacts with FKBP4 (By similarity). May interact with NWD1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NelfeP194262EBI-492813,EBI-6142845
Nr3c1P065372EBI-492813,EBI-492753

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200454. 41 interactions.
DIPiDIP-461N.
IntActiP11499. 30 interactions.
MINTiMINT-152750.
STRINGi10090.ENSMUSP00000024739.

Structurei

3D structure databases

ProteinModelPortaliP11499.
SMRiP11499. Positions 8-691.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi720 – 7245TPR repeat-binding

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
KOG0020. Eukaryota.
COG0326. LUCA.
HOGENOMiHOG000031988.
HOVERGENiHBG007374.
InParanoidiP11499.
KOiK04079.
OMAiAFANDIC.
OrthoDBiEOG091G0270.
TreeFamiTF300686.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA
60 70 80 90 100
LDKIRYESLT DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN
110 120 130 140 150
NLGTIAKSGT KAFMEALQAG ADISMIGQFG VGFYSAYLVA EKVVVITKHN
160 170 180 190 200
DDEQYAWESS AGGSFTVRAD HGEPIGRGTK VILHLKEDQT EYLEERRVKE
210 220 230 240 250
VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE DKEDEEKPKI
260 270 280 290 300
EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE
310 320 330 340 350
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK
360 370 380 390 400
NNIKLYVRRV FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI
410 420 430 440 450
LKVIRKNIVK KCLELFSELA EDKENYKKFY EAFSKNLKLG IHEDSTNRRR
460 470 480 490 500
LSELLRYHTS QSGDEMTSLS EYVSRMKETQ KSIYYITGES KEQVANSAFV
510 520 530 540 550
ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG LELPEDEEEK
560 570 580 590 600
KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA
610 620 630 640 650
NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA
660 670 680 690 700
VKDLVVLLFE TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVTAEEP
710 720
SAAVPDEIPP LEGDEDASRM EEVD
Length:724
Mass (Da):83,281
Last modified:July 27, 2011 - v3
Checksum:iCE323E81CE173ECB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 761I → L in AAA37865 (PubMed:2445630).Curated
Sequence conflicti279 – 2791Q → R in AAC36532 (PubMed:9798653).Curated
Sequence conflicti306 – 3061K → R in AAC36532 (PubMed:9798653).Curated
Sequence conflicti318 – 3181V → I in BAE27449 (PubMed:16141072).Curated
Sequence conflicti332 – 3321L → F in AAA37865 (PubMed:2445630).Curated
Sequence conflicti356 – 3561Y → H in AAC36532 (PubMed:9798653).Curated
Sequence conflicti495 – 4951A → P in AAA37865 (PubMed:2445630).Curated
Sequence conflicti497 – 4971S → P in AAA37866 (PubMed:2469626).Curated
Sequence conflicti531 – 5355KSLVS → GGPGT in AAB23704 (PubMed:1406681).Curated
Sequence conflicti538 – 5381K → N in AAB23704 (PubMed:1406681).Curated
Sequence conflicti575 – 5751V → F in AAB23704 (PubMed:1406681).Curated
Sequence conflicti667 – 6671G → V in AAA37865 (PubMed:2445630).Curated
Sequence conflicti699 – 6991E → G in BAE27449 (PubMed:16141072).Curated
Sequence conflicti719 – 7191R → P in AAA37866 (PubMed:2469626).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36829 mRNA. Translation: AAA37866.1.
M18186 mRNA. Translation: AAA37865.1.
AK146809 mRNA. Translation: BAE27449.1.
AC163677 Genomic DNA. No translation available.
U89426 mRNA. Translation: AAC36532.1.
S46109 mRNA. Translation: AAB23704.1.
CCDSiCCDS28812.1.
PIRiA35569. HHMS84.
I57523.
RefSeqiNP_032328.2. NM_008302.3.
UniGeneiMm.2180.

Genome annotation databases

EnsembliENSMUST00000024739; ENSMUSP00000024739; ENSMUSG00000023944.
GeneIDi15516.
KEGGimmu:15516.
UCSCiuc008cqz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36829 mRNA. Translation: AAA37866.1.
M18186 mRNA. Translation: AAA37865.1.
AK146809 mRNA. Translation: BAE27449.1.
AC163677 Genomic DNA. No translation available.
U89426 mRNA. Translation: AAC36532.1.
S46109 mRNA. Translation: AAB23704.1.
CCDSiCCDS28812.1.
PIRiA35569. HHMS84.
I57523.
RefSeqiNP_032328.2. NM_008302.3.
UniGeneiMm.2180.

3D structure databases

ProteinModelPortaliP11499.
SMRiP11499. Positions 8-691.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200454. 41 interactions.
DIPiDIP-461N.
IntActiP11499. 30 interactions.
MINTiMINT-152750.
STRINGi10090.ENSMUSP00000024739.

PTM databases

iPTMnetiP11499.
PhosphoSiteiP11499.
SwissPalmiP11499.

2D gel databases

SWISS-2DPAGEP11499.

Proteomic databases

EPDiP11499.
PaxDbiP11499.
PeptideAtlasiP11499.
PRIDEiP11499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024739; ENSMUSP00000024739; ENSMUSG00000023944.
GeneIDi15516.
KEGGimmu:15516.
UCSCiuc008cqz.1. mouse.

Organism-specific databases

CTDi3326.
MGIiMGI:96247. Hsp90ab1.

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
KOG0020. Eukaryota.
COG0326. LUCA.
HOGENOMiHOG000031988.
HOVERGENiHBG007374.
InParanoidiP11499.
KOiK04079.
OMAiAFANDIC.
OrthoDBiEOG091G0270.
TreeFamiTF300686.

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3371511. HSF1 activation.
R-MMU-3371568. Attenuation phase.
R-MMU-3371571. HSF1-dependent transactivation.
R-MMU-399954. Sema3A PAK dependent Axon repulsion.
R-MMU-844456. The NLRP3 inflammasome.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.

Miscellaneous databases

ChiTaRSiHsp90ab1. mouse.
PROiP11499.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023944.
ExpressionAtlasiP11499. baseline and differential.
GenevisibleiP11499. MM.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHS90B_MOUSE
AccessioniPrimary (citable) accession number: P11499
Secondary accession number(s): O89078, Q3UIQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 183 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.