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P11494 (BDS1_ANESU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Antihypertensive protein BDS-1
Alternative name(s):
Blood depressing substance I
Short name=BDS-I
OrganismAnemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
Taxonomic identifier6108 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnemonia

Protein attributes

Sequence length43 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocks specifically the Kv3.4/KCNC4 potassium channel. Reduces blood pressure. Ref.2

Subcellular location

Secreted. Nematocyst.

Sequence similarities

Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4343Antihypertensive protein BDS-1
PRO_0000221541

Amino acid modifications

Disulfide bond4 ↔ 39 Ref.3 Ref.4
Disulfide bond6 ↔ 32 Ref.3 Ref.4
Disulfide bond22 ↔ 40 Ref.3 Ref.4

Natural variations

Natural variant181L → F.

Secondary structure

......... 43
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P11494 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 7C17846E88E2F1D8

FASTA434,714
        10         20         30         40 
AAPCFCSGKP GRGDLWILRG TCPGGYGYTS NCYKWPNICC YPH 

« Hide

References

[1]"Polypeptides, process for their preparation, and their use as hypotensive active compounds."
Doppelfeld I.-S., Henschen-Edman A., Graf E., Zwick J., Beress L., Etschenberg E.
Patent number DE3324689, 17-JAN-1985
Cited for: PROTEIN SEQUENCE.
[2]"Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4."
Diochot S., Schweitz H., Beress L., Lazdunski M.
J. Biol. Chem. 273:6744-6749(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION.
[3]"A proton nuclear magnetic resonance study of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: sequential and stereospecific resonance assignment and secondary structure."
Driscoll P.C., Clore G.M., Beress L., Gronenborn A.M.
Biochemistry 28:2178-2187(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.
[4]"Determination of the three-dimensional solution structure of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: a study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing."
Driscoll P.C., Gronenborn A.M., Beress L., Clore G.M.
Biochemistry 28:2188-2198(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

Cross-references

Sequence databases

PIRA33041.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BDSNMR-A1-43[»]
2BDSNMR-A1-43[»]
ProteinModelPortalP11494.
SMRP11494. Positions 1-43.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB8.B.11.1.3. the sea anemone peptide toxin (apetx) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.20.20.10. 1 hit.
InterProIPR012414. BDS_K_chnl_tox.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamPF07936. Defensin_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP11494.

Entry information

Entry nameBDS1_ANESU
AccessionPrimary (citable) accession number: P11494
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 16, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references