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P11494

- BDS1_ANESU

UniProt

P11494 - BDS1_ANESU

Protein

Antihypertensive protein BDS-1

Gene
N/A
Organism
Anemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocks specifically the Kv3.4/KCNC4 potassium channel. Reduces blood pressure.1 Publication

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Protein family/group databases

    TCDBi8.B.11.1.3. the sea anemone peptide toxin (apetx) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Antihypertensive protein BDS-1
    Alternative name(s):
    Blood depressing substance I
    Short name:
    BDS-I
    OrganismiAnemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
    Taxonomic identifieri6108 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnemonia

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. nematocyst Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nematocyst, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4343Antihypertensive protein BDS-1PRO_0000221541Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi4 ↔ 391 Publication
    Disulfide bondi6 ↔ 321 Publication
    Disulfide bondi22 ↔ 401 Publication

    Keywords - PTMi

    Disulfide bond

    Structurei

    Secondary structure

    1
    43
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 63
    Beta strandi14 – 163
    Beta strandi31 – 344
    Beta strandi37 – 404

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BDSNMR-A1-43[»]
    2BDSNMR-A1-43[»]
    ProteinModelPortaliP11494.
    SMRiP11494. Positions 1-43.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11494.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.20.20.10. 1 hit.
    InterProiIPR012414. BDS_K_chnl_tox.
    IPR023355. Myo_neuro_toxin.
    [Graphical view]
    PfamiPF07936. Defensin_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11494-1 [UniParc]FASTAAdd to Basket

    « Hide

    AAPCFCSGKP GRGDLWILRG TCPGGYGYTS NCYKWPNICC YPH          43
    Length:43
    Mass (Da):4,714
    Last modified:October 1, 1989 - v1
    Checksum:i7C17846E88E2F1D8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181L → F.

    Sequence databases

    PIRiA33041.

    Cross-referencesi

    Sequence databases

    PIRi A33041.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BDS NMR - A 1-43 [» ]
    2BDS NMR - A 1-43 [» ]
    ProteinModelPortali P11494.
    SMRi P11494. Positions 1-43.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 8.B.11.1.3. the sea anemone peptide toxin (apetx) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P11494.

    Family and domain databases

    Gene3Di 2.20.20.10. 1 hit.
    InterProi IPR012414. BDS_K_chnl_tox.
    IPR023355. Myo_neuro_toxin.
    [Graphical view ]
    Pfami PF07936. Defensin_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polypeptides, process for their preparation, and their use as hypotensive active compounds."
      Doppelfeld I.-S., Henschen-Edman A., Graf E., Zwick J., Beress L., Etschenberg E.
      Patent number DE3324689, 17-JAN-1985
      Cited for: PROTEIN SEQUENCE.
    2. "Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4."
      Diochot S., Schweitz H., Beress L., Lazdunski M.
      J. Biol. Chem. 273:6744-6749(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION.
    3. "A proton nuclear magnetic resonance study of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: sequential and stereospecific resonance assignment and secondary structure."
      Driscoll P.C., Clore G.M., Beress L., Gronenborn A.M.
      Biochemistry 28:2178-2187(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.
    4. "Determination of the three-dimensional solution structure of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: a study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing."
      Driscoll P.C., Gronenborn A.M., Beress L., Clore G.M.
      Biochemistry 28:2188-2198(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

    Entry informationi

    Entry nameiBDS1_ANESU
    AccessioniPrimary (citable) accession number: P11494
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3