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Reviewed, UniProtKB/Swiss-Prot P11489 (PEPA_MACMU)

Last modified June 16, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Pepsin A
    EC=3.4.23.1
Gene names
Name: PGA
OrganismMacaca mulatta (Rhesus macaque)
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

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Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

Catalytic activity

Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.

Subcellular location

Secreted.

Sequence similarities

Belongs to the peptidase A1 family.

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Ontologies

Keywords
   Biological processDigestion
   Cellular componentSecreted
   DomainSignal
   Molecular functionAspartyl protease
Hydrolase
Protease
   PTMDisulfide bond
Phosphoprotein
Zymogen
Gene Ontology (GO)
   Biological processdigestion

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionaspartic-type endopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515
Propeptide16 – 6247Activation peptide
PRO_0000026024
Chain63 – 388326Pepsin A
PRO_0000026025

Sites

Active site941
Active site2771

Amino acid modifications

Modified residue1301Phosphoserine By similarity
Disulfide bond107 ↔ 112 By similarity
Disulfide bond268 ↔ 272 By similarity
Disulfide bond311 ↔ 344 By similarity

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Sequences

Sequence LengthMass (Da)Tools
P11489-1 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 97F6E5E3F6C2A793

FASTA38841,697
        10         20         30         40         50         60 
MKWLLLLGLV ALSECIIYKV PLVRKKSLRR NLSEHGLLKD FLKKHNRNPA SKYFPQTEAP 

        70         80         90        100        110        120 
TLIDEQPLEN YLDVEYFGTI GIGTPAQDFT VIFDTGSSNL WVPSVYCSSL ACTNHNLFNP 

       130        140        150        160        170        180 
QDSSTYQSTS GTLSITYGTG SMTGILGYDT VQVGGISDTN QIFGLSETEP GSFLYYAPFD 

       190        200        210        220        230        240 
GILGLAYPSI SSSGATPVFD NIWDQGLVSQ DLFSVYLSAD DQSGSVVIFG GIDSSYYTGS 

       250        260        270        280        290        300 
LNWVPVSVEG YWQISVDSIT MNGEAIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS 

       310        320        330        340        350        360 
ENSDGEMVVS CSAISSLPDI VFTINGVQYP LPPSAYILQS QGSCTSGFQG MDVPTESGEL 

       370        380 
WILGDVFIRQ YFTVFDRANN QVGLAPVA

« Hide

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References

[1]"Cloning and sequencing of rhesus monkey pepsinogen A cDNA."
Evers M.P.J., Zelle B., Bebelman J.-P., Pronk J.C., Mager W.H., Planta R.J., Eriksson A.W., Frants R.R.
Gene 65:179-185(1988) [PubMed: 2900796] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Zelle B.
Submitted (SEP-1988) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

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Cross-references

Sequence databases

M20788 mRNA. Translation: AAA36902.1.
PIRPEMQAR. JT0309.
RefSeqNP_001098064.1.
UniGeneMmu.9653

3D structure databases

HSSPHSSP built from PDB template 1PSN based on UniProtKB P00790.
SMRP11489. Positions 17-388.
ModBaseSearch...

Protein family/group databases

MEROPSA01.001.

Genome annotation databases

EnsemblENSMMUG00000011493. Macaca mulatta. [Contig view]
GeneID694562.
KEGGmcc:694562.

Phylogenomic databases

HOVERGENP11489.

Enzyme and pathway databases

BRENDA3.4.23.1. 1774.

Family and domain databases

InterProIPR001461. Peptidase_A1.
IPR001969. Peptidase_aspartic_AS.
IPR009007. Peptidase_aspartic_catalytic.
IPR012848. Propep_A1.
[Graphical view]
Gene3DG3DSA:2.40.70.10. Pept_Aspartc_cat. 2 hits.
PANTHERPTHR13683. Peptidase_A1. 1 hit.
PfamPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSPR00792. PEPSIN.
PROSITEPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePEPA_MACMU
AccessionPrimary (citable) accession number: P11489
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents