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P11486 (PB2_I83A1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polymerase basic protein 2
Alternative name(s):
RNA-directed RNA polymerase subunit P3
Gene names
Name:PB2
OrganismInfluenza A virus (strain A/Chile/1/1983 H1N1) [Complete proteome]
Taxonomic identifier380985 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length759 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication By similarity.

Subunit structure

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.

Subcellular location

Virion. Host nucleus. Host mitochondrion By similarity.

Sequence similarities

Belongs to the influenza viruses PB2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 759759Polymerase basic protein 2
PRO_0000078815

Regions

Motif736 – 7394Nuclear localization signal By similarity

Natural variations

Natural variant5191N → S.

Sequences

Sequence LengthMass (Da)Tools
P11486 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 3DD8535139EE6442

FASTA75986,006
        10         20         30         40         50         60 
MERIKELRNL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPSLRMKWM MAMKYPITAD 

        70         80         90        100        110        120 
KRITEMIPER NEQGQTLWSK MNDAGSDRVM ISPLAVTWWN RNGPVASTVH YPKIYKTYFE 

       130        140        150        160        170        180 
KVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE 

       190        200        210        220        230        240 
SQLTITKEKK EELQNCKISP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW 

       250        260        270        280        290        300 
EQMYTPGGEV RNDDVDQSLI IAARNIVRRA AVSADPLASL LEMCHSTQIG GTRMVDILRQ 

       310        320        330        340        350        360 
NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKR EEEVLTGNLQ TLKLKVHEGF 

       370        380        390        400        410        420 
EEFTMVGKRA TAILRKATRR LIQLIVSGRD EQSIVEAIVV AMVFSQEDCM IKAVRGDLNF 

       430        440        450        460        470        480 
VNRANQRLNP MHQLLRHFQK DAKVLFQNWG IEPIDNVMGM IGILPDMTPS TEMSMRGVRV 

       490        500        510        520        530        540 
SKMGVDEYSN AERVVVSIDR FLRVRDQRGN VLLSPEEVNE TQGTEKLTIT YSSSMMWEIN 

       550        560        570        580        590        600 
GPESVLVNTY QWIIRNWETV KIQWSQNPTM LYNKMEFEPF QSLVPKAIRG QYSGFVRTLF 

       610        620        630        640        650        660 
QQMRDVLGTF DTTQIIKLLP FAAAPPKQSR MQFSSLTVNV RGSGMRILVR GNSPVFNYNK 

       670        680        690        700        710        720 
TTKRLTVLGK DAGTLTEDPD EGTAGVESAV LRGFLILGKE DRRYGPALSI NELSNLAKGE 

       730        740        750 
KANVLIGQGD VVLVMKRKRD SSILTDSQTA TKRIRMAIN 

« Hide

References

[1]"Evolution of influenza polymerase: nucleotide sequence of the PB2 gene of A/Chile/1/83 (H1 N1)."
Schreier E., Petzold D.R., Michel S., Dittmann S.
Arch. Virol. 103:179-187(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"The NIAID influenza genome sequencing project."
Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V., Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H., Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y. expand/collapse author list , Bolotov P., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]The NIAID Influenza Genome Sequencing Consortium
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15283 Genomic RNA. Translation: CAA33357.1.
CY020444 Viral cRNA. Translation: ABO38350.1.

3D structure databases

ProteinModelPortalP11486.
SMRP11486. Positions 319-483, 685-759.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001591. RNA_pol_PB2_orthomyxovir.
[Graphical view]
PfamPF00604. Flu_PB2. 1 hit.
[Graphical view]
ProDomPD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry namePB2_I83A1
AccessionPrimary (citable) accession number: P11486
Secondary accession number(s): A4GCI5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families