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P11475

- ERR2_RAT

UniProt

P11475 - ERR2_RAT

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Protein

Steroid hormone receptor ERR2

Gene

Esrrb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei185 – 1851Important for stabilizing DNA-bindingBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi100 – 18687Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 16325NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. steroid binding Source: InterPro
  5. steroid hormone receptor activity Source: InterPro
  6. transcription coactivator activity Source: Ensembl
  7. zinc ion binding Source: InterPro

GO - Biological processi

  1. embryonic placenta development Source: Ensembl
  2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. regulation of transcription, DNA-templated Source: UniProtKB
  4. stem cell maintenance Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
  6. trophectodermal cell proliferation Source: Ensembl
  7. trophectodermal cellular morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_242509. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid hormone receptor ERR2
Alternative name(s):
Estrogen receptor-like 2
Estrogen-related receptor beta
Short name:
ERR-beta
Nuclear receptor subfamily 3 group B member 2
Gene namesi
Name:Esrrb
Synonyms:Err2, Esrl2, Nr3b2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi1359557. Esrrb.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Steroid hormone receptor ERR2PRO_0000053664Add
BLAST

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro).By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP11475.

PTM databases

PhosphoSiteiP11475.

Expressioni

Gene expression databases

GenevestigatoriP11475.

Interactioni

Subunit structurei

Binds DNA as a monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013867.

Structurei

3D structure databases

ProteinModelPortaliP11475.
SMRiP11475. Positions 97-186, 207-433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 16325NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG282629.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiP11475.
KOiK08553.
OMAiSYEDCAG.
OrthoDBiEOG7288S1.
PhylomeDBiP11475.
TreeFamiTF323751.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11475-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGMALG
60 70 80 90 100
THANGLDSPP MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK
110 120 130 140 150
RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYSCP ATNECEITKR
160 170 180 190 200
RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SENSPYLSLQ
210 220 230 240 250
ISPPAKKPLT KIVSYLLVAE PDKLYAMPPD DVPEGDIKAL TTLCDLADRE
260 270 280 290 300
LVFLISWAKH IPGFSNLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA
310 320 330 340 350
YAEDYIMDEE HSRLVGLLEL YRAILQLVRR YKKLKVEKEE FVMLKALALA
360 370 380 390 400
NSDSMYIENL EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR
410 420 430
QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKV
Length:433
Mass (Da):48,288
Last modified:October 1, 1989 - v1
Checksum:iEE2C4C5B2F9A3E13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51417 mRNA. Translation: CAA35779.1.
AY383731 mRNA. Translation: AAR89824.1.
RefSeqiNP_001008516.2. NM_001008516.2.
UniGeneiRn.104984.

Genome annotation databases

EnsembliENSRNOT00000013867; ENSRNOP00000013867; ENSRNOG00000010259.
GeneIDi299210.
KEGGirno:299210.
UCSCiRGD:1359557. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51417 mRNA. Translation: CAA35779.1 .
AY383731 mRNA. Translation: AAR89824.1 .
RefSeqi NP_001008516.2. NM_001008516.2.
UniGenei Rn.104984.

3D structure databases

ProteinModelPortali P11475.
SMRi P11475. Positions 97-186, 207-433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000013867.

PTM databases

PhosphoSitei P11475.

Proteomic databases

PRIDEi P11475.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013867 ; ENSRNOP00000013867 ; ENSRNOG00000010259 .
GeneIDi 299210.
KEGGi rno:299210.
UCSCi RGD:1359557. rat.

Organism-specific databases

CTDi 2103.
RGDi 1359557. Esrrb.

Phylogenomic databases

eggNOGi NOG282629.
GeneTreei ENSGT00760000118887.
HOGENOMi HOG000233467.
HOVERGENi HBG108344.
InParanoidi P11475.
KOi K08553.
OMAi SYEDCAG.
OrthoDBi EOG7288S1.
PhylomeDBi P11475.
TreeFami TF323751.

Enzyme and pathway databases

Reactomei REACT_242509. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi 645036.
PROi P11475.

Gene expression databases

Genevestigatori P11475.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a new class of steroid hormone receptors."
    Giguere V., Yang N., Segui P., Evans R.M.
    Nature 331:91-94(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Molecular cloning and expression study of estrogen receptor-related receptor beta in rat prostate."
    Lui K., Chen S., Chan F.L.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR."
    Chen F., Zhang Q., McDonald T., Davidoff M.J., Bailey W., Bai C., Liu Q., Caskey C.T.
    Gene 228:101-109(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SHOWS THAT SEQUENCE DESCRIBED IN PUBMED:3267207 ORIGINATES FROM RAT.

Entry informationi

Entry nameiERR2_RAT
AccessioniPrimary (citable) accession number: P11475
Secondary accession number(s): Q5QJB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 26, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally (PubMed:3267207) thought to originate from human but was later shown (PubMed:10072763) to be derived from rat.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3