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P11475

- ERR2_RAT

UniProt

P11475 - ERR2_RAT

Protein

Steroid hormone receptor ERR2

Gene

Esrrb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei185 – 1851Important for stabilizing DNA-bindingBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi100 – 18687Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. steroid binding Source: InterPro
    5. steroid hormone receptor activity Source: InterPro
    6. transcription coactivator activity Source: Ensembl
    7. zinc ion binding Source: InterPro

    GO - Biological processi

    1. embryonic placenta development Source: Ensembl
    2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. regulation of transcription, DNA-templated Source: UniProtKB
    4. stem cell maintenance Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW
    6. trophectodermal cell proliferation Source: Ensembl
    7. trophectodermal cellular morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid hormone receptor ERR2
    Alternative name(s):
    Estrogen receptor-like 2
    Estrogen-related receptor beta
    Short name:
    ERR-beta
    Nuclear receptor subfamily 3 group B member 2
    Gene namesi
    Name:Esrrb
    Synonyms:Err2, Esrl2, Nr3b2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi1359557. Esrrb.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Steroid hormone receptor ERR2PRO_0000053664Add
    BLAST

    Post-translational modificationi

    Acetylated by PCAF/KAT2 (in vitro).By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP11475.

    PTM databases

    PhosphoSiteiP11475.

    Expressioni

    Gene expression databases

    GenevestigatoriP11475.

    Interactioni

    Subunit structurei

    Binds DNA as a monomer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000013867.

    Structurei

    3D structure databases

    ProteinModelPortaliP11475.
    SMRiP11475. Positions 97-186, 207-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG282629.
    GeneTreeiENSGT00730000110346.
    HOGENOMiHOG000233467.
    HOVERGENiHBG108344.
    InParanoidiP11475.
    KOiK08553.
    OMAiSYEDCAG.
    OrthoDBiEOG7288S1.
    PhylomeDBiP11475.
    TreeFamiTF323751.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR027289. Oest-rel_rcp.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002527. ER-like_NR. 1 hit.
    PIRSF500939. ERR1-2-3. 1 hit.
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11475-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGMALG    50
    THANGLDSPP MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK 100
    RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYSCP ATNECEITKR 150
    RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SENSPYLSLQ 200
    ISPPAKKPLT KIVSYLLVAE PDKLYAMPPD DVPEGDIKAL TTLCDLADRE 250
    LVFLISWAKH IPGFSNLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA 300
    YAEDYIMDEE HSRLVGLLEL YRAILQLVRR YKKLKVEKEE FVMLKALALA 350
    NSDSMYIENL EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR 400
    QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKV 433
    Length:433
    Mass (Da):48,288
    Last modified:October 1, 1989 - v1
    Checksum:iEE2C4C5B2F9A3E13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51417 mRNA. Translation: CAA35779.1.
    AY383731 mRNA. Translation: AAR89824.1.
    RefSeqiNP_001008516.2. NM_001008516.2.
    UniGeneiRn.104984.

    Genome annotation databases

    EnsembliENSRNOT00000013867; ENSRNOP00000013867; ENSRNOG00000010259.
    GeneIDi299210.
    KEGGirno:299210.
    UCSCiRGD:1359557. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51417 mRNA. Translation: CAA35779.1 .
    AY383731 mRNA. Translation: AAR89824.1 .
    RefSeqi NP_001008516.2. NM_001008516.2.
    UniGenei Rn.104984.

    3D structure databases

    ProteinModelPortali P11475.
    SMRi P11475. Positions 97-186, 207-433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000013867.

    PTM databases

    PhosphoSitei P11475.

    Proteomic databases

    PRIDEi P11475.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013867 ; ENSRNOP00000013867 ; ENSRNOG00000010259 .
    GeneIDi 299210.
    KEGGi rno:299210.
    UCSCi RGD:1359557. rat.

    Organism-specific databases

    CTDi 2103.
    RGDi 1359557. Esrrb.

    Phylogenomic databases

    eggNOGi NOG282629.
    GeneTreei ENSGT00730000110346.
    HOGENOMi HOG000233467.
    HOVERGENi HBG108344.
    InParanoidi P11475.
    KOi K08553.
    OMAi SYEDCAG.
    OrthoDBi EOG7288S1.
    PhylomeDBi P11475.
    TreeFami TF323751.

    Miscellaneous databases

    NextBioi 645036.
    PROi P11475.

    Gene expression databases

    Genevestigatori P11475.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR027289. Oest-rel_rcp.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002527. ER-like_NR. 1 hit.
    PIRSF500939. ERR1-2-3. 1 hit.
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new class of steroid hormone receptors."
      Giguere V., Yang N., Segui P., Evans R.M.
      Nature 331:91-94(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "Molecular cloning and expression study of estrogen receptor-related receptor beta in rat prostate."
      Lui K., Chen S., Chan F.L.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR."
      Chen F., Zhang Q., McDonald T., Davidoff M.J., Bailey W., Bai C., Liu Q., Caskey C.T.
      Gene 228:101-109(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SHOWS THAT SEQUENCE DESCRIBED IN PUBMED:3267207 ORIGINATES FROM RAT.

    Entry informationi

    Entry nameiERR2_RAT
    AccessioniPrimary (citable) accession number: P11475
    Secondary accession number(s): Q5QJB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally (PubMed:3267207) thought to originate from human but was later shown (PubMed:10072763) to be derived from rat.2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3