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P11475 (ERR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Steroid hormone receptor ERR2
Alternative name(s):
Estrogen receptor-like 2
Estrogen-related receptor beta
Short name=ERR-beta
Nuclear receptor subfamily 3 group B member 2
Gene names
Name:Esrrb
Synonyms:Err2, Esrl2, Nr3b2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle By similarity.

Subunit structure

Binds DNA as a monomer By similarity.

Subcellular location

Nucleus By similarity.

Post-translational modification

Acetylated by PCAF/KAT2 (in vitro) By similarity.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR3 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Caution

Was originally (Ref.1) thought to originate from human but was later shown (Ref.3) to be derived from rat.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionReceptor
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processembryonic placenta development

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

trophectodermal cell proliferation

Inferred from electronic annotation. Source: Ensembl

trophectodermal cellular morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

steroid binding

Inferred from electronic annotation. Source: InterPro

steroid hormone receptor activity

Inferred from electronic annotation. Source: InterPro

transcription coactivator activity

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Steroid hormone receptor ERR2
PRO_0000053664

Regions

DNA binding100 – 18687Nuclear receptor
Zinc finger103 – 12321NR C4-type
Zinc finger139 – 16325NR C4-type

Sites

Site1851Important for stabilizing DNA-binding By similarity

Sequences

Sequence LengthMass (Da)Tools
P11475 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: EE2C4C5B2F9A3E13

FASTA43348,288
        10         20         30         40         50         60 
MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGMALG THANGLDSPP 

        70         80         90        100        110        120 
MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC 

       130        140        150        160        170        180 
EACKAFFKRT IQGNIEYSCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG 

       190        200        210        220        230        240 
GRQKYKRRLD SENSPYLSLQ ISPPAKKPLT KIVSYLLVAE PDKLYAMPPD DVPEGDIKAL 

       250        260        270        280        290        300 
TTLCDLADRE LVFLISWAKH IPGFSNLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA 

       310        320        330        340        350        360 
YAEDYIMDEE HSRLVGLLEL YRAILQLVRR YKKLKVEKEE FVMLKALALA NSDSMYIENL 

       370        380        390        400        410        420 
EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP 

       430 
MHKLFLEMLE AKV 

« Hide

References

[1]"Identification of a new class of steroid hormone receptors."
Giguere V., Yang N., Segui P., Evans R.M.
Nature 331:91-94(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Molecular cloning and expression study of estrogen receptor-related receptor beta in rat prostate."
Lui K., Chen S., Chan F.L.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR."
Chen F., Zhang Q., McDonald T., Davidoff M.J., Bailey W., Bai C., Liu Q., Caskey C.T.
Gene 228:101-109(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: SHOWS THAT SEQUENCE DESCRIBED IN PUBMED:3267207 ORIGINATES FROM RAT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X51417 mRNA. Translation: CAA35779.1.
AY383731 mRNA. Translation: AAR89824.1.
RefSeqNP_001008516.2. NM_001008516.2.
UniGeneRn.104984.

3D structure databases

ProteinModelPortalP11475.
SMRP11475. Positions 97-186, 207-433.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000013867.

PTM databases

PhosphoSiteP11475.

Proteomic databases

PRIDEP11475.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013867; ENSRNOP00000013867; ENSRNOG00000010259.
GeneID299210.
KEGGrno:299210.
UCSCRGD:1359557. rat.

Organism-specific databases

CTD2103.
RGD1359557. Esrrb.

Phylogenomic databases

eggNOGNOG282629.
GeneTreeENSGT00730000110346.
HOGENOMHOG000233467.
HOVERGENHBG108344.
InParanoidP11475.
KOK08553.
OMASYEDCAG.
OrthoDBEOG7288S1.
PhylomeDBP11475.
TreeFamTF323751.

Gene expression databases

GenevestigatorP11475.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio645036.
PROP11475.

Entry information

Entry nameERR2_RAT
AccessionPrimary (citable) accession number: P11475
Secondary accession number(s): Q5QJB1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families