P11475 (ERR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Steroid hormone receptor ERR2

Alternative name(s):
Estrogen receptor-like 2
Estrogen-related receptor beta
Short name=ERR-beta
Nuclear receptor subfamily 3 group B member 2

Gene names

Name:	Esrrb
Synonyms:	Err2, Esrl2, Nr3b2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Nuclear receptor, may regulate ESR1 transcriptional activity By similarity.
Subunit structure	Binds DNA as a monomer By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Caution	Was originally (Ref.1) thought to originate from human but was later shown (Ref.3) to be derived from rat.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	embryonic placenta development Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara stem cell maintenance Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW trophectodermal cell proliferation Inferred from electronic annotation. Source: Compara trophectodermal cellular morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA polymerase II distal enhancer sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro steroid binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription coactivator activity Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Steroid hormone receptor ERR2		PRO_0000053664
Regions
	DNA binding	100 – 186	87	Nuclear receptor
	Zinc finger	103 – 123	21	NR C4-type
	Zinc finger	139 – 163	25	NR C4-type
Sites
	Site	185	1	Important for stabilizing DNA-binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	P11475 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: EE2C4C5B2F9A3E13	FASTA	433	48,288
	10 20 30 40 50 60 MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGMALG THANGLDSPP 70 80 90 100 110 120 MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC 130 140 150 160 170 180 EACKAFFKRT IQGNIEYSCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG 190 200 210 220 230 240 GRQKYKRRLD SENSPYLSLQ ISPPAKKPLT KIVSYLLVAE PDKLYAMPPD DVPEGDIKAL 250 260 270 280 290 300 TTLCDLADRE LVFLISWAKH IPGFSNLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA 310 320 330 340 350 360 YAEDYIMDEE HSRLVGLLEL YRAILQLVRR YKKLKVEKEE FVMLKALALA NSDSMYIENL 370 380 390 400 410 420 EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP 430 MHKLFLEMLE AKV

References

[1]	"Identification of a new class of steroid hormone receptors." Giguere V., Yang N., Segui P., Evans R.M. Nature 331:91-94(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Molecular cloning and expression study of estrogen receptor-related receptor beta in rat prostate." Lui K., Chen S., Chan F.L. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR." Chen F., Zhang Q., McDonald T., Davidoff M.J., Bailey W., Bai C., Liu Q., Caskey C.T. Gene 228:101-109(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SHOWS THAT SEQUENCE DESCRIBED IN PUBMED:3267207 ORIGINATES FROM RAT.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X51417 mRNA. Translation: CAA35779.1. AY383731 mRNA. Translation: AAR89824.1.
IPI	IPI00194043.
RefSeq	NP_001008516.2. NM_001008516.2.
UniGene	Rn.104984.
3D structure databases
ProteinModelPortal	P11475.
SMR	P11475. Positions 97-186, 207-433.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000013867.
PTM databases
PhosphoSite	P11475.
Proteomic databases
PRIDE	P11475.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000013867; ENSRNOP00000013867; ENSRNOG00000010259.
GeneID	299210.
KEGG	rno:299210.
UCSC	RGD:1359557. rat.
Organism-specific databases
CTD	2103.
RGD	1359557. Esrrb.
Phylogenomic databases
eggNOG	NOG282629.
GeneTree	ENSGT00700000104391.
HOGENOM	HOG000233467.
HOVERGEN	HBG108344.
InParanoid	P11475.
KO	K08553.
OMA	EDRHLGS.
OrthoDB	EOG479F71.
Gene expression databases
Genevestigator	P11475.
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR027289. Oest-rel_rcp. IPR024178. Oest_rcpt/oest-rel_rcp. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PIRSF	PIRSF002527. ER-like_NR. 1 hit. PIRSF500939. ERR1-2-3. 1 hit.
PRINTS	PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	645036.

Entry information

Entry name

ERR2_RAT

Accession

Primary (citable) accession number: P11475
Secondary accession number(s): Q5QJB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 126 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program