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Protein

Pregnancy-specific beta-1-glycoprotein 2

Gene

PSG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell migration Source: UniProtKB
  • female pregnancy Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 2
Short name:
PS-beta-G-2
Short name:
PSBG-2
Short name:
Pregnancy-specific glycoprotein 2
Alternative name(s):
Pregnancy-specific beta-1 glycoprotein E
Short name:
PS-beta-E
Gene namesi
Name:PSG2
Synonyms:PSBG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9519. PSG2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5670.
OpenTargetsiENSG00000242221.
PharmGKBiPA33864.

Polymorphism and mutation databases

BioMutaiPSG2.
DMDMi108935879.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000001490935 – 335Pregnancy-specific beta-1-glycoprotein 2Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi261 ↔ 301Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP11465.
PeptideAtlasiP11465.
PRIDEiP11465.

PTM databases

iPTMnetiP11465.
PhosphoSitePlusiP11465.

Expressioni

Gene expression databases

BgeeiENSG00000242221.
CleanExiHS_PSG2.
ExpressionAtlasiP11465. baseline and differential.
GenevisibleiP11465. HS.

Interactioni

Protein-protein interaction databases

BioGridi111645. 2 interactors.
IntActiP11465. 1 interactor.
MINTiMINT-1187536.

Structurei

3D structure databases

ProteinModelPortaliP11465.
SMRiP11465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini239 – 317Ig-like C2-type 2Add BLAST79

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KC7S. Eukaryota.
ENOG4110P8V. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP11465.
KOiK06500.
OMAiYTNYRSG.
OrthoDBiEOG091G0AMM.
PhylomeDBiP11465.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLSAPPCT EHIKWKGLLV TASLLNFWNL PTTAQVTIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET
110 120 130 140 150
AYSNASLLIQ NVTREDAGSY TLHIIKRGDG TRGVTGYFTF TLYLETPKPS
160 170 180 190 200
ISSSNLNPRE AMETVILTCD PETPDTSYQW WMNGQSLPMT HRFQLSETNR
210 220 230 240 250
TLFLFGVTKY TAGPYECEIR NSGSASRSDP VTLNLLHGPD LPRIHPSYTN
260 270 280 290 300
YRSGDNLYLS CFANSNPPAQ YSWTINGKFQ QSGQNLFIPQ ITTKHSGLYV
310 320 330
CSVRNSATGE ESSTSLTVKV SASTRIGLLP LLNPT
Length:335
Mass (Da):37,216
Last modified:June 13, 2006 - v2
Checksum:iC47AFC14DED9C0F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti310E → Q in AAA52604 (PubMed:3260773).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01603920V → L.1 PublicationCorresponds to variant rs3887660dbSNPEnsembl.1
Natural variantiVAR_049918176T → A.Corresponds to variant rs16976431dbSNPEnsembl.1
Natural variantiVAR_049919179Q → L.Corresponds to variant rs1058086dbSNPEnsembl.1
Natural variantiVAR_049920335T → R.Corresponds to variant rs1064937dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20882 mRNA. Translation: AAA52604.1.
AC005791 Genomic DNA. Translation: AAC62831.1.
AC024077 Genomic DNA. No translation available.
BC022316 mRNA. Translation: AAH22316.1.
AH007518 Genomic DNA. Translation: AAD21021.1.
CCDSiCCDS12616.1.
RefSeqiNP_112536.2. NM_031246.3.
UniGeneiHs.709200.

Genome annotation databases

EnsembliENST00000406487; ENSP00000385706; ENSG00000242221.
GeneIDi5670.
KEGGihsa:5670.
UCSCiuc002ovr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20882 mRNA. Translation: AAA52604.1.
AC005791 Genomic DNA. Translation: AAC62831.1.
AC024077 Genomic DNA. No translation available.
BC022316 mRNA. Translation: AAH22316.1.
AH007518 Genomic DNA. Translation: AAD21021.1.
CCDSiCCDS12616.1.
RefSeqiNP_112536.2. NM_031246.3.
UniGeneiHs.709200.

3D structure databases

ProteinModelPortaliP11465.
SMRiP11465.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111645. 2 interactors.
IntActiP11465. 1 interactor.
MINTiMINT-1187536.

PTM databases

iPTMnetiP11465.
PhosphoSitePlusiP11465.

Polymorphism and mutation databases

BioMutaiPSG2.
DMDMi108935879.

Proteomic databases

PaxDbiP11465.
PeptideAtlasiP11465.
PRIDEiP11465.

Protocols and materials databases

DNASUi5670.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000406487; ENSP00000385706; ENSG00000242221.
GeneIDi5670.
KEGGihsa:5670.
UCSCiuc002ovr.4. human.

Organism-specific databases

CTDi5670.
DisGeNETi5670.
GeneCardsiPSG2.
HGNCiHGNC:9519. PSG2.
MIMi176391. gene.
neXtProtiNX_P11465.
OpenTargetsiENSG00000242221.
PharmGKBiPA33864.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC7S. Eukaryota.
ENOG4110P8V. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP11465.
KOiK06500.
OMAiYTNYRSG.
OrthoDBiEOG091G0AMM.
PhylomeDBiP11465.
TreeFamiTF336859.

Miscellaneous databases

GeneWikiiPSG2.
GenomeRNAii5670.
PROiP11465.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242221.
CleanExiHS_PSG2.
ExpressionAtlasiP11465. baseline and differential.
GenevisibleiP11465. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSG2_HUMAN
AccessioniPrimary (citable) accession number: P11465
Secondary accession number(s): Q8TCD9, Q9UEA4, Q9UQ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.