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P11465

- PSG2_HUMAN

UniProt

P11465 - PSG2_HUMAN

Protein

Pregnancy-specific beta-1-glycoprotein 2

Gene

PSG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cell migration Source: UniProtKB
    2. female pregnancy Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 2
    Short name:
    PS-beta-G-2
    Short name:
    PSBG-2
    Short name:
    Pregnancy-specific glycoprotein 2
    Alternative name(s):
    Pregnancy-specific beta-1 glycoprotein E
    Short name:
    PS-beta-E
    Gene namesi
    Name:PSG2
    Synonyms:PSBG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:9519. PSG2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33864.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Add
    BLAST
    Chaini35 – 335301Pregnancy-specific beta-1-glycoprotein 2PRO_0000014909Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi169 ↔ 217Curated
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi261 ↔ 301Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP11465.
    PRIDEiP11465.

    PTM databases

    PhosphoSiteiP11465.

    Expressioni

    Gene expression databases

    BgeeiP11465.
    CleanExiHS_PSG2.
    GenevestigatoriP11465.

    Interactioni

    Protein-protein interaction databases

    BioGridi111645. 2 interactions.
    IntActiP11465. 1 interaction.
    MINTiMINT-1187536.
    STRINGi9606.ENSP00000251275.

    Structurei

    3D structure databases

    ProteinModelPortaliP11465.
    SMRiP11465. Positions 33-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 144110Ig-like V-typeAdd
    BLAST
    Domaini147 – 23488Ig-like C2-type 1Add
    BLAST
    Domaini239 – 31779Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. CEA family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiKOG0619.
    HOGENOMiHOG000233417.
    HOVERGENiHBG007922.
    KOiK06500.
    OMAiLPMTHRF.
    OrthoDBiEOG74BJS7.
    PhylomeDBiP11465.
    TreeFamiTF336859.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11465-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPLSAPPCT EHIKWKGLLV TASLLNFWNL PTTAQVTIEA QPPKVSEGKD    50
    VLLLVHNLPQ NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET 100
    AYSNASLLIQ NVTREDAGSY TLHIIKRGDG TRGVTGYFTF TLYLETPKPS 150
    ISSSNLNPRE AMETVILTCD PETPDTSYQW WMNGQSLPMT HRFQLSETNR 200
    TLFLFGVTKY TAGPYECEIR NSGSASRSDP VTLNLLHGPD LPRIHPSYTN 250
    YRSGDNLYLS CFANSNPPAQ YSWTINGKFQ QSGQNLFIPQ ITTKHSGLYV 300
    CSVRNSATGE ESSTSLTVKV SASTRIGLLP LLNPT 335
    Length:335
    Mass (Da):37,216
    Last modified:June 13, 2006 - v2
    Checksum:iC47AFC14DED9C0F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti310 – 3101E → Q in AAA52604. (PubMed:3260773)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201V → L.1 Publication
    Corresponds to variant rs3887660 [ dbSNP | Ensembl ].
    VAR_016039
    Natural varianti176 – 1761T → A.
    Corresponds to variant rs16976431 [ dbSNP | Ensembl ].
    VAR_049918
    Natural varianti179 – 1791Q → L.
    Corresponds to variant rs1058086 [ dbSNP | Ensembl ].
    VAR_049919
    Natural varianti335 – 3351T → R.
    Corresponds to variant rs1064937 [ dbSNP | Ensembl ].
    VAR_049920

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20882 mRNA. Translation: AAA52604.1.
    AC005791 Genomic DNA. Translation: AAC62831.1.
    AC024077 Genomic DNA. No translation available.
    BC022316 mRNA. Translation: AAH22316.1.
    AH007518 Genomic DNA. Translation: AAD21021.1.
    CCDSiCCDS12616.1.
    RefSeqiNP_112536.2. NM_031246.3.
    UniGeneiHs.709200.

    Genome annotation databases

    EnsembliENST00000406487; ENSP00000385706; ENSG00000242221.
    GeneIDi5670.
    KEGGihsa:5670.
    UCSCiuc002ovr.3. human.

    Polymorphism databases

    DMDMi108935879.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20882 mRNA. Translation: AAA52604.1 .
    AC005791 Genomic DNA. Translation: AAC62831.1 .
    AC024077 Genomic DNA. No translation available.
    BC022316 mRNA. Translation: AAH22316.1 .
    AH007518 Genomic DNA. Translation: AAD21021.1 .
    CCDSi CCDS12616.1.
    RefSeqi NP_112536.2. NM_031246.3.
    UniGenei Hs.709200.

    3D structure databases

    ProteinModelPortali P11465.
    SMRi P11465. Positions 33-322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111645. 2 interactions.
    IntActi P11465. 1 interaction.
    MINTi MINT-1187536.
    STRINGi 9606.ENSP00000251275.

    PTM databases

    PhosphoSitei P11465.

    Polymorphism databases

    DMDMi 108935879.

    Proteomic databases

    PaxDbi P11465.
    PRIDEi P11465.

    Protocols and materials databases

    DNASUi 5670.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000406487 ; ENSP00000385706 ; ENSG00000242221 .
    GeneIDi 5670.
    KEGGi hsa:5670.
    UCSCi uc002ovr.3. human.

    Organism-specific databases

    CTDi 5670.
    GeneCardsi GC19M043568.
    HGNCi HGNC:9519. PSG2.
    MIMi 176391. gene.
    neXtProti NX_P11465.
    PharmGKBi PA33864.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi KOG0619.
    HOGENOMi HOG000233417.
    HOVERGENi HBG007922.
    KOi K06500.
    OMAi LPMTHRF.
    OrthoDBi EOG74BJS7.
    PhylomeDBi P11465.
    TreeFami TF336859.

    Miscellaneous databases

    GeneWikii PSG2.
    GenomeRNAii 5670.
    NextBioi 22020.
    PROi P11465.
    SOURCEi Search...

    Gene expression databases

    Bgeei P11465.
    CleanExi HS_PSG2.
    Genevestigatori P11465.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family."
      Streydio C., Lacka K., Swillens S., Vassart G.
      Biochem. Biophys. Res. Commun. 154:130-137(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-20.
      Tissue: Placenta.
    4. "Characterization of upstream promotor region, exon1 and exon2 of the PSG gene family."
      Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.

    Entry informationi

    Entry nameiPSG2_HUMAN
    AccessioniPrimary (citable) accession number: P11465
    Secondary accession number(s): Q8TCD9, Q9UEA4, Q9UQ78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3