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P11465

- PSG2_HUMAN

UniProt

P11465 - PSG2_HUMAN

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Protein

Pregnancy-specific beta-1-glycoprotein 2

Gene

PSG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. cell migration Source: UniProtKB
  2. female pregnancy Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 2
Short name:
PS-beta-G-2
Short name:
PSBG-2
Short name:
Pregnancy-specific glycoprotein 2
Alternative name(s):
Pregnancy-specific beta-1 glycoprotein E
Short name:
PS-beta-E
Gene namesi
Name:PSG2
Synonyms:PSBG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:9519. PSG2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Add
BLAST
Chaini35 – 335301Pregnancy-specific beta-1-glycoprotein 2PRO_0000014909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi169 ↔ 217Curated
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi261 ↔ 301Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP11465.
PRIDEiP11465.

PTM databases

PhosphoSiteiP11465.

Expressioni

Gene expression databases

BgeeiP11465.
CleanExiHS_PSG2.
GenevestigatoriP11465.

Interactioni

Protein-protein interaction databases

BioGridi111645. 2 interactions.
IntActiP11465. 1 interaction.
MINTiMINT-1187536.
STRINGi9606.ENSP00000251275.

Structurei

3D structure databases

ProteinModelPortaliP11465.
SMRiP11465. Positions 33-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 144110Ig-like V-typeAdd
BLAST
Domaini147 – 23488Ig-like C2-type 1Add
BLAST
Domaini239 – 31779Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP11465.
KOiK06500.
OMAiLPMTHRF.
OrthoDBiEOG74BJS7.
PhylomeDBiP11465.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11465-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPLSAPPCT EHIKWKGLLV TASLLNFWNL PTTAQVTIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET
110 120 130 140 150
AYSNASLLIQ NVTREDAGSY TLHIIKRGDG TRGVTGYFTF TLYLETPKPS
160 170 180 190 200
ISSSNLNPRE AMETVILTCD PETPDTSYQW WMNGQSLPMT HRFQLSETNR
210 220 230 240 250
TLFLFGVTKY TAGPYECEIR NSGSASRSDP VTLNLLHGPD LPRIHPSYTN
260 270 280 290 300
YRSGDNLYLS CFANSNPPAQ YSWTINGKFQ QSGQNLFIPQ ITTKHSGLYV
310 320 330
CSVRNSATGE ESSTSLTVKV SASTRIGLLP LLNPT
Length:335
Mass (Da):37,216
Last modified:June 13, 2006 - v2
Checksum:iC47AFC14DED9C0F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 3101E → Q in AAA52604. (PubMed:3260773)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201V → L.1 Publication
Corresponds to variant rs3887660 [ dbSNP | Ensembl ].
VAR_016039
Natural varianti176 – 1761T → A.
Corresponds to variant rs16976431 [ dbSNP | Ensembl ].
VAR_049918
Natural varianti179 – 1791Q → L.
Corresponds to variant rs1058086 [ dbSNP | Ensembl ].
VAR_049919
Natural varianti335 – 3351T → R.
Corresponds to variant rs1064937 [ dbSNP | Ensembl ].
VAR_049920

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20882 mRNA. Translation: AAA52604.1.
AC005791 Genomic DNA. Translation: AAC62831.1.
AC024077 Genomic DNA. No translation available.
BC022316 mRNA. Translation: AAH22316.1.
AH007518 Genomic DNA. Translation: AAD21021.1.
CCDSiCCDS12616.1.
RefSeqiNP_112536.2. NM_031246.3.
UniGeneiHs.709200.

Genome annotation databases

EnsembliENST00000406487; ENSP00000385706; ENSG00000242221.
GeneIDi5670.
KEGGihsa:5670.
UCSCiuc002ovr.3. human.

Polymorphism databases

DMDMi108935879.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20882 mRNA. Translation: AAA52604.1 .
AC005791 Genomic DNA. Translation: AAC62831.1 .
AC024077 Genomic DNA. No translation available.
BC022316 mRNA. Translation: AAH22316.1 .
AH007518 Genomic DNA. Translation: AAD21021.1 .
CCDSi CCDS12616.1.
RefSeqi NP_112536.2. NM_031246.3.
UniGenei Hs.709200.

3D structure databases

ProteinModelPortali P11465.
SMRi P11465. Positions 33-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111645. 2 interactions.
IntActi P11465. 1 interaction.
MINTi MINT-1187536.
STRINGi 9606.ENSP00000251275.

PTM databases

PhosphoSitei P11465.

Polymorphism databases

DMDMi 108935879.

Proteomic databases

PaxDbi P11465.
PRIDEi P11465.

Protocols and materials databases

DNASUi 5670.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000406487 ; ENSP00000385706 ; ENSG00000242221 .
GeneIDi 5670.
KEGGi hsa:5670.
UCSCi uc002ovr.3. human.

Organism-specific databases

CTDi 5670.
GeneCardsi GC19M043568.
HGNCi HGNC:9519. PSG2.
MIMi 176391. gene.
neXtProti NX_P11465.
PharmGKBi PA33864.
GenAtlasi Search...

Phylogenomic databases

eggNOGi KOG0619.
GeneTreei ENSGT00760000119187.
HOGENOMi HOG000233417.
HOVERGENi HBG007922.
InParanoidi P11465.
KOi K06500.
OMAi LPMTHRF.
OrthoDBi EOG74BJS7.
PhylomeDBi P11465.
TreeFami TF336859.

Miscellaneous databases

GeneWikii PSG2.
GenomeRNAii 5670.
NextBioi 22020.
PROi P11465.
SOURCEi Search...

Gene expression databases

Bgeei P11465.
CleanExi HS_PSG2.
Genevestigatori P11465.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family."
    Streydio C., Lacka K., Swillens S., Vassart G.
    Biochem. Biophys. Res. Commun. 154:130-137(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-20.
    Tissue: Placenta.
  4. "Characterization of upstream promotor region, exon1 and exon2 of the PSG gene family."
    Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.

Entry informationi

Entry nameiPSG2_HUMAN
AccessioniPrimary (citable) accession number: P11465
Secondary accession number(s): Q8TCD9, Q9UEA4, Q9UQ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 13, 2006
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3