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P11465 (PSG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pregnancy-specific beta-1-glycoprotein 2

Short name=PS-beta-G-2
Short name=PSBG-2
Short name=Pregnancy-specific glycoprotein 2
Alternative name(s):
Pregnancy-specific beta-1 glycoprotein E
Short name=PS-beta-E
Gene names
Name:PSG2
Synonyms:PSBG2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the immunoglobulin superfamily. CEA family.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration

Non-traceable author statement Ref.1. Source: UniProtKB

female pregnancy

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434
Chain35 – 335301Pregnancy-specific beta-1-glycoprotein 2
PRO_0000014909

Regions

Domain35 – 144110Ig-like V-type
Domain147 – 23488Ig-like C2-type 1
Domain239 – 31779Ig-like C2-type 2

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Disulfide bond169 ↔ 217 Probable
Disulfide bond261 ↔ 301 Probable

Natural variations

Natural variant201V → L. Ref.3
Corresponds to variant rs3887660 [ dbSNP | Ensembl ].
VAR_016039
Natural variant1761T → A.
Corresponds to variant rs16976431 [ dbSNP | Ensembl ].
VAR_049918
Natural variant1791Q → L.
Corresponds to variant rs1058086 [ dbSNP | Ensembl ].
VAR_049919
Natural variant3351T → R.
Corresponds to variant rs1064937 [ dbSNP | Ensembl ].
VAR_049920

Experimental info

Sequence conflict3101E → Q in AAA52604. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P11465 [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: C47AFC14DED9C0F8

FASTA33537,216
        10         20         30         40         50         60 
MGPLSAPPCT EHIKWKGLLV TASLLNFWNL PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ 

        70         80         90        100        110        120 
NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 

       130        140        150        160        170        180 
TLHIIKRGDG TRGVTGYFTF TLYLETPKPS ISSSNLNPRE AMETVILTCD PETPDTSYQW 

       190        200        210        220        230        240 
WMNGQSLPMT HRFQLSETNR TLFLFGVTKY TAGPYECEIR NSGSASRSDP VTLNLLHGPD 

       250        260        270        280        290        300 
LPRIHPSYTN YRSGDNLYLS CFANSNPPAQ YSWTINGKFQ QSGQNLFIPQ ITTKHSGLYV 

       310        320        330 
CSVRNSATGE ESSTSLTVKV SASTRIGLLP LLNPT 

« Hide

References

« Hide 'large scale' references
[1]"The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family."
Streydio C., Lacka K., Swillens S., Vassart G.
Biochem. Biophys. Res. Commun. 154:130-137(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-20.
Tissue: Placenta.
[4]"Characterization of upstream promotor region, exon1 and exon2 of the PSG gene family."
Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M20882 mRNA. Translation: AAA52604.1.
AC005791 Genomic DNA. Translation: AAC62831.1.
AC024077 Genomic DNA. No translation available.
BC022316 mRNA. Translation: AAH22316.1.
AH007518 Genomic DNA. Translation: AAD21021.1.
CCDSCCDS12616.1.
RefSeqNP_112536.2. NM_031246.3.
UniGeneHs.709200.

3D structure databases

ProteinModelPortalP11465.
SMRP11465. Positions 33-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111645. 2 interactions.
IntActP11465. 1 interaction.
MINTMINT-1187536.
STRING9606.ENSP00000251275.

PTM databases

PhosphoSiteP11465.

Polymorphism databases

DMDM108935879.

Proteomic databases

PaxDbP11465.
PRIDEP11465.

Protocols and materials databases

DNASU5670.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000406487; ENSP00000385706; ENSG00000242221.
GeneID5670.
KEGGhsa:5670.
UCSCuc002ovr.3. human.

Organism-specific databases

CTD5670.
GeneCardsGC19M043568.
HGNCHGNC:9519. PSG2.
MIM176391. gene.
neXtProtNX_P11465.
PharmGKBPA33864.
GenAtlasSearch...

Phylogenomic databases

eggNOGKOG0619.
HOGENOMHOG000233417.
HOVERGENHBG007922.
KOK06500.
OMALPMTHRF.
OrthoDBEOG74BJS7.
PhylomeDBP11465.
TreeFamTF336859.

Gene expression databases

BgeeP11465.
CleanExHS_PSG2.
GenevestigatorP11465.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPSG2.
GenomeRNAi5670.
NextBio22020.
PROP11465.
SOURCESearch...

Entry information

Entry namePSG2_HUMAN
AccessionPrimary (citable) accession number: P11465
Secondary accession number(s): Q8TCD9, Q9UEA4, Q9UQ78
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 13, 2006
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM