ID PSG1_HUMAN Reviewed; 419 AA. AC P11464; O75236; P11462; P11463; Q15231; Q15241; Q15243; Q16660; Q6ICR4; AC Q9P1W5; Q9UQ79; DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 1. DT 24-JAN-2024, entry version 207. DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 1; DE Short=PS-beta-G-1; DE Short=PSBG-1; DE Short=Pregnancy-specific glycoprotein 1; DE AltName: Full=CD66 antigen-like family member F; DE AltName: Full=Fetal liver non-specific cross-reactive antigen 1/2; DE Short=FL-NCA-1/2; DE AltName: Full=PSG95; DE AltName: Full=Pregnancy-specific beta-1 glycoprotein C/D; DE Short=PS-beta-C/D; DE AltName: CD_antigen=CD66f; DE Flags: Precursor; GN Name=PSG1; Synonyms=B1G1, PSBG1, PSGGA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). RX PubMed=3260773; DOI=10.1016/0006-291x(88)90660-2; RA Streydio C., Lacka K., Swillens S., Vassart G.; RT "The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the RT carcinoembryonic antigen (CEA)-related proteins are members of the same RT multigene family."; RL Biochem. Biophys. Res. Commun. 154:130-137(1988). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=3180995; DOI=10.1089/dna.1.1988.7.545; RA Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L.; RT "Characterization of cDNA encoding human pregnancy-specific beta 1- RT glycoprotein from placenta and extraplacental tissues and their comparison RT with carcinoembryonic antigen."; RL DNA 7:545-555(1988). RN [3] RP NUCLEOTIDE SEQUENCE (ISOFORM 1). RX PubMed=2735907; DOI=10.1016/0006-291x(89)92631-4; RA Khan W.N., Hammarstroem S.; RT "Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS- RT beta-G/FL-NCA glycoprotein with a novel domain arrangement."; RL Biochem. Biophys. Res. Commun. 161:525-535(1989). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4). RX PubMed=2783133; DOI=10.1016/0006-291x(89)91105-4; RA Zimmermann W.A., Weiss M., Thompson J.A.; RT "cDNA cloning demonstrates the expression of pregnancy-specific RT glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, RT in fetal liver."; RL Biochem. Biophys. Res. Commun. 163:1197-1209(1989). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4). RX PubMed=2377620; DOI=10.1073/pnas.87.15.5822; RA Leslie K.K., Watanabe S., Lei K.-J., Chou D.Y., Plouzek C.A., Deng H.-C., RA Torres J., Chou J.Y.; RT "Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is RT associated with hydatidiform mole."; RL Proc. Natl. Acad. Sci. U.S.A. 87:5822-5826(1990). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). RX PubMed=3257488; DOI=10.1016/s0021-9258(19)77983-6; RA Watanabe S., Chou J.Y.; RT "Isolation and characterization of complementary DNAs encoding human RT pregnancy-specific beta 1-glycoprotein."; RL J. Biol. Chem. 263:2049-2054(1988). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). RX PubMed=2541441; DOI=10.1073/pnas.86.9.3332; RA Khan W.N., Osterman A., Hammarstroem S.; RT "Molecular cloning and expression of cDNA for a carcinoembryonic antigen- RT related fetal liver glycoprotein."; RL Proc. Natl. Acad. Sci. U.S.A. 86:3332-3336(1989). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). RX PubMed=2350345; DOI=10.1016/0006-291x(90)91455-2; RA Zoubir F., Khan W.N., Hammarstroem S.; RT "Carcinoembryonic antigen gene family members in submandibular salivary RT gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning."; RL Biochem. Biophys. Res. Commun. 169:203-216(1990). RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3). RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [11] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [13] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143. RA Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.; RT "Characterization of upstream promotor region, exon1 and exon2 of the PSG RT gene family."; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. CC -!- INTERACTION: CC P11464; O15294: OGT; NbExp=3; IntAct=EBI-716740, EBI-539828; CC P11464; P01137: TGFB1; NbExp=3; IntAct=EBI-716740, EBI-779636; CC P11464; PRO_0000033762 [P01137]: TGFB1; NbExp=2; IntAct=EBI-716740, EBI-15487336; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; Synonyms=PSG-1a; CC IsoId=P11464-1; Sequence=Displayed; CC Name=2; CC IsoId=P11464-2; Sequence=VSP_002550; CC Name=3; CC IsoId=P11464-3; Sequence=VSP_002549; CC Name=4; Synonyms=PSG-1d; CC IsoId=P11464-4; Sequence=VSP_002548; CC -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during CC pregnancy. CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M20881; AAA52603.1; -; mRNA. DR EMBL; M20879; AAA52602.1; -; mRNA. DR EMBL; M21822; AAA52601.1; -; mRNA. DR EMBL; M25385; AAA36513.1; -; mRNA. DR EMBL; M34715; AAA36511.1; -; mRNA. DR EMBL; M17908; AAA52590.1; -; mRNA. DR EMBL; M17909; AAA52591.1; -; mRNA. DR EMBL; M33663; AAA36517.1; -; mRNA. DR EMBL; M33664; AAA36515.1; -; mRNA. DR EMBL; J04539; AAA60204.1; -; mRNA. DR EMBL; M37397; AAA60960.1; -; mRNA. DR EMBL; CR450329; CAG29325.1; -; mRNA. DR EMBL; AC005238; AAC25488.1; -; Genomic_DNA. DR EMBL; AC005238; AAC25489.1; -; Genomic_DNA. DR EMBL; AC005238; AAC25490.1; -; Genomic_DNA. DR EMBL; CH471126; EAW57156.1; -; Genomic_DNA. DR EMBL; BC022338; AAH22338.1; -; mRNA. DR EMBL; BC058285; AAH58285.1; -; mRNA. DR EMBL; AH007517; AAD21020.1; -; Genomic_DNA. DR CCDS; CCDS12612.1; -. [P11464-4] DR CCDS; CCDS54275.1; -. [P11464-1] DR CCDS; CCDS59392.1; -. [P11464-3] DR CCDS; CCDS74380.1; -. [P11464-2] DR PIR; A27658; A27658. DR PIR; A28277; A28277. DR PIR; A33258; A33258. DR PIR; A35341; A35341. DR PIR; A35964; A35964. DR PIR; B33258; B33258. DR PIR; C43354; C43354. DR PIR; D43354; D43354. DR PIR; E32268; A31135. DR PIR; E43354; E43354. DR RefSeq; NP_001171754.1; NM_001184825.1. [P11464-1] DR RefSeq; NP_001171755.1; NM_001184826.1. [P11464-3] DR RefSeq; NP_001284702.1; NM_001297773.1. [P11464-2] DR RefSeq; NP_008836.2; NM_006905.2. [P11464-4] DR AlphaFoldDB; P11464; -. DR SMR; P11464; -. DR BioGRID; 111644; 52. DR IntAct; P11464; 33. DR STRING; 9606.ENSP00000308970; -. DR GlyCosmos; P11464; 7 sites, No reported glycans. DR GlyGen; P11464; 7 sites. DR iPTMnet; P11464; -. DR PhosphoSitePlus; P11464; -. DR BioMuta; PSG1; -. DR DMDM; 129661; -. DR MassIVE; P11464; -. DR MaxQB; P11464; -. DR PaxDb; 9606-ENSP00000308970; -. DR PeptideAtlas; P11464; -. DR ProteomicsDB; 52775; -. [P11464-1] DR ProteomicsDB; 52776; -. [P11464-2] DR ProteomicsDB; 52777; -. [P11464-3] DR ProteomicsDB; 52778; -. [P11464-4] DR Antibodypedia; 35155; 239 antibodies from 26 providers. DR DNASU; 5669; -. DR Ensembl; ENST00000244296.6; ENSP00000244296.2; ENSG00000231924.10. [P11464-4] DR Ensembl; ENST00000312439.10; ENSP00000308970.6; ENSG00000231924.10. [P11464-2] DR Ensembl; ENST00000436291.7; ENSP00000413041.2; ENSG00000231924.10. [P11464-1] DR Ensembl; ENST00000595356.5; ENSP00000472610.1; ENSG00000231924.10. [P11464-3] DR GeneID; 5669; -. DR KEGG; hsa:5669; -. DR MANE-Select; ENST00000436291.7; ENSP00000413041.2; NM_001184825.2; NP_001171754.1. DR UCSC; uc002ouz.3; human. [P11464-1] DR AGR; HGNC:9514; -. DR CTD; 5669; -. DR DisGeNET; 5669; -. DR GeneCards; PSG1; -. DR HGNC; HGNC:9514; PSG1. DR HPA; ENSG00000231924; Tissue enriched (placenta). DR MIM; 176390; gene. DR neXtProt; NX_P11464; -. DR OpenTargets; ENSG00000231924; -. DR PharmGKB; PA33861; -. DR VEuPathDB; HostDB:ENSG00000231924; -. DR eggNOG; ENOG502RXPD; Eukaryota. DR GeneTree; ENSGT01100000263479; -. DR HOGENOM; CLU_024555_2_0_1; -. DR InParanoid; P11464; -. DR OMA; HEIQDRY; -. DR OrthoDB; 3033616at2759; -. DR PhylomeDB; P11464; -. DR TreeFam; TF336859; -. DR PathwayCommons; P11464; -. DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall. DR SignaLink; P11464; -. DR BioGRID-ORCS; 5669; 10 hits in 1054 CRISPR screens. DR ChiTaRS; PSG1; human. DR GeneWiki; PSG1_(gene); -. DR GenomeRNAi; 5669; -. DR Pharos; P11464; Tbio. DR PRO; PR:P11464; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; P11464; Protein. DR Bgee; ENSG00000231924; Expressed in placenta and 53 other cell types or tissues. DR ExpressionAtlas; P11464; baseline and differential. DR GO; GO:0009986; C:cell surface; IBA:GO_Central. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central. DR GO; GO:0007565; P:female pregnancy; TAS:ProtInc. DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central. DR GO; GO:0007165; P:signal transduction; IBA:GO_Central. DR CDD; cd20948; IgC2_CEACAM5-like; 1. DR CDD; cd05740; IgI_hCEACAM_2_4_6_like; 1. DR CDD; cd05774; IgV_CEACAM_D1; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 4. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR PANTHER; PTHR44427; CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19; 1. DR PANTHER; PTHR44427:SF16; PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 1; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF13927; Ig_3; 2. DR Pfam; PF07686; V-set; 1. DR SMART; SM00409; IG; 4. DR SMART; SM00408; IGc2; 3. DR SUPFAM; SSF48726; Immunoglobulin; 4. DR PROSITE; PS50835; IG_LIKE; 3. DR Genevisible; P11464; HS. PE 1: Evidence at protein level; KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain; KW Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..34 FT CHAIN 35..419 FT /note="Pregnancy-specific beta-1-glycoprotein 1" FT /id="PRO_0000014908" FT DOMAIN 35..144 FT /note="Ig-like V-type" FT DOMAIN 149..234 FT /note="Ig-like C2-type 1" FT DOMAIN 240..327 FT /note="Ig-like C2-type 2" FT DOMAIN 335..410 FT /note="Ig-like C2-type 3" FT CARBOHYD 61 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 104 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 111 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 199 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 259 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 268 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 303 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 169..217 FT /evidence="ECO:0000305" FT DISULFID 262..310 FT /evidence="ECO:0000305" FT DISULFID 354..394 FT /evidence="ECO:0000305" FT VAR_SEQ 415..419 FT /note="DWTVP -> AYSSSINYTSGNRN (in isoform 2)" FT /evidence="ECO:0000303|PubMed:3260773" FT /id="VSP_002550" FT VAR_SEQ 415..419 FT /note="DWTVP -> EAL (in isoform 3)" FT /evidence="ECO:0000303|PubMed:3257488" FT /id="VSP_002549" FT VAR_SEQ 415..419 FT /note="DWTVP -> GKWIPASLAIGF (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:2350345, ECO:0000303|PubMed:2377620, FT ECO:0000303|PubMed:2541441, ECO:0000303|PubMed:2783133, FT ECO:0000303|Ref.9" FT /id="VSP_002548" FT VARIANT 41 FT /note="E -> Q (in dbSNP:rs707744)" FT /id="VAR_056063" FT VARIANT 43 FT /note="T -> P (in dbSNP:rs707745)" FT /id="VAR_056064" FT VARIANT 47 FT /note="E -> K (in dbSNP:rs1058956)" FT /id="VAR_056065" FT VARIANT 63 FT /note="T -> A (in dbSNP:rs1064479)" FT /id="VAR_056066" FT VARIANT 73 FT /note="R -> K (in dbSNP:rs1064480)" FT /id="VAR_056067" FT VARIANT 87 FT /note="E -> Q (in dbSNP:rs1058661)" FT /id="VAR_056068" FT VARIANT 101 FT /note="A -> V (in dbSNP:rs707748)" FT /id="VAR_056069" FT VARIANT 125 FT /note="I -> V (in dbSNP:rs1058960)" FT /id="VAR_059408" FT VARIANT 134 FT /note="V -> E (in dbSNP:rs1058671)" FT /id="VAR_056070" FT VARIANT 197 FT /note="E -> K (in dbSNP:rs1058692)" FT /id="VAR_056071" FT VARIANT 198 FT /note="T -> N (in dbSNP:rs1058693)" FT /id="VAR_056072" FT CONFLICT 41..43 FT /note="EPT -> QPP (in Ref. 4, 5 and 6)" FT /evidence="ECO:0000305" FT CONFLICT 319 FT /note="I -> V (in Ref. 5 and 6)" FT /evidence="ECO:0000305" SQ SEQUENCE 419 AA; 47223 MW; 5E9855162F0C796D CRC64; MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA TGKESSKSMT VEVSDWTVP //