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P11464 (PSG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pregnancy-specific beta-1-glycoprotein 1

Short name=PS-beta-G-1
Short name=PSBG-1
Short name=Pregnancy-specific glycoprotein 1
Alternative name(s):
CD66 antigen-like family member F
Fetal liver non-specific cross-reactive antigen 1/2
Short name=FL-NCA-1/2
PSG95
Pregnancy-specific beta-1 glycoprotein C/D
Short name=PS-beta-C/D
CD_antigen=CD66f
Gene names
Name:PSG1
Synonyms:B1G1, PSBG1, PSGGA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Developmental stage

PSBG are produced in high quantity during pregnancy.

Sequence similarities

Belongs to the immunoglobulin superfamily. CEA family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfemale pregnancy

Traceable author statement PubMed 1572651. Source: ProtInc

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P11464-1)

Also known as: PSG-1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P11464-2)

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → AYSSSINYTSGNRN
Isoform 3 (identifier: P11464-3)

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → EAL
Isoform 4 (identifier: P11464-4)

Also known as: PSG-1d;

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → GKWIPASLAIGF

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434
Chain35 – 419385Pregnancy-specific beta-1-glycoprotein 1
PRO_0000014908

Regions

Domain35 – 144110Ig-like V-type
Domain149 – 23486Ig-like C2-type 1
Domain240 – 32788Ig-like C2-type 2
Domain335 – 41076Ig-like C2-type 3

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation2591N-linked (GlcNAc...) Potential
Glycosylation2681N-linked (GlcNAc...) Potential
Glycosylation3031N-linked (GlcNAc...) Potential
Disulfide bond169 ↔ 217 Probable
Disulfide bond262 ↔ 310 Probable
Disulfide bond354 ↔ 394 Probable

Natural variations

Alternative sequence415 – 4195DWTVP → AYSSSINYTSGNRN in isoform 2.
VSP_002550
Alternative sequence415 – 4195DWTVP → EAL in isoform 3.
VSP_002549
Alternative sequence415 – 4195DWTVP → GKWIPASLAIGF in isoform 4.
VSP_002548
Natural variant411E → Q.
Corresponds to variant rs707744 [ dbSNP | Ensembl ].
VAR_056063
Natural variant431T → P.
Corresponds to variant rs707745 [ dbSNP | Ensembl ].
VAR_056064
Natural variant471E → K.
Corresponds to variant rs1058956 [ dbSNP | Ensembl ].
VAR_056065
Natural variant631T → A.
Corresponds to variant rs1064479 [ dbSNP | Ensembl ].
VAR_056066
Natural variant731R → K.
Corresponds to variant rs1064480 [ dbSNP | Ensembl ].
VAR_056067
Natural variant871E → Q.
Corresponds to variant rs1058661 [ dbSNP | Ensembl ].
VAR_056068
Natural variant1011A → V.
Corresponds to variant rs707748 [ dbSNP | Ensembl ].
VAR_056069
Natural variant1251I → V.
Corresponds to variant rs1058960 [ dbSNP | Ensembl ].
VAR_059408
Natural variant1341V → E.
Corresponds to variant rs1058671 [ dbSNP | Ensembl ].
VAR_056070
Natural variant1971E → K.
Corresponds to variant rs1058692 [ dbSNP | Ensembl ].
VAR_056071
Natural variant1981T → N.
Corresponds to variant rs1058693 [ dbSNP | Ensembl ].
VAR_056072

Experimental info

Sequence conflict41 – 433EPT → QPP Ref.4
Sequence conflict41 – 433EPT → QPP Ref.5
Sequence conflict41 – 433EPT → QPP Ref.6
Sequence conflict3191I → V Ref.5
Sequence conflict3191I → V Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (PSG-1a) [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 5E9855162F0C796D

FASTA41947,223
        10         20         30         40         50         60 
MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ 

        70         80         90        100        110        120 
NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 

       130        140        150        160        170        180 
TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW 

       190        200        210        220        230        240 
WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP 

       250        260        270        280        290        300 
KPYITINNLN PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV 

       310        320        330        340        350        360 
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP 

       370        380        390        400        410 
PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA TGKESSKSMT VEVSDWTVP 

« Hide

Isoform 2 [UniParc].

Checksum: 529C21EFDD8C7159
Show »

FASTA42848,140
Isoform 3 [UniParc].

Checksum: B3888EBC796D37BB
Show »

FASTA41746,937
Isoform 4 (PSG-1d) [UniParc].

Checksum: BF98CAAD8338DD1E
Show »

FASTA42647,866

References

« Hide 'large scale' references
[1]"The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family."
Streydio C., Lacka K., Swillens S., Vassart G.
Biochem. Biophys. Res. Commun. 154:130-137(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen."
Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L.
DNA 7:545-555(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement."
Khan W.N., Hammarstroem S.
Biochem. Biophys. Res. Commun. 161:525-535(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[4]"cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver."
Zimmermann W.A., Weiss M., Thompson J.A.
Biochem. Biophys. Res. Commun. 163:1197-1209(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4).
[5]"Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole."
Leslie K.K., Watanabe S., Lei K.-J., Chou D.Y., Plouzek C.A., Deng H.-C., Torres J., Chou J.Y.
Proc. Natl. Acad. Sci. U.S.A. 87:5822-5826(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4).
[6]"Isolation and characterization of complementary DNAs encoding human pregnancy-specific beta 1-glycoprotein."
Watanabe S., Chou J.Y.
J. Biol. Chem. 263:2049-2054(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[7]"Molecular cloning and expression of cDNA for a carcinoembryonic antigen-related fetal liver glycoprotein."
Khan W.N., Osterman A., Hammarstroem S.
Proc. Natl. Acad. Sci. U.S.A. 86:3332-3336(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[8]"Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning."
Zoubir F., Khan W.N., Hammarstroem S.
Biochem. Biophys. Res. Commun. 169:203-216(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[9]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[10]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
[11]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Placenta.
[13]"Characterization of upstream promotor region, exon1 and exon2 of the PSG gene family."
Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M20881 mRNA. Translation: AAA52603.1.
M20879 mRNA. Translation: AAA52602.1.
M21822 mRNA. Translation: AAA52601.1.
M25385 mRNA. Translation: AAA36513.1.
M34715 mRNA. Translation: AAA36511.1.
M17908 mRNA. Translation: AAA52590.1.
M17909 mRNA. Translation: AAA52591.1.
M33663 mRNA. Translation: AAA36517.1.
M33664 mRNA. Translation: AAA36515.1.
J04539 mRNA. Translation: AAA60204.1.
M37397 mRNA. Translation: AAA60960.1.
CR450329 mRNA. Translation: CAG29325.1.
AC005238 Genomic DNA. Translation: AAC25488.1.
AC005238 Genomic DNA. Translation: AAC25489.1.
AC005238 Genomic DNA. Translation: AAC25490.1.
CH471126 Genomic DNA. Translation: EAW57156.1.
BC022338 mRNA. Translation: AAH22338.1.
BC058285 mRNA. Translation: AAH58285.1.
AH007517 Genomic DNA. Translation: AAD21020.1.
CCDSCCDS12612.1. [P11464-4]
CCDS54275.1. [P11464-1]
CCDS59392.1. [P11464-3]
PIRA27658.
A28277.
A33258.
A35341.
A35964.
B33258.
C43354.
D43354.
A31135. E32268.
E43354.
RefSeqNP_001171754.1. NM_001184825.1. [P11464-1]
NP_001171755.1. NM_001184826.1. [P11464-3]
NP_008836.2. NM_006905.2. [P11464-4]
XP_005259120.1. XM_005259063.2. [P11464-2]
UniGeneHs.709192.

3D structure databases

ProteinModelPortalP11464.
SMRP11464. Positions 34-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111644. 1 interaction.
IntActP11464. 1 interaction.

Protein family/group databases

MEROPSI43.001.

Polymorphism databases

DMDM129661.

Proteomic databases

MaxQBP11464.
PaxDbP11464.
PRIDEP11464.

Protocols and materials databases

DNASU5669.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000244296; ENSP00000244296; ENSG00000231924. [P11464-4]
ENST00000312439; ENSP00000308970; ENSG00000231924. [P11464-2]
ENST00000436291; ENSP00000413041; ENSG00000231924. [P11464-1]
ENST00000595356; ENSP00000472610; ENSG00000231924. [P11464-3]
GeneID5669.
KEGGhsa:5669.
UCSCuc002oug.1. human. [P11464-1]
uc002ouz.2. human. [P11464-3]
uc002ovd.1. human. [P11464-4]

Organism-specific databases

CTD5669.
GeneCardsGC19M043348.
HGNCHGNC:9514. PSG1.
HPAHPA046327.
MIM176390. gene.
neXtProtNX_P11464.
PharmGKBPA33861.
GenAtlasSearch...

Phylogenomic databases

eggNOGKOG0619.
HOVERGENHBG007922.
KOK06500.
OMAWTINEKF.
OrthoDBEOG74BJS7.
PhylomeDBP11464.
TreeFamTF336859.

Gene expression databases

ArrayExpressP11464.
BgeeP11464.
GenevestigatorP11464.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPSG1_(gene).
GenomeRNAi5669.
NextBio22016.
PROP11464.
SOURCESearch...

Entry information

Entry namePSG1_HUMAN
AccessionPrimary (citable) accession number: P11464
Secondary accession number(s): O75236 expand/collapse secondary AC list , P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q6ICR4, Q9P1W5, Q9UQ79
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries