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P11464

- PSG1_HUMAN

UniProt

P11464 - PSG1_HUMAN

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Protein
Pregnancy-specific beta-1-glycoprotein 1
Gene
PSG1, B1G1, PSBG1, PSGGA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. female pregnancy Source: ProtInc
Complete GO annotation...

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 1
Short name:
PS-beta-G-1
Short name:
PSBG-1
Short name:
Pregnancy-specific glycoprotein 1
Alternative name(s):
CD66 antigen-like family member F
Fetal liver non-specific cross-reactive antigen 1/2
Short name:
FL-NCA-1/2
PSG95
Pregnancy-specific beta-1 glycoprotein C/D
Short name:
PS-beta-C/D
CD_antigen: CD66f
Gene namesi
Name:PSG1
Synonyms:B1G1, PSBG1, PSGGA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:9514. PSG1.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33861.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434
Add
BLAST
Chaini35 – 419385Pregnancy-specific beta-1-glycoprotein 1
PRO_0000014908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi169 ↔ 217 Inferred
Glycosylationi199 – 1991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi259 – 2591N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi262 ↔ 310 Inferred
Glycosylationi268 – 2681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi303 – 3031N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi354 ↔ 394 Inferred

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP11464.
PaxDbiP11464.
PRIDEiP11464.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

ArrayExpressiP11464.
BgeeiP11464.
GenevestigatoriP11464.

Organism-specific databases

HPAiHPA046327.

Interactioni

Protein-protein interaction databases

BioGridi111644. 1 interaction.
IntActiP11464. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP11464.
SMRiP11464. Positions 34-416.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 144110Ig-like V-type
Add
BLAST
Domaini149 – 23486Ig-like C2-type 1
Add
BLAST
Domaini240 – 32788Ig-like C2-type 2
Add
BLAST
Domaini335 – 41076Ig-like C2-type 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619.
HOVERGENiHBG007922.
KOiK06500.
OMAiWTINEKF.
OrthoDBiEOG74BJS7.
PhylomeDBiP11464.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P11464-1) [UniParc]FASTAAdd to Basket

Also known as: PSG-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD    50
VLLLVHNLPQ NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET 100
AYSNASLLIQ NVTREDAGSY TLHIIKGDDG TRGVTGRFTF TLHLETPKPS 150
ISSSNLNPRE TMEAVSLTCD PETPDASYLW WMNGQSLPMT HSLKLSETNR 200
TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN 250
PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV 300
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL 350
YLSCSADSNP PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA 400
TGKESSKSMT VEVSDWTVP 419
Length:419
Mass (Da):47,223
Last modified:October 1, 1989 - v1
Checksum:i5E9855162F0C796D
GO
Isoform 2 (identifier: P11464-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → AYSSSINYTSGNRN

Show »
Length:428
Mass (Da):48,140
Checksum:i529C21EFDD8C7159
GO
Isoform 3 (identifier: P11464-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → EAL

Show »
Length:417
Mass (Da):46,937
Checksum:iB3888EBC796D37BB
GO
Isoform 4 (identifier: P11464-4) [UniParc]FASTAAdd to Basket

Also known as: PSG-1d

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → GKWIPASLAIGF

Show »
Length:426
Mass (Da):47,866
Checksum:iBF98CAAD8338DD1E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411E → Q.
Corresponds to variant rs707744 [ dbSNP | Ensembl ].
VAR_056063
Natural varianti43 – 431T → P.
Corresponds to variant rs707745 [ dbSNP | Ensembl ].
VAR_056064
Natural varianti47 – 471E → K.
Corresponds to variant rs1058956 [ dbSNP | Ensembl ].
VAR_056065
Natural varianti63 – 631T → A.
Corresponds to variant rs1064479 [ dbSNP | Ensembl ].
VAR_056066
Natural varianti73 – 731R → K.
Corresponds to variant rs1064480 [ dbSNP | Ensembl ].
VAR_056067
Natural varianti87 – 871E → Q.
Corresponds to variant rs1058661 [ dbSNP | Ensembl ].
VAR_056068
Natural varianti101 – 1011A → V.
Corresponds to variant rs707748 [ dbSNP | Ensembl ].
VAR_056069
Natural varianti125 – 1251I → V.
Corresponds to variant rs1058960 [ dbSNP | Ensembl ].
VAR_059408
Natural varianti134 – 1341V → E.
Corresponds to variant rs1058671 [ dbSNP | Ensembl ].
VAR_056070
Natural varianti197 – 1971E → K.
Corresponds to variant rs1058692 [ dbSNP | Ensembl ].
VAR_056071
Natural varianti198 – 1981T → N.
Corresponds to variant rs1058693 [ dbSNP | Ensembl ].
VAR_056072

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei415 – 4195DWTVP → AYSSSINYTSGNRN in isoform 2.
VSP_002550
Alternative sequencei415 – 4195DWTVP → EAL in isoform 3.
VSP_002549
Alternative sequencei415 – 4195DWTVP → GKWIPASLAIGF in isoform 4.
VSP_002548

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 433EPT → QPP1 Publication
Sequence conflicti41 – 433EPT → QPP1 Publication
Sequence conflicti41 – 433EPT → QPP1 Publication
Sequence conflicti319 – 3191I → V1 Publication
Sequence conflicti319 – 3191I → V1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20881 mRNA. Translation: AAA52603.1.
M20879 mRNA. Translation: AAA52602.1.
M21822 mRNA. Translation: AAA52601.1.
M25385 mRNA. Translation: AAA36513.1.
M34715 mRNA. Translation: AAA36511.1.
M17908 mRNA. Translation: AAA52590.1.
M17909 mRNA. Translation: AAA52591.1.
M33663 mRNA. Translation: AAA36517.1.
M33664 mRNA. Translation: AAA36515.1.
J04539 mRNA. Translation: AAA60204.1.
M37397 mRNA. Translation: AAA60960.1.
CR450329 mRNA. Translation: CAG29325.1.
AC005238 Genomic DNA. Translation: AAC25488.1.
AC005238 Genomic DNA. Translation: AAC25489.1.
AC005238 Genomic DNA. Translation: AAC25490.1.
CH471126 Genomic DNA. Translation: EAW57156.1.
BC022338 mRNA. Translation: AAH22338.1.
BC058285 mRNA. Translation: AAH58285.1.
AH007517 Genomic DNA. Translation: AAD21020.1.
CCDSiCCDS12612.1. [P11464-4]
CCDS54275.1. [P11464-1]
CCDS59392.1. [P11464-3]
PIRiA27658.
A28277.
A33258.
A35341.
A35964.
B33258.
C43354.
D43354.
E32268. A31135.
E43354.
RefSeqiNP_001171754.1. NM_001184825.1. [P11464-1]
NP_001171755.1. NM_001184826.1. [P11464-3]
NP_008836.2. NM_006905.2. [P11464-4]
XP_005259120.1. XM_005259063.2. [P11464-2]
UniGeneiHs.709192.

Genome annotation databases

EnsembliENST00000244296; ENSP00000244296; ENSG00000231924. [P11464-4]
ENST00000312439; ENSP00000308970; ENSG00000231924. [P11464-2]
ENST00000436291; ENSP00000413041; ENSG00000231924. [P11464-1]
ENST00000595356; ENSP00000472610; ENSG00000231924. [P11464-3]
GeneIDi5669.
KEGGihsa:5669.
UCSCiuc002oug.1. human. [P11464-1]
uc002ouz.2. human. [P11464-3]
uc002ovd.1. human. [P11464-4]

Polymorphism databases

DMDMi129661.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20881 mRNA. Translation: AAA52603.1 .
M20879 mRNA. Translation: AAA52602.1 .
M21822 mRNA. Translation: AAA52601.1 .
M25385 mRNA. Translation: AAA36513.1 .
M34715 mRNA. Translation: AAA36511.1 .
M17908 mRNA. Translation: AAA52590.1 .
M17909 mRNA. Translation: AAA52591.1 .
M33663 mRNA. Translation: AAA36517.1 .
M33664 mRNA. Translation: AAA36515.1 .
J04539 mRNA. Translation: AAA60204.1 .
M37397 mRNA. Translation: AAA60960.1 .
CR450329 mRNA. Translation: CAG29325.1 .
AC005238 Genomic DNA. Translation: AAC25488.1 .
AC005238 Genomic DNA. Translation: AAC25489.1 .
AC005238 Genomic DNA. Translation: AAC25490.1 .
CH471126 Genomic DNA. Translation: EAW57156.1 .
BC022338 mRNA. Translation: AAH22338.1 .
BC058285 mRNA. Translation: AAH58285.1 .
AH007517 Genomic DNA. Translation: AAD21020.1 .
CCDSi CCDS12612.1. [P11464-4 ]
CCDS54275.1. [P11464-1 ]
CCDS59392.1. [P11464-3 ]
PIRi A27658.
A28277.
A33258.
A35341.
A35964.
B33258.
C43354.
D43354.
E32268. A31135.
E43354.
RefSeqi NP_001171754.1. NM_001184825.1. [P11464-1 ]
NP_001171755.1. NM_001184826.1. [P11464-3 ]
NP_008836.2. NM_006905.2. [P11464-4 ]
XP_005259120.1. XM_005259063.2. [P11464-2 ]
UniGenei Hs.709192.

3D structure databases

ProteinModelPortali P11464.
SMRi P11464. Positions 34-416.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111644. 1 interaction.
IntActi P11464. 1 interaction.

Protein family/group databases

MEROPSi I43.001.

Polymorphism databases

DMDMi 129661.

Proteomic databases

MaxQBi P11464.
PaxDbi P11464.
PRIDEi P11464.

Protocols and materials databases

DNASUi 5669.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000244296 ; ENSP00000244296 ; ENSG00000231924 . [P11464-4 ]
ENST00000312439 ; ENSP00000308970 ; ENSG00000231924 . [P11464-2 ]
ENST00000436291 ; ENSP00000413041 ; ENSG00000231924 . [P11464-1 ]
ENST00000595356 ; ENSP00000472610 ; ENSG00000231924 . [P11464-3 ]
GeneIDi 5669.
KEGGi hsa:5669.
UCSCi uc002oug.1. human. [P11464-1 ]
uc002ouz.2. human. [P11464-3 ]
uc002ovd.1. human. [P11464-4 ]

Organism-specific databases

CTDi 5669.
GeneCardsi GC19M043348.
HGNCi HGNC:9514. PSG1.
HPAi HPA046327.
MIMi 176390. gene.
neXtProti NX_P11464.
PharmGKBi PA33861.
GenAtlasi Search...

Phylogenomic databases

eggNOGi KOG0619.
HOVERGENi HBG007922.
KOi K06500.
OMAi WTINEKF.
OrthoDBi EOG74BJS7.
PhylomeDBi P11464.
TreeFami TF336859.

Miscellaneous databases

GeneWikii PSG1_(gene).
GenomeRNAii 5669.
NextBioi 22016.
PROi P11464.
SOURCEi Search...

Gene expression databases

ArrayExpressi P11464.
Bgeei P11464.
Genevestigatori P11464.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family."
    Streydio C., Lacka K., Swillens S., Vassart G.
    Biochem. Biophys. Res. Commun. 154:130-137(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen."
    Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L.
    DNA 7:545-555(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement."
    Khan W.N., Hammarstroem S.
    Biochem. Biophys. Res. Commun. 161:525-535(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  4. "cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver."
    Zimmermann W.A., Weiss M., Thompson J.A.
    Biochem. Biophys. Res. Commun. 163:1197-1209(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4).
  5. "Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole."
    Leslie K.K., Watanabe S., Lei K.-J., Chou D.Y., Plouzek C.A., Deng H.-C., Torres J., Chou J.Y.
    Proc. Natl. Acad. Sci. U.S.A. 87:5822-5826(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4).
  6. "Isolation and characterization of complementary DNAs encoding human pregnancy-specific beta 1-glycoprotein."
    Watanabe S., Chou J.Y.
    J. Biol. Chem. 263:2049-2054(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  7. "Molecular cloning and expression of cDNA for a carcinoembryonic antigen-related fetal liver glycoprotein."
    Khan W.N., Osterman A., Hammarstroem S.
    Proc. Natl. Acad. Sci. U.S.A. 86:3332-3336(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  8. "Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning."
    Zoubir F., Khan W.N., Hammarstroem S.
    Biochem. Biophys. Res. Commun. 169:203-216(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  9. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  10. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Placenta.
  13. "Characterization of upstream promotor region, exon1 and exon2 of the PSG gene family."
    Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.

Entry informationi

Entry nameiPSG1_HUMAN
AccessioniPrimary (citable) accession number: P11464
Secondary accession number(s): O75236
, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q6ICR4, Q9P1W5, Q9UQ79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi