Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pregnancy-specific beta-1-glycoprotein 1

Gene

PSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • female pregnancy Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31818-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 1
Short name:
PS-beta-G-1
Short name:
PSBG-1
Short name:
Pregnancy-specific glycoprotein 1
Alternative name(s):
CD66 antigen-like family member F
Fetal liver non-specific cross-reactive antigen 1/2
Short name:
FL-NCA-1/2
PSG95
Pregnancy-specific beta-1 glycoprotein C/D
Short name:
PS-beta-C/D
CD_antigen: CD66f
Gene namesi
Name:PSG1
Synonyms:B1G1, PSBG1, PSGGA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9514. PSG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5669.
OpenTargetsiENSG00000231924.
PharmGKBiPA33861.

Polymorphism and mutation databases

BioMutaiPSG1.
DMDMi129661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000001490835 – 419Pregnancy-specific beta-1-glycoprotein 1Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi262 ↔ 310Curated
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP11464.
PaxDbiP11464.
PeptideAtlasiP11464.
PRIDEiP11464.

PTM databases

iPTMnetiP11464.
PhosphoSitePlusiP11464.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000231924.
ExpressionAtlasiP11464. baseline and differential.
GenevisibleiP11464. HS.

Organism-specific databases

HPAiHPA046327.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
OGTO152943EBI-716740,EBI-539828

Protein-protein interaction databases

BioGridi111644. 46 interactors.
IntActiP11464. 2 interactors.
STRINGi9606.ENSP00000244296.

Structurei

3D structure databases

ProteinModelPortaliP11464.
SMRiP11464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini149 – 234Ig-like C2-type 1Add BLAST86
Domaini240 – 327Ig-like C2-type 2Add BLAST88
Domaini335 – 410Ig-like C2-type 3Add BLAST76

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOVERGENiHBG007922.
InParanoidiP11464.
KOiK06500.
OMAiWTINEKF.
OrthoDBiEOG091G04T1.
PhylomeDBiP11464.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11464-1) [UniParc]FASTAAdd to basket
Also known as: PSG-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET
110 120 130 140 150
AYSNASLLIQ NVTREDAGSY TLHIIKGDDG TRGVTGRFTF TLHLETPKPS
160 170 180 190 200
ISSSNLNPRE TMEAVSLTCD PETPDASYLW WMNGQSLPMT HSLKLSETNR
210 220 230 240 250
TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN
260 270 280 290 300
PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL
360 370 380 390 400
YLSCSADSNP PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA
410
TGKESSKSMT VEVSDWTVP
Length:419
Mass (Da):47,223
Last modified:October 1, 1989 - v1
Checksum:i5E9855162F0C796D
GO
Isoform 2 (identifier: P11464-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → AYSSSINYTSGNRN

Show »
Length:428
Mass (Da):48,140
Checksum:i529C21EFDD8C7159
GO
Isoform 3 (identifier: P11464-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → EAL

Show »
Length:417
Mass (Da):46,937
Checksum:iB3888EBC796D37BB
GO
Isoform 4 (identifier: P11464-4) [UniParc]FASTAAdd to basket
Also known as: PSG-1d

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → GKWIPASLAIGF

Show »
Length:426
Mass (Da):47,866
Checksum:iBF98CAAD8338DD1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41 – 43EPT → QPP (PubMed:2783133).Curated3
Sequence conflicti41 – 43EPT → QPP (PubMed:2377620).Curated3
Sequence conflicti41 – 43EPT → QPP (PubMed:3257488).Curated3
Sequence conflicti319I → V (PubMed:2377620).Curated1
Sequence conflicti319I → V (PubMed:3257488).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05606341E → Q.Corresponds to variant rs707744dbSNPEnsembl.1
Natural variantiVAR_05606443T → P.Corresponds to variant rs707745dbSNPEnsembl.1
Natural variantiVAR_05606547E → K.Corresponds to variant rs1058956dbSNPEnsembl.1
Natural variantiVAR_05606663T → A.Corresponds to variant rs1064479dbSNPEnsembl.1
Natural variantiVAR_05606773R → K.Corresponds to variant rs1064480dbSNPEnsembl.1
Natural variantiVAR_05606887E → Q.Corresponds to variant rs1058661dbSNPEnsembl.1
Natural variantiVAR_056069101A → V.Corresponds to variant rs707748dbSNPEnsembl.1
Natural variantiVAR_059408125I → V.Corresponds to variant rs1058960dbSNPEnsembl.1
Natural variantiVAR_056070134V → E.Corresponds to variant rs1058671dbSNPEnsembl.1
Natural variantiVAR_056071197E → K.Corresponds to variant rs1058692dbSNPEnsembl.1
Natural variantiVAR_056072198T → N.Corresponds to variant rs1058693dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002550415 – 419DWTVP → AYSSSINYTSGNRN in isoform 2. 1 Publication5
Alternative sequenceiVSP_002549415 – 419DWTVP → EAL in isoform 3. 1 Publication5
Alternative sequenceiVSP_002548415 – 419DWTVP → GKWIPASLAIGF in isoform 4. 6 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20881 mRNA. Translation: AAA52603.1.
M20879 mRNA. Translation: AAA52602.1.
M21822 mRNA. Translation: AAA52601.1.
M25385 mRNA. Translation: AAA36513.1.
M34715 mRNA. Translation: AAA36511.1.
M17908 mRNA. Translation: AAA52590.1.
M17909 mRNA. Translation: AAA52591.1.
M33663 mRNA. Translation: AAA36517.1.
M33664 mRNA. Translation: AAA36515.1.
J04539 mRNA. Translation: AAA60204.1.
M37397 mRNA. Translation: AAA60960.1.
CR450329 mRNA. Translation: CAG29325.1.
AC005238 Genomic DNA. Translation: AAC25488.1.
AC005238 Genomic DNA. Translation: AAC25489.1.
AC005238 Genomic DNA. Translation: AAC25490.1.
CH471126 Genomic DNA. Translation: EAW57156.1.
BC022338 mRNA. Translation: AAH22338.1.
BC058285 mRNA. Translation: AAH58285.1.
AH007517 Genomic DNA. Translation: AAD21020.1.
CCDSiCCDS12612.1. [P11464-4]
CCDS54275.1. [P11464-1]
CCDS59392.1. [P11464-3]
CCDS74380.1. [P11464-2]
PIRiA27658.
A28277.
A33258.
A35341.
A35964.
B33258.
C43354.
D43354.
E32268. A31135.
E43354.
RefSeqiNP_001171754.1. NM_001184825.1. [P11464-1]
NP_001171755.1. NM_001184826.1. [P11464-3]
NP_001284702.1. NM_001297773.1. [P11464-2]
NP_008836.2. NM_006905.2. [P11464-4]
UniGeneiHs.709192.

Genome annotation databases

EnsembliENST00000244296; ENSP00000244296; ENSG00000231924. [P11464-4]
ENST00000312439; ENSP00000308970; ENSG00000231924. [P11464-2]
ENST00000436291; ENSP00000413041; ENSG00000231924. [P11464-1]
ENST00000595356; ENSP00000472610; ENSG00000231924. [P11464-3]
GeneIDi5669.
KEGGihsa:5669.
UCSCiuc002ouz.3. human. [P11464-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20881 mRNA. Translation: AAA52603.1.
M20879 mRNA. Translation: AAA52602.1.
M21822 mRNA. Translation: AAA52601.1.
M25385 mRNA. Translation: AAA36513.1.
M34715 mRNA. Translation: AAA36511.1.
M17908 mRNA. Translation: AAA52590.1.
M17909 mRNA. Translation: AAA52591.1.
M33663 mRNA. Translation: AAA36517.1.
M33664 mRNA. Translation: AAA36515.1.
J04539 mRNA. Translation: AAA60204.1.
M37397 mRNA. Translation: AAA60960.1.
CR450329 mRNA. Translation: CAG29325.1.
AC005238 Genomic DNA. Translation: AAC25488.1.
AC005238 Genomic DNA. Translation: AAC25489.1.
AC005238 Genomic DNA. Translation: AAC25490.1.
CH471126 Genomic DNA. Translation: EAW57156.1.
BC022338 mRNA. Translation: AAH22338.1.
BC058285 mRNA. Translation: AAH58285.1.
AH007517 Genomic DNA. Translation: AAD21020.1.
CCDSiCCDS12612.1. [P11464-4]
CCDS54275.1. [P11464-1]
CCDS59392.1. [P11464-3]
CCDS74380.1. [P11464-2]
PIRiA27658.
A28277.
A33258.
A35341.
A35964.
B33258.
C43354.
D43354.
E32268. A31135.
E43354.
RefSeqiNP_001171754.1. NM_001184825.1. [P11464-1]
NP_001171755.1. NM_001184826.1. [P11464-3]
NP_001284702.1. NM_001297773.1. [P11464-2]
NP_008836.2. NM_006905.2. [P11464-4]
UniGeneiHs.709192.

3D structure databases

ProteinModelPortaliP11464.
SMRiP11464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111644. 46 interactors.
IntActiP11464. 2 interactors.
STRINGi9606.ENSP00000244296.

PTM databases

iPTMnetiP11464.
PhosphoSitePlusiP11464.

Polymorphism and mutation databases

BioMutaiPSG1.
DMDMi129661.

Proteomic databases

MaxQBiP11464.
PaxDbiP11464.
PeptideAtlasiP11464.
PRIDEiP11464.

Protocols and materials databases

DNASUi5669.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244296; ENSP00000244296; ENSG00000231924. [P11464-4]
ENST00000312439; ENSP00000308970; ENSG00000231924. [P11464-2]
ENST00000436291; ENSP00000413041; ENSG00000231924. [P11464-1]
ENST00000595356; ENSP00000472610; ENSG00000231924. [P11464-3]
GeneIDi5669.
KEGGihsa:5669.
UCSCiuc002ouz.3. human. [P11464-1]

Organism-specific databases

CTDi5669.
DisGeNETi5669.
GeneCardsiPSG1.
HGNCiHGNC:9514. PSG1.
HPAiHPA046327.
MIMi176390. gene.
neXtProtiNX_P11464.
OpenTargetsiENSG00000231924.
PharmGKBiPA33861.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOVERGENiHBG007922.
InParanoidiP11464.
KOiK06500.
OMAiWTINEKF.
OrthoDBiEOG091G04T1.
PhylomeDBiP11464.
TreeFamiTF336859.

Enzyme and pathway databases

BioCyciZFISH:G66-31818-MONOMER.

Miscellaneous databases

GeneWikiiPSG1_(gene).
GenomeRNAii5669.
PROiP11464.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000231924.
ExpressionAtlasiP11464. baseline and differential.
GenevisibleiP11464. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSG1_HUMAN
AccessioniPrimary (citable) accession number: P11464
Secondary accession number(s): O75236
, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q6ICR4, Q9P1W5, Q9UQ79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.