P11464 (PSG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pregnancy-specific beta-1-glycoprotein 1
Short name=PS-beta-G-1
Short name=PSBG-1
Short name=Pregnancy-specific glycoprotein 1

Alternative name(s):
CD66 antigen-like family member F
Fetal liver non-specific cross-reactive antigen 1/2
Short name=FL-NCA-1/2
PSG95
Pregnancy-specific beta-1 glycoprotein C/D
Short name=PS-beta-C/D
CD_antigen=CD66f

Gene names

Name:	PSG1
Synonyms:	B1G1, PSBG1, PSGGA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Developmental stage	PSBG are produced in high quantity during pregnancy.
Sequence similarities	Belongs to the immunoglobulin superfamily. CEA family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	female pregnancy Traceable author statement PubMed 1572651. Source: ProtInc
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P11464-1)

Also known as: PSG-1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P11464-2)

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → AYSSSINYTSGNRN

Isoform 3 (identifier: P11464-3)

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → EAL

Isoform 4 (identifier: P11464-4)

Also known as: PSG-1d;

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → GKWIPASLAIGF

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34
	Chain	35 – 419	385	Pregnancy-specific beta-1-glycoprotein 1		PRO_0000014908
Regions
	Domain	35 – 144	110	Ig-like V-type
	Domain	149 – 234	86	Ig-like C2-type 1
	Domain	240 – 327	88	Ig-like C2-type 2
	Domain	335 – 410	76	Ig-like C2-type 3
Amino acid modifications
	Glycosylation	61	1	N-linked (GlcNAc...) Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	199	1	N-linked (GlcNAc...) Potential
	Glycosylation	259	1	N-linked (GlcNAc...) Potential
	Glycosylation	268	1	N-linked (GlcNAc...) Potential
	Glycosylation	303	1	N-linked (GlcNAc...) Potential
	Disulfide bond	169 ↔ 217		Probable
	Disulfide bond	262 ↔ 310		Probable
	Disulfide bond	354 ↔ 394		Probable
Natural variations
	Alternative sequence	415 – 419	5	DWTVP → AYSSSINYTSGNRN in isoform 2.		VSP_002550
	Alternative sequence	415 – 419	5	DWTVP → EAL in isoform 3.		VSP_002549
	Alternative sequence	415 – 419	5	DWTVP → GKWIPASLAIGF in isoform 4.		VSP_002548
	Natural variant	41	1	E → Q. Corresponds to variant rs707744 [ dbSNP | Ensembl ].		VAR_056063
	Natural variant	43	1	T → P. Corresponds to variant rs707745 [ dbSNP | Ensembl ].		VAR_056064
	Natural variant	47	1	E → K. Corresponds to variant rs1058956 [ dbSNP | Ensembl ].		VAR_056065
	Natural variant	63	1	T → A. Corresponds to variant rs1064479 [ dbSNP | Ensembl ].		VAR_056066
	Natural variant	73	1	R → K. Corresponds to variant rs1064480 [ dbSNP | Ensembl ].		VAR_056067
	Natural variant	87	1	E → Q. Corresponds to variant rs1058661 [ dbSNP | Ensembl ].		VAR_056068
	Natural variant	101	1	A → V. Corresponds to variant rs707748 [ dbSNP | Ensembl ].		VAR_056069
	Natural variant	125	1	I → V. Corresponds to variant rs1058960 [ dbSNP | Ensembl ].		VAR_059408
	Natural variant	134	1	V → E. Corresponds to variant rs1058671 [ dbSNP | Ensembl ].		VAR_056070
	Natural variant	197	1	E → K. Corresponds to variant rs1058692 [ dbSNP | Ensembl ].		VAR_056071
	Natural variant	198	1	T → N. Corresponds to variant rs1058693 [ dbSNP | Ensembl ].		VAR_056072
Experimental info
	Sequence conflict	41 – 43	3	EPT → QPP Ref.4
	Sequence conflict	41 – 43	3	EPT → QPP Ref.5
	Sequence conflict	41 – 43	3	EPT → QPP Ref.6
	Sequence conflict	319	1	I → V Ref.5
	Sequence conflict	319	1	I → V Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PSG-1a) [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 5E9855162F0C796D	FASTA	419	47,223
	10 20 30 40 50 60 MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ 70 80 90 100 110 120 NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 130 140 150 160 170 180 TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW 190 200 210 220 230 240 WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP 250 260 270 280 290 300 KPYITINNLN PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV 310 320 330 340 350 360 TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP 370 380 390 400 410 PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA TGKESSKSMT VEVSDWTVP
	Isoform 2 [UniParc]. Checksum: 529C21EFDD8C7159	FASTA	428	48,140
	10 20 30 40 50 60 MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ 70 80 90 100 110 120 NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 130 140 150 160 170 180 TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW 190 200 210 220 230 240 WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP 250 260 270 280 290 300 KPYITINNLN PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV 310 320 330 340 350 360 TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP 370 380 390 400 410 420 PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA TGKESSKSMT VEVSAYSSSI NYTSGNRN
	Isoform 3 [UniParc]. Checksum: B3888EBC796D37BB	FASTA	417	46,937
	10 20 30 40 50 60 MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ 70 80 90 100 110 120 NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 130 140 150 160 170 180 TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW 190 200 210 220 230 240 WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP 250 260 270 280 290 300 KPYITINNLN PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV 310 320 330 340 350 360 TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP 370 380 390 400 410 PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA TGKESSKSMT VEVSEAL
	Isoform 4 (PSG-1d) [UniParc]. Checksum: BF98CAAD8338DD1E	FASTA	426	47,866
	10 20 30 40 50 60 MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ 70 80 90 100 110 120 NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 130 140 150 160 170 180 TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW 190 200 210 220 230 240 WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP 250 260 270 280 290 300 KPYITINNLN PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV 310 320 330 340 350 360 TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP 370 380 390 400 410 420 PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA TGKESSKSMT VEVSGKWIPA SLAIGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family." Streydio C., Lacka K., Swillens S., Vassart G. Biochem. Biophys. Res. Commun. 154:130-137(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen." Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L. DNA 7:545-555(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement." Khan W.N., Hammarstroem S. Biochem. Biophys. Res. Commun. 161:525-535(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[4]	"cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver." Zimmermann W.A., Weiss M., Thompson J.A. Biochem. Biophys. Res. Commun. 163:1197-1209(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4).
[5]	"Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole." Leslie K.K., Watanabe S., Lei K.-J., Chou D.Y., Plouzek C.A., Deng H.-C., Torres J., Chou J.Y. Proc. Natl. Acad. Sci. U.S.A. 87:5822-5826(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4).
[6]	"Isolation and characterization of complementary DNAs encoding human pregnancy-specific beta 1-glycoprotein." Watanabe S., Chou J.Y. J. Biol. Chem. 263:2049-2054(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[7]	"Molecular cloning and expression of cDNA for a carcinoembryonic antigen-related fetal liver glycoprotein." Khan W.N., Osterman A., Hammarstroem S. Proc. Natl. Acad. Sci. U.S.A. 86:3332-3336(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[8]	"Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning." Zoubir F., Khan W.N., Hammarstroem S. Biochem. Biophys. Res. Commun. 169:203-216(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[9]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[10]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
[11]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Placenta.
[13]	"Characterization of upstream promotor region, exon1 and exon2 of the PSG gene family." Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M20881 mRNA. Translation: AAA52603.1. M20879 mRNA. Translation: AAA52602.1. M21822 mRNA. Translation: AAA52601.1. M25385 mRNA. Translation: AAA36513.1. M34715 mRNA. Translation: AAA36511.1. M17908 mRNA. Translation: AAA52590.1. M17909 mRNA. Translation: AAA52591.1. M33663 mRNA. Translation: AAA36517.1. M33664 mRNA. Translation: AAA36515.1. J04539 mRNA. Translation: AAA60204.1. M37397 mRNA. Translation: AAA60960.1. CR450329 mRNA. Translation: CAG29325.1. AC005238 Genomic DNA. Translation: AAC25488.1. AC005238 Genomic DNA. Translation: AAC25489.1. AC005238 Genomic DNA. Translation: AAC25490.1. CH471126 Genomic DNA. Translation: EAW57156.1. BC022338 mRNA. Translation: AAH22338.1. BC058285 mRNA. Translation: AAH58285.1. AH007517 Genomic DNA. Translation: AAD21020.1.
IPI	IPI00163720. IPI00335812. IPI00399104. IPI00827782.
PIR	A27658. A28277. A33258. A35341. A35964. B33258. C43354. D43354. A31135. E32268. E43354.
RefSeq	NP_001171754.1. NM_001184825.1. NP_001171755.1. NM_001184826.1. NP_008836.2. NM_006905.2.
UniGene	Hs.709192.
3D structure databases
ProteinModelPortal	P11464.
ModBase	Search...
Protein-protein interaction databases
IntAct	P11464. 1 interaction.
Protein family/group databases
MEROPS	I43.001.
Polymorphism databases
DMDM	129661.
Proteomic databases
PaxDb	P11464.
PRIDE	P11464.
Protocols and materials databases
DNASU	5669.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000244296; ENSP00000244296; ENSG00000231924. ENST00000312439; ENSP00000308970; ENSG00000231924. ENST00000436291; ENSP00000413041; ENSG00000231924. ENST00000595356; ENSP00000472610; ENSG00000231924.
GeneID	5669.
KEGG	hsa:5669.
UCSC	uc002oug.1. human. uc002ouz.2. human. uc002ovd.1. human.
Organism-specific databases
CTD	5669.
GeneCards	GC19M043348.
HGNC	HGNC:9514. PSG1.
HPA	HPA046327.
MIM	176390. gene.
neXtProt	NX_P11464.
PharmGKB	PA33861.
GenAtlas	Search...
Phylogenomic databases
eggNOG	KOG0619.
HOVERGEN	HBG007922.
KO	K06500.
OMA	FIRHITT.
OrthoDB	EOG41ZFBV.
Gene expression databases
ArrayExpress	P11464.
Bgee	P11464.
Genevestigator	P11464.
GermOnline	ENSG00000131113. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 3 hits. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5669.
NextBio	22016.
SOURCE	Search...

Entry information

Entry name

PSG1_HUMAN

Accession

Primary (citable) accession number: P11464
Secondary accession number(s): O75236 , P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q6ICR4, Q9P1W5, Q9UQ79

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	May 1, 2013
This is version 136 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.