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Protein

Cation-dependent mannose-6-phosphate receptor

Gene

M6PR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Miscellaneous

This receptor has optimal binding in the presence of divalent cations.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-BTA-432720. Lysosome Vesicle Biogenesis.
R-BTA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-BTA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-BTA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-dependent mannose-6-phosphate receptor
Short name:
CD Man-6-P receptor
Short name:
CD-MPR
Alternative name(s):
46 kDa mannose 6-phosphate receptor
Short name:
MPR 46
Gene namesi
Name:M6PR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 187LumenalCuratedAdd BLAST159
Transmembranei188 – 213HelicalCuratedAdd BLAST26
Topological domaini214 – 279CytoplasmicCuratedAdd BLAST66

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi246 – 251CRSKPR → AAAAAA: Leads to rapid lysosomal degradation. 1 Publication6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
ChainiPRO_000001922529 – 279Cation-dependent mannose-6-phosphate receptorAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei269PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP11456.
PeptideAtlasiP11456.
PRIDEiP11456.

PTM databases

iPTMnetiP11456.
SwissPalmiP11456.

Expressioni

Gene expression databases

BgeeiENSBTAG00000018207.

Interactioni

Subunit structurei

Homodimer. Interacts with GGA1, GGA2 and GGA3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

ELMiP11456.
STRINGi9913.ENSBTAP00000024233.

Structurei

Secondary structure

1279
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 39Combined sources3
Turni40 – 42Combined sources3
Helixi45 – 53Combined sources9
Helixi55 – 57Combined sources3
Beta strandi62 – 66Combined sources5
Beta strandi73 – 77Combined sources5
Beta strandi79 – 81Combined sources3
Beta strandi84 – 88Combined sources5
Beta strandi90 – 96Combined sources7
Turni97 – 99Combined sources3
Beta strandi102 – 115Combined sources14
Beta strandi117 – 126Combined sources10
Beta strandi131 – 133Combined sources3
Helixi134 – 136Combined sources3
Beta strandi141 – 147Combined sources7
Beta strandi152 – 162Combined sources11
Beta strandi165 – 167Combined sources3
Beta strandi170 – 177Combined sources8
Helixi178 – 180Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C39X-ray1.85A/B31-182[»]
1KEOX-ray2.20A/B29-182[»]
1M6PX-ray1.80A/B31-182[»]
2RL7X-ray2.00A/B/C/D29-182[»]
2RL8X-ray1.45A/B29-182[»]
2RL9X-ray2.40A/B29-182[»]
2RLBX-ray1.75A/B29-182[»]
3CY4X-ray1.51A/B29-182[»]
3K41X-ray1.90A/B29-182[»]
3K42X-ray2.30A/B29-182[»]
3K43X-ray2.00A/B29-182[»]
ProteinModelPortaliP11456.
SMRiP11456.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11456.

Family & Domainsi

Domaini

The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK0D. Eukaryota.
ENOG4111GED. LUCA.
GeneTreeiENSGT00390000002109.
HOGENOMiHOG000013085.
HOVERGENiHBG006395.
InParanoidiP11456.
KOiK10089.
OMAiSDWIMLI.
OrthoDBiEOG091G0WP5.
TreeFamiTF328910.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiView protein in InterPro
IPR028927. Man-6-P_rcpt.
IPR000296. Man-6-P_rcpt_cation_dep.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
PANTHERiPTHR15071:SF11. PTHR15071:SF11. 1 hit.
PfamiView protein in Pfam
PF02157. Man-6-P_recep. 1 hit.
PRINTSiPR00715. MAN6PRECEPTR.
SUPFAMiSSF50911. SSF50911. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSPLHSSWR TGLLLLLLFS VAVRESWQTE EKTCDLVGEK GKESEKELAL
60 70 80 90 100
LKRLTPLFNK SFESTVGQSP DMYSYVFRVC REAGNHSSGA GLVQINKSNG
110 120 130 140 150
KETVVGRFNE TQIFNGSNWI MLIYKGGDEY DNHCGREQRR AVVMISCNRH
160 170 180 190 200
TLADNFNPVS EERGKVQDCF YLFEMDSSLA CSPEISHLSV GSILLVTLAS
210 220 230 240 250
LVAVYIIGGF LYQRLVVGAK GMEQFPHLAF WQDLGNLVAD GCDFVCRSKP
260 270
RNVPAAYRGV GDDQLGEESE ERDDHLLPM
Length:279
Mass (Da):31,201
Last modified:October 1, 1989 - v1
Checksum:i7351C85A32F39A70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17025 mRNA. Translation: AAA30634.1.
BT029887 mRNA. Translation: ABM06137.1.
BC120081 mRNA. Translation: AAI20082.1.
PIRiA27068.
RefSeqiNP_786973.1. NM_175779.3.
UniGeneiBt.5032.

Genome annotation databases

EnsembliENSBTAT00000024233; ENSBTAP00000024233; ENSBTAG00000018207.
GeneIDi281291.
KEGGibta:281291.

Similar proteinsi

Entry informationi

Entry nameiMPRD_BOVIN
AccessioniPrimary (citable) accession number: P11456
Secondary accession number(s): A1L5A0, Q0VCN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 27, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references