P11450 (FCP3C_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Follicle cell protein 3C-1

Gene names

Name:	Fcp3C
ORF Names:	CG4015

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity

Expressed in follicle cells during vitelline membrane formation. Ref.1

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P11450-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform B (identifier: P11450-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Follicle cell protein 3C-1		PRO_0000087209
Natural variations
	Alternative sequence	1 – 69	69	Missing in isoform B.		VSP_037382
	Natural variant	71	1	S → I in strain: Usa13. Ref.2
	Natural variant	74	1	G → A in strain: Usa3, Usa16, Zim7, Zim10, Zim13, Zim16, Zim18, Zim22, Zim39, Zim41, Zim42, Z36 and Z50. Ref.2
	Natural variant	75	1	V → A in strain: Usa3, Zim7, Zim10, Zim13, Zim16, Zim18, Zim22, Zim39, Zim41, Zim42, Z36 and Z50. Ref.2
	Natural variant	77	1	S → T in strain: Usa3, Usa16, Zim7, Zim10, Zim13, Zim16, Zim18, Zim22, Zim39, Zim41, Zim42, Z36 and Z50. Ref.2
	Natural variant	82	1	A → T in strain: Zim39. Ref.2
	Natural variant	108	1	T → S in strain: Zim10, Zim13, Zim16, Zim18, Zim39, Z36 and Z50. Ref.2
	Natural variant	109	1	I → V in strain: Zim10, Zim13, Zim16, Zim18, Zim39, Z36 and Z50. Ref.2
	Natural variant	125	1	I → T in strain: Zim41. Ref.2
	Natural variant	135	1	M → I in strain: Zim15 and Z50. Ref.2
	Natural variant	140	1	A → V in strain: Zim41. Ref.2
	Natural variant	143	1	L → P in strain: Usa1, Zim15, Zim18, Zim22, Zim39 and Zim42. Ref.2
	Natural variant	152	1	S → G in strain: Zim13. Ref.2
	Natural variant	163	1	T → K in strain: Z50. Ref.2
	Natural variant	164	1	A → T in strain: Usa8, Usa12, Usa16, Zim7, Zim10, Zim13, Zim15, Zim16, Zim18, Zim22, Zim39, Zim42, Z36 and Z50. Ref.2
	Natural variant	167	1	P → H in strain: Usa8 and Usa12. Ref.1 Ref.2
	Natural variant	168	1	V → A in strain: Usa8, Usa12, Usa16, Zim18, Zim39 and Zim41. Ref.1 Ref.2
Experimental info
	Sequence conflict	272 – 282	11	SGVPYRCPLMG → LGFPTVAH in AAA29016. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified May 26, 2009. Version 3. Checksum: 77BDD931187DC498	FASTA	282	30,300
	10 20 30 40 50 60 MDGAKAEVFS VSVDTKMGAF KNSLLLLTLL LAIHLEASKI VYKKPLYGNS NIIKDKRIKT 70 80 90 100 110 120 KPVKLETSTM SSTGVASSST TAEEDWPTAV EFVIMTTPAS ELEASTETIG NNGTTETTVG 130 140 150 160 170 180 EAPIIGSSEG STRSMEPTTA SPLMSTNPSS SSSLVSTIPL PPTAGLPVQD NQPVPCTCGV 190 200 210 220 230 240 FLSSQIPNGL PTKPLIHQEL DHMFPCNAIG RKQCQTKCLE TIVQHLPNSA NIVCSALGHD 250 260 270 280 CHKERAYLFI KNCHNQWVNT NLQAGREYCC RSGVPYRCPL MG
	Isoform B [UniParc]. Checksum: A5BF92F6DAAC2AE2	FASTA	213	22,697
	10 20 30 40 50 60 MSSTGVASSS TTAEEDWPTA VEFVIMTTPA SELEASTETI GNNGTTETTV GEAPIIGSSE 70 80 90 100 110 120 GSTRSMEPTT ASPLMSTNPS SSSSLVSTIP LPPTAGLPVQ DNQPVPCTCG VFLSSQIPNG 130 140 150 160 170 180 LPTKPLIHQE LDHMFPCNAI GRKQCQTKCL ETIVQHLPNS ANIVCSALGH DCHKERAYLF 190 200 210 IKNCHNQWVN TNLQAGREYC CRSGVPYRCP LMG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and sequence of follicle cell genes selectively expressed during vitelline membrane formation in Drosophila." Burke T., Waring G.L., Popodi E., Minoo P. Dev. Biol. 124:441-450(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, VARIANTS HIS-167 AND ALA-168. Tissue: Ovary.
[2]	"Multiple signatures of positive selection downstream of notch on the X chromosome in Drosophila melanogaster." DuMont V.B., Aquadro C.F. Genetics 171:639-653(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-71; ALA-74; ALA-75; THR-77; THR-82; SER-108; VAL-109; THR-125; ILE-135; VAL-140; PRO-143; GLY-152; LYS-163; THR-164; HIS-167 AND ALA-168. Strain: Usa1, Usa11, Usa12, Usa13, Usa15, Usa16, Usa17, Usa18, Usa2, Usa3, Usa4, Usa6, Usa7, Usa8, Usa9, Z36, Z50, Zim10, Zim13, Zim15, Zim16, Zim18, Zim22, Zim39, Zim41, Zim42 and Zim7.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[5]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Oregon-R.
[6]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M18281 Genomic DNA. Translation: AAA29016.1. AY795911 Genomic DNA. Translation: AAY27431.1. AY795912 Genomic DNA. Translation: AAY27436.1. AY795914 Genomic DNA. Translation: AAY27444.1. AY795913 Genomic DNA. Translation: AAY27440.1. AY795915 Genomic DNA. Translation: AAY27448.1. AY795916 Genomic DNA. Translation: AAY27452.1. AY795917 Genomic DNA. Translation: AAY27456.1. AY795918 Genomic DNA. Translation: AAY27460.1. AY795919 Genomic DNA. Translation: AAY27464.1. AY795920 Genomic DNA. Translation: AAY27468.1. AY795921 Genomic DNA. Translation: AAY27472.1. AY795922 Genomic DNA. Translation: AAY27476.1. AY795923 Genomic DNA. Translation: AAY27480.1. AY795924 Genomic DNA. Translation: AAY27484.1. AY795925 Genomic DNA. Translation: AAY27488.1. AY795926 Genomic DNA. Translation: AAY27492.1. AY795927 Genomic DNA. Translation: AAY27496.1. AY795928 Genomic DNA. Translation: AAY27500.1. AY795929 Genomic DNA. Translation: AAY27504.1. AY795930 Genomic DNA. Translation: AAY27508.1. AY795931 Genomic DNA. Translation: AAY27512.1. AY795932 Genomic DNA. Translation: AAY27516.1. AY795933 Genomic DNA. Translation: AAY27520.1. AY795934 Genomic DNA. Translation: AAY27524.1. AY795935 Genomic DNA. Translation: AAY27528.1. AY795936 Genomic DNA. Translation: AAY27532.1. AY795937 Genomic DNA. Translation: AAY27536.1. AE014298 Genomic DNA. Translation: AAF45850.2. AL035395 Genomic DNA. Translation: CAB37613.1. BT025893 mRNA. Translation: ABG02137.1.
PIR	B27249.
RefSeq	NP_477482.2. NM_058134.5.
UniGene	Dm.26446.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P11450. 5 interactions.
MINT	MINT-324079.
STRING	7227.FBpp0070517.
Proteomic databases
PaxDb	P11450.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0070542; FBpp0070517; FBgn0000644.
GeneID	31294.
KEGG	dme:Dmel_CG4015.
Organism-specific databases
CTD	31294.
FlyBase	FBgn0000644. Fcp3C.
Phylogenomic databases
eggNOG	NOG128326.
InParanoid	P11450.
OMA	GREYCCR.
OrthoDB	EOG4K98VM.
PhylomeDB	P11450.
Gene expression databases
Bgee	P11450.
GermOnline	CG4015. Drosophila melanogaster.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	31294.
NextBio	772903.

Entry information

Entry name

FCP3C_DROME

Accession

Primary (citable) accession number: P11450
Secondary accession number(s): O97173 , Q32UU7, Q32UV1, Q32UV5, Q32UV9, Q32UW7, Q32UX5, Q32UX9, Q32UY3, Q32UY7, Q32UZ9, Q32V15, Q32V31, Q32V35, Q32V47, Q32V51

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	May 26, 2009
Last modified:	April 3, 2013
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project