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Protein

N-acetyl-gamma-glutamyl-phosphate reductase

Gene

argC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.UniRule annotation1 Publication

Catalytic activityi

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.UniRule annotation1 Publication

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation1 Publication
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase (argA)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine/succinyldiaminopimelate aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei154UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • arginine biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciEcoCyc:N-ACETYLGLUTPREDUCT-MONOMER
MetaCyc:N-ACETYLGLUTPREDUCT-MONOMER
BRENDAi1.2.1.38 2026
UniPathwayiUPA00068; UER00108

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductaseUniRule annotationCurated (EC:1.2.1.38UniRule annotation1 Publication)
Short name:
AGPRUniRule annotationCurated
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase1 PublicationUniRule annotation
Short name:
NAGSA dehydrogenase1 PublicationUniRule annotation
Gene namesi
Name:argCUniRule annotation
Ordered Locus Names:b3958, JW3930
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10065 argC

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001124011 – 334N-acetyl-gamma-glutamyl-phosphate reductaseAdd BLAST334

Proteomic databases

EPDiP11446
PaxDbiP11446
PRIDEiP11446

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi42621906 interactors.
IntActiP11446 1 interactor.
STRINGi316385.ECDH10B_4146

Structurei

3D structure databases

ProteinModelPortaliP11446
SMRiP11446
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105C0N Bacteria
COG0002 LUCA
HOGENOMiHOG000254902
InParanoidiP11446
KOiK00145
OMAiTFVPHLT
PhylomeDBiP11446

Family and domain databases

HAMAPiMF_00150 ArgC_type1, 1 hit
InterProiView protein in InterPro
IPR023013 AGPR_AS
IPR000706 AGPR_type-1
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
IPR012280 Semialdhyde_DH_dimer_dom
PfamiView protein in Pfam
PF01118 Semialdhyde_dh, 1 hit
PF02774 Semialdhyde_dhC, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01850 argC, 1 hit
PROSITEiView protein in PROSITE
PS01224 ARGC, 1 hit

Sequencei

Sequence statusi: Complete.

P11446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNTLIVGAS GYAGAELVTY VNRHPHMNIT ALTVSAQSND AGKLISDLHP
60 70 80 90 100
QLKGIVDLPL QPMSDISEFS PGVDVVFLAT AHEVSHDLAP QFLEAGCVVF
110 120 130 140 150
DLSGAFRVND ATFYEKYYGF THQYPELLEQ AAYGLAEWCG NKLKEANLIA
160 170 180 190 200
VPGCYPTAAQ LALKPLIDAD LLDLNQWPVI NATSGVSGAG RKAAISNSFC
210 220 230 240 250
EVSLQPYGVF THRHQPEIAT HLGADVIFTP HLGNFPRGIL ETITCRLKSG
260 270 280 290 300
VTQAQVAQVL QQAYAHKPLV RLYDKGVPAL KNVVGLPFCD IGFAVQGEHL
310 320 330
IIVATEDNLL KGAAAQAVQC ANIRFGYAET QSLI
Length:334
Mass (Da):35,952
Last modified:October 1, 1989 - v1
Checksum:i67AC195ECE1C4789
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21446 Genomic DNA Translation: AAA23477.1
U00006 Genomic DNA Translation: AAC43064.1
U00096 Genomic DNA Translation: AAC76940.1
AP009048 Genomic DNA Translation: BAE77353.1
J01587 Genomic DNA Translation: AAB59146.1
X55417 Genomic DNA No translation available.
PIRiJT0332 RDECEP
RefSeqiNP_418393.1, NC_000913.3
WP_000935370.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76940; AAC76940; b3958
BAE77353; BAE77353; BAE77353
GeneIDi948455
KEGGiecj:JW3930
eco:b3958
PATRICifig|1411691.4.peg.2747

Similar proteinsi

Entry informationi

Entry nameiARGC_ECOLI
AccessioniPrimary (citable) accession number: P11446
Secondary accession number(s): Q2M8Q3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: March 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome