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Protein

N-acetyl-gamma-glutamyl-phosphate reductase

Gene

argC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.UniRule annotation1 Publication

Catalytic activityi

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.UniRule annotation1 Publication

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation1 Publication
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase (argA)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine/succinyldiaminopimelate aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei154UniRule annotation1

GO - Molecular functioni

  • N-acetyl-gamma-glutamyl-phosphate reductase activity Source: EcoCyc
  • NAD binding Source: InterPro

GO - Biological processi

  • arginine biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciEcoCyc:N-ACETYLGLUTPREDUCT-MONOMER.
MetaCyc:N-ACETYLGLUTPREDUCT-MONOMER.
BRENDAi1.2.1.38. 2026.
UniPathwayiUPA00068; UER00108.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductaseUniRule annotationCurated (EC:1.2.1.38UniRule annotation1 Publication)
Short name:
AGPRUniRule annotationCurated
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase1 PublicationUniRule annotation
Short name:
NAGSA dehydrogenase1 PublicationUniRule annotation
Gene namesi
Name:argCUniRule annotation
Ordered Locus Names:b3958, JW3930
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10065. argC.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001124011 – 334N-acetyl-gamma-glutamyl-phosphate reductaseAdd BLAST334

Proteomic databases

EPDiP11446.
PaxDbiP11446.
PRIDEiP11446.

Interactioni

Protein-protein interaction databases

BioGridi4262190. 6 interactors.
IntActiP11446. 1 interactor.
STRINGi511145.b3958.

Structurei

3D structure databases

ProteinModelPortaliP11446.
SMRiP11446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105C0N. Bacteria.
COG0002. LUCA.
HOGENOMiHOG000254902.
InParanoidiP11446.
KOiK00145.
OMAiTFVPHLT.
PhylomeDBiP11446.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00150. ArgC_type1. 1 hit.
InterProiView protein in InterPro
IPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
PfamiView protein in Pfam
PF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
PROSITEiView protein in PROSITE
PS01224. ARGC. 1 hit.

Sequencei

Sequence statusi: Complete.

P11446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNTLIVGAS GYAGAELVTY VNRHPHMNIT ALTVSAQSND AGKLISDLHP
60 70 80 90 100
QLKGIVDLPL QPMSDISEFS PGVDVVFLAT AHEVSHDLAP QFLEAGCVVF
110 120 130 140 150
DLSGAFRVND ATFYEKYYGF THQYPELLEQ AAYGLAEWCG NKLKEANLIA
160 170 180 190 200
VPGCYPTAAQ LALKPLIDAD LLDLNQWPVI NATSGVSGAG RKAAISNSFC
210 220 230 240 250
EVSLQPYGVF THRHQPEIAT HLGADVIFTP HLGNFPRGIL ETITCRLKSG
260 270 280 290 300
VTQAQVAQVL QQAYAHKPLV RLYDKGVPAL KNVVGLPFCD IGFAVQGEHL
310 320 330
IIVATEDNLL KGAAAQAVQC ANIRFGYAET QSLI
Length:334
Mass (Da):35,952
Last modified:October 1, 1989 - v1
Checksum:i67AC195ECE1C4789
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21446 Genomic DNA. Translation: AAA23477.1.
U00006 Genomic DNA. Translation: AAC43064.1.
U00096 Genomic DNA. Translation: AAC76940.1.
AP009048 Genomic DNA. Translation: BAE77353.1.
J01587 Genomic DNA. Translation: AAB59146.1.
X55417 Genomic DNA. No translation available.
PIRiJT0332. RDECEP.
RefSeqiNP_418393.1. NC_000913.3.
WP_000935370.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76940; AAC76940; b3958.
BAE77353; BAE77353; BAE77353.
GeneIDi948455.
KEGGiecj:JW3930.
eco:b3958.
PATRICi32123437. VBIEscCol129921_4079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21446 Genomic DNA. Translation: AAA23477.1.
U00006 Genomic DNA. Translation: AAC43064.1.
U00096 Genomic DNA. Translation: AAC76940.1.
AP009048 Genomic DNA. Translation: BAE77353.1.
J01587 Genomic DNA. Translation: AAB59146.1.
X55417 Genomic DNA. No translation available.
PIRiJT0332. RDECEP.
RefSeqiNP_418393.1. NC_000913.3.
WP_000935370.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP11446.
SMRiP11446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262190. 6 interactors.
IntActiP11446. 1 interactor.
STRINGi511145.b3958.

Proteomic databases

EPDiP11446.
PaxDbiP11446.
PRIDEiP11446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76940; AAC76940; b3958.
BAE77353; BAE77353; BAE77353.
GeneIDi948455.
KEGGiecj:JW3930.
eco:b3958.
PATRICi32123437. VBIEscCol129921_4079.

Organism-specific databases

EchoBASEiEB0063.
EcoGeneiEG10065. argC.

Phylogenomic databases

eggNOGiENOG4105C0N. Bacteria.
COG0002. LUCA.
HOGENOMiHOG000254902.
InParanoidiP11446.
KOiK00145.
OMAiTFVPHLT.
PhylomeDBiP11446.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00108.
BioCyciEcoCyc:N-ACETYLGLUTPREDUCT-MONOMER.
MetaCyc:N-ACETYLGLUTPREDUCT-MONOMER.
BRENDAi1.2.1.38. 2026.

Miscellaneous databases

PROiP11446.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00150. ArgC_type1. 1 hit.
InterProiView protein in InterPro
IPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
PfamiView protein in Pfam
PF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
PROSITEiView protein in PROSITE
PS01224. ARGC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARGC_ECOLI
AccessioniPrimary (citable) accession number: P11446
Secondary accession number(s): Q2M8Q3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: March 15, 2017
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.