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Protein

Ubiquitin-like protein 4A

Gene

UBL4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting.1 Publication

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL
  • ubiquitin-like protein transferase activity Source: ProtInc

GO - Biological processi

  • cellular protein modification process Source: ProtInc
  • tail-anchored membrane protein insertion into ER membrane Source: UniProtKB
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 4A
Alternative name(s):
Ubiquitin-like protein GDX
Gene namesi
Name:UBL4A
Synonyms:DXS254E, GDX, UBL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12505. UBL4A.

Subcellular locationi

GO - Cellular componenti

  • BAT3 complex Source: UniProtKB
  • cytoplasm Source: ParkinsonsUK-UCL
  • cytosol Source: UniProtKB
  • membrane Source: ParkinsonsUK-UCL
  • nucleus Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi8266.
OpenTargetsiENSG00000102178.
PharmGKBiPA37152.

Polymorphism and mutation databases

DMDMi136662.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001148641 – 157Ubiquitin-like protein 4AAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP11441.
MaxQBiP11441.
PaxDbiP11441.
PeptideAtlasiP11441.
PRIDEiP11441.

PTM databases

iPTMnetiP11441.
PhosphoSitePlusiP11441.

Expressioni

Gene expression databases

BgeeiENSG00000102178.
CleanExiHS_UBL4A.
ExpressionAtlasiP11441. baseline and differential.
GenevisibleiP11441. HS.

Organism-specific databases

HPAiHPA003617.

Interactioni

Subunit structurei

Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET4/TRC35.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDCA7LQ96GN53EBI-356983,EBI-5278764
MEOX2A4D1273EBI-356983,EBI-10172134
SGTAO437654EBI-356983,EBI-347996
TRAF4Q9BUZ43EBI-356983,EBI-3650647
vifP125042EBI-356983,EBI-779991From a different organism.

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi113885. 307 interactors.
IntActiP11441. 49 interactors.
MINTiMINT-1147351.
STRINGi9606.ENSP00000358674.

Structurei

Secondary structure

1157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 7Combined sources7
Beta strandi12 – 17Combined sources6
Helixi23 – 33Combined sources11
Turni38 – 40Combined sources3
Beta strandi42 – 45Combined sources4
Helixi56 – 59Combined sources4
Beta strandi63 – 65Combined sources3
Beta strandi68 – 70Combined sources3
Helixi95 – 106Combined sources12
Helixi109 – 129Combined sources21
Helixi132 – 142Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DZINMR-A1-74[»]
4WWRX-ray2.00B/D/F/H93-139[»]
4X86X-ray1.85A95-147[»]
ProteinModelPortaliP11441.
SMRiP11441.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11441.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00730000111022.
HOGENOMiHOG000006827.
HOVERGENiHBG072205.
InParanoidiP11441.
OMAiQRDYDRS.
PhylomeDBiP11441.
TreeFamiTF354228.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLTVKALQG RECSLQVPED ELVSTLKQLV SEKLNVPVRQ QRLLFKGKAL
60 70 80 90 100
ADGKRLSDYS IGPNSKLNLV VKPLEKVLLE EGEAQRLADS PPPQVWQLIS
110 120 130 140 150
KVLARHFSAA DASRVLEQLQ RDYERSLSRL TLDDIERLAS RFLHPEVTET

MEKGFSK
Length:157
Mass (Da):17,777
Last modified:October 1, 1989 - v1
Checksum:i9D6EE2D20D2C4C60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03589 Genomic DNA. Translation: AAA36790.1.
L44140 Genomic DNA. Translation: AAA92650.1.
BX664739 Genomic DNA. Translation: CAI43235.1.
CH471172 Genomic DNA. Translation: EAW72700.1.
BC043346 mRNA. Translation: AAH43346.1.
BC053589 mRNA. Translation: AAH53589.1.
CCDSiCCDS14754.1.
PIRiA31084.
RefSeqiNP_055050.1. NM_014235.4.
UniGeneiHs.76480.

Genome annotation databases

EnsembliENST00000369660; ENSP00000358674; ENSG00000102178.
GeneIDi8266.
KEGGihsa:8266.
UCSCiuc004flo.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03589 Genomic DNA. Translation: AAA36790.1.
L44140 Genomic DNA. Translation: AAA92650.1.
BX664739 Genomic DNA. Translation: CAI43235.1.
CH471172 Genomic DNA. Translation: EAW72700.1.
BC043346 mRNA. Translation: AAH43346.1.
BC053589 mRNA. Translation: AAH53589.1.
CCDSiCCDS14754.1.
PIRiA31084.
RefSeqiNP_055050.1. NM_014235.4.
UniGeneiHs.76480.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DZINMR-A1-74[»]
4WWRX-ray2.00B/D/F/H93-139[»]
4X86X-ray1.85A95-147[»]
ProteinModelPortaliP11441.
SMRiP11441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113885. 307 interactors.
IntActiP11441. 49 interactors.
MINTiMINT-1147351.
STRINGi9606.ENSP00000358674.

PTM databases

iPTMnetiP11441.
PhosphoSitePlusiP11441.

Polymorphism and mutation databases

DMDMi136662.

Proteomic databases

EPDiP11441.
MaxQBiP11441.
PaxDbiP11441.
PeptideAtlasiP11441.
PRIDEiP11441.

Protocols and materials databases

DNASUi8266.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369660; ENSP00000358674; ENSG00000102178.
GeneIDi8266.
KEGGihsa:8266.
UCSCiuc004flo.4. human.

Organism-specific databases

CTDi8266.
DisGeNETi8266.
GeneCardsiUBL4A.
HGNCiHGNC:12505. UBL4A.
HPAiHPA003617.
MIMi312070. gene.
neXtProtiNX_P11441.
OpenTargetsiENSG00000102178.
PharmGKBiPA37152.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00730000111022.
HOGENOMiHOG000006827.
HOVERGENiHBG072205.
InParanoidiP11441.
OMAiQRDYDRS.
PhylomeDBiP11441.
TreeFamiTF354228.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102178-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP11441.
GeneWikiiUBL4A.
GenomeRNAii8266.
PROiP11441.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102178.
CleanExiHS_UBL4A.
ExpressionAtlasiP11441. baseline and differential.
GenevisibleiP11441. HS.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBL4A_HUMAN
AccessioniPrimary (citable) accession number: P11441
Secondary accession number(s): Q5HY80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.