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Protein

Lysosome-associated membrane glycoprotein 1

Gene

Lamp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

GO - Molecular functioni

  • enzyme binding Source: MGI
  • protein domain specific binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
120 kDa lysosomal membrane glycoprotein
CD107 antigen-like family member A
LGP-120
Lysosomal membrane glycoprotein A
Short name:
LGP-A
P2B
CD_antigen: CD107a
Gene namesi
Name:Lamp1
Synonyms:Lamp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96745. Lamp1.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Endosome membrane By similarity; Single-pass type I membrane protein By similarity
  • Lysosome membrane By similarity; Single-pass type I membrane protein By similarity
  • Late endosome By similarity

  • Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 370LumenalSequence analysisAdd BLAST346
Transmembranei371 – 394HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini395 – 406CytoplasmicPROSITE-ProRule annotationAdd BLAST12

GO - Cellular componenti

  • alveolar lamellar body Source: Ensembl
  • autolysosome Source: MGI
  • cell surface Source: BHF-UCL
  • cytolytic granule Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: GOC
  • dendrite Source: Ensembl
  • endosome Source: MGI
  • endosome membrane Source: UniProtKB
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: MGI
  • lysosome Source: MGI
  • melanosome Source: MGI
  • membrane Source: MGI
  • multivesicular body Source: MGI
  • neuronal cell body Source: Ensembl
  • perinuclear region of cytoplasm Source: MGI
  • phagocytic vesicle Source: AgBase
  • phagolysosome membrane Source: MGI
  • plasma membrane Source: MGI
  • sarcolemma Source: MGI
  • synaptic vesicle Source: MGI
  • vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001710525 – 406Lysosome-associated membrane glycoprotein 1Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi35 ↔ 74PROSITE-ProRule annotation1 Publication
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Glycosylationi97N-linked (GlcNAc...)2 Publications1
Glycosylationi101N-linked (GlcNAc...)1 Publication1
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 185PROSITE-ProRule annotation1 Publication
Glycosylationi159N-linked (GlcNAc...)1 Publication1
Glycosylationi177N-linked (GlcNAc...)2 Publications1
Glycosylationi214N-linked (GlcNAc...)Sequence analysis1
Glycosylationi219N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi222 ↔ 259PROSITE-ProRule annotation1 Publication
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Glycosylationi240N-linked (GlcNAc...)Sequence analysis1
Glycosylationi252N-linked (GlcNAc...) (high mannose)1 Publication1
Glycosylationi282N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi327 ↔ 364PROSITE-ProRule annotation1 Publication

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP11438.
PaxDbiP11438.
PeptideAtlasiP11438.
PRIDEiP11438.

PTM databases

iPTMnetiP11438.
PhosphoSitePlusiP11438.
UniCarbKBiP11438.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031447.
CleanExiMM_LAMP1.
ExpressionAtlasiP11438. baseline and differential.
GenevisibleiP11438. MM.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: MGI
  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

IntActiP11438. 18 interactors.
MINTiMINT-1858576.
STRINGi10090.ENSMUSP00000033824.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GV0X-ray1.50A208-370[»]
ProteinModelPortaliP11438.
SMRiP11438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 188First lumenal domainAdd BLAST164
Regioni189 – 218HingeAdd BLAST30
Regioni219 – 370Second lumenal domainAdd BLAST152

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP11438.
KOiK06528.
OMAiETRCEQD.
OrthoDBiEOG091G09EV.
PhylomeDBiP11438.
TreeFamiTF316339.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGARRPL LLLLLAGLAH GASALFEVKN NGTTCIMASF SASFLTTYET
60 70 80 90 100
ANGSQIVNIS LPASAEVLKN GSSCGKENVS DPSLTITFGR GYLLTLNFTK
110 120 130 140 150
NTTRYSVQHM YFTYNLSDTE HFPNAISKEI YTMDSTTDIK ADINKAYRCV
160 170 180 190 200
SDIRVYMKNV TVVLRDATIQ AYLSSGNFSK EETHCTQDGP SPTTGPPSPS
210 220 230 240 250
PPLVPTNPTV SKYNVTGNNG TCLLASMALQ LNITYLKKDN KTVTRAFNIS
260 270 280 290 300
PNDTSSGSCG INLVTLKVEN KNRALELQFG MNASSSLFFL QGVRLNMTLP
310 320 330 340 350
DALVPTFSIS NHSLKALQAT VGNSYKCNTE EHIFVSKMLS LNVFSVQVQA
360 370 380 390 400
FKVDSDRFGS VEECVQDGNN MLIPIAVGGA LAGLVLIVLI AYLIGRKRSH

AGYQTI
Length:406
Mass (Da):43,865
Last modified:August 1, 1990 - v2
Checksum:iC1BD373548BB9655
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 10MAAPGARRPL → MRPPRAAAV (PubMed:2676155).Curated10
Sequence conflicti25 – 26LF → IP in AAA39411 (PubMed:3379044).Curated2
Sequence conflicti385V → I (PubMed:2676155).Curated1
Sequence conflicti385V → I (PubMed:3379044).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32015 mRNA. Translation: AAA39428.1.
M25244 mRNA. Translation: AAA39869.1.
BC049097 mRNA. Translation: AAH49097.1.
J03881 mRNA. Translation: AAA39411.1.
CCDSiCCDS22106.1.
PIRiA28067.
A60534.
RefSeqiNP_001304282.1. NM_001317353.1.
NP_034814.2. NM_010684.3.
UniGeneiMm.16716.

Genome annotation databases

EnsembliENSMUST00000033824; ENSMUSP00000033824; ENSMUSG00000031447.
GeneIDi16783.
KEGGimmu:16783.
UCSCiuc009kxa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32015 mRNA. Translation: AAA39428.1.
M25244 mRNA. Translation: AAA39869.1.
BC049097 mRNA. Translation: AAH49097.1.
J03881 mRNA. Translation: AAA39411.1.
CCDSiCCDS22106.1.
PIRiA28067.
A60534.
RefSeqiNP_001304282.1. NM_001317353.1.
NP_034814.2. NM_010684.3.
UniGeneiMm.16716.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GV0X-ray1.50A208-370[»]
ProteinModelPortaliP11438.
SMRiP11438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11438. 18 interactors.
MINTiMINT-1858576.
STRINGi10090.ENSMUSP00000033824.

PTM databases

iPTMnetiP11438.
PhosphoSitePlusiP11438.
UniCarbKBiP11438.

Proteomic databases

EPDiP11438.
PaxDbiP11438.
PeptideAtlasiP11438.
PRIDEiP11438.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033824; ENSMUSP00000033824; ENSMUSG00000031447.
GeneIDi16783.
KEGGimmu:16783.
UCSCiuc009kxa.1. mouse.

Organism-specific databases

CTDi3916.
MGIiMGI:96745. Lamp1.

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP11438.
KOiK06528.
OMAiETRCEQD.
OrthoDBiEOG091G09EV.
PhylomeDBiP11438.
TreeFamiTF316339.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiLamp1. mouse.
PROiP11438.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031447.
CleanExiMM_LAMP1.
ExpressionAtlasiP11438. baseline and differential.
GenevisibleiP11438. MM.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP1_MOUSE
AccessioniPrimary (citable) accession number: P11438
Secondary accession number(s): Q62020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.