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Protein

Carboxyvinyl-carboxyphosphonate phosphorylmutase

Gene

bcpA

Organism
Streptomyces hygroscopicus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos (BA). Catalyzes the rearrangement of the carboxyphosphono group of CPEP to form the C-P bond of phosphinopyruvate.

Catalytic activityi

1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2.

Pathwayi: bialaphos biosynthesis

This protein is involved in the pathway bialaphos biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bialaphos biosynthesis and in Secondary metabolite biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAntibiotic biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15044.
UniPathwayiUPA00197.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxyvinyl-carboxyphosphonate phosphorylmutase (EC:2.7.8.23)
Alternative name(s):
Carboxyphosphonoenolpyruvate phosphonomutase
Short name:
CPEP phosphonomutase
Gene namesi
Name:bcpA
OrganismiStreptomyces hygroscopicus
Taxonomic identifieri1912 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000688182 – 295Carboxyvinyl-carboxyphosphonate phosphorylmutaseAdd BLAST294

Proteomic databases

PRIDEiP11435.

Structurei

3D structure databases

ProteinModelPortaliP11435.
SMRiP11435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK12909.

Family and domain databases

InterProiView protein in InterPro
IPR012697. CPEP_Pphonmut.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02319. CPEP_Pphonmut. 1 hit.
PROSITEiView protein in PROSITE
PS00161. ISOCITRATE_LYASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTKARTFR ELMNAPEILV VPSAYDALSA KVIQQAGFPA VHMTGSGTSA
60 70 80 90 100
SMLGLPDLGF TSVSEQAINL KNIVLTVDVP VIMDADAGYG NAMSVWRATR
110 120 130 140 150
EFERVGIVGY HLEDQVNPKR CGHLEGKRLI STEEMTGKIE AAVEAREDED
160 170 180 190 200
FTIIARTDAR ESFGLDEAIR RSREYVAAGA DCIFLEAMLD VEEMKRVRDE
210 220 230 240 250
IDAPLLANMV EGGKTPWLTT KELESIGYNL AIYPLSGWMA AASVLRKLFT
260 270 280 290
ELREAGTTQK FWDDMGLKMS FAELFEVFEY SKISELEARF VRDQD
Length:295
Mass (Da):32,781
Last modified:January 23, 2007 - v3
Checksum:i0C45482B24984256
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti68I → T in strain: ATCC 21705. 1
Natural varianti70L → A in strain: ATCC 21705. 1
Natural varianti76T → A in strain: ATCC 21705. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00609 Genomic DNA. Translation: BAA00484.1.
M17150 Genomic DNA. Translation: AAA26711.1.
X67953 Genomic DNA. Translation: CAA48139.1.
PIRiS23585.

Genome annotation databases

KEGGiag:CAA48139.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCPPM_STRHY
AccessioniPrimary (citable) accession number: P11435
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 84 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families