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Protein

Cell division control protein 24

Gene

CDC24

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the exchange of CDC42-bound GDP by GTP. Controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. CDC24 may be involved in the initial selection and organization of the budding site.1 Publication

GO - Molecular functioni

  • Rho guanyl-nucleotide exchange factor activity Source: SGD

GO - Biological processi

  • cellular bud site selection Source: SGD
  • protein localization to cell cortex Source: SGD
  • regulation of exit from mitosis Source: SGD
  • regulation of Rho protein signal transduction Source: InterPro
  • septin ring organization Source: SGD
  • small GTPase mediated signal transduction Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

BioCyciYEAST:G3O-28849-MONOMER.
ReactomeiR-SCE-193648. NRAGE signals death through JNK.
R-SCE-194840. Rho GTPase cycle.
R-SCE-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 24
Alternative name(s):
Calcium regulatory protein
Gene namesi
Name:CDC24
Synonyms:CLS4
Ordered Locus Names:YAL041W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL041W.
SGDiS000000039. CDC24.

Subcellular locationi

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • cellular bud tip Source: SGD
  • cytoplasm Source: SGD
  • incipient cellular bud site Source: SGD
  • mating projection tip Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 854854Cell division control protein 24PRO_0000080934Add
BLAST

Proteomic databases

MaxQBiP11433.

PTM databases

iPTMnetiP11433.

Interactioni

Subunit structurei

Interacts with AXL2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BEM1P2936613EBI-4220,EBI-3508
FAR1P212688EBI-4220,EBI-6780
NBA1Q082296EBI-4220,EBI-36841

Protein-protein interaction databases

BioGridi31724. 176 interactions.
DIPiDIP-2228N.
IntActiP11433. 40 interactions.
MINTiMINT-553834.

Structurei

Secondary structure

1
854
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi762 – 7687Combined sources
Beta strandi780 – 7845Combined sources
Helixi792 – 80110Combined sources
Turni802 – 8065Combined sources
Beta strandi817 – 8204Combined sources
Turni821 – 8233Combined sources
Beta strandi824 – 8274Combined sources
Helixi833 – 84412Combined sources
Beta strandi848 – 8525Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PQSNMR-A778-854[»]
1Q1ONMR-A761-854[»]
1TZ1NMR-A780-854[»]
2KFJNMR-A761-854[»]
2KFKNMR-B761-854[»]
ProteinModelPortaliP11433.
SMRiP11433. Positions 194-555, 780-854.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11433.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini278 – 454177DHPROSITE-ProRule annotationAdd
BLAST
Domaini478 – 668191PHPROSITE-ProRule annotationAdd
BLAST
Domaini761 – 85494PB1PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi494 – 600107Ser/Thr-richAdd
BLAST
Compositional biasi681 – 77898Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PB1 domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00800000124085.
HOGENOMiHOG000248760.
InParanoidiP11433.
KOiK11236.
OMAiLNPIYEL.
OrthoDBiEOG77DJF5.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR033511. Cdc24/Scd1.
IPR010481. Cdc24/Scd1_N.
IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000270. PB1_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR22826:SF133. PTHR22826:SF133. 3 hits.
PfamiPF06395. CDC24. 1 hit.
PF00564. PB1. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00666. PB1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS51745. PB1. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIQTRFASG TSLSDLKPKP SATSISIPMQ NVMNKPVTEQ DSLFHICANI
60 70 80 90 100
RKRLEVLPQL KPFLQLAYQS SEVLSERQSL LLSQKQHQEL LKSNGANRDS
110 120 130 140 150
SDLAPTLRSS SISTATSLMS MEGISYTNSN PSATPNMEDT LLTFSMGILP
160 170 180 190 200
ITMDCDPVTQ LSQLFQQGAP LCILFNSVKP QFKLPVIASD DLKVCKKSIY
210 220 230 240 250
DFILGCKKHF AFNDEELFTI SDVFANSTSQ LVKVLEVVET LMNSSPTIFP
260 270 280 290 300
SKSKTQQIMN AENQHRHQPQ QSSKKHNEYV KIIKEFVATE RKYVHDLEIL
310 320 330 340 350
DKYRQQLLDS NLITSEELYM LFPNLGDAID FQRRFLISLE INALVEPSKQ
360 370 380 390 400
RIGALFMHSK HFFKLYEPWS IGQNAAIEFL SSTLHKMRVD ESQRFIINNK
410 420 430 440 450
LELQSFLYKP VQRLCRYPLL VKELLAESSD DNNTKELEAA LDISKNIARS
460 470 480 490 500
INENQRRTEN HQVVKKLYGR VVNWKGYRIS KFGELLYFDK VFISTTNSSS
510 520 530 540 550
EPEREFEVYL FEKIIILFSE VVTKKSASSL ILKKKSSTSA SISASNITDN
560 570 580 590 600
NGSPHHSYHK RHSNSSSSNN IHLSSSSAAA IIHSSTNSSD NNSNNSSSSS
610 620 630 640 650
LFKLSANEPK LDLRGRIMIM NLNQIIPQNN RSLNITWESI KEQGNFLLKF
660 670 680 690 700
KNEETRDNWS SCLQQLIHDL KNEQFKARHH SSTSTTSSTA KSSSMMSPTT
710 720 730 740 750
TMNTPNHHNS RQTHDSMASF SSSHMKRVSD VLPKRRTTSS SFESEIKSIS
760 770 780 790 800
ENFKNSIPES SILFRISYNN NSNNTSSSEI FTLLVEKVWN FDDLIMAINS
810 820 830 840 850
KISNTHNNNI SPITKIKYQD EDGDFVVLGS DEDWNVAKEM LAENNEKFLN

IRLY
Length:854
Mass (Da):96,940
Last modified:February 1, 1996 - v2
Checksum:i856BCAF4EB0A67D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16809 Genomic DNA. Translation: AAA82871.1.
U12980 Genomic DNA. Translation: AAC04990.1.
BK006935 Genomic DNA. Translation: DAA06945.1.
PIRiA27477.
RefSeqiNP_009359.1. NM_001178186.1.

Genome annotation databases

EnsemblFungiiYAL041W; YAL041W; YAL041W.
GeneIDi851190.
KEGGisce:YAL041W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16809 Genomic DNA. Translation: AAA82871.1.
U12980 Genomic DNA. Translation: AAC04990.1.
BK006935 Genomic DNA. Translation: DAA06945.1.
PIRiA27477.
RefSeqiNP_009359.1. NM_001178186.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PQSNMR-A778-854[»]
1Q1ONMR-A761-854[»]
1TZ1NMR-A780-854[»]
2KFJNMR-A761-854[»]
2KFKNMR-B761-854[»]
ProteinModelPortaliP11433.
SMRiP11433. Positions 194-555, 780-854.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31724. 176 interactions.
DIPiDIP-2228N.
IntActiP11433. 40 interactions.
MINTiMINT-553834.

PTM databases

iPTMnetiP11433.

Proteomic databases

MaxQBiP11433.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL041W; YAL041W; YAL041W.
GeneIDi851190.
KEGGisce:YAL041W.

Organism-specific databases

EuPathDBiFungiDB:YAL041W.
SGDiS000000039. CDC24.

Phylogenomic databases

GeneTreeiENSGT00800000124085.
HOGENOMiHOG000248760.
InParanoidiP11433.
KOiK11236.
OMAiLNPIYEL.
OrthoDBiEOG77DJF5.

Enzyme and pathway databases

BioCyciYEAST:G3O-28849-MONOMER.
ReactomeiR-SCE-193648. NRAGE signals death through JNK.
R-SCE-194840. Rho GTPase cycle.
R-SCE-416482. G alpha (12/13) signalling events.

Miscellaneous databases

EvolutionaryTraceiP11433.
PROiP11433.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR033511. Cdc24/Scd1.
IPR010481. Cdc24/Scd1_N.
IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000270. PB1_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR22826:SF133. PTHR22826:SF133. 3 hits.
PfamiPF06395. CDC24. 1 hit.
PF00564. PB1. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00666. PB1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS51745. PB1. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the CLS4 (CDC24) gene of Saccharomyces cerevisiae."
    Miyamoto S., Ohya Y., Ohsumi Y., Anraku Y.
    Gene 54:125-132(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A DBL-homologous region of the yeast CLS4/CDC24 gene product is important for Ca(2+)-modulated bud assembly."
    Miyamoto S., Ohya Y., Sano Y., Sakaguchi S., Iida H., Anraku Y.
    Biochem. Biophys. Res. Commun. 181:604-610(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION, SIMILARITY TO CDC24 FAMILY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle."
    Gao X.D., Sperber L.M., Kane S.A., Tong Z., Tong A.H., Boone C., Bi E.
    Mol. Biol. Cell 18:2542-2560(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AXL2, FUNCTION.
  8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCDC24_YEAST
AccessioniPrimary (citable) accession number: P11433
Secondary accession number(s): D6VPH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1996
Last modified: July 6, 2016
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1010 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.