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Protein

Cell division control protein 24

Gene

CDC24

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the exchange of CDC42-bound GDP by GTP. Controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. CDC24 may be involved in the initial selection and organization of the budding site.1 Publication

Miscellaneous

Present with 1010 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • Rho guanyl-nucleotide exchange factor activity Source: SGD

GO - Biological processi

  • cellular bud site selection Source: SGD
  • protein localization to cell cortex Source: SGD
  • regulation of exit from mitosis Source: SGD
  • regulation of Rho protein signal transduction Source: InterPro
  • septin ring organization Source: SGD
  • small GTPase mediated signal transduction Source: SGD

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

BioCyciYEAST:G3O-28849-MONOMER
ReactomeiR-SCE-193648 NRAGE signals death through JNK
R-SCE-194840 Rho GTPase cycle
R-SCE-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 24
Alternative name(s):
Calcium regulatory protein
Gene namesi
Name:CDC24
Synonyms:CLS4
Ordered Locus Names:YAL041W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL041W
SGDiS000000039 CDC24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809341 – 854Cell division control protein 24Add BLAST854

Proteomic databases

MaxQBiP11433
PaxDbiP11433
PRIDEiP11433

PTM databases

iPTMnetiP11433

Interactioni

Subunit structurei

Interacts with AXL2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • Rho guanyl-nucleotide exchange factor activity Source: SGD

Protein-protein interaction databases

BioGridi31724, 693 interactors
DIPiDIP-2228N
IntActiP11433, 49 interactors
MINTiP11433
STRINGi4932.YAL041W

Structurei

Secondary structure

1854
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi762 – 768Combined sources7
Beta strandi780 – 784Combined sources5
Helixi792 – 801Combined sources10
Turni802 – 806Combined sources5
Beta strandi817 – 820Combined sources4
Turni821 – 823Combined sources3
Beta strandi824 – 827Combined sources4
Helixi833 – 844Combined sources12
Beta strandi848 – 852Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PQSNMR-A778-854[»]
1Q1ONMR-A761-854[»]
1TZ1NMR-A780-854[»]
2KFJNMR-A761-854[»]
2KFKNMR-B761-854[»]
ProteinModelPortaliP11433
SMRiP11433
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11433

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 246Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST112
Domaini278 – 454DHPROSITE-ProRule annotationAdd BLAST177
Domaini478 – 668PHPROSITE-ProRule annotationAdd BLAST191
Domaini761 – 854PB1PROSITE-ProRule annotationAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi494 – 600Ser/Thr-richAdd BLAST107
Compositional biasi681 – 778Ser/Thr-richAdd BLAST98

Phylogenomic databases

GeneTreeiENSGT00910000144110
HOGENOMiHOG000248760
InParanoidiP11433
KOiK11236
OMAiCKKSVYD
OrthoDBiEOG092C2MTU

Family and domain databases

CDDicd13246 PH_Scd1, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
InterProiView protein in InterPro
IPR010481 Cdc24/Scd1_N
IPR033511 Cdc24/Scd1_PH_dom
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR000270 PB1_dom
IPR001849 PH_domain
PfamiView protein in Pfam
PF06395 CDC24, 1 hit
PF00564 PB1, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00666 PB1, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS51745 PB1, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

P11433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIQTRFASG TSLSDLKPKP SATSISIPMQ NVMNKPVTEQ DSLFHICANI
60 70 80 90 100
RKRLEVLPQL KPFLQLAYQS SEVLSERQSL LLSQKQHQEL LKSNGANRDS
110 120 130 140 150
SDLAPTLRSS SISTATSLMS MEGISYTNSN PSATPNMEDT LLTFSMGILP
160 170 180 190 200
ITMDCDPVTQ LSQLFQQGAP LCILFNSVKP QFKLPVIASD DLKVCKKSIY
210 220 230 240 250
DFILGCKKHF AFNDEELFTI SDVFANSTSQ LVKVLEVVET LMNSSPTIFP
260 270 280 290 300
SKSKTQQIMN AENQHRHQPQ QSSKKHNEYV KIIKEFVATE RKYVHDLEIL
310 320 330 340 350
DKYRQQLLDS NLITSEELYM LFPNLGDAID FQRRFLISLE INALVEPSKQ
360 370 380 390 400
RIGALFMHSK HFFKLYEPWS IGQNAAIEFL SSTLHKMRVD ESQRFIINNK
410 420 430 440 450
LELQSFLYKP VQRLCRYPLL VKELLAESSD DNNTKELEAA LDISKNIARS
460 470 480 490 500
INENQRRTEN HQVVKKLYGR VVNWKGYRIS KFGELLYFDK VFISTTNSSS
510 520 530 540 550
EPEREFEVYL FEKIIILFSE VVTKKSASSL ILKKKSSTSA SISASNITDN
560 570 580 590 600
NGSPHHSYHK RHSNSSSSNN IHLSSSSAAA IIHSSTNSSD NNSNNSSSSS
610 620 630 640 650
LFKLSANEPK LDLRGRIMIM NLNQIIPQNN RSLNITWESI KEQGNFLLKF
660 670 680 690 700
KNEETRDNWS SCLQQLIHDL KNEQFKARHH SSTSTTSSTA KSSSMMSPTT
710 720 730 740 750
TMNTPNHHNS RQTHDSMASF SSSHMKRVSD VLPKRRTTSS SFESEIKSIS
760 770 780 790 800
ENFKNSIPES SILFRISYNN NSNNTSSSEI FTLLVEKVWN FDDLIMAINS
810 820 830 840 850
KISNTHNNNI SPITKIKYQD EDGDFVVLGS DEDWNVAKEM LAENNEKFLN

IRLY
Length:854
Mass (Da):96,940
Last modified:February 1, 1996 - v2
Checksum:i856BCAF4EB0A67D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16809 Genomic DNA Translation: AAA82871.1
U12980 Genomic DNA Translation: AAC04990.1
BK006935 Genomic DNA Translation: DAA06945.1
PIRiA27477
RefSeqiNP_009359.1, NM_001178186.1

Genome annotation databases

EnsemblFungiiYAL041W; YAL041W; YAL041W
GeneIDi851190
KEGGisce:YAL041W

Similar proteinsi

Entry informationi

Entry nameiCDC24_YEAST
AccessioniPrimary (citable) accession number: P11433
Secondary accession number(s): D6VPH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health