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Protein

Superoxide dismutase [Cu-Zn] 2

Gene

SODCC.1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Copper; catalyticBy similarity
Metal bindingi46 – 461Copper; catalyticBy similarity
Metal bindingi61 – 611Copper; catalyticBy similarity
Metal bindingi61 – 611Zinc; structuralBy similarity
Metal bindingi69 – 691Zinc; structuralBy similarity
Metal bindingi78 – 781Zinc; structuralBy similarity
Metal bindingi81 – 811Zinc; structuralBy similarity
Metal bindingi118 – 1181Copper; catalyticBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] 2 (EC:1.15.1.1)
Gene namesi
Name:SODCC.1
Synonyms:SOD2
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea
ProteomesiUP000007305: Chromosome 7

Organism-specific databases

GrameneiP11428.
MaizeGDBi47586.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 151150Superoxide dismutase [Cu-Zn] 2PRO_0000164141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 144By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP11428.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP11428.
SMRiP11428. Positions 1-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Phylogenomic databases

HOGENOMiHOG000263447.
KOiK04565.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKAVAVLAG TDVKGTIFFS QEGDGPTTVT GSISGLKPGL HGFHVHALGD
60 70 80 90 100
TTNGCMSTGP HFNPVGKEHG APEDEDRHAG DLGNVTAGED GVVNVNITDS
110 120 130 140 150
QIPLAGPHSI IGRAVVVHAD PDDLGKGGHE LSKSTGNAGG RVACGIIGLQ

G
Length:151
Mass (Da):15,104
Last modified:January 23, 2007 - v2
Checksum:i6B1E8C703B17D216
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15175 mRNA. Translation: AAA33511.1.
M54936 mRNA. Translation: AAA33510.1.
PIRiA29077.
RefSeqiNP_001105335.1. NM_001111865.1.
XP_008651856.1. XM_008653634.1.
UniGeneiZm.25.

Genome annotation databases

EnsemblPlantsiGRMZM2G025992_T03; GRMZM2G025992_P03; GRMZM2G025992.
GRMZM2G025992_T04; GRMZM2G025992_P04; GRMZM2G025992.
GRMZM2G025992_T05; GRMZM2G025992_P05; GRMZM2G025992.
GeneIDi542260.
KEGGizma:542260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15175 mRNA. Translation: AAA33511.1.
M54936 mRNA. Translation: AAA33510.1.
PIRiA29077.
RefSeqiNP_001105335.1. NM_001111865.1.
XP_008651856.1. XM_008653634.1.
UniGeneiZm.25.

3D structure databases

ProteinModelPortaliP11428.
SMRiP11428. Positions 1-151.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP11428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGRMZM2G025992_T03; GRMZM2G025992_P03; GRMZM2G025992.
GRMZM2G025992_T04; GRMZM2G025992_P04; GRMZM2G025992.
GRMZM2G025992_T05; GRMZM2G025992_P05; GRMZM2G025992.
GeneIDi542260.
KEGGizma:542260.

Organism-specific databases

GrameneiP11428.
MaizeGDBi47586.

Phylogenomic databases

HOGENOMiHOG000263447.
KOiK04565.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of cDNA for maize superoxide dismutase 2 (SOD2)."
    Cannon R.E., White J.A., Scandalios J.G.
    Proc. Natl. Acad. Sci. U.S.A. 84:179-183(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The superoxide dismutase-2 gene of maize."
    Cannon R.E., Scandalios J.G.
    Isozymes Curr. Top. Biol. Med. Res. 14:73-81(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSODC2_MAIZE
AccessioniPrimary (citable) accession number: P11428
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.