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P11410

- G6PD_CYBJA

UniProt

P11410 - G6PD_CYBJA

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
N/A
Organism
Cyberlindnera jadinii (Torula yeast) (Pichia jadinii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491NADP By similarity
Binding sitei149 – 1491NADP; via carbonyl oxygen By similarity
Binding sitei149 – 1491Substrate By similarity
Binding sitei217 – 2171Substrate By similarity
Binding sitei236 – 2361Substrate By similarity
Active sitei241 – 2411Proton acceptor By similarity
Binding sitei335 – 3351Substrate By similarity
Binding sitei369 – 3691Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
OrganismiCyberlindnera jadinii (Torula yeast) (Pichia jadinii)
Taxonomic identifieri4903 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylserineUniRule annotation

Keywords - PTMi

Acetylation

Structurei

3D structure databases

ProteinModelPortaliP11410.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni179 – 1835Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11410-1 [UniParc]FASTAAdd to Basket

« Hide

SYDSFGDRVT IIVFGASGDL ARKKTFPALF GLFREKQLPS TVQIIGYARS    50
HLSDKDFKDY ISSHFKGGDD KTKEDFLNLC SYISDPYDTD EGYKKLEARC 100
QEYESKHNVK VPERLFYLAL PPSVFHTVCE QVKKNVYPKN EKSRIIIEKP 150
FGRDLETYRE LQKQISPLFT EDEVYRIDHY LGKEMVKNLL VLRFGNELFS 200
GIWNNKHITS VQISFKEAFG TEGRGGYFDN IGIIRDVMQN HLLQVLTLLT 250
MERPVSFDPE AVRDEKVKVL KAFDKIDVND VLLGQYGKSE DGTKPGYLDD 300
STVKPNSKAV TYAAFRVNIH NERWDGVPIV LRAGKALDEG KAEIRIQFKP 350
VAKGMFKEIQ RNELVIRIQP NEAIYLKINS KIPGISTETS LTDLDLTYST 400
RYSKDFWIPE AYEALIRDCY LGNHSNFVRD DELEVSWKLF TPLLEAVEKE 450
ENVKLESYPY GSKGPKELRK YLIDHGYVFN DPGTYQWPLT NTDVK 495
Length:495
Mass (Da):57,029
Last modified:April 1, 1993 - v2
Checksum:iB6944216F4B4C8D8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071H → G.
Natural varianti138 – 1381P → M.
Natural varianti416 – 4161I → T.

Sequence databases

PIRiS11078.
S29381.

Cross-referencesi

Sequence databases

PIRi S11078.
S29381.

3D structure databases

ProteinModelPortali P11410.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Glucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure."
    Jeffery J., Persson B., Wood I., Bergman T., Jeffery R., Joernvall H.
    Eur. J. Biochem. 212:41-49(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
  2. "Glucose-6-phosphate dehydrogenase. Characterization of a reactive lysine residue in the Pichia jadinii enzyme reveals a limited structural variation in a functionally significant segment."
    Jeffery J., Wood I., McLeod A., Jeffery R., Joernvall H.
    Biochem. Biophys. Res. Commun. 160:1290-1295(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 177-187.
    Strain: ATCC 9950 / CBS 5609 / DSM 2361 / NBRC 0998 / NRRL Y-900.
  3. "Alcoholytic deblocking of N-terminally acetylated peptides and proteins for sequence analysis."
    Bergman T., Gheorghe M.T., Hjelmqvist L., Joernvall H.
    FEBS Lett. 390:199-202(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-10.

Entry informationi

Entry nameiG6PD_CYBJA
AccessioniPrimary (citable) accession number: P11410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 1, 1993
Last modified: February 19, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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