Reviewed, UniProtKB/Swiss-Prot P11410 (G6PD_PICJA)

Names and origin

Protein names	Recommended name:     Glucose-6-phosphate 1-dehydrogenase       Short name=G6PD     EC=1.1.1.49
Organism	Pichia jadinii (Yeast) (Candida utilis)
Taxonomic identifier	4903 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Pichia

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068105
Sites
	Active site	241	1	Proton acceptor By similarity
	Binding site	17	1	NADP By similarity
	Binding site	49	1	NADP By similarity
	Binding site	179	1	Substrate By similarity
	Binding site	183	1	Substrate By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylserine
Natural variations
	Natural variant	107	1	H → G
	Natural variant	138	1	P → M
	Natural variant	416	1	I → T

Sequences

	Sequence		Length	Mass (Da)
	P11410-1 [UniParc]. Last modified April 1, 1993. Version 2. Checksum: B6944216F4B4C8D8	FASTA	495	57,029
	10 20 30 40 50 60 SYDSFGDRVT IIVFGASGDL ARKKTFPALF GLFREKQLPS TVQIIGYARS HLSDKDFKDY 70 80 90 100 110 120 ISSHFKGGDD KTKEDFLNLC SYISDPYDTD EGYKKLEARC QEYESKHNVK VPERLFYLAL 130 140 150 160 170 180 PPSVFHTVCE QVKKNVYPKN EKSRIIIEKP FGRDLETYRE LQKQISPLFT EDEVYRIDHY 190 200 210 220 230 240 LGKEMVKNLL VLRFGNELFS GIWNNKHITS VQISFKEAFG TEGRGGYFDN IGIIRDVMQN 250 260 270 280 290 300 HLLQVLTLLT MERPVSFDPE AVRDEKVKVL KAFDKIDVND VLLGQYGKSE DGTKPGYLDD 310 320 330 340 350 360 STVKPNSKAV TYAAFRVNIH NERWDGVPIV LRAGKALDEG KAEIRIQFKP VAKGMFKEIQ 370 380 390 400 410 420 RNELVIRIQP NEAIYLKINS KIPGISTETS LTDLDLTYST RYSKDFWIPE AYEALIRDCY 430 440 450 460 470 480 LGNHSNFVRD DELEVSWKLF TPLLEAVEKE ENVKLESYPY GSKGPKELRK YLIDHGYVFN 490 DPGTYQWPLT NTDVK

References

[1]	"Glucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure." Jeffery J., Persson B., Wood I., Bergman T., Jeffery R., Joernvall H. Eur. J. Biochem. 212:41-49(1993) [PubMed: 8444164] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"Glucose-6-phosphate dehydrogenase. Characterization of a reactive lysine residue in the Pichia jadinii enzyme reveals a limited structural variation in a functionally significant segment." Jeffery J., Wood I., McLeod A., Jeffery R., Joernvall H. Biochem. Biophys. Res. Commun. 160:1290-1295(1989) [PubMed: 2499329] [Abstract] Cited for: PROTEIN SEQUENCE OF 177-187. Strain: ATCC 9950 / CBS 5609 / DSM 2361 / IFO 0998 / NRRL Y-900.
[3]	"Alcoholytic deblocking of N-terminally acetylated peptides and proteins for sequence analysis." Bergman T., Gheorghe M.T., Hjelmqvist L., Joernvall H. FEBS Lett. 390:199-202(1996) [PubMed: 8706859] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-10.

Cross-references

Sequence databases
PIR	S11078. S29381.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_PICJA

Accession

Primary (citable) accession number: P11410

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	April 1, 1993
Last modified:	November 25, 2008
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)