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Protein

Fatty acid-binding protein, heart

Gene

Fabp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Fatty acidBy similarity1
Binding sitei129Fatty acidBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cholesterol homeostasis Source: BHF-UCL
  • fatty acid metabolic process Source: Ensembl
  • long-chain fatty acid import Source: BHF-UCL
  • phospholipid homeostasis Source: BHF-UCL
  • positive regulation of phospholipid biosynthetic process Source: BHF-UCL
  • regulation of fatty acid oxidation Source: BHF-UCL
  • regulation of phosphatidylcholine biosynthetic process Source: MGI
  • response to drug Source: Ensembl
  • response to fatty acid Source: Ensembl
  • response to insulin Source: Ensembl

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-163560. Triglyceride catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Mammary-derived growth inhibitor
Short name:
MDGI
Gene namesi
Name:Fabp3
Synonyms:Fabph1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95476. Fabp3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673222 – 133Fatty acid-binding protein, heartAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei20Phosphotyrosine; by Tyr-kinasesBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11404.
PeptideAtlasiP11404.
PRIDEiP11404.

2D gel databases

REPRODUCTION-2DPAGEiIPI00230124.
P11404.
SWISS-2DPAGEiP11404.
UCD-2DPAGEiP11404.

PTM databases

iPTMnetiP11404.
PhosphoSitePlusiP11404.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028773.
CleanExiMM_FABP3.
ExpressionAtlasiP11404. baseline and differential.
GenevisibleiP11404. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199582. 1 interactor.
IntActiP11404. 5 interactors.
MINTiMINT-4094950.
STRINGi10090.ENSMUSP00000070709.

Structurei

3D structure databases

ProteinModelPortaliP11404.
SMRiP11404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP11404.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
PhylomeDBiP11404.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR000463. Fatty_acid-bd.
IPR031259. ILBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00214. FABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAFVGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDTI
60 70 80 90 100
TIKTQSTFKN TEINFQLGIE FDEVTADDRK VKSLVTLDGG KLIHVQKWNG
110 120 130
QETTLTRELV DGKLILTLTH GSVVSTRTYE KEA
Length:133
Mass (Da):14,819
Last modified:January 23, 2007 - v5
Checksum:iF78BFF5A7533DD9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → G in CAA33084 (PubMed:2740224).Curated1
Sequence conflicti99N → D in CAA33084 (PubMed:2740224).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14961 mRNA. Translation: CAA33084.1.
U02884 Genomic DNA. Translation: AAA61933.1.
U02883 mRNA. Translation: AAA03445.1.
BC002082 mRNA. Translation: AAH02082.1.
CCDSiCCDS18709.1.
PIRiPC4011.
RefSeqiNP_034304.1. NM_010174.1.
UniGeneiMm.388886.

Genome annotation databases

EnsembliENSMUST00000070532; ENSMUSP00000070709; ENSMUSG00000028773.
GeneIDi14077.
KEGGimmu:14077.
UCSCiuc008uzd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiFABPH_MOUSE
AccessioniPrimary (citable) accession number: P11404
Secondary accession number(s): Q91W23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 163 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families