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Protein

Fatty acid-binding protein, heart

Gene

Fabp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Fatty acidBy similarity1
Binding sitei129Fatty acidBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cholesterol homeostasis Source: BHF-UCL
  • long-chain fatty acid import Source: BHF-UCL
  • phospholipid homeostasis Source: BHF-UCL
  • positive regulation of phospholipid biosynthetic process Source: BHF-UCL
  • regulation of fatty acid oxidation Source: BHF-UCL
  • regulation of phosphatidylcholine biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Mammary-derived growth inhibitor
Short name:
MDGI
Gene namesi
Name:Fabp3
Synonyms:Fabph1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95476. Fabp3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673222 – 133Fatty acid-binding protein, heartAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei20Phosphotyrosine; by Tyr-kinasesBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11404.
PeptideAtlasiP11404.
PRIDEiP11404.

2D gel databases

REPRODUCTION-2DPAGEIPI00230124.
P11404.
SWISS-2DPAGEP11404.
UCD-2DPAGEP11404.

PTM databases

iPTMnetiP11404.
PhosphoSitePlusiP11404.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028773.
CleanExiMM_FABP3.
ExpressionAtlasiP11404. baseline and differential.
GenevisibleiP11404. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199582. 1 interactor.
IntActiP11404. 5 interactors.
MINTiMINT-4094950.
STRINGi10090.ENSMUSP00000070709.

Structurei

3D structure databases

ProteinModelPortaliP11404.
SMRiP11404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP11404.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
PhylomeDBiP11404.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAFVGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDTI
60 70 80 90 100
TIKTQSTFKN TEINFQLGIE FDEVTADDRK VKSLVTLDGG KLIHVQKWNG
110 120 130
QETTLTRELV DGKLILTLTH GSVVSTRTYE KEA
Length:133
Mass (Da):14,819
Last modified:January 23, 2007 - v5
Checksum:iF78BFF5A7533DD9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → G in CAA33084 (PubMed:2740224).Curated1
Sequence conflicti99N → D in CAA33084 (PubMed:2740224).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14961 mRNA. Translation: CAA33084.1.
U02884 Genomic DNA. Translation: AAA61933.1.
U02883 mRNA. Translation: AAA03445.1.
BC002082 mRNA. Translation: AAH02082.1.
CCDSiCCDS18709.1.
PIRiPC4011.
RefSeqiNP_034304.1. NM_010174.1.
UniGeneiMm.388886.

Genome annotation databases

EnsembliENSMUST00000070532; ENSMUSP00000070709; ENSMUSG00000028773.
GeneIDi14077.
KEGGimmu:14077.
UCSCiuc008uzd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14961 mRNA. Translation: CAA33084.1.
U02884 Genomic DNA. Translation: AAA61933.1.
U02883 mRNA. Translation: AAA03445.1.
BC002082 mRNA. Translation: AAH02082.1.
CCDSiCCDS18709.1.
PIRiPC4011.
RefSeqiNP_034304.1. NM_010174.1.
UniGeneiMm.388886.

3D structure databases

ProteinModelPortaliP11404.
SMRiP11404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199582. 1 interactor.
IntActiP11404. 5 interactors.
MINTiMINT-4094950.
STRINGi10090.ENSMUSP00000070709.

PTM databases

iPTMnetiP11404.
PhosphoSitePlusiP11404.

2D gel databases

REPRODUCTION-2DPAGEIPI00230124.
P11404.
SWISS-2DPAGEP11404.
UCD-2DPAGEP11404.

Proteomic databases

PaxDbiP11404.
PeptideAtlasiP11404.
PRIDEiP11404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070532; ENSMUSP00000070709; ENSMUSG00000028773.
GeneIDi14077.
KEGGimmu:14077.
UCSCiuc008uzd.1. mouse.

Organism-specific databases

CTDi2170.
MGIiMGI:95476. Fabp3.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP11404.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
PhylomeDBiP11404.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-MMU-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

PROiP11404.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028773.
CleanExiMM_FABP3.
ExpressionAtlasiP11404. baseline and differential.
GenevisibleiP11404. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABPH_MOUSE
AccessioniPrimary (citable) accession number: P11404
Secondary accession number(s): Q91W23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 156 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.