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Protein

Fatty acid-binding protein, heart

Gene

Fabp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271Fatty acidBy similarity
Binding sitei129 – 1291Fatty acidBy similarity

GO - Molecular functioni

GO - Biological processi

  • cholesterol homeostasis Source: BHF-UCL
  • long-chain fatty acid import Source: BHF-UCL
  • phospholipid homeostasis Source: BHF-UCL
  • positive regulation of phospholipid biosynthetic process Source: BHF-UCL
  • regulation of fatty acid oxidation Source: BHF-UCL
  • regulation of phosphatidylcholine biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Mammary-derived growth inhibitor
Short name:
MDGI
Gene namesi
Name:Fabp3
Synonyms:Fabph1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95476. Fabp3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 133132Fatty acid-binding protein, heartPRO_0000067322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei8 – 81PhosphothreonineBy similarity
Modified residuei20 – 201Phosphotyrosine; by Tyr-kinasesBy similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei30 – 301PhosphothreonineBy similarity
Modified residuei83 – 831PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11404.
PeptideAtlasiP11404.
PRIDEiP11404.

2D gel databases

REPRODUCTION-2DPAGEIPI00230124.
P11404.
SWISS-2DPAGEP11404.
UCD-2DPAGEP11404.

PTM databases

iPTMnetiP11404.
PhosphoSiteiP11404.

Expressioni

Gene expression databases

BgeeiP11404.
CleanExiMM_FABP3.
ExpressionAtlasiP11404. baseline and differential.
GenevisibleiP11404. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199582. 1 interaction.
IntActiP11404. 5 interactions.
MINTiMINT-4094950.
STRINGi10090.ENSMUSP00000070709.

Structurei

3D structure databases

ProteinModelPortaliP11404.
SMRiP11404. Positions 3-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP11404.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP11404.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAFVGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDTI
60 70 80 90 100
TIKTQSTFKN TEINFQLGIE FDEVTADDRK VKSLVTLDGG KLIHVQKWNG
110 120 130
QETTLTRELV DGKLILTLTH GSVVSTRTYE KEA
Length:133
Mass (Da):14,819
Last modified:January 23, 2007 - v5
Checksum:iF78BFF5A7533DD9A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341A → G in CAA33084 (PubMed:2740224).Curated
Sequence conflicti99 – 991N → D in CAA33084 (PubMed:2740224).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14961 mRNA. Translation: CAA33084.1.
U02884 Genomic DNA. Translation: AAA61933.1.
U02883 mRNA. Translation: AAA03445.1.
BC002082 mRNA. Translation: AAH02082.1.
CCDSiCCDS18709.1.
PIRiPC4011.
RefSeqiNP_034304.1. NM_010174.1.
UniGeneiMm.388886.

Genome annotation databases

EnsembliENSMUST00000070532; ENSMUSP00000070709; ENSMUSG00000028773.
GeneIDi14077.
KEGGimmu:14077.
UCSCiuc008uzd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14961 mRNA. Translation: CAA33084.1.
U02884 Genomic DNA. Translation: AAA61933.1.
U02883 mRNA. Translation: AAA03445.1.
BC002082 mRNA. Translation: AAH02082.1.
CCDSiCCDS18709.1.
PIRiPC4011.
RefSeqiNP_034304.1. NM_010174.1.
UniGeneiMm.388886.

3D structure databases

ProteinModelPortaliP11404.
SMRiP11404. Positions 3-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199582. 1 interaction.
IntActiP11404. 5 interactions.
MINTiMINT-4094950.
STRINGi10090.ENSMUSP00000070709.

PTM databases

iPTMnetiP11404.
PhosphoSiteiP11404.

2D gel databases

REPRODUCTION-2DPAGEIPI00230124.
P11404.
SWISS-2DPAGEP11404.
UCD-2DPAGEP11404.

Proteomic databases

PaxDbiP11404.
PeptideAtlasiP11404.
PRIDEiP11404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070532; ENSMUSP00000070709; ENSMUSG00000028773.
GeneIDi14077.
KEGGimmu:14077.
UCSCiuc008uzd.1. mouse.

Organism-specific databases

CTDi2170.
MGIiMGI:95476. Fabp3.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP11404.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP11404.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-MMU-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

PROiP11404.
SOURCEiSearch...

Gene expression databases

BgeeiP11404.
CleanExiMM_FABP3.
ExpressionAtlasiP11404. baseline and differential.
GenevisibleiP11404. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequence for mouse heart fatty acid binding protein, H-FABP."
    Tweedie S., Edwards Y.
    Nucleic Acids Res. 17:4374-4374(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
  2. Tweedie S.
    Submitted (AUG-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 3-4.
  3. "Cloning and characterization of the mouse gene encoding mammary-derived growth inhibitor/heart-fatty acid-binding protein."
    Treuner M., Kozak C.A., Gallahan D., Grosse R., Mueller T.
    Gene 147:237-242(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ICR X Swiss Webster.
    Tissue: Liver.
  4. "Hormonal induction of functional differentiation and mammary-derived growth inhibitor expression in cultured mouse mammary gland explants."
    Binas B., Spitzer E., Zschiesche W., Erdmann B., Kurtz A., Mueller T., Niemann C., Blenau W., Grosse R.
    In Vitro Cell. Dev. Biol. 28A:625-634(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cJ.
    Tissue: Mammary gland.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  6. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 60-79 AND 114-127, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue and Heart.

Entry informationi

Entry nameiFABPH_MOUSE
AccessioniPrimary (citable) accession number: P11404
Secondary accession number(s): Q91W23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 153 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.