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Protein

Fibroblast growth factor 4

Gene

Fgf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis.

GO - Molecular functioni

GO - Biological processi

  • apoptotic process involved in morphogenesis Source: MGI
  • cartilage condensation Source: MGI
  • cellular response to leukemia inhibitory factor Source: MGI
  • chondroblast differentiation Source: MGI
  • cranial suture morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • mesenchymal cell proliferation Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of endothelial cell chemotaxis to fibroblast growth factor Source: MGI
  • regulation of gene expression Source: MGI
  • stem cell population maintenance Source: MGI

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190322. FGFR4 ligand binding and activation.
R-MMU-190372. FGFR3c ligand binding and activation.
R-MMU-190373. FGFR1c ligand binding and activation.
R-MMU-190375. FGFR2c ligand binding and activation.
R-MMU-5654219. Phospholipase C-mediated cascade: FGFR1.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654227. Phospholipase C-mediated cascade, FGFR3.
R-MMU-5654228. Phospholipase C-mediated cascade, FGFR4.
R-MMU-5654687. Downstream signaling of activated FGFR1.
R-MMU-5654688. SHC-mediated cascade:FGFR1.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654704. SHC-mediated cascade:FGFR3.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654710. PI-3K cascade:FGFR3.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654719. SHC-mediated cascade:FGFR4.
R-MMU-5654720. PI-3K cascade:FGFR4.
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5654732. Negative regulation of FGFR3 signaling.
R-MMU-5654733. Negative regulation of FGFR4 signaling.
R-MMU-5658623. FGFRL1 modulation of FGFR1 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 4
Short name:
FGF-4
Alternative name(s):
Heparin-binding growth factor 4
Short name:
HBGF-4
K-fibroblast growth factor
Gene namesi
Name:Fgf4
Synonyms:Fgf-4, Kfgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95518. Fgf4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000895430 – 202Fibroblast growth factor 4Add BLAST173

Proteomic databases

PaxDbiP11403.
PeptideAtlasiP11403.
PRIDEiP11403.

PTM databases

iPTMnetiP11403.
PhosphoSitePlusiP11403.

Expressioni

Tissue specificityi

Expressed in the blastocyst inner cell mass and later in distinct embryonic tissues.

Gene expression databases

BgeeiENSMUSG00000050917.
CleanExiMM_FGF4.
ExpressionAtlasiP11403. baseline and differential.
GenevisibleiP11403. MM.

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056752.

Structurei

3D structure databases

ProteinModelPortaliP11403.
SMRiP11403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP11403.
KOiK04358.
OMAiYNAYESH.
OrthoDBiEOG091G0NAY.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR028239. FGF4.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF119. PTHR11486:SF119. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
PRINTSiPR00263. HBGFFGF.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00247. HBGF_FGF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRGPTTGT LLPRVLLALV VALADRGTAA PNGTRHAELG HGWDGLVARS
60 70 80 90 100
LARLPVAAQP PQAAVRSGAG DYLLGLKRLR RLYCNVGIGF HLQVLPDGRI
110 120 130 140 150
GGVHADTRDS LLELSPVQRG VVSIFGVASR FFVAMSSRGK LFGVPFFTDE
160 170 180 190 200
CKFKEILLPN NYNAYESYAY PGMFMALSKN GRTKKGNRVS PTMKVTHFLP

RL
Length:202
Mass (Da):21,919
Last modified:October 3, 2012 - v2
Checksum:i62D4563AF7D9AA31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167S → A in CAA32967 (PubMed:2740210).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14849 Genomic DNA. Translation: CAA32967.1.
M30642 mRNA. Translation: AAA37619.1.
AK082814 mRNA. Translation: BAC38631.1.
AC149593 Genomic DNA. No translation available.
AC161763 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL18271.1.
BC104312 mRNA. Translation: AAI04313.1.
BC104313 mRNA. Translation: AAI04314.1.
CCDSiCCDS22052.1.
PIRiS04741. TVMSHS.
RefSeqiNP_034332.2. NM_010202.6.
UniGeneiMm.4956.

Genome annotation databases

EnsembliENSMUST00000060336; ENSMUSP00000056752; ENSMUSG00000050917.
GeneIDi14175.
KEGGimmu:14175.
UCSCiuc009kqq.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiFGF4_MOUSE
AccessioniPrimary (citable) accession number: P11403
Secondary accession number(s): P15657, Q542N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2012
Last modified: August 30, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families