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P11403

- FGF4_MOUSE

UniProt

P11403 - FGF4_MOUSE

Protein

Fibroblast growth factor 4

Gene

Fgf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis.

    GO - Molecular functioni

    1. fibroblast growth factor receptor binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. apoptotic process involved in morphogenesis Source: MGI
    2. cartilage condensation Source: MGI
    3. chondroblast differentiation Source: Ensembl
    4. cranial suture morphogenesis Source: MGI
    5. embryonic hindlimb morphogenesis Source: MGI
    6. embryonic limb morphogenesis Source: MGI
    7. fibroblast growth factor receptor signaling pathway Source: MGI
    8. mesenchymal cell proliferation Source: Ensembl
    9. negative regulation of apoptotic process Source: MGI
    10. odontogenesis of dentin-containing tooth Source: MGI
    11. positive regulation of cell division Source: UniProtKB-KW
    12. positive regulation of cell proliferation Source: MGI
    13. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    14. positive regulation of gene expression Source: MGI
    15. positive regulation of protein phosphorylation Source: MGI
    16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    17. regulation of gene expression Source: MGI
    18. stem cell maintenance Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196505. Signaling by FGFR3 mutants.
    REACT_196507. Signaling by activated point mutants of FGFR3.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196538. Signaling by activated point mutants of FGFR1.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_220750. FGFR3c ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_225874. FGFR1c ligand binding and activation.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 4
    Short name:
    FGF-4
    Alternative name(s):
    Heparin-binding growth factor 4
    Short name:
    HBGF-4
    K-fibroblast growth factor
    Gene namesi
    Name:Fgf4
    Synonyms:Fgf-4, Kfgf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:95518. Fgf4.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. extracellular region Source: UniProtKB-SubCell
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 202173Fibroblast growth factor 4PRO_0000008954Add
    BLAST

    Proteomic databases

    PRIDEiP11403.

    PTM databases

    PhosphoSiteiP11403.

    Expressioni

    Tissue specificityi

    Expressed in the blastocyst inner cell mass and later in distinct embryonic tissues.

    Gene expression databases

    CleanExiMM_FGF4.
    GenevestigatoriP11403.

    Interactioni

    Subunit structurei

    Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000056752.

    Structurei

    3D structure databases

    ProteinModelPortaliP11403.
    SMRiP11403. Positions 75-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG290420.
    GeneTreeiENSGT00730000110487.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP11403.
    KOiK04358.
    OMAiYNAYESH.
    OrthoDBiEOG7992S1.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028239. FGF4.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF31. PTHR11486:SF31. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11403-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKRGPTTGT LLPRVLLALV VALADRGTAA PNGTRHAELG HGWDGLVARS    50
    LARLPVAAQP PQAAVRSGAG DYLLGLKRLR RLYCNVGIGF HLQVLPDGRI 100
    GGVHADTRDS LLELSPVQRG VVSIFGVASR FFVAMSSRGK LFGVPFFTDE 150
    CKFKEILLPN NYNAYESYAY PGMFMALSKN GRTKKGNRVS PTMKVTHFLP 200
    RL 202
    Length:202
    Mass (Da):21,919
    Last modified:October 3, 2012 - v2
    Checksum:i62D4563AF7D9AA31
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti167 – 1671S → A in CAA32967. (PubMed:2740210)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14849 Genomic DNA. Translation: CAA32967.1.
    M30642 mRNA. Translation: AAA37619.1.
    AK082814 mRNA. Translation: BAC38631.1.
    AC149593 Genomic DNA. No translation available.
    AC161763 Genomic DNA. No translation available.
    CH466531 Genomic DNA. Translation: EDL18271.1.
    BC104312 mRNA. Translation: AAI04313.1.
    BC104313 mRNA. Translation: AAI04314.1.
    CCDSiCCDS22052.1.
    PIRiS04741. TVMSHS.
    RefSeqiNP_034332.2. NM_010202.5.
    UniGeneiMm.4956.

    Genome annotation databases

    EnsembliENSMUST00000060336; ENSMUSP00000056752; ENSMUSG00000050917.
    GeneIDi14175.
    KEGGimmu:14175.
    UCSCiuc009kqq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14849 Genomic DNA. Translation: CAA32967.1 .
    M30642 mRNA. Translation: AAA37619.1 .
    AK082814 mRNA. Translation: BAC38631.1 .
    AC149593 Genomic DNA. No translation available.
    AC161763 Genomic DNA. No translation available.
    CH466531 Genomic DNA. Translation: EDL18271.1 .
    BC104312 mRNA. Translation: AAI04313.1 .
    BC104313 mRNA. Translation: AAI04314.1 .
    CCDSi CCDS22052.1.
    PIRi S04741. TVMSHS.
    RefSeqi NP_034332.2. NM_010202.5.
    UniGenei Mm.4956.

    3D structure databases

    ProteinModelPortali P11403.
    SMRi P11403. Positions 75-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000056752.

    PTM databases

    PhosphoSitei P11403.

    Proteomic databases

    PRIDEi P11403.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060336 ; ENSMUSP00000056752 ; ENSMUSG00000050917 .
    GeneIDi 14175.
    KEGGi mmu:14175.
    UCSCi uc009kqq.1. mouse.

    Organism-specific databases

    CTDi 2249.
    MGIi MGI:95518. Fgf4.

    Phylogenomic databases

    eggNOGi NOG290420.
    GeneTreei ENSGT00730000110487.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P11403.
    KOi K04358.
    OMAi YNAYESH.
    OrthoDBi EOG7992S1.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196505. Signaling by FGFR3 mutants.
    REACT_196507. Signaling by activated point mutants of FGFR3.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196538. Signaling by activated point mutants of FGFR1.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_220750. FGFR3c ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_225874. FGFR1c ligand binding and activation.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 285350.
    PROi P11403.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_FGF4.
    Genevestigatori P11403.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028239. FGF4.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF31. PTHR11486:SF31. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse homologue of hst/k-FGF: sequence, genome organization and location relative to int-2."
      Dickson C.
      Nucleic Acids Res. 17:4037-4045(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis."
      Hebert J.M., Basilico C., Goldfarb M., Haub O., Martin G.R.
      Dev. Biol. 138:454-463(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiFGF4_MOUSE
    AccessioniPrimary (citable) accession number: P11403
    Secondary accession number(s): P15657, Q542N0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3