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Protein

Secretin

Gene

Sct

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

GO - Molecular functioni

  1. protein N-terminus binding Source: RGD
  2. receptor binding Source: RGD

GO - Biological processi

  1. brain development Source: RGD
  2. dentate gyrus development Source: Ensembl
  3. embryonic digestive tract development Source: RGD
  4. negative regulation of gastric acid secretion Source: RGD
  5. negative regulation of neuron apoptotic process Source: Ensembl
  6. neuronal stem cell maintenance Source: Ensembl
  7. positive regulation of cAMP biosynthetic process Source: RGD
  8. positive regulation of pancreatic juice secretion Source: RGD
  9. positive regulation of somatostatin secretion Source: RGD
  10. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_235881. Glucagon-type ligand receptors.
REACT_246814. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin
Gene namesi
Name:Sct
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi3643. Sct.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 3110PRO_0000011432
Peptidei33 – 5927SecretinPRO_0000011433Add
BLAST
Propeptidei63 – 13472PRO_0000011434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591Valine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Expressioni

Gene expression databases

GenevestigatoriP11384.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024094.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG329190.
GeneTreeiENSGT00390000002624.
HOGENOMiHOG000133017.
HOVERGENiHBG017786.
InParanoidiP11384.
KOiK05263.
OMAiMPILQAW.
OrthoDBiEOG77DJ88.
PhylomeDBiP11384.
TreeFamiTF338215.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERiPTHR17378. PTHR17378. 1 hit.
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11384-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPLLPTPPL LLLLLLLLSS SFVLPAPPRT PRHSDGTFTS ELSRLQDSAR
60 70 80 90 100
LQRLLQGLVG KRSEEDTENI PENSVARPKP LEDQLCLLWS NTQALQDWLL
110 120 130
PRLSLDGSLS LWLPPGPRPA VDHSEWTETT RQPR
Length:134
Mass (Da):15,072
Last modified:April 1, 1990 - v2
Checksum:iD9FA1A4C1F7C86E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31495 mRNA. Translation: AAA42126.1.
M64033 Genomic DNA. Translation: AAA42128.1.
M63984 Genomic DNA. Translation: AAA42127.1.
PIRiA40886. A40959.
RefSeqiNP_073161.1. NM_022670.2.
XP_006230580.1. XM_006230518.2.
UniGeneiRn.9919.

Genome annotation databases

EnsembliENSRNOT00000024094; ENSRNOP00000024094; ENSRNOG00000017873.
GeneIDi24769.
KEGGirno:24769.
UCSCiRGD:3643. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31495 mRNA. Translation: AAA42126.1.
M64033 Genomic DNA. Translation: AAA42128.1.
M63984 Genomic DNA. Translation: AAA42127.1.
PIRiA40886. A40959.
RefSeqiNP_073161.1. NM_022670.2.
XP_006230580.1. XM_006230518.2.
UniGeneiRn.9919.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024094; ENSRNOP00000024094; ENSRNOG00000017873.
GeneIDi24769.
KEGGirno:24769.
UCSCiRGD:3643. rat.

Organism-specific databases

CTDi6343.
RGDi3643. Sct.

Phylogenomic databases

eggNOGiNOG329190.
GeneTreeiENSGT00390000002624.
HOGENOMiHOG000133017.
HOVERGENiHBG017786.
InParanoidiP11384.
KOiK05263.
OMAiMPILQAW.
OrthoDBiEOG77DJ88.
PhylomeDBiP11384.
TreeFamiTF338215.

Enzyme and pathway databases

ReactomeiREACT_235881. Glucagon-type ligand receptors.
REACT_246814. G alpha (s) signalling events.

Miscellaneous databases

NextBioi604336.
PROiP11384.

Gene expression databases

GenevestigatoriP11384.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERiPTHR17378. PTHR17378. 1 hit.
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Secretin: structure of the precursor and tissue distribution of the mRNA."
    Kopin A.S., Wheeler M.B., Leiter A.B.
    Proc. Natl. Acad. Sci. U.S.A. 87:2299-2303(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The secretin gene: evolutionary history, alternative splicing, and developmental regulation."
    Kopin A.S., Wheeler M.B., Nishitani J., McBride E.W., Chang T.M., Chey W.Y., Leiter A.B.
    Proc. Natl. Acad. Sci. U.S.A. 88:5335-5339(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The secretin precursor gene. Structure of the coding region and expression in the brain."
    Itoh N., Furuya T., Ozaki K., Kawasaki T.
    J. Biol. Chem. 266:12595-12598(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  4. Cited for: PROTEIN SEQUENCE OF 33-59, AMIDATION AT VAL-59.

Entry informationi

Entry nameiSECR_RAT
AccessioniPrimary (citable) accession number: P11384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: February 4, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.