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P11384

- SECR_RAT

UniProt

P11384 - SECR_RAT

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Protein

Secretin

Gene
Sct
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

GO - Biological processi

  1. dentate gyrus development Source: Ensembl
  2. negative regulation of neuron apoptotic process Source: Ensembl
  3. neuronal stem cell maintenance Source: Ensembl
  4. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin
Gene namesi
Name:Sct
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi3643. Sct.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Propeptidei22 – 3110PRO_0000011432
Peptidei33 – 5927Secretin1 PublicationPRO_0000011433Add
BLAST
Propeptidei63 – 13472PRO_0000011434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591Valine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Expressioni

Gene expression databases

GenevestigatoriP11384.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024094.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG329190.
GeneTreeiENSGT00390000002624.
HOGENOMiHOG000133017.
HOVERGENiHBG017786.
KOiK05263.
OMAiNSTAWTR.
OrthoDBiEOG77DJ88.
PhylomeDBiP11384.
TreeFamiTF338215.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERiPTHR17378. PTHR17378. 1 hit.
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11384-1 [UniParc]FASTAAdd to Basket

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MEPLLPTPPL LLLLLLLLSS SFVLPAPPRT PRHSDGTFTS ELSRLQDSAR    50
LQRLLQGLVG KRSEEDTENI PENSVARPKP LEDQLCLLWS NTQALQDWLL 100
PRLSLDGSLS LWLPPGPRPA VDHSEWTETT RQPR 134
Length:134
Mass (Da):15,072
Last modified:April 1, 1990 - v2
Checksum:iD9FA1A4C1F7C86E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31495 mRNA. Translation: AAA42126.1.
M64033 Genomic DNA. Translation: AAA42128.1.
M63984 Genomic DNA. Translation: AAA42127.1.
PIRiA40886. A40959.
RefSeqiNP_073161.1. NM_022670.2.
XP_006230580.1. XM_006230518.1.
XP_006230581.1. XM_006230519.1.
UniGeneiRn.9919.

Genome annotation databases

EnsembliENSRNOT00000024094; ENSRNOP00000024094; ENSRNOG00000017873.
GeneIDi24769.
KEGGirno:24769.
UCSCiRGD:3643. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31495 mRNA. Translation: AAA42126.1 .
M64033 Genomic DNA. Translation: AAA42128.1 .
M63984 Genomic DNA. Translation: AAA42127.1 .
PIRi A40886. A40959.
RefSeqi NP_073161.1. NM_022670.2.
XP_006230580.1. XM_006230518.1.
XP_006230581.1. XM_006230519.1.
UniGenei Rn.9919.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000024094.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024094 ; ENSRNOP00000024094 ; ENSRNOG00000017873 .
GeneIDi 24769.
KEGGi rno:24769.
UCSCi RGD:3643. rat.

Organism-specific databases

CTDi 6343.
RGDi 3643. Sct.

Phylogenomic databases

eggNOGi NOG329190.
GeneTreei ENSGT00390000002624.
HOGENOMi HOG000133017.
HOVERGENi HBG017786.
KOi K05263.
OMAi NSTAWTR.
OrthoDBi EOG77DJ88.
PhylomeDBi P11384.
TreeFami TF338215.

Miscellaneous databases

NextBioi 604336.
PROi P11384.

Gene expression databases

Genevestigatori P11384.

Family and domain databases

InterProi IPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view ]
PANTHERi PTHR17378. PTHR17378. 1 hit.
Pfami PF00123. Hormone_2. 1 hit.
[Graphical view ]
SMARTi SM00070. GLUCA. 1 hit.
[Graphical view ]
PROSITEi PS00260. GLUCAGON. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Secretin: structure of the precursor and tissue distribution of the mRNA."
    Kopin A.S., Wheeler M.B., Leiter A.B.
    Proc. Natl. Acad. Sci. U.S.A. 87:2299-2303(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The secretin gene: evolutionary history, alternative splicing, and developmental regulation."
    Kopin A.S., Wheeler M.B., Nishitani J., McBride E.W., Chang T.M., Chey W.Y., Leiter A.B.
    Proc. Natl. Acad. Sci. U.S.A. 88:5335-5339(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The secretin precursor gene. Structure of the coding region and expression in the brain."
    Itoh N., Furuya T., Ozaki K., Kawasaki T.
    J. Biol. Chem. 266:12595-12598(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  4. Cited for: PROTEIN SEQUENCE OF 33-59, AMIDATION AT VAL-59.

Entry informationi

Entry nameiSECR_RAT
AccessioniPrimary (citable) accession number: P11384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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