P11384 (SECR_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Secretin

Gene names

Name:

Sct

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.
Subcellular location	Secreted.
Sequence similarities	Belongs to the glucagon family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Propeptide	22 – 31	10			PRO_0000011432
	Peptide	33 – 59	27	Secretin Ref.4		PRO_0000011433
	Propeptide	63 – 134	72			PRO_0000011434
Amino acid modifications
	Modified residue	59	1	Valine amide

Sequences

	Sequence		Length	Mass (Da)
	P11384 [UniParc]. Last modified April 1, 1990. Version 2. Checksum: D9FA1A4C1F7C86E6	FASTA	134	15,072
	10 20 30 40 50 60 MEPLLPTPPL LLLLLLLLSS SFVLPAPPRT PRHSDGTFTS ELSRLQDSAR LQRLLQGLVG 70 80 90 100 110 120 KRSEEDTENI PENSVARPKP LEDQLCLLWS NTQALQDWLL PRLSLDGSLS LWLPPGPRPA 130 VDHSEWTETT RQPR

References

[1]	"Secretin: structure of the precursor and tissue distribution of the mRNA." Kopin A.S., Wheeler M.B., Leiter A.B. Proc. Natl. Acad. Sci. U.S.A. 87:2299-2303(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secretin gene: evolutionary history, alternative splicing, and developmental regulation." Kopin A.S., Wheeler M.B., Nishitani J., McBride E.W., Chang T.M., Chey W.Y., Leiter A.B. Proc. Natl. Acad. Sci. U.S.A. 88:5335-5339(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The secretin precursor gene. Structure of the coding region and expression in the brain." Itoh N., Furuya T., Ozaki K., Kawasaki T. J. Biol. Chem. 266:12595-12598(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[4]	"Isolation and primary structure of rat secretin." Gossen D., Vandermeers A., Vandermeers-Piret M.-C., Rathe J., Cauvin A., Robberecht P., Christophe J. Biochem. Biophys. Res. Commun. 160:862-867(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 33-59.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M31495 mRNA. Translation: AAA42126.1. M64033 Genomic DNA. Translation: AAA42128.1. M63984 Genomic DNA. Translation: AAA42127.1.
IPI	IPI00193235.
PIR	A40959. A40886.
RefSeq	NP_073161.1. NM_022670.2.
UniGene	Rn.9919.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000024094.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000024094; ENSRNOP00000024094; ENSRNOG00000017873.
GeneID	24769.
KEGG	rno:24769.
UCSC	RGD:3643. rat.
Organism-specific databases
CTD	6343.
RGD	3643. Sct.
Phylogenomic databases
eggNOG	NOG329190.
GeneTree	ENSGT00390000002624.
HOGENOM	HOG000133017.
HOVERGEN	HBG017786.
KO	K05263.
OrthoDB	EOG454916.
Gene expression databases
Genevestigator	P11384.
GermOnline	ENSRNOG00000017873. Rattus norvegicus.
Family and domain databases
InterPro	IPR000532. Glucagon_GIP_secretin_VIP. IPR015675. Secretin. [Graphical view]
PANTHER	PTHR17378. PTHR17378. 1 hit.
Pfam	PF00123. Hormone_2. 1 hit. [Graphical view]
SMART	SM00070. GLUCA. 1 hit. [Graphical view]
PROSITE	PS00260. GLUCAGON. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	604336.

Entry information

Entry name

SECR_RAT

Accession

Primary (citable) accession number: P11384

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	April 1, 1990
Last modified:	April 3, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program