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Protein

Secretin

Gene

Sct

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates formation of NaHCO3-rich pancreatic juice and secretion of NaHCO3-rich bile and inhibits HCl production by the stomach.

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • protein N-terminus binding Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • embryonic digestive tract development Source: RGD
  • negative regulation of gastrin-induced gastric acid secretion Source: RGD
  • positive regulation of cAMP biosynthetic process Source: RGD
  • positive regulation of pancreatic juice secretion Source: RGD
  • positive regulation of somatostatin secretion Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin
Gene namesi
Name:Sct
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3643. Sct.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001143222 – 3110
PeptideiPRO_000001143333 – 59SecretinAdd BLAST27
PropeptideiPRO_000001143463 – 134Add BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59Valine amide1 Publication1
Modified residuei63PhosphoserineCombined sources1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP11384.

PTM databases

iPTMnetiP11384.
PhosphoSitePlusiP11384.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017873.
GenevisibleiP11384. RN.

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • protein N-terminus binding Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024094.

Structurei

3D structure databases

SMRiP11384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JG0Y. Eukaryota.
ENOG4111AMM. LUCA.
GeneTreeiENSGT00390000002624.
HOGENOMiHOG000133017.
HOVERGENiHBG017786.
InParanoidiP11384.
KOiK05263.
OMAiMPILQAW.
OrthoDBiEOG091G12NH.
PhylomeDBiP11384.
TreeFamiTF338215.

Family and domain databases

InterProiView protein in InterPro
IPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
PANTHERiPTHR17378. PTHR17378. 1 hit.
PfamiView protein in Pfam
PF00123. Hormone_2. 1 hit.
SMARTiView protein in SMART
SM00070. GLUCA. 1 hit.
PROSITEiView protein in PROSITE
PS00260. GLUCAGON. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLLPTPPL LLLLLLLLSS SFVLPAPPRT PRHSDGTFTS ELSRLQDSAR
60 70 80 90 100
LQRLLQGLVG KRSEEDTENI PENSVARPKP LEDQLCLLWS NTQALQDWLL
110 120 130
PRLSLDGSLS LWLPPGPRPA VDHSEWTETT RQPR
Length:134
Mass (Da):15,072
Last modified:April 1, 1990 - v2
Checksum:iD9FA1A4C1F7C86E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31495 mRNA. Translation: AAA42126.1.
M64033 Genomic DNA. Translation: AAA42128.1.
M63984 Genomic DNA. Translation: AAA42127.1.
PIRiA40886. A40959.
RefSeqiNP_073161.1. NM_022670.2.
XP_006230580.1. XM_006230518.3.
UniGeneiRn.9919.

Genome annotation databases

EnsembliENSRNOT00000024094; ENSRNOP00000024094; ENSRNOG00000017873.
GeneIDi24769.
KEGGirno:24769.
UCSCiRGD:3643. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSECR_RAT
AccessioniPrimary (citable) accession number: P11384
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: May 10, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families