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P11384

- SECR_RAT

UniProt

P11384 - SECR_RAT

Protein

Secretin

Gene

Sct

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

    GO - Biological processi

    1. dentate gyrus development Source: Ensembl
    2. negative regulation of neuron apoptotic process Source: Ensembl
    3. neuronal stem cell maintenance Source: Ensembl
    4. visual learning Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secretin
    Gene namesi
    Name:Sct
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi3643. Sct.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 3110PRO_0000011432
    Peptidei33 – 5927SecretinPRO_0000011433Add
    BLAST
    Propeptidei63 – 13472PRO_0000011434Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei59 – 591Valine amide1 Publication

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Expressioni

    Gene expression databases

    GenevestigatoriP11384.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024094.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucagon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG329190.
    GeneTreeiENSGT00390000002624.
    HOGENOMiHOG000133017.
    HOVERGENiHBG017786.
    KOiK05263.
    OMAiNSTAWTR.
    OrthoDBiEOG77DJ88.
    PhylomeDBiP11384.
    TreeFamiTF338215.

    Family and domain databases

    InterProiIPR000532. Glucagon_GIP_secretin_VIP.
    IPR015675. Prosecretin.
    [Graphical view]
    PANTHERiPTHR17378. PTHR17378. 1 hit.
    PfamiPF00123. Hormone_2. 1 hit.
    [Graphical view]
    SMARTiSM00070. GLUCA. 1 hit.
    [Graphical view]
    PROSITEiPS00260. GLUCAGON. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11384-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPLLPTPPL LLLLLLLLSS SFVLPAPPRT PRHSDGTFTS ELSRLQDSAR    50
    LQRLLQGLVG KRSEEDTENI PENSVARPKP LEDQLCLLWS NTQALQDWLL 100
    PRLSLDGSLS LWLPPGPRPA VDHSEWTETT RQPR 134
    Length:134
    Mass (Da):15,072
    Last modified:April 1, 1990 - v2
    Checksum:iD9FA1A4C1F7C86E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31495 mRNA. Translation: AAA42126.1.
    M64033 Genomic DNA. Translation: AAA42128.1.
    M63984 Genomic DNA. Translation: AAA42127.1.
    PIRiA40886. A40959.
    RefSeqiNP_073161.1. NM_022670.2.
    XP_006230580.1. XM_006230518.1.
    XP_006230581.1. XM_006230519.1.
    UniGeneiRn.9919.

    Genome annotation databases

    EnsembliENSRNOT00000024094; ENSRNOP00000024094; ENSRNOG00000017873.
    GeneIDi24769.
    KEGGirno:24769.
    UCSCiRGD:3643. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31495 mRNA. Translation: AAA42126.1 .
    M64033 Genomic DNA. Translation: AAA42128.1 .
    M63984 Genomic DNA. Translation: AAA42127.1 .
    PIRi A40886. A40959.
    RefSeqi NP_073161.1. NM_022670.2.
    XP_006230580.1. XM_006230518.1.
    XP_006230581.1. XM_006230519.1.
    UniGenei Rn.9919.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024094.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024094 ; ENSRNOP00000024094 ; ENSRNOG00000017873 .
    GeneIDi 24769.
    KEGGi rno:24769.
    UCSCi RGD:3643. rat.

    Organism-specific databases

    CTDi 6343.
    RGDi 3643. Sct.

    Phylogenomic databases

    eggNOGi NOG329190.
    GeneTreei ENSGT00390000002624.
    HOGENOMi HOG000133017.
    HOVERGENi HBG017786.
    KOi K05263.
    OMAi NSTAWTR.
    OrthoDBi EOG77DJ88.
    PhylomeDBi P11384.
    TreeFami TF338215.

    Miscellaneous databases

    NextBioi 604336.
    PROi P11384.

    Gene expression databases

    Genevestigatori P11384.

    Family and domain databases

    InterProi IPR000532. Glucagon_GIP_secretin_VIP.
    IPR015675. Prosecretin.
    [Graphical view ]
    PANTHERi PTHR17378. PTHR17378. 1 hit.
    Pfami PF00123. Hormone_2. 1 hit.
    [Graphical view ]
    SMARTi SM00070. GLUCA. 1 hit.
    [Graphical view ]
    PROSITEi PS00260. GLUCAGON. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Secretin: structure of the precursor and tissue distribution of the mRNA."
      Kopin A.S., Wheeler M.B., Leiter A.B.
      Proc. Natl. Acad. Sci. U.S.A. 87:2299-2303(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The secretin gene: evolutionary history, alternative splicing, and developmental regulation."
      Kopin A.S., Wheeler M.B., Nishitani J., McBride E.W., Chang T.M., Chey W.Y., Leiter A.B.
      Proc. Natl. Acad. Sci. U.S.A. 88:5335-5339(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The secretin precursor gene. Structure of the coding region and expression in the brain."
      Itoh N., Furuya T., Ozaki K., Kawasaki T.
      J. Biol. Chem. 266:12595-12598(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    4. Cited for: PROTEIN SEQUENCE OF 33-59, AMIDATION AT VAL-59.

    Entry informationi

    Entry nameiSECR_RAT
    AccessioniPrimary (citable) accession number: P11384
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3