Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P11384 (SECR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secretin
Gene names
Name:Sct
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length134 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

Subcellular location

Secreted.

Sequence similarities

Belongs to the glucagon family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Propeptide22 – 3110
PRO_0000011432
Peptide33 – 5927Secretin Ref.4
PRO_0000011433
Propeptide63 – 13472
PRO_0000011434

Amino acid modifications

Modified residue591Valine amide Ref.4

Sequences

Sequence LengthMass (Da)Tools
P11384 [UniParc].

Last modified April 1, 1990. Version 2.
Checksum: D9FA1A4C1F7C86E6

FASTA13415,072
        10         20         30         40         50         60 
MEPLLPTPPL LLLLLLLLSS SFVLPAPPRT PRHSDGTFTS ELSRLQDSAR LQRLLQGLVG 

        70         80         90        100        110        120 
KRSEEDTENI PENSVARPKP LEDQLCLLWS NTQALQDWLL PRLSLDGSLS LWLPPGPRPA 

       130 
VDHSEWTETT RQPR 

« Hide

References

[1]"Secretin: structure of the precursor and tissue distribution of the mRNA."
Kopin A.S., Wheeler M.B., Leiter A.B.
Proc. Natl. Acad. Sci. U.S.A. 87:2299-2303(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The secretin gene: evolutionary history, alternative splicing, and developmental regulation."
Kopin A.S., Wheeler M.B., Nishitani J., McBride E.W., Chang T.M., Chey W.Y., Leiter A.B.
Proc. Natl. Acad. Sci. U.S.A. 88:5335-5339(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The secretin precursor gene. Structure of the coding region and expression in the brain."
Itoh N., Furuya T., Ozaki K., Kawasaki T.
J. Biol. Chem. 266:12595-12598(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[4]"Isolation and primary structure of rat secretin."
Gossen D., Vandermeers A., Vandermeers-Piret M.-C., Rathe J., Cauvin A., Robberecht P., Christophe J.
Biochem. Biophys. Res. Commun. 160:862-867(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 33-59, AMIDATION AT VAL-59.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31495 mRNA. Translation: AAA42126.1.
M64033 Genomic DNA. Translation: AAA42128.1.
M63984 Genomic DNA. Translation: AAA42127.1.
PIRA40959. A40886.
RefSeqNP_073161.1. NM_022670.2.
XP_006230580.1. XM_006230518.1.
XP_006230581.1. XM_006230519.1.
UniGeneRn.9919.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000024094.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000024094; ENSRNOP00000024094; ENSRNOG00000017873.
GeneID24769.
KEGGrno:24769.
UCSCRGD:3643. rat.

Organism-specific databases

CTD6343.
RGD3643. Sct.

Phylogenomic databases

eggNOGNOG329190.
GeneTreeENSGT00390000002624.
HOGENOMHOG000133017.
HOVERGENHBG017786.
KOK05263.
OMANSTAWTR.
OrthoDBEOG77DJ88.
PhylomeDBP11384.
TreeFamTF338215.

Gene expression databases

GenevestigatorP11384.

Family and domain databases

InterProIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERPTHR17378. PTHR17378. 1 hit.
PfamPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604336.
PROP11384.

Entry information

Entry nameSECR_RAT
AccessionPrimary (citable) accession number: P11384
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families