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Protein

Secretin

Gene

Sct

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

GO - Molecular functioni

  • protein N-terminus binding Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • embryonic digestive tract development Source: RGD
  • negative regulation of gastrin-induced gastric acid secretion Source: RGD
  • positive regulation of cAMP biosynthetic process Source: RGD
  • positive regulation of pancreatic juice secretion Source: RGD
  • positive regulation of somatostatin secretion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin
Gene namesi
Name:Sct
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3643. Sct.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 3110PRO_0000011432
Peptidei33 – 5927SecretinPRO_0000011433Add
BLAST
Propeptidei63 – 13472PRO_0000011434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591Valine amide1 Publication
Modified residuei63 – 631PhosphoserineCombined sources

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP11384.

PTM databases

iPTMnetiP11384.
PhosphoSiteiP11384.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017873.
GenevisibleiP11384. RN.

Interactioni

GO - Molecular functioni

  • protein N-terminus binding Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024094.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JG0Y. Eukaryota.
ENOG4111AMM. LUCA.
GeneTreeiENSGT00390000002624.
HOGENOMiHOG000133017.
HOVERGENiHBG017786.
InParanoidiP11384.
KOiK05263.
OMAiMPILQAW.
OrthoDBiEOG091G12NH.
PhylomeDBiP11384.
TreeFamiTF338215.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERiPTHR17378. PTHR17378. 1 hit.
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLLPTPPL LLLLLLLLSS SFVLPAPPRT PRHSDGTFTS ELSRLQDSAR
60 70 80 90 100
LQRLLQGLVG KRSEEDTENI PENSVARPKP LEDQLCLLWS NTQALQDWLL
110 120 130
PRLSLDGSLS LWLPPGPRPA VDHSEWTETT RQPR
Length:134
Mass (Da):15,072
Last modified:April 1, 1990 - v2
Checksum:iD9FA1A4C1F7C86E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31495 mRNA. Translation: AAA42126.1.
M64033 Genomic DNA. Translation: AAA42128.1.
M63984 Genomic DNA. Translation: AAA42127.1.
PIRiA40886. A40959.
RefSeqiNP_073161.1. NM_022670.2.
XP_006230580.1. XM_006230518.2.
UniGeneiRn.9919.

Genome annotation databases

EnsembliENSRNOT00000024094; ENSRNOP00000024094; ENSRNOG00000017873.
GeneIDi24769.
KEGGirno:24769.
UCSCiRGD:3643. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31495 mRNA. Translation: AAA42126.1.
M64033 Genomic DNA. Translation: AAA42128.1.
M63984 Genomic DNA. Translation: AAA42127.1.
PIRiA40886. A40959.
RefSeqiNP_073161.1. NM_022670.2.
XP_006230580.1. XM_006230518.2.
UniGeneiRn.9919.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024094.

PTM databases

iPTMnetiP11384.
PhosphoSiteiP11384.

Proteomic databases

PaxDbiP11384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024094; ENSRNOP00000024094; ENSRNOG00000017873.
GeneIDi24769.
KEGGirno:24769.
UCSCiRGD:3643. rat.

Organism-specific databases

CTDi6343.
RGDi3643. Sct.

Phylogenomic databases

eggNOGiENOG410JG0Y. Eukaryota.
ENOG4111AMM. LUCA.
GeneTreeiENSGT00390000002624.
HOGENOMiHOG000133017.
HOVERGENiHBG017786.
InParanoidiP11384.
KOiK05263.
OMAiMPILQAW.
OrthoDBiEOG091G12NH.
PhylomeDBiP11384.
TreeFamiTF338215.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Miscellaneous databases

PROiP11384.

Gene expression databases

BgeeiENSRNOG00000017873.
GenevisibleiP11384. RN.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERiPTHR17378. PTHR17378. 1 hit.
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECR_RAT
AccessioniPrimary (citable) accession number: P11384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.