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P11372 (CP2CF_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C15

EC=1.14.14.1
Alternative name(s):
CYPIIC15
Cytochrome P450 B32-3
Gene names
Name:CYP2C15
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length378 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 378›378Cytochrome P450 2C15
PRO_0000051705

Sites

Metal binding3231Iron (heme axial ligand)

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P11372 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 14D524173EB07480

FASTA37843,514
        10         20         30         40         50         60 
LGILFSNANT WKEMRRFSLM TLRNFGMGKR SIEDRVQEEA RCLVEELRKT NASPCDPTFI 

        70         80         90        100        110        120 
LGCAPCNVIC SIIFHNRFDY KDEHFLKLME KFNENVRILS SPWLQICNNF PVLTDYLPGI 

       130        140        150        160        170        180 
HNTLVKNIEY TKNFIMEKVK EHQKSLDVNN PRDFIDCFLI KMDQENHLEF TLESLVTTVS 

       190        200        210        220        230        240 
DLFGAGTETT STTLSISLLL LLKHPEVAAK VQEEIERVIG RHRSPCMQDR SRMPYTDAVI 

       250        260        270        280        290        300 
HEIQRYIDLI PINLPHAVTR DIKFRNYFIP KGMNIITSLT SVLHDEKEFP NPKVFDPGHF 

       310        320        330        340        350        360 
LDESGNFKKS DYFMPFSAGK RMCVGEGLAR MELFLFLTSI LQNFKLQSLV EPKDLDITAV 

       370 
VNGFASVPPA YQLCFSPV 

« Hide

References

[1]"Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits."
Imai Y., Komori M., Sato R.
Biochemistry 27:80-88(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M19234 mRNA. Translation: AAA31218.1.
PIRB27718.

3D structure databases

ProteinModelPortalP11372.
SMRP11372. Positions 1-378.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000012210.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2CF_RABIT
AccessionPrimary (citable) accession number: P11372
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families