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P11371 (CP2C4_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C4

EC=1.14.14.1
Alternative name(s):
CYPIIC4
Cytochrome P450 PBc4
P1-88
Progesterone 21-hydroxylase
Gene names
Name:CYP2C4
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane By similarity. Microsome membrane By similarity.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Miscellaneous

This protein differs from other forms of cytochrome P450 in that it catalyzes the 21-hydroxylation of progesterone, resulting in the formation of deoxycorticosterone.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487Cytochrome P450 2C4
PRO_0000051695

Sites

Metal binding4321Iron (heme axial ligand)

Sequences

Sequence LengthMass (Da)Tools
P11371 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: F0E7F55F7512F36A

FASTA48755,387
        10         20         30         40         50         60 
MDPVAGLVLG LCCLLLLSLW KQNSGRGKLP PGPTPFPIIG NILQIDVKDI SKSLTKFSER 

        70         80         90        100        110        120 
YGPVFTVYLG MKPTVVLHGY KAVKEALVDL GEEFAGRGHF PIAEKVNKGL GIVFTNANTW 

       130        140        150        160        170        180 
KEMRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTN ALPCDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
VILHNRFDYK DEEFLKLMER LNENIRILSS PWLQVYNNFP ALLDYFPGIH KTLLKNADYT 

       250        260        270        280        290        300 
KNFIMEKVKE HQKLLDVNNP RDFIDCFLIK MEKENNLEFT LGSLVIAVFD LFGAGTETTS 

       310        320        330        340        350        360 
TTLRYSLLLL LKHPEVAARV QEEIERVIGR HRSPCMQDRS HMPYTDAVIH EIQRFIDLLP 

       370        380        390        400        410        420 
TNLPHAVTRD VKFRNYFIPK GTDIITSLTS VLHDEKAFPN PKVFDPGHFL DESGNFKKSD 

       430        440        450        460        470        480 
YFMPFSAGKR MCVGEGLARM ELFLFLTSIL QNFKLQSLVE PKDLDITAVV NGFVSVPPSY 


QLCFIPI 

« Hide

References

[1]"Characterization of a second gene product related to rabbit cytochrome P-450 1."
Johnson E.F., Barnes H.J., Griffin K.J., Okino S., Tukey R.H.
J. Biol. Chem. 262:5918-5923(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Structure of 5' regions and expression of phenobarbital-inducible rabbit cytochrome P450IIC genes."
Zhao J., Chan G., Govind S., Bell P., Kemper B.W.
DNA Cell Biol. 9:37-48(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02716 mRNA. Translation: AAA31216.1.
M74200 Genomic DNA. No translation available.
PIRA26731.
RefSeqNP_001177360.1. NM_001190431.1.
UniGeneOcu.6430.

3D structure databases

ProteinModelPortalP11371.
SMRP11371. Positions 27-487.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000021536.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100349436.

Organism-specific databases

CTD100349436.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2C4_RABIT
AccessionPrimary (citable) accession number: P11371
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families