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P11371

- CP2C4_RABIT

UniProt

P11371 - CP2C4_RABIT

Protein

Cytochrome P450 2C4

Gene

CYP2C4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi432 – 4321Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C4 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC4
    Cytochrome P450 PBc4
    P1-88
    Progesterone 21-hydroxylase
    Gene namesi
    Name:CYP2C4
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487Cytochrome P450 2C4PRO_0000051695Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000021536.

    Structurei

    3D structure databases

    ProteinModelPortaliP11371.
    SMRiP11371. Positions 27-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11371-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPVAGLVLG LCCLLLLSLW KQNSGRGKLP PGPTPFPIIG NILQIDVKDI    50
    SKSLTKFSER YGPVFTVYLG MKPTVVLHGY KAVKEALVDL GEEFAGRGHF 100
    PIAEKVNKGL GIVFTNANTW KEMRRFSLMT LRNFGMGKRS IEDRVQEEAR 150
    CLVEELRKTN ALPCDPTFIL GCAPCNVICS VILHNRFDYK DEEFLKLMER 200
    LNENIRILSS PWLQVYNNFP ALLDYFPGIH KTLLKNADYT KNFIMEKVKE 250
    HQKLLDVNNP RDFIDCFLIK MEKENNLEFT LGSLVIAVFD LFGAGTETTS 300
    TTLRYSLLLL LKHPEVAARV QEEIERVIGR HRSPCMQDRS HMPYTDAVIH 350
    EIQRFIDLLP TNLPHAVTRD VKFRNYFIPK GTDIITSLTS VLHDEKAFPN 400
    PKVFDPGHFL DESGNFKKSD YFMPFSAGKR MCVGEGLARM ELFLFLTSIL 450
    QNFKLQSLVE PKDLDITAVV NGFVSVPPSY QLCFIPI 487
    Length:487
    Mass (Da):55,387
    Last modified:July 1, 1989 - v1
    Checksum:iF0E7F55F7512F36A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02716 mRNA. Translation: AAA31216.1.
    M74200 Genomic DNA. No translation available.
    PIRiA26731.
    RefSeqiNP_001177360.1. NM_001190431.1.
    UniGeneiOcu.6430.

    Genome annotation databases

    GeneIDi100349436.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02716 mRNA. Translation: AAA31216.1 .
    M74200 Genomic DNA. No translation available.
    PIRi A26731.
    RefSeqi NP_001177360.1. NM_001190431.1.
    UniGenei Ocu.6430.

    3D structure databases

    ProteinModelPortali P11371.
    SMRi P11371. Positions 27-487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000021536.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100349436.

    Organism-specific databases

    CTDi 100349436.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a second gene product related to rabbit cytochrome P-450 1."
      Johnson E.F., Barnes H.J., Griffin K.J., Okino S., Tukey R.H.
      J. Biol. Chem. 262:5918-5923(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Structure of 5' regions and expression of phenobarbital-inducible rabbit cytochrome P450IIC genes."
      Zhao J., Chan G., Govind S., Bell P., Kemper B.W.
      DNA Cell Biol. 9:37-48(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.

    Entry informationi

    Entry nameiCP2C4_RABIT
    AccessioniPrimary (citable) accession number: P11371
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein differs from other forms of cytochrome P450 in that it catalyzes the 21-hydroxylation of progesterone, resulting in the formation of deoxycorticosterone.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3