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P11371

- CP2C4_RABIT

UniProt

P11371 - CP2C4_RABIT

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Protein

Cytochrome P450 2C4

Gene

CYP2C4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi432 – 4321Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C4 (EC:1.14.14.1)
Alternative name(s):
CYPIIC4
Cytochrome P450 PBc4
P1-88
Progesterone 21-hydroxylase
Gene namesi
Name:CYP2C4
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Cytochrome P450 2C4PRO_0000051695Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021536.

Structurei

3D structure databases

ProteinModelPortaliP11371.
SMRiP11371. Positions 27-487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP11371.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11371 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPVAGLVLG LCCLLLLSLW KQNSGRGKLP PGPTPFPIIG NILQIDVKDI
60 70 80 90 100
SKSLTKFSER YGPVFTVYLG MKPTVVLHGY KAVKEALVDL GEEFAGRGHF
110 120 130 140 150
PIAEKVNKGL GIVFTNANTW KEMRRFSLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN ALPCDPTFIL GCAPCNVICS VILHNRFDYK DEEFLKLMER
210 220 230 240 250
LNENIRILSS PWLQVYNNFP ALLDYFPGIH KTLLKNADYT KNFIMEKVKE
260 270 280 290 300
HQKLLDVNNP RDFIDCFLIK MEKENNLEFT LGSLVIAVFD LFGAGTETTS
310 320 330 340 350
TTLRYSLLLL LKHPEVAARV QEEIERVIGR HRSPCMQDRS HMPYTDAVIH
360 370 380 390 400
EIQRFIDLLP TNLPHAVTRD VKFRNYFIPK GTDIITSLTS VLHDEKAFPN
410 420 430 440 450
PKVFDPGHFL DESGNFKKSD YFMPFSAGKR MCVGEGLARM ELFLFLTSIL
460 470 480
QNFKLQSLVE PKDLDITAVV NGFVSVPPSY QLCFIPI
Length:487
Mass (Da):55,387
Last modified:July 1, 1989 - v1
Checksum:iF0E7F55F7512F36A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02716 mRNA. Translation: AAA31216.1.
M74200 Genomic DNA. No translation available.
PIRiA26731.
RefSeqiNP_001177360.1. NM_001190431.1.
UniGeneiOcu.6430.

Genome annotation databases

GeneIDi100349436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02716 mRNA. Translation: AAA31216.1 .
M74200 Genomic DNA. No translation available.
PIRi A26731.
RefSeqi NP_001177360.1. NM_001190431.1.
UniGenei Ocu.6430.

3D structure databases

ProteinModelPortali P11371.
SMRi P11371. Positions 27-487.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000021536.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100349436.

Organism-specific databases

CTDi 100349436.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P11371.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of a second gene product related to rabbit cytochrome P-450 1."
    Johnson E.F., Barnes H.J., Griffin K.J., Okino S., Tukey R.H.
    J. Biol. Chem. 262:5918-5923(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Structure of 5' regions and expression of phenobarbital-inducible rabbit cytochrome P450IIC genes."
    Zhao J., Chan G., Govind S., Bell P., Kemper B.W.
    DNA Cell Biol. 9:37-48(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.

Entry informationi

Entry nameiCP2C4_RABIT
AccessioniPrimary (citable) accession number: P11371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein differs from other forms of cytochrome P450 in that it catalyzes the 21-hydroxylation of progesterone, resulting in the formation of deoxycorticosterone.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3