P11365 (GAG_IPMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retrovirus-related Gag polyprotein

Cleaved into the following chain:

1. Protease
   EC=3.4.23.-

Gene names

Name:

gag

Organism

Mouse intracisternal a-particle MIA14 (IAP-MIA14)

Taxonomic identifier

11753 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › unclassified Retroviridae › Intracisternal A-particles › Mouse intracisternal a-particle MIAE

Virus host

Mus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length	827 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted

General annotation (Comments)

Miscellaneous	This particle is a defective retrovirus.
Sequence similarities	Contains 2 CCHC-type zinc fingers. Contains 1 G-patch domain. Contains 1 peptidase A2 domain.

Ontologies

Keywords
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Aspartyl protease Hydrolase Protease
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW viral reproduction Inferred from electronic annotation. Source: InterPro
Molecular_function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – ?				PRO_0000026111
	Chain	? – 827		Protease		PRO_0000026112
Regions
	Domain	690 – 765	76	Peptidase A2
	Domain	783 – 827	45	G-patch
	Zinc finger	458 – 475	18	CCHC-type 1
	Zinc finger	484 – 501	18	CCHC-type 2
Sites
	Active site	695	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P11365 [UniParc]. Last modified March 27, 2002. Version 2. Checksum: 697EC68C314375DC	FASTA	827	91,593
	10 20 30 40 50 60 MFGLEFFLVL EALLFLFTCY QVVKAGRILD EIQDKLSEVK RGERVGTKRK YGTQNKYTGL 70 80 90 100 110 120 SKGLEPEEKL RLGRNTWREI RRKRGKREKK KDQLAEVSRK RSLCSSLDGL GEPALSSSEA 130 140 150 160 170 180 DEEFSSEETD WEEEAAHYEK KGYQPGKVLA NQLRKPKAAG EGQFADWPQG SRLQGPPYAE 190 200 210 220 230 240 SPPCVVRQPC AERQCAKRQC ADSFIPREEQ RKIQQAFPVF EGAEGGRVHA PVEYLQIKEL 250 260 270 280 290 300 AESVRKYGTN ANFTLVQLDR LAGMALTPAD WQTVVKAALP MMGKYMEWRA LWHETAQAQA 310 320 330 340 350 360 RANAAALTPE QRDWTFDLLT GQGAYSADQT NYHWGAYAQI SSTAIRRWKG LSRAGETTGQ 370 380 390 400 410 420 LTKVVQGPQE SFSDFVARMT EAAERIFGES EQAAPLIEQL IYEQATKECR AAIAPRKNKG 430 440 450 460 470 480 LQDWLRVCRE LGGPLTNAGL AAAILQSQNR SMSRNDQRTC FNCGKPGHFK KDCRAPDKQG 490 500 510 520 530 540 GTLTLCSKCG KGYHRADQCR SVRDIKGRVL PPPDSQSAYV PKNGSSGPRS QGLKDMGTGL 550 560 570 580 590 600 SGPRKQSERR PRKTHKVDLR AASDFLLMPQ MSIQPVPVEP IPSLPLGTMG LILGRGSAST 610 620 630 640 650 660 LQGLVVHPEL WIVNIPQKYQ VLCSSPKGVF SISKGDRIPQ LLLLLPDNTR EKSAGPEIKK 670 680 690 700 710 720 MGSSGNDSAY LVVSLNDRPK LRLKINGKEF EGILDTGADK SIISTHWWPK AWPTTESSHS 730 740 750 760 770 780 LQGLGYQSCP TISSVALTWE SSEGQQGKFI PYVLPLPVNL WGRDIMQHLG LILSNENAPS 790 800 810 820 GGYSAKAKNI MAKMGYKEGK GLGHQEQGRI EPISPNGNQD RQGLGFP

References

[1]	"Nucleotide sequence of a complete mouse intracisternal A-particle genome: relationship to known aspects of particle assembly and function." Mietz J.A., Grossman Z., Lueders K.K., Kuff E.L. J. Virol. 61:3020-3029(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M17551 Genomic DNA. Translation: AAC12789.1.
PIR	FOMSIA. A26787.
3D structure databases
ProteinModelPortal	P11365.
ModBase	Search...
Protein family/group databases
MEROPS	A02.016.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.1200.30. 1 hit. 1.10.375.10. 1 hit. 2.40.70.10. 1 hit. 4.10.60.10. 1 hit.
InterPro	IPR008180. dUTP_pyroPase. IPR000467. G_patch_dom. IPR000721. Gag_p24. IPR018061. Pept_A2A_retrovirus_sg. IPR001995. Peptidase_A2_cat. IPR021109. Peptidase_aspartic. IPR001969. Peptidase_aspartic_AS. IPR008916. Retrov_capsid_C. IPR008919. Retrov_capsid_N. IPR001878. Znf_CCHC. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. PF01585. G-patch. 1 hit. PF00607. Gag_p24. 1 hit. PF00077. RVP. 1 hit. PF00098. zf-CCHC. 1 hit. [Graphical view]
SMART	SM00443. G_patch. 1 hit. SM00343. ZnF_C2HC. 2 hits. [Graphical view]
SUPFAM	SSF50630. Pept_Aspartic. 1 hit. SSF47353. Retrov_capsid_C. 1 hit. SSF47943. Retrov_capsid_N. 1 hit. SSF57756. SSF57756. 1 hit.
PROSITE	PS50175. ASP_PROT_RETROV. 1 hit. PS00141. ASP_PROTEASE. 1 hit. PS50174. G_PATCH. 1 hit. PS50158. ZF_CCHC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAG_IPMA

Accession

Primary (citable) accession number: P11365
Secondary accession number(s): Q61577

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	March 27, 2002
Last modified:	April 3, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program