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Protein

Retrovirus-related Gag polyprotein

Gene

gag

Organism
Mouse intracisternal a-particle MIA14 (IAP-MIA14)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei695 – 6951PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri458 – 47518CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50118CCHC-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiA02.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Retrovirus-related Gag polyprotein
Cleaved into the following chain:
Gene namesi
Name:gag
OrganismiMouse intracisternal a-particle MIA14 (IAP-MIA14)
Taxonomic identifieri11753 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeIntracisternal A-particles
Virus hostiMus musculus (Mouse) [TaxID: 10090]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 827ProteasePRO_0000026112
Propeptidei1 – ?PRO_0000026111

Structurei

3D structure databases

ProteinModelPortaliP11365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini690 – 76576Peptidase A2PROSITE-ProRule annotationAdd
BLAST
Domaini783 – 82745G-patchPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 CCHC-type zinc fingers.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 1 peptidase A2 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri458 – 47518CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50118CCHC-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
2.40.70.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR000467. G_patch_dom.
IPR000721. Gag_p24.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00077. RVP. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGLEFFLVL EALLFLFTCY QVVKAGRILD EIQDKLSEVK RGERVGTKRK
60 70 80 90 100
YGTQNKYTGL SKGLEPEEKL RLGRNTWREI RRKRGKREKK KDQLAEVSRK
110 120 130 140 150
RSLCSSLDGL GEPALSSSEA DEEFSSEETD WEEEAAHYEK KGYQPGKVLA
160 170 180 190 200
NQLRKPKAAG EGQFADWPQG SRLQGPPYAE SPPCVVRQPC AERQCAKRQC
210 220 230 240 250
ADSFIPREEQ RKIQQAFPVF EGAEGGRVHA PVEYLQIKEL AESVRKYGTN
260 270 280 290 300
ANFTLVQLDR LAGMALTPAD WQTVVKAALP MMGKYMEWRA LWHETAQAQA
310 320 330 340 350
RANAAALTPE QRDWTFDLLT GQGAYSADQT NYHWGAYAQI SSTAIRRWKG
360 370 380 390 400
LSRAGETTGQ LTKVVQGPQE SFSDFVARMT EAAERIFGES EQAAPLIEQL
410 420 430 440 450
IYEQATKECR AAIAPRKNKG LQDWLRVCRE LGGPLTNAGL AAAILQSQNR
460 470 480 490 500
SMSRNDQRTC FNCGKPGHFK KDCRAPDKQG GTLTLCSKCG KGYHRADQCR
510 520 530 540 550
SVRDIKGRVL PPPDSQSAYV PKNGSSGPRS QGLKDMGTGL SGPRKQSERR
560 570 580 590 600
PRKTHKVDLR AASDFLLMPQ MSIQPVPVEP IPSLPLGTMG LILGRGSAST
610 620 630 640 650
LQGLVVHPEL WIVNIPQKYQ VLCSSPKGVF SISKGDRIPQ LLLLLPDNTR
660 670 680 690 700
EKSAGPEIKK MGSSGNDSAY LVVSLNDRPK LRLKINGKEF EGILDTGADK
710 720 730 740 750
SIISTHWWPK AWPTTESSHS LQGLGYQSCP TISSVALTWE SSEGQQGKFI
760 770 780 790 800
PYVLPLPVNL WGRDIMQHLG LILSNENAPS GGYSAKAKNI MAKMGYKEGK
810 820
GLGHQEQGRI EPISPNGNQD RQGLGFP
Length:827
Mass (Da):91,593
Last modified:March 27, 2002 - v2
Checksum:i697EC68C314375DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17551 Genomic DNA. Translation: AAC12789.1.
PIRiA26787. FOMSIA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17551 Genomic DNA. Translation: AAC12789.1.
PIRiA26787. FOMSIA.

3D structure databases

ProteinModelPortaliP11365.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA02.016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
2.40.70.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR000467. G_patch_dom.
IPR000721. Gag_p24.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00077. RVP. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of a complete mouse intracisternal A-particle genome: relationship to known aspects of particle assembly and function."
    Mietz J.A., Grossman Z., Lueders K.K., Kuff E.L.
    J. Virol. 61:3020-3029(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGAG_IPMA
AccessioniPrimary (citable) accession number: P11365
Secondary accession number(s): Q61577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 27, 2002
Last modified: January 20, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This particle is a defective retrovirus.

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.