Reviewed, UniProtKB/Swiss-Prot P11356 (ACOX2_CANTR)

Names and origin

Protein names

Recommended name:
    Acyl-coenzyme A oxidase 2
      Short name=Acyl-CoA oxidase 2
    EC=1.3.3.6
Alternative name(s):
    PXP-2

Gene names

Name:

POX2

Organism

Candida tropicalis (Yeast)

Taxonomic identifier

5482 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	724 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subcellular location	Peroxisome.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 724	723	Acyl-coenzyme A oxidase 2		PRO_0000204695

Sequences

	Sequence		Length	Mass (Da)
	P11356-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: B2A145C5DDAF7379	FASTA	724	81,936
	10 20 30 40 50 60 MAMLSQPNDG HDHPEKKDPD TTPKQVAGVI SSQDPPHPAK DVAEERARTD WDLKEMHEFL 70 80 90 100 110 120 EGDEAKSEQI LRLYQSIERD PILQTRPEQF DYTQKQEREL VANRINQMTK FLETEPYGKF 130 140 150 160 170 180 RRRLQLMTVI DPSLGIRMLV NIGLFLNCVR GNGTQKQFDF WSNKKEAGIV KQLYGCFGMT 190 200 210 220 230 240 ELGHGSNVAG CETTATFDEK TDEFIIDTPH IGATKWWIGG AAHSATHTVC YARLIVKDVD 250 260 270 280 290 300 YGVKTFIVPL RDSRHSLLPG IAIGDIGAKM GRQGVDNGWI QFTEVRVPRF FMLQRWCKVD 310 320 330 340 350 360 RQGNVTLPPL EQLSYISLLE GRVGMATDSY RIGARYTTIA LRYAVGRRQF SKKAGEPETK 370 380 390 400 410 420 LIDYTLHQRR LLPYLALTYA AAVGTDRLER QHEELLANLD IALAKKDKLL LKNTITGTKS 430 440 450 460 470 480 MFVDSGSLKS TLTWLAADLI NETRQACGGH GYSSYNGFGK TYDDWVVQCT WEGDNNVLAM 490 500 510 520 530 540 SAGKTIIKTV QQVLNGKELK DSTLEFLNAA PELSKAKKAV IRIRDHVDDV DRVLKAIAGL 550 560 570 580 590 600 ISKFSKDLIP ISYQSWDSIG AQRVILSKLR CHYYLLETFN ERLNDKIKAK SPARPHLENI 610 620 630 640 650 660 IKLYYVTNIL GPFIDEFLRF GVISPQVAKY ITYEYPQKLC ANIRPYVIGL TDSFQQPDNF 670 680 690 700 710 720 INSLIGKYDG NIYTNYLESV KDVNDPSNYK APYSEALEAM LNRSALENRE RSERGKAAAD ILSK

References

[1]	"Peroxisomal acyl-coenzyme A oxidase multigene family of the yeast Candida tropicalis; nucleotide sequence of a third gene and its protein product." Okazaki K., Tan H., Fukui S., Kubota I., Kamiryo T. Gene 58:37-44(1987) [PubMed: 3692174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M18259 Genomic DNA. Translation: AAA34361.1.
PIR	OXCKP2. A27331.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.3.3.6. 1242.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACOX2_CANTR

Accession

Primary (citable) accession number: P11356

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 61 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)