Reviewed,
UniProtKB/Swiss-Prot P11352 (GPX1_MOUSE)
Last modified
June 16, 2009.
Version 100.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glutathione peroxidase 1 EC=1.11.1.9 Alternative name(s): GSHPx-1 Short name=GPx-1 Cellular glutathione peroxidase | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 201 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Protects the hemoglobin in erythrocytes from oxidative breakdown. |
| Catalytic activity | 2 glutathione + H2O2 = glutathione disulfide + 2 H2O. |
| Subunit structure | Homotetramer. |
| Subcellular location | |
| Sequence similarities | Belongs to the glutathione peroxidase family. |
| Caution | Ref.3 sequence was originally thought to originate from human. |
| Sequence caution | The sequence CAB43535.1 differs from that shown. Reason: Miscellaneous discrepancy. Number of sequencing artifacts. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 201 | 201 | Glutathione peroxidase 1 | PRO_0000066613 | |||||
Sites | |||||||||
| Active site | 47 | 1 | |||||||
Amino acid modifications | |||||||||
| Non-standard residue | 47 | 1 | Selenocysteine | ||||||
| Modified residue | 146 | 1 | N6-acetyllysine Ref.4 | ||||||
| Modified residue | 201 | 1 | Phosphoserine Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA." Chambers I., Frampton J., Goldfarb P., Affara N., McBain W., Harrison P.R. EMBO J. 5:1221-1227(1986) [PubMed: 3015592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SELENOCYSTEINE AT SEC-47. Tissue: Erythrocyte. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Bone marrow, Embryonic liver, Kidney and Liver. |
| [3] | "A human cDNA sequence for a novel glutathione peroxidase-related selenopeptide, GPRP." Dunn D.K., Howells D.D., Richardson J., Goldfarb P.S. Nucleic Acids Res. 17:6390-6390(1989) [PubMed: 2771650] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [4] | "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey." Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y. Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-146, MASS SPECTROMETRY. Tissue: Liver. |
| [5] | "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed: 17203969] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201, MASS SPECTROMETRY. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X03920 Genomic DNA. Translation: CAA27558.1. AK002245 mRNA. Translation: BAC55244.1. AK010999 mRNA. Translation: BAC55252.1. AK011019 mRNA. Translation: BAC55253.1. AK028171 mRNA. Translation: BAC55257.1. AK150548 mRNA. Translation: BAE29650.1. AK154833 mRNA. Translation: BAE32862.1. AK160388 mRNA. Translation: BAE35760.1. X15667 mRNA. Translation: CAB43535.1. Sequence problems. | |
| IPI | IPI00319652. |
| PIR | OPMSE. A25106. S05317. |
| RefSeq | NP_032186.2. |
| UniGene | Mm.1090 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GP1 based on UniProtKB P00435. |
| SMR | P11352. Positions 13-195. |
| ModBase | Search... |
Protein family/group databases | |
| PeroxiBase | 3709. MmGPx01. |
PTM databases | |
| PhosphoSite | P11352. |
2-D gel databases | |
| SWISS-2DPAGE | P11352. |
| REPRODUCTION-2DPAGE | P11352. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000063856. Mus musculus. [Contig view] |
| GeneID | 14775. |
| KEGG | mmu:14775. |
Organism-specific databases | |
| MGI | MGI:104887. Gpx1. |
Phylogenomic databases | |
| HOGENOM | P11352. |
| HOVERGEN | P11352. |
| OMA | P11352. VPVRRYS. |
Enzyme and pathway databases | |
| BRENDA | 1.11.1.9. 244. |
Gene expression databases | |
| ArrayExpress | P11352. |
| Bgee | P11352. |
| CleanEx | MM_GPX1. |
| GermOnline | ENSMUSG00000063856. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000889. Glutathione_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| PANTHER | PTHR11592. Glut_peroxidase. 1 hit. |
| Pfam | PF00255. GSHPx. 1 hit. [Graphical view] |
| PIRSF | PIRSF000303. Glutathion_perox. 1 hit. |
| PRINTS | PR01011. GLUTPROXDASE. |
| PROSITE | PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 286877. |
| SOURCE | Search... |
Entry information
| Entry name | GPX1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P11352 Secondary accession number(s): P12079, Q544W3, Q9CR54 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


