ID SIGM2_REOVL Reviewed; 418 AA. AC P11314; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 2. DT 24-JAN-2024, entry version 102. DE RecName: Full=Inner capsid protein sigma-2; DE Short=Sigma2; GN Name=S2; OS Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1). OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes; OC Reovirales; Spinareoviridae; Orthoreovirus; Mammalian orthoreovirus. OX NCBI_TaxID=10884; OH NCBI_TaxID=40674; Mammalia. RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX PubMed=1920614; DOI=10.1128/jvi.65.11.5721-5731.1991; RA Dermody T.S., Schiff L.A., Nibert M.L., Coombs K.M., Fields B.N.; RT "The S2 gene nucleotide sequences of prototype strains of the three RT reovirus serotypes: characterization of reovirus core protein sigma 2."; RL J. Virol. 65:5721-5731(1991). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=3663211; DOI=10.1016/s0006-291x(87)80190-0; RA George C.X., Crowe A., Munemitsu S.M., Atwater J.A., Samuel C.E.; RT "Biosynthesis of reovirus-specified polypeptides. Molecular cDNA cloning RT and nucleotide sequence of the reovirus serotype 1 Lang strain s2 mRNA RT which encodes the virion core polypeptide sigma 2."; RL Biochem. Biophys. Res. Commun. 147:1153-1161(1987). RN [3] RP INTERACTION WITH PROTEIN MU-NS. RX PubMed=14747553; DOI=10.1128/jvi.78.4.1882-1892.2004; RA Broering T.J., Kim J., Miller C.L., Piggott C.D., Dinoso J.B., Nibert M.L., RA Parker J.S.L.; RT "Reovirus nonstructural protein mu NS recruits viral core surface proteins RT and entering core particles to factory-like inclusions."; RL J. Virol. 78:1882-1892(2004). RN [4] RP STRUCTURE BY ELECTRON MICROSCOPY (7.0 ANGSTROMS). RX PubMed=16216585; DOI=10.1016/j.str.2005.07.012; RA Zhang X., Ji Y., Zhang L., Harrison S.C., Marinescu D.C., Nibert M.L., RA Baker T.S.; RT "Features of reovirus outer capsid protein mu1 revealed by electron RT cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom RT resolution."; RL Structure 13:1545-1557(2005). RN [5] RP X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS). RC STRAIN=Reassortant F18; RX PubMed=10801118; DOI=10.1038/35010041; RA Reinisch K.M., Nibert M.L., Harrison S.C.; RT "Structure of the reovirus core at 3.6 A resolution."; RL Nature 404:960-967(2000). CC -!- FUNCTION: Inner capsid (core) component. CC -!- SUBUNIT: Interacts with protein mu-NS; in viral inclusions. CC {ECO:0000269|PubMed:14747553}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Note=Found in the inner CC capsid (150 copies). CC -!- SIMILARITY: Belongs to the orthoreovirus sigma-1 protein family. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAA47278.1; Type=Frameshift; Evidence={ECO:0000305}; CC -!- WEB RESOURCE: Name=Virus Particle ExploreR db; Note=Icosahedral capsid CC structure; CC URL="https://viperdb.scripps.edu/Info_Page.php?VDB=1ej6"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L19774; AAA47239.1; -; Genomic_RNA. DR EMBL; M17598; AAA47278.1; ALT_FRAME; mRNA. DR PIR; A41306; FOXRL2. DR PDB; 1EJ6; X-ray; 3.60 A; D/E=1-418. DR PDB; 2CSE; EM; 7.00 A; X/Y/Z=1-418. DR PDB; 6XF8; EM; 6.50 A; E=2-418. DR PDB; 6ZTZ; EM; -; D/P=2-418. DR PDBsum; 1EJ6; -. DR PDBsum; 2CSE; -. DR PDBsum; 6XF8; -. DR PDBsum; 6ZTZ; -. DR EMDB; EMD-22166; -. DR SMR; P11314; -. DR BindingDB; P11314; -. DR EvolutionaryTrace; P11314; -. DR Proteomes; UP000007253; Genome. DR GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW. DR Gene3D; 1.10.287.1520; -; 1. DR InterPro; IPR004317; Sigma_1_2_reovir. DR Pfam; PF03084; Sigma_1_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Capsid protein; Inner capsid protein; Reference proteome; KW Virion. FT CHAIN 1..418 FT /note="Inner capsid protein sigma-2" FT /id="PRO_0000222751" FT CONFLICT 89 FT /note="I -> V (in Ref. 2; AAA47278)" FT /evidence="ECO:0000305" FT CONFLICT 205 FT /note="H -> Y (in Ref. 2; AAA47278)" FT /evidence="ECO:0000305" FT STRAND 14..18 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 23..27 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 39..44 FT /evidence="ECO:0007829|PDB:6ZTZ" FT TURN 45..48 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 61..76 FT /evidence="ECO:0007829|PDB:6ZTZ" FT TURN 77..79 FT /evidence="ECO:0007829|PDB:6ZTZ" FT STRAND 91..97 FT /evidence="ECO:0007829|PDB:6ZTZ" FT STRAND 104..106 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 109..113 FT /evidence="ECO:0007829|PDB:6ZTZ" FT STRAND 125..127 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 132..134 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 138..151 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 152..155 FT /evidence="ECO:0007829|PDB:6ZTZ" FT STRAND 157..159 FT /evidence="ECO:0007829|PDB:6ZTZ" FT STRAND 162..164 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 173..180 FT /evidence="ECO:0007829|PDB:6ZTZ" FT TURN 181..184 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 187..200 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 208..224 FT /evidence="ECO:0007829|PDB:6ZTZ" FT STRAND 230..234 FT /evidence="ECO:0007829|PDB:6ZTZ" FT STRAND 237..245 FT /evidence="ECO:0007829|PDB:6ZTZ" FT STRAND 251..255 FT /evidence="ECO:0007829|PDB:6ZTZ" FT STRAND 270..272 FT /evidence="ECO:0007829|PDB:6ZTZ" FT STRAND 275..277 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 278..280 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 284..296 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 311..313 FT /evidence="ECO:0007829|PDB:6ZTZ" FT TURN 317..319 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 332..346 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 351..385 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 399..402 FT /evidence="ECO:0007829|PDB:6ZTZ" FT HELIX 407..417 FT /evidence="ECO:0007829|PDB:6ZTZ" SQ SEQUENCE 418 AA; 47110 MW; 4B30CF9217BA1DDB CRC64; MARAAFLFKT VGFGGLQNVP INDELSSHLL RAGNSPWQLT QFLDWISLGR GLATSALVPT AGSRYYQMSC LLSGTLQIPF RPNHRWGDIR FLRLVWSAPT LDGLVVAPPQ VLAQPALQAQ ADRVYDCDDY PFLARDPRFK HRVYQQLSAV TLLNLTGFGP ISYVRVDEDM WSGDVNQLLM NYFGHTFAEI AYTLCQASAN RPWEHDGTYA RMTQIILSLF WLSYVGVIHQ QNTYRTFYFQ CNRRGDAAEV WILSCSLNHS AQIRPGNRSL FVMPTSPDWN MDVNLILSST LTGCLCSGSQ LPLIDNNSVP AVSRNIHGWT GRAGNQLHGF QVRRMVTEFC DRLRRDGVMT QAQQNQIEAL ADQTQQFKRD KLEAWAREDD QYNQANPNST MFRTKPFTNA QWGRGNTGAT SAAIAALI //