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P11314

- SIGM2_REOVL

UniProt

P11314 - SIGM2_REOVL

Protein

Inner capsid protein sigma-2

Gene

S2

Organism
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Inner capsid (core) component.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein sigma-2
    Short name:
    Sigma2
    Gene namesi
    Name:S2
    OrganismiReovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1)
    Taxonomic identifieri10884 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
    Virus hostiMammalia [TaxID: 40674]
    ProteomesiUP000007253: Genome

    Subcellular locationi

    Virion Curated
    Note: Found in the inner capsid (150 copies).

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Inner capsid protein sigma-2PRO_0000222751Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with protein mu-NS; in viral inclusions.1 Publication

    Structurei

    Secondary structure

    1
    418
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi7 – 93
    Helixi23 – 297
    Helixi39 – 457
    Helixi64 – 729
    Turni76 – 805
    Helixi109 – 1124
    Beta strandi124 – 1263
    Helixi127 – 1293
    Helixi131 – 1344
    Helixi137 – 15418
    Beta strandi162 – 1665
    Helixi168 – 1703
    Helixi175 – 1795
    Helixi180 – 1823
    Helixi187 – 20014
    Helixi209 – 22416
    Beta strandi232 – 2343
    Beta strandi237 – 2415
    Beta strandi251 – 2555
    Beta strandi268 – 2725
    Helixi277 – 2815
    Helixi283 – 2919
    Helixi306 – 3083
    Helixi311 – 3133
    Helixi332 – 34514
    Helixi351 – 38535
    Helixi399 – 4013
    Helixi410 – 4156

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EJ6X-ray3.60D/E1-418[»]
    2CSEelectron microscopy7.00X/Y/Z1-418[»]
    ProteinModelPortaliP11314.
    SMRiP11314. Positions 2-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11314.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR004317. Sigma_1_2_reovir.
    [Graphical view]
    PfamiPF03084. Sigma_1_2. 1 hit.
    [Graphical view]
    ProDomiPD004419. Sigma_1_2_reovir. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P11314-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARAAFLFKT VGFGGLQNVP INDELSSHLL RAGNSPWQLT QFLDWISLGR    50
    GLATSALVPT AGSRYYQMSC LLSGTLQIPF RPNHRWGDIR FLRLVWSAPT 100
    LDGLVVAPPQ VLAQPALQAQ ADRVYDCDDY PFLARDPRFK HRVYQQLSAV 150
    TLLNLTGFGP ISYVRVDEDM WSGDVNQLLM NYFGHTFAEI AYTLCQASAN 200
    RPWEHDGTYA RMTQIILSLF WLSYVGVIHQ QNTYRTFYFQ CNRRGDAAEV 250
    WILSCSLNHS AQIRPGNRSL FVMPTSPDWN MDVNLILSST LTGCLCSGSQ 300
    LPLIDNNSVP AVSRNIHGWT GRAGNQLHGF QVRRMVTEFC DRLRRDGVMT 350
    QAQQNQIEAL ADQTQQFKRD KLEAWAREDD QYNQANPNST MFRTKPFTNA 400
    QWGRGNTGAT SAAIAALI 418
    Length:418
    Mass (Da):47,110
    Last modified:October 1, 1993 - v2
    Checksum:i4B30CF9217BA1DDB
    GO

    Sequence cautioni

    The sequence AAA47278.1 differs from that shown. Reason: Frameshift at position 323.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 891I → V in AAA47278. (PubMed:3663211)Curated
    Sequence conflicti205 – 2051H → Y in AAA47278. (PubMed:3663211)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19774 Genomic RNA. Translation: AAA47239.1.
    M17598 mRNA. Translation: AAA47278.1. Frameshift.
    PIRiA41306. FOXRL2.

    Cross-referencesi

    Web resourcesi

    Virus Particle ExploreR db

    Icosahedral capsid structure

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19774 Genomic RNA. Translation: AAA47239.1 .
    M17598 mRNA. Translation: AAA47278.1 . Frameshift.
    PIRi A41306. FOXRL2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EJ6 X-ray 3.60 D/E 1-418 [» ]
    2CSE electron microscopy 7.00 X/Y/Z 1-418 [» ]
    ProteinModelPortali P11314.
    SMRi P11314. Positions 2-418.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P11314.

    Family and domain databases

    InterProi IPR004317. Sigma_1_2_reovir.
    [Graphical view ]
    Pfami PF03084. Sigma_1_2. 1 hit.
    [Graphical view ]
    ProDomi PD004419. Sigma_1_2_reovir. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The S2 gene nucleotide sequences of prototype strains of the three reovirus serotypes: characterization of reovirus core protein sigma 2."
      Dermody T.S., Schiff L.A., Nibert M.L., Coombs K.M., Fields B.N.
      J. Virol. 65:5721-5731(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Biosynthesis of reovirus-specified polypeptides. Molecular cDNA cloning and nucleotide sequence of the reovirus serotype 1 Lang strain s2 mRNA which encodes the virion core polypeptide sigma 2."
      George C.X., Crowe A., Munemitsu S.M., Atwater J.A., Samuel C.E.
      Biochem. Biophys. Res. Commun. 147:1153-1161(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Reovirus nonstructural protein mu NS recruits viral core surface proteins and entering core particles to factory-like inclusions."
      Broering T.J., Kim J., Miller C.L., Piggott C.D., Dinoso J.B., Nibert M.L., Parker J.S.L.
      J. Virol. 78:1882-1892(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PROTEIN MU-NS.
    4. "Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution."
      Zhang X., Ji Y., Zhang L., Harrison S.C., Marinescu D.C., Nibert M.L., Baker T.S.
      Structure 13:1545-1557(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (7.0 ANGSTROMS).
    5. "Structure of the reovirus core at 3.6 A resolution."
      Reinisch K.M., Nibert M.L., Harrison S.C.
      Nature 404:960-967(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS).
      Strain: Reassortant F18.

    Entry informationi

    Entry nameiSIGM2_REOVL
    AccessioniPrimary (citable) accession number: P11314
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3