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P11314

- SIGM2_REOVL

UniProt

P11314 - SIGM2_REOVL

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Protein
Inner capsid protein sigma-2
Gene
S2
Organism
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Inner capsid (core) component.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein sigma-2
Short name:
Sigma2
Gene namesi
Name:S2
OrganismiReovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1)
Taxonomic identifieri10884 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000007253: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Found in the inner capsid (150 copies).

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Inner capsid protein sigma-2
PRO_0000222751Add
BLAST

Interactioni

Subunit structurei

Interacts with protein mu-NS; in viral inclusions.1 Publication

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 93
Helixi23 – 297
Helixi39 – 457
Helixi64 – 729
Turni76 – 805
Helixi109 – 1124
Beta strandi124 – 1263
Helixi127 – 1293
Helixi131 – 1344
Helixi137 – 15418
Beta strandi162 – 1665
Helixi168 – 1703
Helixi175 – 1795
Helixi180 – 1823
Helixi187 – 20014
Helixi209 – 22416
Beta strandi232 – 2343
Beta strandi237 – 2415
Beta strandi251 – 2555
Beta strandi268 – 2725
Helixi277 – 2815
Helixi283 – 2919
Helixi306 – 3083
Helixi311 – 3133
Helixi332 – 34514
Helixi351 – 38535
Helixi399 – 4013
Helixi410 – 4156

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EJ6X-ray3.60D/E1-418[»]
2CSEelectron microscopy7.00X/Y/Z1-418[»]
ProteinModelPortaliP11314.
SMRiP11314. Positions 2-418.

Miscellaneous databases

EvolutionaryTraceiP11314.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR004317. Sigma_1_2_reovir.
[Graphical view]
PfamiPF03084. Sigma_1_2. 1 hit.
[Graphical view]
ProDomiPD004419. Sigma_1_2_reovir. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P11314-1 [UniParc]FASTAAdd to Basket

« Hide

MARAAFLFKT VGFGGLQNVP INDELSSHLL RAGNSPWQLT QFLDWISLGR    50
GLATSALVPT AGSRYYQMSC LLSGTLQIPF RPNHRWGDIR FLRLVWSAPT 100
LDGLVVAPPQ VLAQPALQAQ ADRVYDCDDY PFLARDPRFK HRVYQQLSAV 150
TLLNLTGFGP ISYVRVDEDM WSGDVNQLLM NYFGHTFAEI AYTLCQASAN 200
RPWEHDGTYA RMTQIILSLF WLSYVGVIHQ QNTYRTFYFQ CNRRGDAAEV 250
WILSCSLNHS AQIRPGNRSL FVMPTSPDWN MDVNLILSST LTGCLCSGSQ 300
LPLIDNNSVP AVSRNIHGWT GRAGNQLHGF QVRRMVTEFC DRLRRDGVMT 350
QAQQNQIEAL ADQTQQFKRD KLEAWAREDD QYNQANPNST MFRTKPFTNA 400
QWGRGNTGAT SAAIAALI 418
Length:418
Mass (Da):47,110
Last modified:October 1, 1993 - v2
Checksum:i4B30CF9217BA1DDB
GO

Sequence cautioni

The sequence AAA47278.1 differs from that shown. Reason: Frameshift at position 323.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891I → V in AAA47278. 1 Publication
Sequence conflicti205 – 2051H → Y in AAA47278. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19774 Genomic RNA. Translation: AAA47239.1.
M17598 mRNA. Translation: AAA47278.1. Frameshift.
PIRiA41306. FOXRL2.

Cross-referencesi

Web resourcesi

Virus Particle ExploreR db

Icosahedral capsid structure

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19774 Genomic RNA. Translation: AAA47239.1 .
M17598 mRNA. Translation: AAA47278.1 . Frameshift.
PIRi A41306. FOXRL2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EJ6 X-ray 3.60 D/E 1-418 [» ]
2CSE electron microscopy 7.00 X/Y/Z 1-418 [» ]
ProteinModelPortali P11314.
SMRi P11314. Positions 2-418.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P11314.

Family and domain databases

InterProi IPR004317. Sigma_1_2_reovir.
[Graphical view ]
Pfami PF03084. Sigma_1_2. 1 hit.
[Graphical view ]
ProDomi PD004419. Sigma_1_2_reovir. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "The S2 gene nucleotide sequences of prototype strains of the three reovirus serotypes: characterization of reovirus core protein sigma 2."
    Dermody T.S., Schiff L.A., Nibert M.L., Coombs K.M., Fields B.N.
    J. Virol. 65:5721-5731(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Biosynthesis of reovirus-specified polypeptides. Molecular cDNA cloning and nucleotide sequence of the reovirus serotype 1 Lang strain s2 mRNA which encodes the virion core polypeptide sigma 2."
    George C.X., Crowe A., Munemitsu S.M., Atwater J.A., Samuel C.E.
    Biochem. Biophys. Res. Commun. 147:1153-1161(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Reovirus nonstructural protein mu NS recruits viral core surface proteins and entering core particles to factory-like inclusions."
    Broering T.J., Kim J., Miller C.L., Piggott C.D., Dinoso J.B., Nibert M.L., Parker J.S.L.
    J. Virol. 78:1882-1892(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PROTEIN MU-NS.
  4. "Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution."
    Zhang X., Ji Y., Zhang L., Harrison S.C., Marinescu D.C., Nibert M.L., Baker T.S.
    Structure 13:1545-1557(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (7.0 ANGSTROMS).
  5. "Structure of the reovirus core at 3.6 A resolution."
    Reinisch K.M., Nibert M.L., Harrison S.C.
    Nature 404:960-967(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS).
    Strain: Reassortant F18.

Entry informationi

Entry nameiSIGM2_REOVL
AccessioniPrimary (citable) accession number: P11314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1993
Last modified: October 16, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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