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Protein

Transcriptional regulator ERG

Gene

ERG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi318 – 398ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • DNA binding Source: ProtInc
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • sequence-specific DNA binding Source: InterPro
  • signal transducer activity Source: ProtInc

GO - Biological processi

  • cell differentiation Source: GO_Central
  • cell migration Source: Ensembl
  • cell proliferation Source: ProtInc
  • endocardial cushion development Source: Ensembl
  • endocardial cushion to mesenchymal transition involved in heart valve formation Source: Ensembl
  • multicellular organism development Source: ProtInc
  • positive regulation of blood vessel remodeling Source: Ensembl
  • protein phosphorylation Source: ProtInc
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • signal transduction Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157554-MONOMER.
SignaLinkiP11308.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator ERG
Alternative name(s):
Transforming protein ERG
Gene namesi
Name:ERG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:3446. ERG.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Ewing sarcoma (ES)1 Publication
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1.1 Publication
Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
See also OMIM:612219

Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS (PubMed:8187069). Translocation t(X;21)(q25-26;q22) with ELF4 (PubMed:16303180).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei469 – 470Breakpoint for translocation to form ELF4-ERG oncogene2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2078.
MalaCardsiERG.
MIMi612219. phenotype.
OpenTargetsiENSG00000157554.
Orphaneti319. Ewing sarcoma.
370334. Extraskeletal Ewing sarcoma.
370348. Peripheral primitive neuroectodermal tumor.
PharmGKBiPA27858.

Chemistry databases

ChEMBLiCHEMBL1293191.

Polymorphism and mutation databases

BioMutaiERG.
DMDMi152031600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041031 – 486Transcriptional regulator ERGAdd BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP11308.
PeptideAtlasiP11308.
PRIDEiP11308.
TopDownProteomicsiP11308-6. [P11308-6]

PTM databases

iPTMnetiP11308.
PhosphoSitePlusiP11308.

Expressioni

Gene expression databases

BgeeiENSG00000157554.
CleanExiHS_ERG.
ExpressionAtlasiP11308. baseline and differential.
GenevisibleiP11308. HS.

Organism-specific databases

HPAiCAB018377.
HPA046598.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102753EBI-79704,EBI-608057
PARP1P098747EBI-79704,EBI-355676

Protein-protein interaction databases

BioGridi108389. 79 interactors.
DIPiDIP-31028N.
IntActiP11308. 16 interactors.
MINTiMINT-4910866.
STRINGi9606.ENSP00000381891.

Chemistry databases

BindingDBiP11308.

Structurei

Secondary structure

1486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi116 – 119Combined sources4
Turni127 – 130Combined sources4
Beta strandi131 – 134Combined sources4
Helixi143 – 157Combined sources15
Helixi164 – 166Combined sources3
Helixi172 – 175Combined sources4
Helixi180 – 183Combined sources4
Turni184 – 186Combined sources3
Helixi189 – 202Combined sources14
Helixi320 – 328Combined sources9
Helixi331 – 333Combined sources3
Turni334 – 336Combined sources3
Beta strandi337 – 339Combined sources3
Beta strandi345 – 347Combined sources3
Helixi351 – 362Combined sources12
Helixi369 – 381Combined sources13
Beta strandi384 – 387Combined sources4
Beta strandi394 – 397Combined sources4
Helixi399 – 405Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SXENMR-A115-208[»]
4IRGX-ray1.70A313-412[»]
4IRHX-ray2.10A287-412[»]
4IRIX-ray2.77A287-412[»]
ProteinModelPortaliP11308.
SMRiP11308.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11308.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 206PNTPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOVERGENiHBG001553.
InParanoidiP11308.
KOiK09435.
OMAiNSNCITW.
OrthoDBiEOG091G0EWP.
PhylomeDBiP11308.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform ERG-3 (identifier: P11308-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ
60 70 80 90 100
TSKMSPRVPQ QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM
110 120 130 140 150
VGSPDTVGMN YGSYMEEKHM PPPNMTTNER RVIVPADPTL WSTDHVRQWL
160 170 180 190 200
EWAVKEYGLP DVNILLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH
210 220 230 240 250
YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR
260 270 280 290 300
ITTRPDLPYE PPRRSAWTGH GHPTPQSKAA QPSPSTVPKT EDQRPQLDPY
310 320 330 340 350
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSSCITWE GTNGEFKMTD
360 370 380 390 400
PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH
410 420 430 440 450
GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVAP HPPALPVTSS
460 470 480
SFFAAPNPYW NSPTGGIYPN TRLPTSHMPS HLGTYY
Length:486
Mass (Da):54,608
Last modified:July 10, 2007 - v2
Checksum:iA0B548DFAE25029E
GO
Isoform ERG-2 (identifier: P11308-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-255: Missing.

Show »
Length:462
Mass (Da):52,031
Checksum:iB29F14B0F5C2C697
GO
Isoform ERG-1 (identifier: P11308-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     232-255: Missing.

Show »
Length:363
Mass (Da):41,397
Checksum:iB77B652BEBAFDAFA
GO
Isoform 5 (identifier: P11308-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MIQTVPDPAAH → MAST

Show »
Length:479
Mass (Da):53,838
Checksum:iA5069C393E409483
GO
Isoform 7 (identifier: P11308-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-317: SGQ → WTQ
     318-486: Missing.

Show »
Length:317
Mass (Da):35,286
Checksum:iA30FAAD4E5E119CC
GO
Isoform 8 (identifier: P11308-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-325: DLPYEPPRRS...GQIQLWQFLL → GTKTPLCDLF...KTTLKELRAD
     326-486: Missing.

Show »
Length:325
Mass (Da):36,541
Checksum:iCF149350960CCE05
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0014691 – 99Missing in isoform ERG-1. 2 PublicationsAdd BLAST99
Alternative sequenceiVSP_0265841 – 11MIQTVPDPAAH → MAST in isoform 5. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_026579232 – 255Missing in isoform ERG-1 and isoform ERG-2. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_026580256 – 325DLPYE…WQFLL → GTKTPLCDLFIERHPRCPAE IRALSHVIQRELIPELKPVP DSLILPLLIWRLNPLKPFHS KTTLKELRAD in isoform 8. CuratedAdd BLAST70
Alternative sequenceiVSP_026582315 – 317SGQ → WTQ in isoform 7. 1 Publication3
Alternative sequenceiVSP_026583318 – 486Missing in isoform 7. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_026581326 – 486Missing in isoform 8. CuratedAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17254 mRNA. Translation: AAA52398.1.
M21535 mRNA. Translation: AAA35811.1.
AY204741 mRNA. Translation: AAP41719.1.
AY204742 mRNA. Translation: AAP41720.1.
AK300395 mRNA. Translation: BAG62127.1.
AK303518 mRNA. Translation: BAG64546.1.
BC040168 mRNA. Translation: AAH40168.1.
S68130 mRNA. Translation: AAB29724.1.
CCDSiCCDS13657.1. [P11308-1]
CCDS13658.1. [P11308-4]
CCDS46648.1. [P11308-3]
CCDS58789.1. [P11308-2]
PIRiA94294. TVHUEG.
RefSeqiNP_001129626.1. NM_001136154.1. [P11308-3]
NP_001129627.1. NM_001136155.1.
NP_001230357.1. NM_001243428.1. [P11308-3]
NP_001230358.1. NM_001243429.1. [P11308-2]
NP_001230361.1. NM_001243432.2. [P11308-5]
NP_001278320.1. NM_001291391.1. [P11308-6]
NP_004440.1. NM_004449.4. [P11308-1]
NP_891548.1. NM_182918.3. [P11308-4]
UniGeneiHs.473819.

Genome annotation databases

EnsembliENST00000288319; ENSP00000288319; ENSG00000157554. [P11308-4]
ENST00000398897; ENSP00000381871; ENSG00000157554. [P11308-2]
ENST00000398911; ENSP00000381882; ENSG00000157554. [P11308-1]
ENST00000398919; ENSP00000381891; ENSG00000157554. [P11308-3]
ENST00000417133; ENSP00000414150; ENSG00000157554. [P11308-3]
ENST00000442448; ENSP00000394694; ENSG00000157554. [P11308-1]
GeneIDi2078.
KEGGihsa:2078.
UCSCiuc002yxa.4. human. [P11308-3]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17254 mRNA. Translation: AAA52398.1.
M21535 mRNA. Translation: AAA35811.1.
AY204741 mRNA. Translation: AAP41719.1.
AY204742 mRNA. Translation: AAP41720.1.
AK300395 mRNA. Translation: BAG62127.1.
AK303518 mRNA. Translation: BAG64546.1.
BC040168 mRNA. Translation: AAH40168.1.
S68130 mRNA. Translation: AAB29724.1.
CCDSiCCDS13657.1. [P11308-1]
CCDS13658.1. [P11308-4]
CCDS46648.1. [P11308-3]
CCDS58789.1. [P11308-2]
PIRiA94294. TVHUEG.
RefSeqiNP_001129626.1. NM_001136154.1. [P11308-3]
NP_001129627.1. NM_001136155.1.
NP_001230357.1. NM_001243428.1. [P11308-3]
NP_001230358.1. NM_001243429.1. [P11308-2]
NP_001230361.1. NM_001243432.2. [P11308-5]
NP_001278320.1. NM_001291391.1. [P11308-6]
NP_004440.1. NM_004449.4. [P11308-1]
NP_891548.1. NM_182918.3. [P11308-4]
UniGeneiHs.473819.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SXENMR-A115-208[»]
4IRGX-ray1.70A313-412[»]
4IRHX-ray2.10A287-412[»]
4IRIX-ray2.77A287-412[»]
ProteinModelPortaliP11308.
SMRiP11308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108389. 79 interactors.
DIPiDIP-31028N.
IntActiP11308. 16 interactors.
MINTiMINT-4910866.
STRINGi9606.ENSP00000381891.

Chemistry databases

BindingDBiP11308.
ChEMBLiCHEMBL1293191.

PTM databases

iPTMnetiP11308.
PhosphoSitePlusiP11308.

Polymorphism and mutation databases

BioMutaiERG.
DMDMi152031600.

Proteomic databases

PaxDbiP11308.
PeptideAtlasiP11308.
PRIDEiP11308.
TopDownProteomicsiP11308-6. [P11308-6]

Protocols and materials databases

DNASUi2078.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288319; ENSP00000288319; ENSG00000157554. [P11308-4]
ENST00000398897; ENSP00000381871; ENSG00000157554. [P11308-2]
ENST00000398911; ENSP00000381882; ENSG00000157554. [P11308-1]
ENST00000398919; ENSP00000381891; ENSG00000157554. [P11308-3]
ENST00000417133; ENSP00000414150; ENSG00000157554. [P11308-3]
ENST00000442448; ENSP00000394694; ENSG00000157554. [P11308-1]
GeneIDi2078.
KEGGihsa:2078.
UCSCiuc002yxa.4. human. [P11308-3]

Organism-specific databases

CTDi2078.
DisGeNETi2078.
GeneCardsiERG.
HGNCiHGNC:3446. ERG.
HPAiCAB018377.
HPA046598.
MalaCardsiERG.
MIMi165080. gene.
612219. phenotype.
neXtProtiNX_P11308.
OpenTargetsiENSG00000157554.
Orphaneti319. Ewing sarcoma.
370334. Extraskeletal Ewing sarcoma.
370348. Peripheral primitive neuroectodermal tumor.
PharmGKBiPA27858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOVERGENiHBG001553.
InParanoidiP11308.
KOiK09435.
OMAiNSNCITW.
OrthoDBiEOG091G0EWP.
PhylomeDBiP11308.
TreeFamiTF350537.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157554-MONOMER.
SignaLinkiP11308.

Miscellaneous databases

ChiTaRSiERG. human.
EvolutionaryTraceiP11308.
GeneWikiiERG_(gene).
GenomeRNAii2078.
PROiP11308.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157554.
CleanExiHS_ERG.
ExpressionAtlasiP11308. baseline and differential.
GenevisibleiP11308. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERG_HUMAN
AccessioniPrimary (citable) accession number: P11308
Secondary accession number(s): B4DTW5
, B4E0T4, Q16113, Q6XXX4, Q6XXX5, Q8IXK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 180 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.