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P11308

- ERG_HUMAN

UniProt

P11308 - ERG_HUMAN

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Protein

Transcriptional regulator ERG

Gene

ERG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei469 – 4702Breakpoint for translocation to form ELF4-ERG oncogene

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi318 – 39881ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  4. signal transducer activity Source: ProtInc

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. cell proliferation Source: ProtInc
  3. multicellular organismal development Source: ProtInc
  4. protein phosphorylation Source: ProtInc
  5. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  6. signal transduction Source: ProtInc
  7. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP11308.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator ERG
Alternative name(s):
Transforming protein ERG
Gene namesi
Name:ERG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:3446. ERG.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation. Cytoplasm 1 Publication
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: RefGenome
  3. ribonucleoprotein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1.
Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi612219. phenotype.
Orphaneti319. Ewing sarcoma.
370334. Extraskeletal Ewing sarcoma.
370348. Peripheral primitive neuroectodermal tumor.
PharmGKBiPA27858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Transcriptional regulator ERGPRO_0000204103Add
BLAST

Proteomic databases

MaxQBiP11308.
PaxDbiP11308.
PRIDEiP11308.

Expressioni

Gene expression databases

BgeeiP11308.
CleanExiHS_ERG.
ExpressionAtlasiP11308. baseline and differential.
GenevestigatoriP11308.

Organism-specific databases

HPAiCAB018377.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102753EBI-79704,EBI-608057
PARP1P098747EBI-79704,EBI-355676

Protein-protein interaction databases

BioGridi108389. 78 interactions.
DIPiDIP-31028N.
IntActiP11308. 12 interactions.
MINTiMINT-4910866.
STRINGi9606.ENSP00000381891.

Structurei

Secondary structure

1
486
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi116 – 1194Combined sources
Turni127 – 1304Combined sources
Beta strandi131 – 1344Combined sources
Helixi143 – 15715Combined sources
Helixi164 – 1663Combined sources
Helixi172 – 1754Combined sources
Helixi180 – 1834Combined sources
Turni184 – 1863Combined sources
Helixi189 – 20214Combined sources
Helixi320 – 3289Combined sources
Helixi331 – 3333Combined sources
Turni334 – 3363Combined sources
Beta strandi337 – 3393Combined sources
Beta strandi345 – 3473Combined sources
Helixi351 – 36212Combined sources
Helixi369 – 38113Combined sources
Beta strandi384 – 3874Combined sources
Beta strandi394 – 3974Combined sources
Helixi399 – 4057Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SXENMR-A115-208[»]
4IRGX-ray1.70A313-412[»]
4IRHX-ray2.10A287-412[»]
4IRIX-ray2.77A287-412[»]
ProteinModelPortaliP11308.
SMRiP11308. Positions 112-208, 307-408.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11308.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 20687PNTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG242679.
GeneTreeiENSGT00760000118907.
HOVERGENiHBG001553.
InParanoidiP11308.
KOiK09435.
OMAiNSNCITW.
PhylomeDBiP11308.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform ERG-3 (identifier: P11308-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ
60 70 80 90 100
TSKMSPRVPQ QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM
110 120 130 140 150
VGSPDTVGMN YGSYMEEKHM PPPNMTTNER RVIVPADPTL WSTDHVRQWL
160 170 180 190 200
EWAVKEYGLP DVNILLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH
210 220 230 240 250
YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR
260 270 280 290 300
ITTRPDLPYE PPRRSAWTGH GHPTPQSKAA QPSPSTVPKT EDQRPQLDPY
310 320 330 340 350
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSSCITWE GTNGEFKMTD
360 370 380 390 400
PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH
410 420 430 440 450
GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVAP HPPALPVTSS
460 470 480
SFFAAPNPYW NSPTGGIYPN TRLPTSHMPS HLGTYY
Length:486
Mass (Da):54,608
Last modified:July 10, 2007 - v2
Checksum:iA0B548DFAE25029E
GO
Isoform ERG-2 (identifier: P11308-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-255: Missing.

Show »
Length:462
Mass (Da):52,031
Checksum:iB29F14B0F5C2C697
GO
Isoform ERG-1 (identifier: P11308-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     232-255: Missing.

Show »
Length:363
Mass (Da):41,397
Checksum:iB77B652BEBAFDAFA
GO
Isoform 5 (identifier: P11308-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MIQTVPDPAAH → MAST

Show »
Length:479
Mass (Da):53,838
Checksum:iA5069C393E409483
GO
Isoform 7 (identifier: P11308-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-317: SGQ → WTQ
     318-486: Missing.

Show »
Length:317
Mass (Da):35,286
Checksum:iA30FAAD4E5E119CC
GO
Isoform 8 (identifier: P11308-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-325: DLPYEPPRRS...GQIQLWQFLL → GTKTPLCDLF...KTTLKELRAD
     326-486: Missing.

Show »
Length:325
Mass (Da):36,541
Checksum:iCF149350960CCE05
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9999Missing in isoform ERG-1. 2 PublicationsVSP_001469Add
BLAST
Alternative sequencei1 – 1111MIQTVPDPAAH → MAST in isoform 5. 2 PublicationsVSP_026584Add
BLAST
Alternative sequencei232 – 25524Missing in isoform ERG-1 and isoform ERG-2. 3 PublicationsVSP_026579Add
BLAST
Alternative sequencei256 – 32570DLPYE…WQFLL → GTKTPLCDLFIERHPRCPAE IRALSHVIQRELIPELKPVP DSLILPLLIWRLNPLKPFHS KTTLKELRAD in isoform 8. CuratedVSP_026580Add
BLAST
Alternative sequencei315 – 3173SGQ → WTQ in isoform 7. 1 PublicationVSP_026582
Alternative sequencei318 – 486169Missing in isoform 7. 1 PublicationVSP_026583Add
BLAST
Alternative sequencei326 – 486161Missing in isoform 8. CuratedVSP_026581Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17254 mRNA. Translation: AAA52398.1.
M21535 mRNA. Translation: AAA35811.1.
AY204741 mRNA. Translation: AAP41719.1.
AY204742 mRNA. Translation: AAP41720.1.
AK300395 mRNA. Translation: BAG62127.1.
AK303518 mRNA. Translation: BAG64546.1.
BC040168 mRNA. Translation: AAH40168.1.
S68130 mRNA. Translation: AAB29724.1.
CCDSiCCDS13657.1. [P11308-1]
CCDS13658.1. [P11308-4]
CCDS46648.1. [P11308-3]
CCDS58789.1. [P11308-2]
PIRiA94294. TVHUEG.
RefSeqiNP_001129626.1. NM_001136154.1. [P11308-3]
NP_001129627.1. NM_001136155.1.
NP_001230357.1. NM_001243428.1. [P11308-3]
NP_001230358.1. NM_001243429.1. [P11308-2]
NP_001230361.1. NM_001243432.2. [P11308-5]
NP_001278320.1. NM_001291391.1. [P11308-6]
NP_004440.1. NM_004449.4. [P11308-1]
NP_891548.1. NM_182918.3. [P11308-4]
UniGeneiHs.473819.

Genome annotation databases

EnsembliENST00000288319; ENSP00000288319; ENSG00000157554. [P11308-4]
ENST00000398897; ENSP00000381871; ENSG00000157554. [P11308-2]
ENST00000398911; ENSP00000381882; ENSG00000157554. [P11308-1]
ENST00000398919; ENSP00000381891; ENSG00000157554. [P11308-3]
ENST00000417133; ENSP00000414150; ENSG00000157554. [P11308-3]
ENST00000442448; ENSP00000394694; ENSG00000157554. [P11308-1]
ENST00000453032; ENSP00000396268; ENSG00000157554.
GeneIDi2078.
KEGGihsa:2078.
UCSCiuc002yxa.3. human. [P11308-4]
uc002yxb.3. human. [P11308-1]
uc002yxc.4. human. [P11308-6]
uc010gnw.3. human. [P11308-3]
uc021wjd.1. human. [P11308-5]

Polymorphism databases

DMDMi152031600.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17254 mRNA. Translation: AAA52398.1 .
M21535 mRNA. Translation: AAA35811.1 .
AY204741 mRNA. Translation: AAP41719.1 .
AY204742 mRNA. Translation: AAP41720.1 .
AK300395 mRNA. Translation: BAG62127.1 .
AK303518 mRNA. Translation: BAG64546.1 .
BC040168 mRNA. Translation: AAH40168.1 .
S68130 mRNA. Translation: AAB29724.1 .
CCDSi CCDS13657.1. [P11308-1 ]
CCDS13658.1. [P11308-4 ]
CCDS46648.1. [P11308-3 ]
CCDS58789.1. [P11308-2 ]
PIRi A94294. TVHUEG.
RefSeqi NP_001129626.1. NM_001136154.1. [P11308-3 ]
NP_001129627.1. NM_001136155.1.
NP_001230357.1. NM_001243428.1. [P11308-3 ]
NP_001230358.1. NM_001243429.1. [P11308-2 ]
NP_001230361.1. NM_001243432.2. [P11308-5 ]
NP_001278320.1. NM_001291391.1. [P11308-6 ]
NP_004440.1. NM_004449.4. [P11308-1 ]
NP_891548.1. NM_182918.3. [P11308-4 ]
UniGenei Hs.473819.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SXE NMR - A 115-208 [» ]
4IRG X-ray 1.70 A 313-412 [» ]
4IRH X-ray 2.10 A 287-412 [» ]
4IRI X-ray 2.77 A 287-412 [» ]
ProteinModelPortali P11308.
SMRi P11308. Positions 112-208, 307-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108389. 78 interactions.
DIPi DIP-31028N.
IntActi P11308. 12 interactions.
MINTi MINT-4910866.
STRINGi 9606.ENSP00000381891.

Chemistry

BindingDBi P11308.
ChEMBLi CHEMBL1293191.

Polymorphism databases

DMDMi 152031600.

Proteomic databases

MaxQBi P11308.
PaxDbi P11308.
PRIDEi P11308.

Protocols and materials databases

DNASUi 2078.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000288319 ; ENSP00000288319 ; ENSG00000157554 . [P11308-4 ]
ENST00000398897 ; ENSP00000381871 ; ENSG00000157554 . [P11308-2 ]
ENST00000398911 ; ENSP00000381882 ; ENSG00000157554 . [P11308-1 ]
ENST00000398919 ; ENSP00000381891 ; ENSG00000157554 . [P11308-3 ]
ENST00000417133 ; ENSP00000414150 ; ENSG00000157554 . [P11308-3 ]
ENST00000442448 ; ENSP00000394694 ; ENSG00000157554 . [P11308-1 ]
ENST00000453032 ; ENSP00000396268 ; ENSG00000157554 .
GeneIDi 2078.
KEGGi hsa:2078.
UCSCi uc002yxa.3. human. [P11308-4 ]
uc002yxb.3. human. [P11308-1 ]
uc002yxc.4. human. [P11308-6 ]
uc010gnw.3. human. [P11308-3 ]
uc021wjd.1. human. [P11308-5 ]

Organism-specific databases

CTDi 2078.
GeneCardsi GC21M039751.
HGNCi HGNC:3446. ERG.
HPAi CAB018377.
MIMi 165080. gene.
612219. phenotype.
neXtProti NX_P11308.
Orphaneti 319. Ewing sarcoma.
370334. Extraskeletal Ewing sarcoma.
370348. Peripheral primitive neuroectodermal tumor.
PharmGKBi PA27858.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242679.
GeneTreei ENSGT00760000118907.
HOVERGENi HBG001553.
InParanoidi P11308.
KOi K09435.
OMAi NSNCITW.
PhylomeDBi P11308.
TreeFami TF350537.

Enzyme and pathway databases

SignaLinki P11308.

Miscellaneous databases

ChiTaRSi ERG. human.
EvolutionaryTracei P11308.
GeneWikii ERG_(gene).
GenomeRNAii 2078.
NextBioi 8447.
PROi P11308.
SOURCEi Search...

Gene expression databases

Bgeei P11308.
CleanExi HS_ERG.
ExpressionAtlasi P11308. baseline and differential.
Genevestigatori P11308.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProi IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation."
    Rao V.N., Papas T.S., Shyam E., Reddy P.
    Science 237:635-639(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ERG-2).
  2. "The erg gene: a human gene related to the ets oncogene."
    Reddy E.S.P., Rao V.N., Papas T.S.
    Proc. Natl. Acad. Sci. U.S.A. 84:6131-6135(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ERG-1).
  3. "Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16."
    Owczarek C.M., Portbury K.J., Hardy M.P., O'Leary D.A., Kudoh J., Shibuya K., Shimizu N., Kola I., Hertzog P.J.
    Gene 324:65-77(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND ERG-1).
    Tissue: Thymus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Testis.
  6. "Differentially spliced erg-3 product functions as a transcriptional activator."
    Prasad D.D., Rao V.N., Lee L., Reddy E.S.
    Oncogene 9:669-673(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 230-259 (ISOFORM ERG-3).
  7. "ERG gene is translocated in an Ewing's sarcoma cell line."
    Dunn T., Praissman L., Hagag N., Viola M.V.
    Cancer Genet. Cytogenet. 76:19-22(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH EWSR1.
  8. "An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation."
    Ichikawa H., Shimizu K., Hayashi Y., Ohki M.
    Cancer Res. 54:2865-2868(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH FUS.
  9. "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)."
    Moore S.D., Offor O., Ferry J.A., Amrein P.C., Morton C.C., Dal Cin P.
    Leuk. Res. 30:1037-1042(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH ELF4.
  10. Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  11. Cited for: STRUCTURE BY NMR OF 112-208.

Entry informationi

Entry nameiERG_HUMAN
AccessioniPrimary (citable) accession number: P11308
Secondary accession number(s): B4DTW5
, B4E0T4, Q16113, Q6XXX4, Q6XXX5, Q8IXK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 10, 2007
Last modified: November 26, 2014
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3