P11308 (ERG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional regulator ERG

Alternative name(s):
Transforming protein ERG

Gene names

Name:

ERG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
Subunit structure	Interacts with SETDB1 By similarity. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Ref.10
Subcellular location	Nucleus. Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Ref.10
Involvement in disease	Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1. Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4.
Sequence similarities	Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Disease	Proto-oncogene
Ligand	DNA-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement Ref.2. Source: ProtInc multicellular organismal development Traceable author statement PubMed 8502479. Source: ProtInc protein phosphorylation Traceable author statement PubMed 8502479. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Traceable author statement PubMed 8502479. Source: ProtInc ribonucleoprotein complex Inferred from direct assay Ref.10. Source: UniProtKB
Molecular_function	DNA binding Traceable author statement PubMed 8502479. Source: ProtInc sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro signal transducer activity Traceable author statement PubMed 8502479. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AR	P10275	2	EBI-79704,EBI-608057
PARP1	P09874	7	EBI-79704,EBI-355676

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform ERG-3 (identifier: P11308-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform ERG-2 (identifier: P11308-1)

The sequence of this isoform differs from the canonical sequence as follows:
     232-255: Missing.

Isoform ERG-1 (identifier: P11308-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.

Isoform 5 (identifier: P11308-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MIQTVPDPAAH → MAST

Isoform 7 (identifier: P11308-5)

The sequence of this isoform differs from the canonical sequence as follows:
     315-317: SGQ → WTQ
     318-486: Missing.

Isoform 8 (identifier: P11308-6)

The sequence of this isoform differs from the canonical sequence as follows:
     256-325: DLPYEPPRRS...GQIQLWQFLL → GTKTPLCDLF...KTTLKELRAD
     326-486: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 486

486

Transcriptional regulator ERG

PRO_0000204103

Regions

Domain

120 – 206

87

PNT

DNA binding

318 – 398

81

ETS

Sites

Site

469 – 470

2

Breakpoint for translocation to form ELF4-ERG oncogene

Natural variations

Alternative sequence

1 – 99

99

Missing in isoform ERG-1.

VSP_001469

Alternative sequence

1 – 11

11

MIQTVPDPAAH → MAST in isoform 5.

VSP_026584

Alternative sequence

232 – 255

24

Missing in isoform ERG-2.

VSP_026579

Alternative sequence

256 – 325

70

DLPYE…WQFLL → GTKTPLCDLFIERHPRCPAE IRALSHVIQRELIPELKPVP DSLILPLLIWRLNPLKPFHS KTTLKELRAD in isoform 8.

VSP_026580

Alternative sequence

315 – 317

3

SGQ → WTQ in isoform 7.

VSP_026582

Alternative sequence

318 – 486

169

Missing in isoform 7.

VSP_026583

Alternative sequence

326 – 486

161

Missing in isoform 8.

VSP_026581

Secondary structure

1

.

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.

.

.

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.

.

.

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.

.

.

486

Helix Strand Turn

Details...

Helix

116 – 119

4

Turn

127 – 130

4

Beta strand

131 – 134

4

Helix

143 – 157

15

Helix

164 – 166

3

Helix

172 – 175

4

Helix

180 – 183

4

Turn

184 – 186

3

Helix

189 – 202

14

Sequences

	Sequence		Length	Mass (Da)
	Isoform ERG-3 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: A0B548DFAE25029E	FASTA	486	54,608
	10 20 30 40 50 60 MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ TSKMSPRVPQ 70 80 90 100 110 120 QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM VGSPDTVGMN YGSYMEEKHM 130 140 150 160 170 180 PPPNMTTNER RVIVPADPTL WSTDHVRQWL EWAVKEYGLP DVNILLFQNI DGKELCKMTK 190 200 210 220 230 240 DDFQRLTPSY NADILLSHLH YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN 250 260 270 280 290 300 TSVYPEATQR ITTRPDLPYE PPRRSAWTGH GHPTPQSKAA QPSPSTVPKT EDQRPQLDPY 310 320 330 340 350 360 QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSSCITWE GTNGEFKMTD PDEVARRWGE 370 380 390 400 410 420 RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH GIAQALQPHP PESSLYKYPS 430 440 450 460 470 480 DLPYMGSYHA HPQKMNFVAP HPPALPVTSS SFFAAPNPYW NSPTGGIYPN TRLPTSHMPS HLGTYY
	Isoform ERG-2 [UniParc]. Checksum: B29F14B0F5C2C697	FASTA	462	52,031
	10 20 30 40 50 60 MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ TSKMSPRVPQ 70 80 90 100 110 120 QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM VGSPDTVGMN YGSYMEEKHM 130 140 150 160 170 180 PPPNMTTNER RVIVPADPTL WSTDHVRQWL EWAVKEYGLP DVNILLFQNI DGKELCKMTK 190 200 210 220 230 240 DDFQRLTPSY NADILLSHLH YLRETPLPHL TSDDVDKALQ NSPRLMHARN TDLPYEPPRR 250 260 270 280 290 300 SAWTGHGHPT PQSKAAQPSP STVPKTEDQR PQLDPYQILG PTSSRLANPG SGQIQLWQFL 310 320 330 340 350 360 LELLSDSSNS SCITWEGTNG EFKMTDPDEV ARRWGERKSK PNMNYDKLSR ALRYYYDKNI 370 380 390 400 410 420 MTKVHGKRYA YKFDFHGIAQ ALQPHPPESS LYKYPSDLPY MGSYHAHPQK MNFVAPHPPA 430 440 450 460 LPVTSSSFFA APNPYWNSPT GGIYPNTRLP TSHMPSHLGT YY
	Isoform ERG-1 [UniParc]. Checksum: 6C19CE3D70C769EA	FASTA	387	43,974
	10 20 30 40 50 60 MVGSPDTVGM NYGSYMEEKH MPPPNMTTNE RRVIVPADPT LWSTDHVRQW LEWAVKEYGL 70 80 90 100 110 120 PDVNILLFQN IDGKELCKMT KDDFQRLTPS YNADILLSHL HYLRETPLPH LTSDDVDKAL 130 140 150 160 170 180 QNSPRLMHAR NTGGAAFIFP NTSVYPEATQ RITTRPDLPY EPPRRSAWTG HGHPTPQSKA 190 200 210 220 230 240 AQPSPSTVPK TEDQRPQLDP YQILGPTSSR LANPGSGQIQ LWQFLLELLS DSSNSSCITW 250 260 270 280 290 300 EGTNGEFKMT DPDEVARRWG ERKSKPNMNY DKLSRALRYY YDKNIMTKVH GKRYAYKFDF 310 320 330 340 350 360 HGIAQALQPH PPESSLYKYP SDLPYMGSYH AHPQKMNFVA PHPPALPVTS SSFFAAPNPY 370 380 WNSPTGGIYP NTRLPTSHMP SHLGTYY
	Isoform 5 [UniParc]. Checksum: A5069C393E409483	FASTA	479	53,838
	10 20 30 40 50 60 MASTIKEALS VVSEDQSLFE CAYGTPHLAK TEMTASSSSD YGQTSKMSPR VPQQDWLSQP 70 80 90 100 110 120 PARVTIKMEC NPSQVNGSRN SPDECSVAKG GKMVGSPDTV GMNYGSYMEE KHMPPPNMTT 130 140 150 160 170 180 NERRVIVPAD PTLWSTDHVR QWLEWAVKEY GLPDVNILLF QNIDGKELCK MTKDDFQRLT 190 200 210 220 230 240 PSYNADILLS HLHYLRETPL PHLTSDDVDK ALQNSPRLMH ARNTGGAAFI FPNTSVYPEA 250 260 270 280 290 300 TQRITTRPDL PYEPPRRSAW TGHGHPTPQS KAAQPSPSTV PKTEDQRPQL DPYQILGPTS 310 320 330 340 350 360 SRLANPGSGQ IQLWQFLLEL LSDSSNSSCI TWEGTNGEFK MTDPDEVARR WGERKSKPNM 370 380 390 400 410 420 NYDKLSRALR YYYDKNIMTK VHGKRYAYKF DFHGIAQALQ PHPPESSLYK YPSDLPYMGS 430 440 450 460 470 YHAHPQKMNF VAPHPPALPV TSSSFFAAPN PYWNSPTGGI YPNTRLPTSH MPSHLGTYY
	Isoform 7 [UniParc]. Checksum: A30FAAD4E5E119CC	FASTA	317	35,286
	10 20 30 40 50 60 MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ TSKMSPRVPQ 70 80 90 100 110 120 QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM VGSPDTVGMN YGSYMEEKHM 130 140 150 160 170 180 PPPNMTTNER RVIVPADPTL WSTDHVRQWL EWAVKEYGLP DVNILLFQNI DGKELCKMTK 190 200 210 220 230 240 DDFQRLTPSY NADILLSHLH YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN 250 260 270 280 290 300 TSVYPEATQR ITTRPDLPYE PPRRSAWTGH GHPTPQSKAA QPSPSTVPKT EDQRPQLDPY 310 QILGPTSSRL ANPGWTQ
	Isoform 8 [UniParc]. Checksum: CF149350960CCE05	FASTA	325	36,541
	10 20 30 40 50 60 MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ TSKMSPRVPQ 70 80 90 100 110 120 QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM VGSPDTVGMN YGSYMEEKHM 130 140 150 160 170 180 PPPNMTTNER RVIVPADPTL WSTDHVRQWL EWAVKEYGLP DVNILLFQNI DGKELCKMTK 190 200 210 220 230 240 DDFQRLTPSY NADILLSHLH YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN 250 260 270 280 290 300 TSVYPEATQR ITTRPGTKTP LCDLFIERHP RCPAEIRALS HVIQRELIPE LKPVPDSLIL 310 320 PLLIWRLNPL KPFHSKTTLK ELRAD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation." Rao V.N., Papas T.S., Shyam E., Reddy P. Science 237:635-639(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ERG-2).
[2]	"The erg gene: a human gene related to the ets oncogene." Reddy E.S.P., Rao V.N., Papas T.S. Proc. Natl. Acad. Sci. U.S.A. 84:6131-6135(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ERG-1).
[3]	"Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16." Owczarek C.M., Portbury K.J., Hardy M.P., O'Leary D.A., Kudoh J., Shibuya K., Shimizu N., Kola I., Hertzog P.J. Gene 324:65-77(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND ERG-1). Tissue: Thymus.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Testis.
[6]	"Differentially spliced erg-3 product functions as a transcriptional activator." Prasad D.D., Rao V.N., Lee L., Reddy E.S. Oncogene 9:669-673(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 230-259 (ISOFORM ERG-3).
[7]	"ERG gene is translocated in an Ewing's sarcoma cell line." Dunn T., Praissman L., Hagag N., Viola M.V. Cancer Genet. Cytogenet. 76:19-22(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH EWSR1.
[8]	"An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation." Ichikawa H., Shimizu K., Hayashi Y., Ohki M. Cancer Res. 54:2865-2868(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH FUS.
[9]	"ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)." Moore S.D., Offor O., Ferry J.A., Amrein P.C., Morton C.C., Dal Cin P. Leuk. Res. 30:1037-1042(2006) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH ELF4.
[10]	"Molecular composition of IMP1 ribonucleoprotein granules." Joeson L., Vikesaa J., Krogh A., Nielsen L.K., Hansen T., Borup R., Johnsen A.H., Christiansen J., Nielsen F.C. Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[11]	"Diversity in structure and function of the Ets family PNT domains." Mackereth C.D., Scharpf M., Gentile L.N., MacIntosh S.E., Slupsky C.M., McIntosh L.P. J. Mol. Biol. 342:1249-1264(2004) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 112-208.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M17254 mRNA. Translation: AAA52398.1.
M21535 mRNA. Translation: AAA35811.1.
AY204741 mRNA. Translation: AAP41719.1.
AY204742 mRNA. Translation: AAP41720.1.
AK300395 mRNA. Translation: BAG62127.1.
AK303518 mRNA. Translation: BAG64546.1.
BC040168 mRNA. Translation: AAH40168.1.
S68130 mRNA. Translation: AAB29724.1.

IPI

IPI00005012.
IPI00217544.
IPI00220990.
IPI00549287.
IPI00788647.
IPI00853428.

PIR

TVHUEG. A94294.

RefSeq

NP_001129626.1. NM_001136154.1.
NP_001129627.1. NM_001136155.1.
NP_001230357.1. NM_001243428.1.
NP_001230358.1. NM_001243429.1.
NP_001230361.1. NM_001243432.1.
NP_004440.1. NM_004449.4.
NP_891548.1. NM_182918.3.

UniGene

Hs.473819.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1SXE	NMR	-	A	112-208	[»]

ProteinModelPortal

P11308.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-31028N.

IntAct

P11308. 8 interactions.

STRING

9606.ENSP00000381891.

Polymorphism databases

DMDM

152031600.

Proteomic databases

PaxDb

P11308.

PRIDE

P11308.

Protocols and materials databases

DNASU

2078.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000288319; ENSP00000288319; ENSG00000157554.
ENST00000398897; ENSP00000381871; ENSG00000157554.
ENST00000398911; ENSP00000381882; ENSG00000157554.
ENST00000398919; ENSP00000381891; ENSG00000157554.
ENST00000417133; ENSP00000414150; ENSG00000157554.
ENST00000442448; ENSP00000394694; ENSG00000157554.
ENST00000453032; ENSP00000396268; ENSG00000157554.

GeneID

2078.

KEGG

hsa:2078.

UCSC

uc002yxa.3. human.
uc002yxb.3. human.
uc002yxc.4. human.
uc010gnw.3. human.
uc021wjd.1. human.

Organism-specific databases

CTD

2078.

GeneCards

GC21M039751.

HGNC

HGNC:3446. ERG.

HPA

CAB018377.

MIM

165080. gene.
612219. phenotype.

neXtProt

NX_P11308.

Orphanet

319. Ewing sarcoma.

PharmGKB

PA27858.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG242679.

HOVERGEN

HBG001553.

KO

K09435.

OMA

NSNCITW.

Gene expression databases

ArrayExpress

P11308.

Bgee

P11308.

CleanEx

HS_ERG.

Genevestigator

P11308.

GermOnline

ENSG00000157554. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.10. 1 hit.
1.10.150.50. 1 hit.

InterPro

IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]

Pfam

PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]

PRINTS

PR00454. ETSDOMAIN.

SMART

SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]

SUPFAM

SSF47769. SAM_homology. 1 hit.

PROSITE

PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P11308.

ChEMBL

CHEMBL1293191.

ChiTaRS

ERG. human.

EvolutionaryTrace

P11308.

GenomeRNAi

2078.

NextBio

8447.

SOURCE

Search...

Entry information

Entry name

ERG_HUMAN

Accession

Primary (citable) accession number: P11308
Secondary accession number(s): B4DTW5 , B4E0T4, Q16113, Q6XXX4, Q6XXX5, Q8IXK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 10, 2007
Last modified:	May 1, 2013
This is version 145 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.