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P11308 (ERG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 154. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulator ERG
Alternative name(s):
Transforming protein ERG
Gene names
Name:ERG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Subunit structure

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1. Ref.10

Subcellular location

Nucleus. Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Ref.10

Involvement in disease

Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1.

Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4.

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Contains 1 PNT (pointed) domain.

Binary interactions

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform ERG-3 (identifier: P11308-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform ERG-2 (identifier: P11308-1)

The sequence of this isoform differs from the canonical sequence as follows:
     232-255: Missing.
Isoform ERG-1 (identifier: P11308-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
Isoform 5 (identifier: P11308-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MIQTVPDPAAH → MAST
Isoform 7 (identifier: P11308-5)

The sequence of this isoform differs from the canonical sequence as follows:
     315-317: SGQ → WTQ
     318-486: Missing.
Isoform 8 (identifier: P11308-6)

The sequence of this isoform differs from the canonical sequence as follows:
     256-325: DLPYEPPRRS...GQIQLWQFLL → GTKTPLCDLF...KTTLKELRAD
     326-486: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Transcriptional regulator ERG
PRO_0000204103

Regions

Domain120 – 20687PNT
DNA binding318 – 39881ETS

Sites

Site469 – 4702Breakpoint for translocation to form ELF4-ERG oncogene

Natural variations

Alternative sequence1 – 9999Missing in isoform ERG-1.
VSP_001469
Alternative sequence1 – 1111MIQTVPDPAAH → MAST in isoform 5.
VSP_026584
Alternative sequence232 – 25524Missing in isoform ERG-2.
VSP_026579
Alternative sequence256 – 32570DLPYE…WQFLL → GTKTPLCDLFIERHPRCPAE IRALSHVIQRELIPELKPVP DSLILPLLIWRLNPLKPFHS KTTLKELRAD in isoform 8.
VSP_026580
Alternative sequence315 – 3173SGQ → WTQ in isoform 7.
VSP_026582
Alternative sequence318 – 486169Missing in isoform 7.
VSP_026583
Alternative sequence326 – 486161Missing in isoform 8.
VSP_026581

Secondary structure

................................... 486
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform ERG-3 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: A0B548DFAE25029E

FASTA48654,608
        10         20         30         40         50         60 
MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ TSKMSPRVPQ 

        70         80         90        100        110        120 
QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM VGSPDTVGMN YGSYMEEKHM 

       130        140        150        160        170        180 
PPPNMTTNER RVIVPADPTL WSTDHVRQWL EWAVKEYGLP DVNILLFQNI DGKELCKMTK 

       190        200        210        220        230        240 
DDFQRLTPSY NADILLSHLH YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN 

       250        260        270        280        290        300 
TSVYPEATQR ITTRPDLPYE PPRRSAWTGH GHPTPQSKAA QPSPSTVPKT EDQRPQLDPY 

       310        320        330        340        350        360 
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSSCITWE GTNGEFKMTD PDEVARRWGE 

       370        380        390        400        410        420 
RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH GIAQALQPHP PESSLYKYPS 

       430        440        450        460        470        480 
DLPYMGSYHA HPQKMNFVAP HPPALPVTSS SFFAAPNPYW NSPTGGIYPN TRLPTSHMPS 


HLGTYY 

« Hide

Isoform ERG-2 [UniParc].

Checksum: B29F14B0F5C2C697
Show »

FASTA46252,031
Isoform ERG-1 [UniParc].

Checksum: 6C19CE3D70C769EA
Show »

FASTA38743,974
Isoform 5 [UniParc].

Checksum: A5069C393E409483
Show »

FASTA47953,838
Isoform 7 [UniParc].

Checksum: A30FAAD4E5E119CC
Show »

FASTA31735,286
Isoform 8 [UniParc].

Checksum: CF149350960CCE05
Show »

FASTA32536,541

References

« Hide 'large scale' references
[1]"erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation."
Rao V.N., Papas T.S., Shyam E., Reddy P.
Science 237:635-639(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ERG-2).
[2]"The erg gene: a human gene related to the ets oncogene."
Reddy E.S.P., Rao V.N., Papas T.S.
Proc. Natl. Acad. Sci. U.S.A. 84:6131-6135(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ERG-1).
[3]"Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16."
Owczarek C.M., Portbury K.J., Hardy M.P., O'Leary D.A., Kudoh J., Shibuya K., Shimizu N., Kola I., Hertzog P.J.
Gene 324:65-77(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND ERG-1).
Tissue: Thymus.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
Tissue: Testis.
[6]"Differentially spliced erg-3 product functions as a transcriptional activator."
Prasad D.D., Rao V.N., Lee L., Reddy E.S.
Oncogene 9:669-673(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 230-259 (ISOFORM ERG-3).
[7]"ERG gene is translocated in an Ewing's sarcoma cell line."
Dunn T., Praissman L., Hagag N., Viola M.V.
Cancer Genet. Cytogenet. 76:19-22(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL TRANSLOCATION WITH EWSR1.
[8]"An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation."
Ichikawa H., Shimizu K., Hayashi Y., Ohki M.
Cancer Res. 54:2865-2868(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL TRANSLOCATION WITH FUS.
[9]"ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)."
Moore S.D., Offor O., Ferry J.A., Amrein P.C., Morton C.C., Dal Cin P.
Leuk. Res. 30:1037-1042(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL TRANSLOCATION WITH ELF4.
[10]"Molecular composition of IMP1 ribonucleoprotein granules."
Joeson L., Vikesaa J., Krogh A., Nielsen L.K., Hansen T., Borup R., Johnsen A.H., Christiansen J., Nielsen F.C.
Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[11]"Diversity in structure and function of the Ets family PNT domains."
Mackereth C.D., Scharpf M., Gentile L.N., MacIntosh S.E., Slupsky C.M., McIntosh L.P.
J. Mol. Biol. 342:1249-1264(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 112-208.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M17254 mRNA. Translation: AAA52398.1.
M21535 mRNA. Translation: AAA35811.1.
AY204741 mRNA. Translation: AAP41719.1.
AY204742 mRNA. Translation: AAP41720.1.
AK300395 mRNA. Translation: BAG62127.1.
AK303518 mRNA. Translation: BAG64546.1.
BC040168 mRNA. Translation: AAH40168.1.
S68130 mRNA. Translation: AAB29724.1.
PIRTVHUEG. A94294.
RefSeqNP_001129626.1. NM_001136154.1.
NP_001129627.1. NM_001136155.1.
NP_001230357.1. NM_001243428.1.
NP_001230358.1. NM_001243429.1.
NP_001230361.1. NM_001243432.1.
NP_004440.1. NM_004449.4.
NP_891548.1. NM_182918.3.
UniGeneHs.473819.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SXENMR-A112-208[»]
4IRGX-ray1.70A313-412[»]
4IRHX-ray2.10A287-412[»]
4IRIX-ray2.77A287-412[»]
ProteinModelPortalP11308.
SMRP11308. Positions 112-208, 307-408.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108389. 36 interactions.
DIPDIP-31028N.
IntActP11308. 11 interactions.
MINTMINT-4910866.
STRING9606.ENSP00000381891.

Chemistry

BindingDBP11308.
ChEMBLCHEMBL1293191.

Polymorphism databases

DMDM152031600.

Proteomic databases

PaxDbP11308.
PRIDEP11308.

Protocols and materials databases

DNASU2078.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000288319; ENSP00000288319; ENSG00000157554. [P11308-4]
ENST00000398897; ENSP00000381871; ENSG00000157554.
ENST00000398911; ENSP00000381882; ENSG00000157554. [P11308-1]
ENST00000398919; ENSP00000381891; ENSG00000157554. [P11308-3]
ENST00000417133; ENSP00000414150; ENSG00000157554. [P11308-3]
ENST00000442448; ENSP00000394694; ENSG00000157554. [P11308-1]
ENST00000453032; ENSP00000396268; ENSG00000157554. [P11308-2]
GeneID2078.
KEGGhsa:2078.
UCSCuc002yxa.3. human. [P11308-4]
uc002yxb.3. human. [P11308-1]
uc002yxc.4. human. [P11308-6]
uc010gnw.3. human. [P11308-3]
uc021wjd.1. human. [P11308-5]

Organism-specific databases

CTD2078.
GeneCardsGC21M039751.
HGNCHGNC:3446. ERG.
HPACAB018377.
MIM165080. gene.
612219. phenotype.
neXtProtNX_P11308.
Orphanet319. Ewing sarcoma.
370334. Extraskeletal Ewing sarcoma.
370348. Peripheral primitive neuroectodermal tumor.
PharmGKBPA27858.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG242679.
HOVERGENHBG001553.
KOK09435.
OMANSNCITW.
PhylomeDBP11308.
TreeFamTF350537.

Enzyme and pathway databases

SignaLinkP11308.

Gene expression databases

ArrayExpressP11308.
BgeeP11308.
CleanExHS_ERG.
GenevestigatorP11308.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
PROSITEPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSERG. human.
EvolutionaryTraceP11308.
GeneWikiERG_(gene).
GenomeRNAi2078.
NextBio8447.
PROP11308.
SOURCESearch...

Entry information

Entry nameERG_HUMAN
AccessionPrimary (citable) accession number: P11308
Secondary accession number(s): B4DTW5 expand/collapse secondary AC list , B4E0T4, Q16113, Q6XXX4, Q6XXX5, Q8IXK9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM