Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P11308

- ERG_HUMAN

UniProt

P11308 - ERG_HUMAN

Protein

Transcriptional regulator ERG

Gene

ERG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei469 – 4702Breakpoint for translocation to form ELF4-ERG oncogene

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi318 – 39881ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    5. signal transducer activity Source: ProtInc

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. cell proliferation Source: ProtInc
    3. multicellular organismal development Source: ProtInc
    4. protein phosphorylation Source: ProtInc
    5. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    6. signal transduction Source: ProtInc
    7. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP11308.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulator ERG
    Alternative name(s):
    Transforming protein ERG
    Gene namesi
    Name:ERG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:3446. ERG.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation. Cytoplasm 1 Publication
    Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: RefGenome
    3. ribonucleoprotein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
    Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1.
    Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    MIMi612219. phenotype.
    Orphaneti319. Ewing sarcoma.
    370334. Extraskeletal Ewing sarcoma.
    370348. Peripheral primitive neuroectodermal tumor.
    PharmGKBiPA27858.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Transcriptional regulator ERGPRO_0000204103Add
    BLAST

    Proteomic databases

    PaxDbiP11308.
    PRIDEiP11308.

    Expressioni

    Gene expression databases

    ArrayExpressiP11308.
    BgeeiP11308.
    CleanExiHS_ERG.
    GenevestigatoriP11308.

    Organism-specific databases

    HPAiCAB018377.

    Interactioni

    Subunit structurei

    Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARP102753EBI-79704,EBI-608057
    PARP1P098747EBI-79704,EBI-355676

    Protein-protein interaction databases

    BioGridi108389. 78 interactions.
    DIPiDIP-31028N.
    IntActiP11308. 12 interactions.
    MINTiMINT-4910866.
    STRINGi9606.ENSP00000381891.

    Structurei

    Secondary structure

    1
    486
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi116 – 1194
    Turni127 – 1304
    Beta strandi131 – 1344
    Helixi143 – 15715
    Helixi164 – 1663
    Helixi172 – 1754
    Helixi180 – 1834
    Turni184 – 1863
    Helixi189 – 20214
    Helixi320 – 3289
    Helixi331 – 3333
    Turni334 – 3363
    Beta strandi337 – 3393
    Beta strandi345 – 3473
    Helixi351 – 36212
    Helixi369 – 38113
    Beta strandi384 – 3874
    Beta strandi394 – 3974
    Helixi399 – 4057

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1SXENMR-A115-208[»]
    4IRGX-ray1.70A313-412[»]
    4IRHX-ray2.10A287-412[»]
    4IRIX-ray2.77A287-412[»]
    ProteinModelPortaliP11308.
    SMRiP11308. Positions 112-208, 307-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11308.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini120 – 20687PNTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG242679.
    HOVERGENiHBG001553.
    KOiK09435.
    OMAiNSNCITW.
    PhylomeDBiP11308.
    TreeFamiTF350537.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform ERG-3 (identifier: P11308-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ    50
    TSKMSPRVPQ QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM 100
    VGSPDTVGMN YGSYMEEKHM PPPNMTTNER RVIVPADPTL WSTDHVRQWL 150
    EWAVKEYGLP DVNILLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH 200
    YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR 250
    ITTRPDLPYE PPRRSAWTGH GHPTPQSKAA QPSPSTVPKT EDQRPQLDPY 300
    QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSSCITWE GTNGEFKMTD 350
    PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH 400
    GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVAP HPPALPVTSS 450
    SFFAAPNPYW NSPTGGIYPN TRLPTSHMPS HLGTYY 486
    Length:486
    Mass (Da):54,608
    Last modified:July 10, 2007 - v2
    Checksum:iA0B548DFAE25029E
    GO
    Isoform ERG-2 (identifier: P11308-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         232-255: Missing.

    Show »
    Length:462
    Mass (Da):52,031
    Checksum:iB29F14B0F5C2C697
    GO
    Isoform ERG-1 (identifier: P11308-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-99: Missing.
         232-255: Missing.

    Show »
    Length:363
    Mass (Da):41,397
    Checksum:iB77B652BEBAFDAFA
    GO
    Isoform 5 (identifier: P11308-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: MIQTVPDPAAH → MAST

    Show »
    Length:479
    Mass (Da):53,838
    Checksum:iA5069C393E409483
    GO
    Isoform 7 (identifier: P11308-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         315-317: SGQ → WTQ
         318-486: Missing.

    Show »
    Length:317
    Mass (Da):35,286
    Checksum:iA30FAAD4E5E119CC
    GO
    Isoform 8 (identifier: P11308-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         256-325: DLPYEPPRRS...GQIQLWQFLL → GTKTPLCDLF...KTTLKELRAD
         326-486: Missing.

    Show »
    Length:325
    Mass (Da):36,541
    Checksum:iCF149350960CCE05
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9999Missing in isoform ERG-1. 2 PublicationsVSP_001469Add
    BLAST
    Alternative sequencei1 – 1111MIQTVPDPAAH → MAST in isoform 5. 2 PublicationsVSP_026584Add
    BLAST
    Alternative sequencei232 – 25524Missing in isoform ERG-1 and isoform ERG-2. 3 PublicationsVSP_026579Add
    BLAST
    Alternative sequencei256 – 32570DLPYE…WQFLL → GTKTPLCDLFIERHPRCPAE IRALSHVIQRELIPELKPVP DSLILPLLIWRLNPLKPFHS KTTLKELRAD in isoform 8. CuratedVSP_026580Add
    BLAST
    Alternative sequencei315 – 3173SGQ → WTQ in isoform 7. 1 PublicationVSP_026582
    Alternative sequencei318 – 486169Missing in isoform 7. 1 PublicationVSP_026583Add
    BLAST
    Alternative sequencei326 – 486161Missing in isoform 8. CuratedVSP_026581Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17254 mRNA. Translation: AAA52398.1.
    M21535 mRNA. Translation: AAA35811.1.
    AY204741 mRNA. Translation: AAP41719.1.
    AY204742 mRNA. Translation: AAP41720.1.
    AK300395 mRNA. Translation: BAG62127.1.
    AK303518 mRNA. Translation: BAG64546.1.
    BC040168 mRNA. Translation: AAH40168.1.
    S68130 mRNA. Translation: AAB29724.1.
    CCDSiCCDS13657.1. [P11308-1]
    CCDS13658.1. [P11308-4]
    CCDS46648.1. [P11308-3]
    CCDS58789.1. [P11308-2]
    PIRiA94294. TVHUEG.
    RefSeqiNP_001129626.1. NM_001136154.1. [P11308-3]
    NP_001129627.1. NM_001136155.1.
    NP_001230357.1. NM_001243428.1. [P11308-3]
    NP_001230358.1. NM_001243429.1. [P11308-2]
    NP_001230361.1. NM_001243432.2. [P11308-5]
    NP_001278320.1. NM_001291391.1. [P11308-6]
    NP_004440.1. NM_004449.4. [P11308-1]
    NP_891548.1. NM_182918.3. [P11308-4]
    UniGeneiHs.473819.

    Genome annotation databases

    EnsembliENST00000288319; ENSP00000288319; ENSG00000157554. [P11308-4]
    ENST00000398897; ENSP00000381871; ENSG00000157554. [P11308-2]
    ENST00000398911; ENSP00000381882; ENSG00000157554. [P11308-1]
    ENST00000398919; ENSP00000381891; ENSG00000157554. [P11308-3]
    ENST00000417133; ENSP00000414150; ENSG00000157554. [P11308-3]
    ENST00000442448; ENSP00000394694; ENSG00000157554. [P11308-1]
    ENST00000453032; ENSP00000396268; ENSG00000157554. [P11308-2]
    GeneIDi2078.
    KEGGihsa:2078.
    UCSCiuc002yxa.3. human. [P11308-4]
    uc002yxb.3. human. [P11308-1]
    uc002yxc.4. human. [P11308-6]
    uc010gnw.3. human. [P11308-3]
    uc021wjd.1. human. [P11308-5]

    Polymorphism databases

    DMDMi152031600.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17254 mRNA. Translation: AAA52398.1 .
    M21535 mRNA. Translation: AAA35811.1 .
    AY204741 mRNA. Translation: AAP41719.1 .
    AY204742 mRNA. Translation: AAP41720.1 .
    AK300395 mRNA. Translation: BAG62127.1 .
    AK303518 mRNA. Translation: BAG64546.1 .
    BC040168 mRNA. Translation: AAH40168.1 .
    S68130 mRNA. Translation: AAB29724.1 .
    CCDSi CCDS13657.1. [P11308-1 ]
    CCDS13658.1. [P11308-4 ]
    CCDS46648.1. [P11308-3 ]
    CCDS58789.1. [P11308-2 ]
    PIRi A94294. TVHUEG.
    RefSeqi NP_001129626.1. NM_001136154.1. [P11308-3 ]
    NP_001129627.1. NM_001136155.1.
    NP_001230357.1. NM_001243428.1. [P11308-3 ]
    NP_001230358.1. NM_001243429.1. [P11308-2 ]
    NP_001230361.1. NM_001243432.2. [P11308-5 ]
    NP_001278320.1. NM_001291391.1. [P11308-6 ]
    NP_004440.1. NM_004449.4. [P11308-1 ]
    NP_891548.1. NM_182918.3. [P11308-4 ]
    UniGenei Hs.473819.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1SXE NMR - A 115-208 [» ]
    4IRG X-ray 1.70 A 313-412 [» ]
    4IRH X-ray 2.10 A 287-412 [» ]
    4IRI X-ray 2.77 A 287-412 [» ]
    ProteinModelPortali P11308.
    SMRi P11308. Positions 112-208, 307-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108389. 78 interactions.
    DIPi DIP-31028N.
    IntActi P11308. 12 interactions.
    MINTi MINT-4910866.
    STRINGi 9606.ENSP00000381891.

    Chemistry

    BindingDBi P11308.
    ChEMBLi CHEMBL1293191.

    Polymorphism databases

    DMDMi 152031600.

    Proteomic databases

    PaxDbi P11308.
    PRIDEi P11308.

    Protocols and materials databases

    DNASUi 2078.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000288319 ; ENSP00000288319 ; ENSG00000157554 . [P11308-4 ]
    ENST00000398897 ; ENSP00000381871 ; ENSG00000157554 . [P11308-2 ]
    ENST00000398911 ; ENSP00000381882 ; ENSG00000157554 . [P11308-1 ]
    ENST00000398919 ; ENSP00000381891 ; ENSG00000157554 . [P11308-3 ]
    ENST00000417133 ; ENSP00000414150 ; ENSG00000157554 . [P11308-3 ]
    ENST00000442448 ; ENSP00000394694 ; ENSG00000157554 . [P11308-1 ]
    ENST00000453032 ; ENSP00000396268 ; ENSG00000157554 . [P11308-2 ]
    GeneIDi 2078.
    KEGGi hsa:2078.
    UCSCi uc002yxa.3. human. [P11308-4 ]
    uc002yxb.3. human. [P11308-1 ]
    uc002yxc.4. human. [P11308-6 ]
    uc010gnw.3. human. [P11308-3 ]
    uc021wjd.1. human. [P11308-5 ]

    Organism-specific databases

    CTDi 2078.
    GeneCardsi GC21M039751.
    HGNCi HGNC:3446. ERG.
    HPAi CAB018377.
    MIMi 165080. gene.
    612219. phenotype.
    neXtProti NX_P11308.
    Orphaneti 319. Ewing sarcoma.
    370334. Extraskeletal Ewing sarcoma.
    370348. Peripheral primitive neuroectodermal tumor.
    PharmGKBi PA27858.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242679.
    HOVERGENi HBG001553.
    KOi K09435.
    OMAi NSNCITW.
    PhylomeDBi P11308.
    TreeFami TF350537.

    Enzyme and pathway databases

    SignaLinki P11308.

    Miscellaneous databases

    ChiTaRSi ERG. human.
    EvolutionaryTracei P11308.
    GeneWikii ERG_(gene).
    GenomeRNAii 2078.
    NextBioi 8447.
    PROi P11308.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11308.
    Bgeei P11308.
    CleanExi HS_ERG.
    Genevestigatori P11308.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation."
      Rao V.N., Papas T.S., Shyam E., Reddy P.
      Science 237:635-639(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ERG-2).
    2. "The erg gene: a human gene related to the ets oncogene."
      Reddy E.S.P., Rao V.N., Papas T.S.
      Proc. Natl. Acad. Sci. U.S.A. 84:6131-6135(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ERG-1).
    3. "Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16."
      Owczarek C.M., Portbury K.J., Hardy M.P., O'Leary D.A., Kudoh J., Shibuya K., Shimizu N., Kola I., Hertzog P.J.
      Gene 324:65-77(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND ERG-1).
      Tissue: Thymus.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Testis.
    6. "Differentially spliced erg-3 product functions as a transcriptional activator."
      Prasad D.D., Rao V.N., Lee L., Reddy E.S.
      Oncogene 9:669-673(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 230-259 (ISOFORM ERG-3).
    7. "ERG gene is translocated in an Ewing's sarcoma cell line."
      Dunn T., Praissman L., Hagag N., Viola M.V.
      Cancer Genet. Cytogenet. 76:19-22(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH EWSR1.
    8. "An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation."
      Ichikawa H., Shimizu K., Hayashi Y., Ohki M.
      Cancer Res. 54:2865-2868(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH FUS.
    9. "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)."
      Moore S.D., Offor O., Ferry J.A., Amrein P.C., Morton C.C., Dal Cin P.
      Leuk. Res. 30:1037-1042(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH ELF4.
    10. Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    11. Cited for: STRUCTURE BY NMR OF 112-208.

    Entry informationi

    Entry nameiERG_HUMAN
    AccessioniPrimary (citable) accession number: P11308
    Secondary accession number(s): B4DTW5
    , B4E0T4, Q16113, Q6XXX4, Q6XXX5, Q8IXK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 159 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3