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Protein

Transcriptional regulator ERG

Gene

ERG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi318 – 398ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • cell migration Source: Ensembl
  • cell proliferation Source: ProtInc
  • endocardial cushion development Source: Ensembl
  • endocardial cushion to mesenchymal transition involved in heart valve formation Source: Ensembl
  • multicellular organism development Source: ProtInc
  • positive regulation of blood vessel remodeling Source: Ensembl
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • protein phosphorylation Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP11308
SIGNORiP11308

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator ERG
Alternative name(s):
Transforming protein ERG
Gene namesi
Name:ERG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000157554.18
HGNCiHGNC:3446 ERG
MIMi165080 gene
neXtProtiNX_P11308

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Ewing sarcoma (ES)1 Publication
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1.1 Publication
Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
See also OMIM:612219
Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS (PubMed:8187069). Translocation t(X;21)(q25-26;q22) with ELF4 (PubMed:16303180).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei469 – 470Breakpoint for translocation to form ELF4-ERG oncogene2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2078
MalaCardsiERG
MIMi612219 phenotype
OpenTargetsiENSG00000157554
Orphaneti319 Ewing sarcoma
370334 Extraskeletal Ewing sarcoma
370348 Peripheral primitive neuroectodermal tumor
PharmGKBiPA27858

Chemistry databases

ChEMBLiCHEMBL1293191

Polymorphism and mutation databases

BioMutaiERG
DMDMi152031600

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041031 – 486Transcriptional regulator ERGAdd BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP11308
PeptideAtlasiP11308
PRIDEiP11308
ProteomicsDBi52735
52736 [P11308-1]
52737 [P11308-2]
52738 [P11308-4]
52739 [P11308-5]
52740 [P11308-6]
TopDownProteomicsiP11308-6 [P11308-6]

PTM databases

iPTMnetiP11308
PhosphoSitePlusiP11308

Expressioni

Gene expression databases

BgeeiENSG00000157554
CleanExiHS_ERG
ExpressionAtlasiP11308 baseline and differential
GenevisibleiP11308 HS

Organism-specific databases

HPAiCAB018377
HPA046598

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108389, 93 interactors
CORUMiP11308
DIPiDIP-31028N
ELMiP11308
IntActiP11308, 17 interactors
MINTiP11308
STRINGi9606.ENSP00000381891

Chemistry databases

BindingDBiP11308

Structurei

Secondary structure

1486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi116 – 119Combined sources4
Turni127 – 130Combined sources4
Beta strandi131 – 134Combined sources4
Helixi143 – 157Combined sources15
Helixi164 – 166Combined sources3
Helixi172 – 175Combined sources4
Helixi180 – 183Combined sources4
Turni184 – 186Combined sources3
Helixi189 – 202Combined sources14
Helixi320 – 328Combined sources9
Helixi331 – 333Combined sources3
Turni334 – 336Combined sources3
Beta strandi337 – 339Combined sources3
Beta strandi345 – 347Combined sources3
Helixi351 – 362Combined sources12
Helixi369 – 381Combined sources13
Beta strandi384 – 387Combined sources4
Beta strandi394 – 397Combined sources4
Helixi399 – 405Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SXENMR-A115-208[»]
4IRGX-ray1.70A313-412[»]
4IRHX-ray2.10A287-412[»]
4IRIX-ray2.77A287-412[»]
ProteinModelPortaliP11308
SMRiP11308
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11308

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 206PNTPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOVERGENiHBG001553
InParanoidiP11308
KOiK09435
OMAiLPASHMP
OrthoDBiEOG091G0EWP
PhylomeDBiP11308
TreeFamiTF350537

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform ERG-3 (identifier: P11308-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ
60 70 80 90 100
TSKMSPRVPQ QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM
110 120 130 140 150
VGSPDTVGMN YGSYMEEKHM PPPNMTTNER RVIVPADPTL WSTDHVRQWL
160 170 180 190 200
EWAVKEYGLP DVNILLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH
210 220 230 240 250
YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR
260 270 280 290 300
ITTRPDLPYE PPRRSAWTGH GHPTPQSKAA QPSPSTVPKT EDQRPQLDPY
310 320 330 340 350
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSSCITWE GTNGEFKMTD
360 370 380 390 400
PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH
410 420 430 440 450
GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVAP HPPALPVTSS
460 470 480
SFFAAPNPYW NSPTGGIYPN TRLPTSHMPS HLGTYY
Length:486
Mass (Da):54,608
Last modified:July 10, 2007 - v2
Checksum:iA0B548DFAE25029E
GO
Isoform ERG-2 (identifier: P11308-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-255: Missing.

Show »
Length:462
Mass (Da):52,031
Checksum:iB29F14B0F5C2C697
GO
Isoform ERG-1 (identifier: P11308-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     232-255: Missing.

Show »
Length:363
Mass (Da):41,397
Checksum:iB77B652BEBAFDAFA
GO
Isoform 5 (identifier: P11308-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MIQTVPDPAAH → MAST

Show »
Length:479
Mass (Da):53,838
Checksum:iA5069C393E409483
GO
Isoform 7 (identifier: P11308-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-317: SGQ → WTQ
     318-486: Missing.

Show »
Length:317
Mass (Da):35,286
Checksum:iA30FAAD4E5E119CC
GO
Isoform 8 (identifier: P11308-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-325: DLPYEPPRRS...GQIQLWQFLL → GTKTPLCDLF...KTTLKELRAD
     326-486: Missing.

Show »
Length:325
Mass (Da):36,541
Checksum:iCF149350960CCE05
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0014691 – 99Missing in isoform ERG-1. 2 PublicationsAdd BLAST99
Alternative sequenceiVSP_0265841 – 11MIQTVPDPAAH → MAST in isoform 5. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_026579232 – 255Missing in isoform ERG-1 and isoform ERG-2. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_026580256 – 325DLPYE…WQFLL → GTKTPLCDLFIERHPRCPAE IRALSHVIQRELIPELKPVP DSLILPLLIWRLNPLKPFHS KTTLKELRAD in isoform 8. CuratedAdd BLAST70
Alternative sequenceiVSP_026582315 – 317SGQ → WTQ in isoform 7. 1 Publication3
Alternative sequenceiVSP_026583318 – 486Missing in isoform 7. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_026581326 – 486Missing in isoform 8. CuratedAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17254 mRNA Translation: AAA52398.1
M21535 mRNA Translation: AAA35811.1
AY204741 mRNA Translation: AAP41719.1
AY204742 mRNA Translation: AAP41720.1
AK300395 mRNA Translation: BAG62127.1
AK303518 mRNA Translation: BAG64546.1
BC040168 mRNA Translation: AAH40168.1
S68130 mRNA Translation: AAB29724.1
CCDSiCCDS13657.1 [P11308-1]
CCDS13658.1 [P11308-4]
CCDS46648.1 [P11308-3]
CCDS58789.1 [P11308-2]
PIRiA94294 TVHUEG
RefSeqiNP_001129626.1, NM_001136154.1 [P11308-3]
NP_001129627.1, NM_001136155.1
NP_001230357.1, NM_001243428.1 [P11308-3]
NP_001230358.1, NM_001243429.1 [P11308-2]
NP_001230361.1, NM_001243432.2 [P11308-5]
NP_001278320.1, NM_001291391.1 [P11308-6]
NP_004440.1, NM_004449.4 [P11308-1]
NP_891548.1, NM_182918.3 [P11308-4]
UniGeneiHs.473819

Genome annotation databases

EnsembliENST00000288319; ENSP00000288319; ENSG00000157554 [P11308-4]
ENST00000398897; ENSP00000381871; ENSG00000157554 [P11308-2]
ENST00000398911; ENSP00000381882; ENSG00000157554 [P11308-1]
ENST00000398919; ENSP00000381891; ENSG00000157554 [P11308-3]
ENST00000417133; ENSP00000414150; ENSG00000157554 [P11308-3]
ENST00000442448; ENSP00000394694; ENSG00000157554 [P11308-1]
GeneIDi2078
KEGGihsa:2078
UCSCiuc002yxa.4 human [P11308-3]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiERG_HUMAN
AccessioniPrimary (citable) accession number: P11308
Secondary accession number(s): B4DTW5
, B4E0T4, Q16113, Q6XXX4, Q6XXX5, Q8IXK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 10, 2007
Last modified: June 20, 2018
This is version 195 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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