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Protein

Lysosome-associated membrane glycoprotein 1

Gene

LAMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
Acts as a receptor for Lassa virus protein.1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  • autophagic cell death Source: Ensembl
  • autophagy Source: Ensembl
  • establishment of protein localization to organelle Source: UniProtKB
  • Golgi to lysosome transport Source: UniProtKB
  • granzyme-mediated apoptotic signaling pathway Source: UniProtKB
  • positive regulation of natural killer cell degranulation Source: UniProtKB
  • positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • regulation of organelle transport along microtubule Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:G66-33014-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Protein family/group databases

TCDBi9.A.16.1.1. the lysosomal protein import (lpi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
CD107 antigen-like family member A
CD_antigen: CD107a
Gene namesi
Name:LAMP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:6499. LAMP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 382LumenalSequence analysisAdd BLAST354
Transmembranei383 – 405HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini406 – 417CytoplasmicPROSITE-ProRule annotationAdd BLAST12

GO - Cellular componenti

  • alveolar lamellar body Source: Ensembl
  • cytolytic granule Source: Ensembl
  • cytoplasm Source: MGI
  • cytosol Source: GOC
  • dendrite Source: Ensembl
  • endosome membrane Source: UniProtKB
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • late endosome Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • lysosome Source: UniProtKB
  • melanosome Source: Ensembl
  • membrane Source: UniProtKB
  • multivesicular body Source: Ensembl
  • neuronal cell body Source: Ensembl
  • perinuclear region of cytoplasm Source: AgBase
  • phagolysosome membrane Source: Ensembl
  • plasma membrane Source: UniProtKB
  • sarcolemma Source: Ensembl
  • synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi76N → S: Complete loss of interaction with Lassa virus protein GPC. 1 Publication1

Organism-specific databases

DisGeNETi3916.
OpenTargetsiENSG00000185896.
PharmGKBiPA30283.

Polymorphism and mutation databases

BioMutaiLAMP1.
DMDMi206729915.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 282 PublicationsAdd BLAST28
ChainiPRO_000001710429 – 417Lysosome-associated membrane glycoprotein 1Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)1 Publication1
Disulfide bondi41 ↔ 80PROSITE-ProRule annotation1 Publication
Glycosylationi45N-linked (GlcNAc...)1 Publication1
Glycosylationi62N-linked (GlcNAc...) (polylactosaminoglycan)2 Publications1
Glycosylationi76N-linked (GlcNAc...)2 Publications1
Glycosylationi84N-linked (GlcNAc...)1 Publication1
Glycosylationi103N-linked (GlcNAc...)3 Publications1
Glycosylationi107N-linked (GlcNAc...)1 Publication1
Glycosylationi121N-linked (GlcNAc...) (polylactosaminoglycan)1 Publication1
Glycosylationi130N-linked (GlcNAc...) (polylactosaminoglycan)1 Publication1
Disulfide bondi155 ↔ 191PROSITE-ProRule annotation1 Publication
Glycosylationi165N-linked (GlcNAc...)2 Publications1
Glycosylationi181N-linked (GlcNAc...)2 Publications1
Glycosylationi197O-linked (GalNAc...); partial1 Publication1
Glycosylationi199O-linked (GalNAc...)1 Publication1
Glycosylationi200O-linked (GalNAc...)1 Publication1
Glycosylationi207O-linked (GalNAc...)1 Publication1
Glycosylationi209O-linked (GalNAc...)1 Publication1
Glycosylationi211O-linked (GalNAc...)1 Publication1
Glycosylationi223N-linked (GlcNAc...) (polylactosaminoglycan)1 Publication1
Glycosylationi228N-linked (GlcNAc...) (polylactosaminoglycan)1 Publication1
Disulfide bondi231 ↔ 269PROSITE-ProRule annotation1 Publication
Glycosylationi241N-linked (GlcNAc...)1 Publication1
Glycosylationi249N-linked (GlcNAc...)2 Publications1
Glycosylationi261N-linked (GlcNAc...)2 Publications1
Glycosylationi293N-linked (GlcNAc...)1 Publication1
Glycosylationi322N-linked (GlcNAc...)1 Publication1
Disulfide bondi338 ↔ 375PROSITE-ProRule annotation1 Publication

Post-translational modificationi

O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.5 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP11279.
MaxQBiP11279.
PaxDbiP11279.
PeptideAtlasiP11279.
PRIDEiP11279.
TopDownProteomicsiP11279-1. [P11279-1]

PTM databases

iPTMnetiP11279.
PhosphoSitePlusiP11279.
SwissPalmiP11279.
UniCarbKBiP11279.

Expressioni

Gene expression databases

BgeeiENSG00000185896.
CleanExiHS_LAMP1.
ExpressionAtlasiP11279. baseline and differential.
GenevisibleiP11279. HS.

Organism-specific databases

HPAiCAB004260.
HPA014750.

Interactioni

Subunit structurei

(Microbial infection) Interacts with Lassa virus protein glycoprotein.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GPCP086694EBI-2805407,EBI-8411266From a different organism.
RRAGBQ5VZM22EBI-2805407,EBI-993049

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110110. 40 interactors.
DIPiDIP-44670N.
IntActiP11279. 18 interactors.
MINTiMINT-3007678.
STRINGi9606.ENSP00000333298.

Structurei

3D structure databases

ProteinModelPortaliP11279.
SMRiP11279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 194First lumenal domainAdd BLAST166
Regioni195 – 227HingeAdd BLAST33
Regioni228 – 382Second lumenal domainAdd BLAST155

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP11279.
KOiK06528.
OMAiETRCEQD.
OrthoDBiEOG091G09EV.
PhylomeDBiP11279.
TreeFamiTF316339.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11279-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF
60 70 80 90 100
SVNYDTKSGP KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL
110 120 130 140 150
TLNFTRNATR YSVQLMSFVY NLSDTHLFPN ASSKEIKTVE SITDIRADID
160 170 180 190 200
KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS NSSFSRGETR CEQDRPSPTT
210 220 230 240 250
APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL NLTYERKDNT
260 270 280 290 300
TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF
310 320 330 340 350
LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF
360 370 380 390 400
SVNIFKVWVQ AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL
410
IAYLVGRKRS HAGYQTI
Length:417
Mass (Da):44,882
Last modified:September 23, 2008 - v3
Checksum:i3E0A285744DD6588
GO
Isoform 2 (identifier: P11279-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-187: Missing.

Note: No experimental confirmation available.
Show »
Length:364
Mass (Da):38,986
Checksum:iD61B19312DC62CF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → M in AAA60382 (PubMed:3198605).Curated1
Sequence conflicti5G → R in AAA60382 (PubMed:3198605).Curated1
Sequence conflicti16 – 26LLLLLGLMHCA → PVAAARPHALS in AAA60382 (PubMed:3198605).CuratedAdd BLAST11
Sequence conflicti33 – 40VKNGNGTA → MARGGRVR in AAA59524 (PubMed:3131762).Curated8
Sequence conflicti262K → T in AAF66141 (PubMed:8517882).Curated1
Sequence conflicti377Missing in AAF66141 (PubMed:8517882).Curated1
Sequence conflicti382M → T in AAA60382 (PubMed:3198605).Curated1
Sequence conflicti382M → T in AAA59524 (PubMed:3131762).Curated1
Sequence conflicti382M → T in AAF66141 (PubMed:8517882).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046450309I → T.Corresponds to variant rs9577230dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056032135 – 187Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04182 mRNA. Translation: AAA60382.1.
AK301584 mRNA. Translation: BAG63075.1.
AL136221 Genomic DNA. Translation: CAI13797.1.
CH471085 Genomic DNA. Translation: EAX09202.1.
BC006345 mRNA. Translation: AAH06345.2.
BC007845 mRNA. Translation: AAH07845.2.
BC021288 mRNA. Translation: AAH21288.1.
BC093044 mRNA. Translation: AAH93044.1.
J03263 mRNA. Translation: AAA59524.1.
AH003113 Genomic DNA. Translation: AAF66141.1.
CCDSiCCDS41909.1. [P11279-1]
PIRiA31959.
RefSeqiNP_005552.3. NM_005561.3. [P11279-1]
UniGeneiHs.494419.

Genome annotation databases

EnsembliENST00000332556; ENSP00000333298; ENSG00000185896. [P11279-1]
GeneIDi3916.
KEGGihsa:3916.
UCSCiuc001vtm.2. human. [P11279-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04182 mRNA. Translation: AAA60382.1.
AK301584 mRNA. Translation: BAG63075.1.
AL136221 Genomic DNA. Translation: CAI13797.1.
CH471085 Genomic DNA. Translation: EAX09202.1.
BC006345 mRNA. Translation: AAH06345.2.
BC007845 mRNA. Translation: AAH07845.2.
BC021288 mRNA. Translation: AAH21288.1.
BC093044 mRNA. Translation: AAH93044.1.
J03263 mRNA. Translation: AAA59524.1.
AH003113 Genomic DNA. Translation: AAF66141.1.
CCDSiCCDS41909.1. [P11279-1]
PIRiA31959.
RefSeqiNP_005552.3. NM_005561.3. [P11279-1]
UniGeneiHs.494419.

3D structure databases

ProteinModelPortaliP11279.
SMRiP11279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110110. 40 interactors.
DIPiDIP-44670N.
IntActiP11279. 18 interactors.
MINTiMINT-3007678.
STRINGi9606.ENSP00000333298.

Protein family/group databases

TCDBi9.A.16.1.1. the lysosomal protein import (lpi) family.

PTM databases

iPTMnetiP11279.
PhosphoSitePlusiP11279.
SwissPalmiP11279.
UniCarbKBiP11279.

Polymorphism and mutation databases

BioMutaiLAMP1.
DMDMi206729915.

Proteomic databases

EPDiP11279.
MaxQBiP11279.
PaxDbiP11279.
PeptideAtlasiP11279.
PRIDEiP11279.
TopDownProteomicsiP11279-1. [P11279-1]

Protocols and materials databases

DNASUi3916.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332556; ENSP00000333298; ENSG00000185896. [P11279-1]
GeneIDi3916.
KEGGihsa:3916.
UCSCiuc001vtm.2. human. [P11279-1]

Organism-specific databases

CTDi3916.
DisGeNETi3916.
GeneCardsiLAMP1.
H-InvDBHIX0030831.
HGNCiHGNC:6499. LAMP1.
HPAiCAB004260.
HPA014750.
MIMi153330. gene.
neXtProtiNX_P11279.
OpenTargetsiENSG00000185896.
PharmGKBiPA30283.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP11279.
KOiK06528.
OMAiETRCEQD.
OrthoDBiEOG091G09EV.
PhylomeDBiP11279.
TreeFamiTF316339.

Enzyme and pathway databases

BioCyciZFISH:G66-33014-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiLAMP1. human.
GeneWikiiLAMP1.
GenomeRNAii3916.
PROiP11279.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185896.
CleanExiHS_LAMP1.
ExpressionAtlasiP11279. baseline and differential.
GenevisibleiP11279. HS.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP1_HUMAN
AccessioniPrimary (citable) accession number: P11279
Secondary accession number(s): B4DWL3
, Q8WU33, Q96I40, Q9BRD2, Q9NP13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 165 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.