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Protein

Breakpoint cluster region protein

Gene

BCR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1839117. Signaling by cytosolic FGFR1 fusion mutants.
R-HSA-194840. Rho GTPase cycle.
R-HSA-5655302. Signaling by FGFR1 in disease.
SignaLinkiP11274.
SIGNORiP11274.

Names & Taxonomyi

Protein namesi
Recommended name:
Breakpoint cluster region protein (EC:2.7.11.1)
Alternative name(s):
Renal carcinoma antigen NY-REN-26
Gene namesi
Name:BCR
Synonyms:BCR1, D22S11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:1014. BCR.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • postsynaptic density Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB-KW
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Leukemia, chronic myeloid (CML)3 Publications
The gene represented in this entry is involved in disease pathogenesis.
Disease descriptionA clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts.
See also OMIM:608232

A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi177 – 1771Y → F: Abolishes interaction with FES and GRB2. 2 Publications
Mutagenesisi1269 – 12713Missing : Abolishes interaction with PDZK1. 1 Publication
Mutagenesisi1271 – 12711V → A: Reduces interaction with PDZK1. 1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei426 – 4272Breakpoint for translocation to form BCR-ABL oncogene

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MalaCardsiBCR.
MIMi608232. phenotype.
Orphaneti521. Chronic myeloid leukemia.
261330. Distal 22q11.2 microdeletion syndrome.
99860. Precursor B-cell acute lymphoblastic leukemia.
99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA25321.

Chemistry

ChEMBLiCHEMBL2096618.
DrugBankiDB06616. Bosutinib.
DB08901. Ponatinib.

Polymorphism and mutation databases

BioMutaiBCR.
DMDMi143811366.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12711271Breakpoint cluster region proteinPRO_0000080933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei122 – 1221PhosphoserineCombined sources
Modified residuei139 – 1391PhosphoserineCombined sources
Modified residuei177 – 1771Phosphotyrosine; by HCKCombined sources1 Publication
Modified residuei202 – 2021PhosphoserineCombined sources
Modified residuei215 – 2151PhosphoserineCombined sources
Modified residuei222 – 2221PhosphoserineCombined sources
Modified residuei236 – 2361PhosphoserineBy similarity
Modified residuei246 – 2461Phosphotyrosine; by FES1 Publication
Modified residuei356 – 3561PhosphoserineCombined sources
Modified residuei377 – 3771PhosphoserineCombined sources
Modified residuei382 – 3821PhosphoserineBy similarity
Modified residuei385 – 3851PhosphothreonineBy similarity
Modified residuei459 – 4591PhosphoserineCombined sources
Modified residuei463 – 4631PhosphoserineCombined sources
Modified residuei473 – 4731PhosphoserineCombined sources
Modified residuei488 – 4881PhosphoserineCombined sources
Modified residuei554 – 5541PhosphotyrosineCombined sources
Modified residuei641 – 6411PhosphothreonineCombined sources
Modified residuei644 – 6441PhosphotyrosineCombined sources
Modified residuei693 – 6931PhosphothreonineCombined sources
Modified residuei894 – 8941PhosphoserineCombined sources
Modified residuei1264 – 12641PhosphoserineCombined sources

Post-translational modificationi

Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP11274.
MaxQBiP11274.
PaxDbiP11274.
PeptideAtlasiP11274.
PRIDEiP11274.

PTM databases

iPTMnetiP11274.
PhosphoSiteiP11274.

Expressioni

Gene expression databases

BgeeiENSG00000186716.
CleanExiHS_BCR.
ExpressionAtlasiP11274. baseline and differential.
GenevisibleiP11274. HS.

Organism-specific databases

HPAiCAB010421.
CAB018545.
HPA038337.

Interactioni

Subunit structurei

Homotetramer. Interacts with PDZK1. May interact with CCPG1 (By similarity). Interacts with FES/FPS, ABL1, PIK3R1 and GRB2. Interacts with HCK. Interacts with SH2D5 (PubMed:25331951).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629938EBI-712838,EBI-401755
PTPN1P180313EBI-8658094,EBI-968788
TNKS2Q9H2K23EBI-712838,EBI-4398527
TP53P046372EBI-712838,EBI-366083

Protein-protein interaction databases

BioGridi107083. 64 interactions.
IntActiP11274. 29 interactions.
MINTiMINT-1207264.
STRINGi9606.ENSP00000303507.

Chemistry

BindingDBiP11274.

Structurei

Secondary structure

1
1271
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1411Combined sources
Helixi28 – 6437Combined sources
Beta strandi1268 – 12714Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K1FX-ray2.20A/B/C/D/E/F/G/H1-72[»]
2AINNMR-B1266-1271[»]
ProteinModelPortaliP11274.
SMRiP11274. Positions 1-67, 487-771, 909-1007, 1051-1252.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11274.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini498 – 691194DHPROSITE-ProRule annotationAdd
BLAST
Domaini708 – 866159PHPROSITE-ProRule annotationAdd
BLAST
Domaini870 – 1002133C2PROSITE-ProRule annotationAdd
BLAST
Domaini1054 – 1248195Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 426426KinaseAdd
BLAST
Regioni197 – 385189Binding to ABL SH2-domainAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi824 – 8274Poly-Leu

Domaini

The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.
The DH domain is involved in interaction with CCPG1.By similarity

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4269. Eukaryota.
ENOG410XPGZ. LUCA.
GeneTreeiENSGT00840000129703.
HOGENOMiHOG000006779.
HOVERGENiHBG004165.
InParanoidiP11274.
KOiK08878.
OMAiVGGMMVE.
OrthoDBiEOG091G03M3.
PhylomeDBiP11274.
TreeFamiTF105082.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
4.10.280.30. 1 hit.
InterProiIPR015123. Bcr-Abl_oncoprot_oligo.
IPR000008. C2_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF09036. Bcr-Abl_Oligo. 1 hit.
PF00168. C2. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF69036. SSF69036. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11274-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN
60 70 80 90 100
QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA
110 120 130 140 150
PADGADPPPA EEPEARPDGE GSPGKARPGT ARRPGAAASG ERDDRGPPAS
160 170 180 190 200
VAALRSNFER IRKGHGQPGA DAEKPFYVNV EFHHERGLVK VNDKEVSDRI
210 220 230 240 250
SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC GVDGDYEDAE
260 270 280 290 300
LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ
310 320 330 340 350
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS
360 370 380 390 400
SRVSPSPTTY RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS
410 420 430 440 450
EATIVGVRKT GQIWPNDGEG AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ
460 470 480 490 500
DGLPYIDDSP SSSPHLSSKG RGSRDALVSG ALESTKASEL DLEKGLEMRK
510 520 530 540 550
WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS QQIETIFFKV
560 570 580 590 600
PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV
610 620 630 640 650
AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV
660 670 680 690 700
TRSTLVLHDL LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPRRQSMT
710 720 730 740 750
VKKGEHRQLL KDSFMVELVE GARKLRHVFL FTDLLLCTKL KKQSGGKTQQ
760 770 780 790 800
YDCKWYIPLT DLSFQMVDEL EAVPNIPLVP DEELDALKIK ISQIKNDIQR
810 820 830 840 850
EKRANKGSKA TERLKKKLSE QESLLLLMSP SMAFRVHSRN GKSYTFLISS
860 870 880 890 900
DYERAEWREN IREQQKKCFR SFSLTSVELQ MLTNSCVKLQ TVHSIPLTIN
910 920 930 940 950
KEDDESPGLY GFLNVIVHSA TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY
960 970 980 990 1000
RDTAEPNWNE EFEIELEGSQ TLRILCYEKC YNKTKIPKED GESTDRLMGK
1010 1020 1030 1040 1050
GQVQLDPQAL QDRDWQRTVI AMNGIEVKLS VKFNSREFSL KRMPSRKQTG
1060 1070 1080 1090 1100
VFGVKIAVVT KRERSKVPYI VRQCVEEIER RGMEEVGIYR VSGVATDIQA
1110 1120 1130 1140 1150
LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF TDEFYPNFAE
1160 1170 1180 1190 1200
GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKEAVNKMSL
1210 1220 1230 1240 1250
HNLATVFGPT LLRPSEKESK LPANPSQPIT MTDSWSLEVM SQVQVLLYFL
1260 1270
QLEAIPAPDS KRQSILFSTE V
Length:1,271
Mass (Da):142,819
Last modified:April 3, 2007 - v2
Checksum:i4BF66FA1E9D205FE
GO
Isoform 2 (identifier: P11274-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     961-1004: Missing.

Note: No experimental confirmation available.
Show »
Length:1,227
Mass (Da):137,729
Checksum:iEFEE4915DE3FE893
GO

Sequence cautioni

The sequence BAE06073 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti287 – 2871M → I in CAA68676 (PubMed:3285291).Curated
Sequence conflicti418 – 4181G → D in CAA68676 (PubMed:3285291).Curated
Sequence conflicti483 – 4831E → K in CAA68676 (PubMed:3285291).Curated
Sequence conflicti560 – 5601F → S in CAA68676 (PubMed:3285291).Curated
Sequence conflicti690 – 6901E → D (PubMed:2407300).Curated
Sequence conflicti733 – 7331D → E in CAA26441 (PubMed:3107980).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti400 – 4001S → P in a bladder transitional cell carcinoma sample; somatic mutation. 1 Publication
VAR_041883
Natural varianti413 – 4131I → M.1 Publication
Corresponds to variant rs56321828 [ dbSNP | Ensembl ].
VAR_041884
Natural varianti558 – 5581K → T.
Corresponds to variant rs4437065 [ dbSNP | Ensembl ].
VAR_051983
Natural varianti752 – 7521D → E.1 Publication
Corresponds to variant rs12484731 [ dbSNP | Ensembl ].
VAR_041885
Natural varianti796 – 7961N → S.5 Publications
Corresponds to variant rs140504 [ dbSNP | Ensembl ].
VAR_031552
Natural varianti910 – 9101Y → C.1 Publication
Corresponds to variant rs35537221 [ dbSNP | Ensembl ].
VAR_041886
Natural varianti949 – 9491V → I.1 Publication
Corresponds to variant rs2229038 [ dbSNP | Ensembl ].
VAR_041887
Natural varianti1037 – 10371E → K.1 Publication
Corresponds to variant rs16999516 [ dbSNP | Ensembl ].
VAR_031553
Natural varianti1091 – 10911V → M.1 Publication
Corresponds to variant rs778229520 [ dbSNP | Ensembl ].
VAR_041888
Natural varianti1096 – 10961T → A.1 Publication
Corresponds to variant rs745459086 [ dbSNP | Ensembl ].
VAR_041889
Natural varianti1104 – 11041A → G.1 Publication
Corresponds to variant rs11558696 [ dbSNP | Ensembl ].
VAR_041890
Natural varianti1106 – 11061D → N.1 Publication
VAR_041891
Natural varianti1127 – 11271T → M.
Corresponds to variant rs35812689 [ dbSNP | Ensembl ].
VAR_031554
Natural varianti1149 – 11491A → T.1 Publication
Corresponds to variant rs200099830 [ dbSNP | Ensembl ].
VAR_041892
Natural varianti1161 – 11611E → K.1 Publication
VAR_041893
Natural varianti1187 – 11871K → E.1 Publication
VAR_041894
Natural varianti1189 – 11891V → M.1 Publication
Corresponds to variant rs55816482 [ dbSNP | Ensembl ].
VAR_041895
Natural varianti1204 – 12041A → G.1 Publication
Corresponds to variant rs56265970 [ dbSNP | Ensembl ].
VAR_041896
Natural varianti1235 – 12351W → R.1 Publication
Corresponds to variant rs55719322 [ dbSNP | Ensembl ].
VAR_041897

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei961 – 100444Missing in isoform 2. 1 PublicationVSP_024352Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00661 mRNA. Translation: CAA68676.1.
U07000 Genomic DNA. Translation: AAB60388.1.
AB209991 mRNA. Translation: BAE06073.1. Different initiation.
X02596 mRNA. Translation: CAA26441.1.
M15025 Genomic DNA. Translation: AAA35594.1.
X52828 Genomic DNA. Translation: CAA37010.1.
X52829 Genomic DNA. Translation: CAA37011.1.
X14676 mRNA. Translation: CAA32806.1.
M64437 mRNA. No translation available.
CCDSiCCDS13806.1. [P11274-1]
CCDS13807.1. [P11274-2]
PIRiA26664. TVHUA2.
A91064. TVHUBR.
RefSeqiNP_004318.3. NM_004327.3. [P11274-1]
NP_067585.2. NM_021574.2. [P11274-2]
UniGeneiHs.517461.
Hs.715409.

Genome annotation databases

EnsembliENST00000305877; ENSP00000303507; ENSG00000186716. [P11274-1]
ENST00000359540; ENSP00000352535; ENSG00000186716. [P11274-2]
GeneIDi613.
KEGGihsa:613.
UCSCiuc002zww.4. human. [P11274-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00661 mRNA. Translation: CAA68676.1.
U07000 Genomic DNA. Translation: AAB60388.1.
AB209991 mRNA. Translation: BAE06073.1. Different initiation.
X02596 mRNA. Translation: CAA26441.1.
M15025 Genomic DNA. Translation: AAA35594.1.
X52828 Genomic DNA. Translation: CAA37010.1.
X52829 Genomic DNA. Translation: CAA37011.1.
X14676 mRNA. Translation: CAA32806.1.
M64437 mRNA. No translation available.
CCDSiCCDS13806.1. [P11274-1]
CCDS13807.1. [P11274-2]
PIRiA26664. TVHUA2.
A91064. TVHUBR.
RefSeqiNP_004318.3. NM_004327.3. [P11274-1]
NP_067585.2. NM_021574.2. [P11274-2]
UniGeneiHs.517461.
Hs.715409.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K1FX-ray2.20A/B/C/D/E/F/G/H1-72[»]
2AINNMR-B1266-1271[»]
ProteinModelPortaliP11274.
SMRiP11274. Positions 1-67, 487-771, 909-1007, 1051-1252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107083. 64 interactions.
IntActiP11274. 29 interactions.
MINTiMINT-1207264.
STRINGi9606.ENSP00000303507.

Chemistry

BindingDBiP11274.
ChEMBLiCHEMBL2096618.
DrugBankiDB06616. Bosutinib.
DB08901. Ponatinib.

PTM databases

iPTMnetiP11274.
PhosphoSiteiP11274.

Polymorphism and mutation databases

BioMutaiBCR.
DMDMi143811366.

Proteomic databases

EPDiP11274.
MaxQBiP11274.
PaxDbiP11274.
PeptideAtlasiP11274.
PRIDEiP11274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305877; ENSP00000303507; ENSG00000186716. [P11274-1]
ENST00000359540; ENSP00000352535; ENSG00000186716. [P11274-2]
GeneIDi613.
KEGGihsa:613.
UCSCiuc002zww.4. human. [P11274-1]

Organism-specific databases

CTDi613.
GeneCardsiBCR.
H-InvDBHIX0016226.
HIX0016271.
HIX0027936.
HIX0041406.
HGNCiHGNC:1014. BCR.
HPAiCAB010421.
CAB018545.
HPA038337.
MalaCardsiBCR.
MIMi151410. gene.
608232. phenotype.
neXtProtiNX_P11274.
Orphaneti521. Chronic myeloid leukemia.
261330. Distal 22q11.2 microdeletion syndrome.
99860. Precursor B-cell acute lymphoblastic leukemia.
99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA25321.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4269. Eukaryota.
ENOG410XPGZ. LUCA.
GeneTreeiENSGT00840000129703.
HOGENOMiHOG000006779.
HOVERGENiHBG004165.
InParanoidiP11274.
KOiK08878.
OMAiVGGMMVE.
OrthoDBiEOG091G03M3.
PhylomeDBiP11274.
TreeFamiTF105082.

Enzyme and pathway databases

ReactomeiR-HSA-1839117. Signaling by cytosolic FGFR1 fusion mutants.
R-HSA-194840. Rho GTPase cycle.
R-HSA-5655302. Signaling by FGFR1 in disease.
SignaLinkiP11274.
SIGNORiP11274.

Miscellaneous databases

ChiTaRSiBCR. human.
EvolutionaryTraceiP11274.
GeneWikiiBCR_(gene).
GenomeRNAii613.
PROiP11274.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186716.
CleanExiHS_BCR.
ExpressionAtlasiP11274. baseline and differential.
GenevisibleiP11274. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
4.10.280.30. 1 hit.
InterProiIPR015123. Bcr-Abl_oncoprot_oligo.
IPR000008. C2_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF09036. Bcr-Abl_Oligo. 1 hit.
PF00168. C2. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF69036. SSF69036. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCR_HUMAN
AccessioniPrimary (citable) accession number: P11274
Secondary accession number(s): P78501
, Q12842, Q4LE80, Q6NZI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 197 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.