P11273 (ERBB_AVIEU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase transforming protein erbB
EC=2.7.10.1

Gene names

Name:

V-ERBB

Organism

Avian erythroblastosis virus (strain ts167)

Taxonomic identifier

103898 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Alpharetrovirus

Virus host

Galliformes [TaxID: 8976]

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Disease	Oncogene
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 540	540	Tyrosine-protein kinase transforming protein erbB		PRO_0000160253
Regions
	Domain	132 – 399	268	Protein kinase
	Nucleotide binding	138 – 146	9	ATP By similarity
Sites
	Active site	257	1	Proton acceptor By similarity
	Binding site	165	1	ATP By similarity
Natural variations
	Natural variant	270	1	H → D in thermolabile v-erbB.

Sequences

	Sequence		Length	Mass (Da)
	P11273 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 5B53297AA068B65D	FASTA	540	60,413
	10 20 30 40 50 60 MKCAHFIDGP HCVKACPAGV LGENDTLVWK YADANAVCQL CHPNCTRGCK GPGLEGCPNG 70 80 90 100 110 120 SKTPSIAAGV VGGLLCLVVV GLGIGLYLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN 130 140 150 160 170 180 QAHLRILKET EFKKVKVLGF GAFGTVYKGL WIPEGEKVTI PVAIKELREA TSPKANKEIL 190 200 210 220 230 240 DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPYGCLLD YIREHKDNIG SQYLLNWCVQ 250 260 270 280 290 300 IAKGMNYLEE RHMVHRDLAA RNVLVKTPQH VKITDFGLAK QLGADEKEYH AEGGKVPIKW 310 320 330 340 350 360 MALESILHRI YTHQSDVWSY GVTVWELMTF GSKPYDGIPA SEISSVLEKG ERLPQPPICT 370 380 390 400 410 420 IDVYMIMVKC WMSDADSRPK FRELIAEFSK MARDPPRYLV IQGDERMHLP SPTDSKFYRT 430 440 450 460 470 480 LMEEEDMEDI VDADEYLVPH QGFFNSPSTS RTPLLSSLSA TSNNSATNCI DRNGGHPVRE 490 500 510 520 530 540 DGFLPAPEYV NQLMPKKPST AMVQNQIYNY ISLTAISKLP IDSRYQNSHS TAVDNPEYLE

References

[1]	"A single amino acid substitution in v-erbB confers a thermolabile phenotype to ts167 avian erythroblastosis virus-transformed erythroid cells." Choi O.R., Trainor C., Graf T., Beug H., Engel J.D. Mol. Cell. Biol. 6:1751-1759(1986) [PubMed: 2878364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M13179 Genomic RNA. Translation: AAA42401.1.
PIR	TVFVEB. A25231.
3D structure databases
ProteinModelPortal	P11273.
SMR	P11273. Positions 1-58, 89-423.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.10.1. 589.
Family and domain databases
InterPro	IPR009030. Growth_fac_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERBB_AVIEU

Accession

Primary (citable) accession number: P11273

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	July 27, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program